Incidental Mutation 'IGL01612:Cdk15'
ID92164
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdk15
Ensembl Gene ENSMUSG00000026023
Gene Namecyclin-dependent kinase 15
SynonymsAls2cr7, Pftk2
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01612
Quality Score
Status
Chromosome1
Chromosomal Location59256906-59352993 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 59289773 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 282 (D282G)
Ref Sequence ENSEMBL: ENSMUSP00000124680 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114248] [ENSMUST00000160662]
Predicted Effect possibly damaging
Transcript: ENSMUST00000114248
AA Change: D280G

PolyPhen 2 Score 0.925 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000109886
Gene: ENSMUSG00000026023
AA Change: D280G

DomainStartEndE-ValueType
S_TKc 101 385 7.9e-86 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000160662
AA Change: D282G

PolyPhen 2 Score 0.925 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000124680
Gene: ENSMUSG00000026023
AA Change: D282G

DomainStartEndE-ValueType
S_TKc 103 387 7.9e-86 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik T C 14: 32,660,031 T1326A possibly damaging Het
Afg3l1 C T 8: 123,494,853 R484C probably benign Het
Atg2a C A 19: 6,252,484 Q946K probably benign Het
Cdh20 T C 1: 104,994,170 Y731H probably benign Het
Ctnnd2 T C 15: 31,005,018 S1073P probably damaging Het
Dnah2 T C 11: 69,465,063 probably benign Het
Evi2a T A 11: 79,527,152 R211W probably damaging Het
Fmo1 T A 1: 162,833,599 I372F probably benign Het
Glyctk T C 9: 106,155,272 D514G probably damaging Het
Gmnc G A 16: 26,960,319 Q313* probably null Het
Grik1 T C 16: 87,946,735 T520A probably damaging Het
Gtsf2 A T 15: 103,444,913 C9S probably damaging Het
Ift80 T G 3: 68,963,663 N200T possibly damaging Het
Ints1 A G 5: 139,756,292 S1771P probably benign Het
Lrba A G 3: 86,776,177 T2769A possibly damaging Het
Lrfn2 G T 17: 49,070,397 V169L possibly damaging Het
Mei1 G A 15: 82,089,552 R80H probably damaging Het
Nbeal2 A T 9: 110,644,678 V31E probably damaging Het
Ncapd2 G T 6: 125,177,872 P546T probably benign Het
Olfr685 A G 7: 105,180,722 V212A probably damaging Het
Pan3 T C 5: 147,453,242 probably benign Het
Rab3b T A 4: 108,924,026 probably null Het
Rabl2 T C 15: 89,583,412 K119E probably benign Het
Reln A G 5: 21,896,930 V3334A probably damaging Het
Rfx1 A G 8: 84,092,972 probably null Het
Rhod T C 19: 4,426,219 Y168C probably damaging Het
Sag T C 1: 87,805,349 I13T probably damaging Het
Sat2 T C 11: 69,622,963 probably null Het
Scn5a A T 9: 119,486,025 D1872E possibly damaging Het
Sh2b2 T G 5: 136,231,802 I187L probably benign Het
Slit3 G A 11: 35,700,384 G1341D possibly damaging Het
Tmed11 A T 5: 108,779,884 S95T possibly damaging Het
Tmem186 A G 16: 8,635,869 V176A possibly damaging Het
Trim12c A T 7: 104,348,215 S45T possibly damaging Het
Ube4b C A 4: 149,383,818 R167L probably damaging Het
Zfp335 A T 2: 164,910,620 probably null Het
Other mutations in Cdk15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01307:Cdk15 APN 1 59287796 missense probably benign 0.37
IGL02179:Cdk15 APN 1 59330941 missense possibly damaging 0.84
IGL03228:Cdk15 APN 1 59258753 missense possibly damaging 0.95
FR4449:Cdk15 UTSW 1 59257823 small insertion probably benign
R0270:Cdk15 UTSW 1 59310806 missense probably damaging 0.99
R1720:Cdk15 UTSW 1 59289758 missense probably damaging 1.00
R1958:Cdk15 UTSW 1 59344316 missense probably damaging 0.99
R1969:Cdk15 UTSW 1 59330951 missense probably damaging 1.00
R3159:Cdk15 UTSW 1 59301281 missense probably damaging 1.00
R6000:Cdk15 UTSW 1 59289659 missense probably damaging 1.00
R6226:Cdk15 UTSW 1 59265633 missense probably damaging 1.00
R6257:Cdk15 UTSW 1 59257105 critical splice donor site probably null
R7184:Cdk15 UTSW 1 59265655 missense probably benign 0.33
R7446:Cdk15 UTSW 1 59289695 missense probably damaging 1.00
R7467:Cdk15 UTSW 1 59289779 missense probably null 0.96
Posted On2013-12-09