Incidental Mutation 'IGL01617:Rufy4'
ID 92414
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rufy4
Ensembl Gene ENSMUSG00000061815
Gene Name RUN and FYVE domain containing 4
Synonyms F930048N03Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.202) question?
Stock # IGL01617
Quality Score
Status
Chromosome 1
Chromosomal Location 74164700-74187382 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 74168513 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Arginine at position 99 (G99R)
Ref Sequence ENSEMBL: ENSMUSP00000115873 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080167] [ENSMUST00000127134] [ENSMUST00000169786] [ENSMUST00000191104] [ENSMUST00000212888]
AlphaFold Q3TYX8
Predicted Effect probably damaging
Transcript: ENSMUST00000080167
AA Change: G15R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000079062
Gene: ENSMUSG00000061815
AA Change: G15R

DomainStartEndE-ValueType
Pfam:RUN 2 81 1.5e-8 PFAM
coiled coil region 331 404 N/A INTRINSIC
Blast:FYVE 415 472 2e-6 BLAST
SCOP:d1vfya_ 428 473 4e-7 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000127134
AA Change: G99R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000115873
Gene: ENSMUSG00000061815
AA Change: G99R

DomainStartEndE-ValueType
Pfam:RUN 41 165 6.2e-10 PFAM
coiled coil region 415 488 N/A INTRINSIC
Blast:FYVE 499 556 2e-6 BLAST
SCOP:d1vfya_ 512 557 3e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000169786
SMART Domains Protein: ENSMUSP00000127715
Gene: ENSMUSG00000055322

DomainStartEndE-ValueType
low complexity region 15 33 N/A INTRINSIC
C1 62 108 1.77e-2 SMART
low complexity region 154 167 N/A INTRINSIC
SCOP:d1d5ra2 176 348 3e-32 SMART
PTEN_C2 350 477 1.12e-51 SMART
low complexity region 822 833 N/A INTRINSIC
low complexity region 905 922 N/A INTRINSIC
low complexity region 1227 1239 N/A INTRINSIC
low complexity region 1284 1300 N/A INTRINSIC
low complexity region 1459 1470 N/A INTRINSIC
low complexity region 1518 1530 N/A INTRINSIC
SH2 1614 1716 6.85e-17 SMART
PTB 1747 1888 1.69e-29 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000191104
SMART Domains Protein: ENSMUSP00000140317
Gene: ENSMUSG00000055322

