Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01612:Cdk15'

92164

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cdk15

Ensembl Gene

ENSMUSG00000026023

Gene Name

cyclin dependent kinase 15

Synonyms

Pftk2, Als2cr7

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01612

Quality Score

Status

Chromosome

Chromosomal Location

59296029-59391656 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 59328932 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 282 (D282G)

Ref Sequence

ENSEMBL: ENSMUSP00000124680 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000114248] [ENSMUST00000160662]

AlphaFold

Q3V3A1

Predicted Effect

possibly damaging
Transcript: ENSMUST00000114248
AA Change: D280G

PolyPhen 2 Score 0.925 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000109886
Gene: ENSMUSG00000026023
AA Change: D280G

Domain	Start	End	E-Value	Type
S_TKc	101	385	7.9e-86	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000160662
AA Change: D282G

PolyPhen 2 Score 0.925 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000124680
Gene: ENSMUSG00000026023
AA Change: D282G

Domain	Start	End	E-Value	Type
S_TKc	103	387	7.9e-86	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3425401B19Rik	T	C	14: 32,381,988 (GRCm39)	T1326A	possibly damaging	Het
Afg3l1	C	T	8: 124,221,592 (GRCm39)	R484C	probably benign	Het
Atg2a	C	A	19: 6,302,514 (GRCm39)	Q946K	probably benign	Het
Cdh20	T	C	1: 104,921,895 (GRCm39)	Y731H	probably benign	Het
Ctnnd2	T	C	15: 31,005,164 (GRCm39)	S1073P	probably damaging	Het
Dnah2	T	C	11: 69,355,889 (GRCm39)		probably benign	Het
Evi2a	T	A	11: 79,417,978 (GRCm39)	R211W	probably damaging	Het
Fmo1	T	A	1: 162,661,168 (GRCm39)	I372F	probably benign	Het
Glyctk	T	C	9: 106,032,471 (GRCm39)	D514G	probably damaging	Het
Gmnc	G	A	16: 26,779,069 (GRCm39)	Q313*	probably null	Het
Grik1	T	C	16: 87,743,623 (GRCm39)	T520A	probably damaging	Het
Gtsf2	A	T	15: 103,353,340 (GRCm39)	C9S	probably damaging	Het
Ift80	T	G	3: 68,870,996 (GRCm39)	N200T	possibly damaging	Het
Ints1	A	G	5: 139,742,047 (GRCm39)	S1771P	probably benign	Het
Lrba	A	G	3: 86,683,484 (GRCm39)	T2769A	possibly damaging	Het
Lrfn2	G	T	17: 49,377,425 (GRCm39)	V169L	possibly damaging	Het
Mei1	G	A	15: 81,973,753 (GRCm39)	R80H	probably damaging	Het
Nbeal2	A	T	9: 110,473,746 (GRCm39)	V31E	probably damaging	Het
Ncapd2	G	T	6: 125,154,835 (GRCm39)	P546T	probably benign	Het
Or52l1	A	G	7: 104,829,929 (GRCm39)	V212A	probably damaging	Het
Pan3	T	C	5: 147,390,052 (GRCm39)		probably benign	Het
Rab3b	T	A	4: 108,781,223 (GRCm39)		probably null	Het
Rabl2	T	C	15: 89,467,615 (GRCm39)	K119E	probably benign	Het
Reln	A	G	5: 22,101,928 (GRCm39)	V3334A	probably damaging	Het
Rfx1	A	G	8: 84,819,601 (GRCm39)		probably null	Het
Rhod	T	C	19: 4,476,247 (GRCm39)	Y168C	probably damaging	Het
Sag	T	C	1: 87,733,071 (GRCm39)	I13T	probably damaging	Het
Sat2	T	C	11: 69,513,789 (GRCm39)		probably null	Het
Scn5a	A	T	9: 119,315,091 (GRCm39)	D1872E	possibly damaging	Het
Sh2b2	T	G	5: 136,260,656 (GRCm39)	I187L	probably benign	Het
Slit3	G	A	11: 35,591,211 (GRCm39)	G1341D	possibly damaging	Het
Tmed11	A	T	5: 108,927,750 (GRCm39)	S95T	possibly damaging	Het
Tmem186	A	G	16: 8,453,733 (GRCm39)	V176A	possibly damaging	Het
Trim12c	A	T	7: 103,997,422 (GRCm39)	S45T	possibly damaging	Het
Ube4b	C	A	4: 149,468,275 (GRCm39)	R167L	probably damaging	Het
Zfp335	A	T	2: 164,752,540 (GRCm39)		probably null	Het

Other mutations in Cdk15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01307:Cdk15	APN	1	59,326,955 (GRCm39)	missense	probably benign	0.37
IGL02179:Cdk15	APN	1	59,370,100 (GRCm39)	missense	possibly damaging	0.84
IGL03228:Cdk15	APN	1	59,297,912 (GRCm39)	missense	possibly damaging	0.95
FR4449:Cdk15	UTSW	1	59,296,982 (GRCm39)	small insertion	probably benign
R0270:Cdk15	UTSW	1	59,349,965 (GRCm39)	missense	probably damaging	0.99
R1720:Cdk15	UTSW	1	59,328,917 (GRCm39)	missense	probably damaging	1.00
R1958:Cdk15	UTSW	1	59,383,475 (GRCm39)	missense	probably damaging	0.99
R1969:Cdk15	UTSW	1	59,370,110 (GRCm39)	missense	probably damaging	1.00
R3159:Cdk15	UTSW	1	59,340,440 (GRCm39)	missense	probably damaging	1.00
R6000:Cdk15	UTSW	1	59,328,818 (GRCm39)	missense	probably damaging	1.00
R6226:Cdk15	UTSW	1	59,304,792 (GRCm39)	missense	probably damaging	1.00
R6257:Cdk15	UTSW	1	59,296,264 (GRCm39)	critical splice donor site	probably null
R7184:Cdk15	UTSW	1	59,304,814 (GRCm39)	missense	probably benign	0.33
R7446:Cdk15	UTSW	1	59,328,854 (GRCm39)	missense	probably damaging	1.00
R7467:Cdk15	UTSW	1	59,328,938 (GRCm39)	missense	probably null	0.96
R7588:Cdk15	UTSW	1	59,383,458 (GRCm39)	missense	possibly damaging	0.95
R8540:Cdk15	UTSW	1	59,349,992 (GRCm39)	missense	possibly damaging	0.93
R9024:Cdk15	UTSW	1	59,326,957 (GRCm39)	missense	probably damaging	1.00
R9372:Cdk15	UTSW	1	59,370,142 (GRCm39)	missense	probably benign	0.00
R9404:Cdk15	UTSW	1	59,328,914 (GRCm39)	missense	possibly damaging	0.55
R9493:Cdk15	UTSW	1	59,326,943 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-12-09