Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01614:Mettl14'

92336

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mettl14

Ensembl Gene

ENSMUSG00000028114

Gene Name

methyltransferase 14, N6-adenosine-methyltransferase subunit

Synonyms

G430022H21Rik

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL01614

Quality Score

Status

Chromosome

Chromosomal Location

123161944-123179639 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 123167609 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000134198 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000029759] [ENSMUST00000090371] [ENSMUST00000174006] [ENSMUST00000174323]

AlphaFold

Q3UIK4

Predicted Effect

probably benign
Transcript: ENSMUST00000029759

SMART Domains

Protein: ENSMUSP00000029759
Gene: ENSMUSG00000028114

Domain	Start	End	E-Value	Type
low complexity region	4	23	N/A	INTRINSIC
coiled coil region	65	90	N/A	INTRINSIC
Pfam:MT-A70	186	363	2.7e-66	PFAM
low complexity region	397	406	N/A	INTRINSIC
low complexity region	408	452	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000090371

SMART Domains

Protein: ENSMUSP00000087848
Gene: ENSMUSG00000028114

Domain	Start	End	E-Value	Type
low complexity region	4	23	N/A	INTRINSIC
coiled coil region	65	90	N/A	INTRINSIC
Pfam:MT-A70	186	289	3e-33	PFAM
low complexity region	310	319	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000174006

SMART Domains

Protein: ENSMUSP00000133741
Gene: ENSMUSG00000028114

Domain	Start	End	E-Value	Type
low complexity region	4	13	N/A	INTRINSIC
Pfam:MT-A70	28	146	6e-45	PFAM
low complexity region	180	189	N/A	INTRINSIC
low complexity region	191	202	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000174323

SMART Domains

Protein: ENSMUSP00000134198
Gene: ENSMUSG00000028114

Domain	Start	End	E-Value	Type
low complexity region	4	23	N/A	INTRINSIC
coiled coil region	65	90	N/A	INTRINSIC
Pfam:MT-A70	186	360	7.3e-63	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrf5	T	A	17: 43,735,362 (GRCm39)	S143T	possibly damaging	Het
Arhgap32	G	T	9: 32,171,801 (GRCm39)	S1527I	probably damaging	Het
Atp8a2	A	G	14: 60,282,437 (GRCm39)	V128A	probably damaging	Het
Bpi	T	C	2: 158,113,866 (GRCm39)	F255L	probably damaging	Het
Clptm1	A	T	7: 19,371,625 (GRCm39)	D269E	probably benign	Het
Cyria	T	C	12: 12,411,574 (GRCm39)		probably null	Het
E2f7	T	C	10: 110,595,839 (GRCm39)	V63A	probably damaging	Het
Eif4e1b	T	A	13: 54,934,729 (GRCm39)	I184N	probably damaging	Het
Gal3st1	T	A	11: 3,948,996 (GRCm39)	L401Q	probably damaging	Het
Gm7808	G	A	9: 19,839,442 (GRCm39)		probably benign	Het
Hdac5	G	A	11: 102,090,854 (GRCm39)	T741I	probably benign	Het
Ipo5	A	G	14: 121,172,507 (GRCm39)	T522A	probably benign	Het
Lama5	A	C	2: 179,822,657 (GRCm39)	F2832V	probably damaging	Het
Ltk	A	C	2: 119,583,968 (GRCm39)	L230R	probably damaging	Het
Myom1	T	C	17: 71,433,173 (GRCm39)	F1507L	possibly damaging	Het
Nsd3	T	A	8: 26,156,095 (GRCm39)	I554K	possibly damaging	Het
Or1j12	T	G	2: 36,342,636 (GRCm39)	I13S	probably benign	Het
Or1o1	G	A	17: 37,716,529 (GRCm39)	C30Y	probably benign	Het
Or51a43	C	T	7: 103,717,576 (GRCm39)	V221I	probably benign	Het
Or8u9	A	T	2: 86,001,741 (GRCm39)	I140N	possibly damaging	Het
Prr14	T	A	7: 127,074,305 (GRCm39)	L279H	probably damaging	Het
Rbm25	G	T	12: 83,706,341 (GRCm39)	D229Y	probably damaging	Het
Sdk2	T	C	11: 113,684,684 (GRCm39)	K1926E	probably damaging	Het
Slc25a23	C	T	17: 57,352,579 (GRCm39)	R435Q	probably null	Het
Srebf2	A	G	15: 82,063,054 (GRCm39)	N457S	probably benign	Het
Stac2	T	C	11: 97,943,774 (GRCm39)	D12G	probably benign	Het
Tal1	A	C	4: 114,920,325 (GRCm39)		probably null	Het
Usp25	G	A	16: 76,874,005 (GRCm39)	R527Q	probably damaging	Het

Other mutations in Mettl14

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00718:Mettl14	APN	3	123,164,988 (GRCm39)	missense	probably damaging	1.00
IGL00846:Mettl14	APN	3	123,165,012 (GRCm39)	missense	probably damaging	1.00
IGL02219:Mettl14	APN	3	123,168,540 (GRCm39)	splice site	probably benign
IGL02960:Mettl14	APN	3	123,168,534 (GRCm39)	missense	probably damaging	1.00
R0147:Mettl14	UTSW	3	123,165,043 (GRCm39)	missense	probably damaging	1.00
R0148:Mettl14	UTSW	3	123,165,043 (GRCm39)	missense	probably damaging	1.00
R0266:Mettl14	UTSW	3	123,176,475 (GRCm39)	missense	probably benign	0.05
R0468:Mettl14	UTSW	3	123,165,061 (GRCm39)	missense	probably damaging	1.00
R0543:Mettl14	UTSW	3	123,168,411 (GRCm39)	missense	possibly damaging	0.65
R1181:Mettl14	UTSW	3	123,167,651 (GRCm39)	missense	probably damaging	1.00
R1463:Mettl14	UTSW	3	123,167,722 (GRCm39)	splice site	probably benign
R4256:Mettl14	UTSW	3	123,177,254 (GRCm39)	missense	probably damaging	1.00
R4679:Mettl14	UTSW	3	123,163,063 (GRCm39)	utr 3 prime	probably benign
R4845:Mettl14	UTSW	3	123,165,004 (GRCm39)	missense	probably damaging	1.00
R5163:Mettl14	UTSW	3	123,168,474 (GRCm39)	missense	possibly damaging	0.90
R6476:Mettl14	UTSW	3	123,167,686 (GRCm39)	missense	probably damaging	1.00
R7499:Mettl14	UTSW	3	123,168,503 (GRCm39)	missense	probably benign	0.30
R7682:Mettl14	UTSW	3	123,177,253 (GRCm39)	missense	possibly damaging	0.86
R7808:Mettl14	UTSW	3	123,166,234 (GRCm39)	missense	possibly damaging	0.46
R8044:Mettl14	UTSW	3	123,163,309 (GRCm39)	missense	probably benign	0.14
R8381:Mettl14	UTSW	3	123,168,447 (GRCm39)	missense	probably damaging	1.00
R8955:Mettl14	UTSW	3	123,167,693 (GRCm39)	missense	probably benign	0.39
R9518:Mettl14	UTSW	3	123,167,687 (GRCm39)	missense	probably benign	0.16

Posted On

2013-12-09