DomainStartEndE-ValueType
low complexity region 15 33 N/A INTRINSIC
C1 62 108 8.6e-5 SMART
low complexity region 154 167 N/A INTRINSIC
PTPc_DSPc 241 363 9.9e-6 SMART
PTEN_C2 350 477 5.6e-56 SMART
low complexity region 822 833 N/A INTRINSIC
low complexity region 905 922 N/A INTRINSIC
low complexity region 1206 1218 N/A INTRINSIC
low complexity region 1263 1279 N/A INTRINSIC
low complexity region 1438 1449 N/A INTRINSIC
low complexity region 1497 1509 N/A INTRINSIC
SH2 1593 1695 4.3e-19 SMART
PTB 1726 1867 9e-32 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000212888
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass T A 6: 23,115,149 (GRCm39) I160F possibly damaging Het
Cacna1d C T 14: 29,824,328 (GRCm39) A1030T probably damaging Het
Ceacam13 A T 7: 17,745,308 (GRCm39) D126V possibly damaging Het
Cep68 G T 11: 20,189,510 (GRCm39) Q501K probably benign Het
Cfhr1 A T 1: 139,481,417 (GRCm39) C154* probably null Het
Chd3 A G 11: 69,249,060 (GRCm39) probably benign Het
Chrna5 A G 9: 54,912,297 (GRCm39) M262V probably damaging Het
Csrnp2 T C 15: 100,382,524 (GRCm39) Y172C probably benign Het
Dzip1 G T 14: 119,118,477 (GRCm39) P752Q probably benign Het
Frem1 G A 4: 82,854,376 (GRCm39) T1630I probably benign Het
Gabrr1 G A 4: 33,162,634 (GRCm39) S400N probably benign Het
Hmcn1 C T 1: 150,547,783 (GRCm39) A2723T probably benign Het
Htt A G 5: 35,034,099 (GRCm39) H1895R possibly damaging Het
Kif21a T C 15: 90,879,840 (GRCm39) probably benign Het
Mitf A G 6: 97,973,389 (GRCm39) I241V probably benign Het
Mterf1b A T 5: 4,246,503 (GRCm39) D48V probably benign Het
Nmbr G T 10: 14,646,173 (GRCm39) R349M probably benign Het
Pik3r4 T C 9: 105,532,164 (GRCm39) S579P probably benign Het
Polr2i T C 7: 29,931,817 (GRCm39) F16S possibly damaging Het
Psmg2 G A 18: 67,786,293 (GRCm39) V218I probably benign Het
Rgs11 A G 17: 26,427,224 (GRCm39) H385R probably damaging Het
Slc29a1 A G 17: 45,900,375 (GRCm39) F185S probably benign Het
Spag17 G A 3: 100,016,824 (GRCm39) V2200I possibly damaging Het
Trappc14 A T 5: 138,260,478 (GRCm39) L47Q probably damaging Het
Ttc7b G T 12: 100,352,215 (GRCm39) A414D possibly damaging Het
Ugt2b37 A T 5: 87,399,738 (GRCm39) W257R probably damaging Het
Ythdc2 A G 18: 44,974,482 (GRCm39) I381M possibly damaging Het
Other mutations in Rufy4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02075:Rufy4 APN 1 74,168,518 (GRCm39) missense probably damaging 1.00
IGL02604:Rufy4 APN 1 74,173,348 (GRCm39) missense probably damaging 1.00
IGL02606:Rufy4 APN 1 74,172,509 (GRCm39) splice site probably benign
IGL02928:Rufy4 APN 1 74,168,241 (GRCm39) unclassified probably benign
R0091:Rufy4 UTSW 1 74,168,095 (GRCm39) unclassified probably benign
R0507:Rufy4 UTSW 1 74,185,875 (GRCm39) missense probably benign 0.02
R0589:Rufy4 UTSW 1 74,172,042 (GRCm39) missense probably damaging 1.00
R0595:Rufy4 UTSW 1 74,180,089 (GRCm39) missense possibly damaging 0.94
R0742:Rufy4 UTSW 1 74,185,875 (GRCm39) missense probably benign 0.02
R1533:Rufy4 UTSW 1 74,169,002 (GRCm39) critical splice donor site probably null
R1666:Rufy4 UTSW 1 74,186,837 (GRCm39) missense probably benign 0.06
R1668:Rufy4 UTSW 1 74,186,837 (GRCm39) missense probably benign 0.06
R1827:Rufy4 UTSW 1 74,173,279 (GRCm39) missense probably damaging 1.00
R2018:Rufy4 UTSW 1 74,180,106 (GRCm39) missense possibly damaging 0.49
R2095:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R2306:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R2307:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R2472:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R2475:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R3022:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R3054:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R3055:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R3056:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R3117:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R3118:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R3236:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R3237:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R3545:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R3546:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R3547:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R3548:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R3767:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R3768:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R3770:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R3816:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R3817:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R3818:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R3819:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R3895:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4050:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4091:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4117:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4124:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4125:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4127:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4231:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4233:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4234:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4236:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4254:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4255:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4319:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4320:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4321:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4321:Rufy4 UTSW 1 74,171,943 (GRCm39) missense possibly damaging 0.93
R4322:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4323:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4324:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4360:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4361:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4406:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4408:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4516:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4517:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4520:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4522:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4524:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4531:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4533:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4617:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4661:Rufy4 UTSW 1 74,172,266 (GRCm39) missense probably damaging 0.99
R4778:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4779:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4840:Rufy4 UTSW 1 74,168,198 (GRCm39) missense possibly damaging 0.82
R4897:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4898:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4899:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4915:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4917:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4918:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R4997:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R5092:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R5097:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R5189:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R5191:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R5195:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R5196:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R5197:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R5226:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R5227:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R5228:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R5230:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R5372:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R5373:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R5374:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R5375:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R5376:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R5377:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R5378:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R5699:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R5748:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R5750:Rufy4 UTSW 1 74,172,068 (GRCm39) missense probably benign 0.01
R5767:Rufy4 UTSW 1 74,186,822 (GRCm39) missense probably damaging 0.99
R5865:Rufy4 UTSW 1 74,185,914 (GRCm39) missense probably damaging 0.99
R6083:Rufy4 UTSW 1 74,168,556 (GRCm39) missense probably damaging 0.99
R6149:Rufy4 UTSW 1 74,186,892 (GRCm39) missense probably benign 0.15
R6279:Rufy4 UTSW 1 74,172,383 (GRCm39) missense probably benign 0.00
R6300:Rufy4 UTSW 1 74,172,383 (GRCm39) missense probably benign 0.00
R6629:Rufy4 UTSW 1 74,171,526 (GRCm39) splice site probably null
R6809:Rufy4 UTSW 1 74,172,206 (GRCm39) missense probably benign 0.00
R7179:Rufy4 UTSW 1 74,172,035 (GRCm39) missense probably benign 0.12
R7218:Rufy4 UTSW 1 74,172,174 (GRCm39) missense probably damaging 0.99
R7453:Rufy4 UTSW 1 74,168,493 (GRCm39) splice site probably null
R9377:Rufy4 UTSW 1 74,171,879 (GRCm39) missense probably benign 0.08
X0023:Rufy4 UTSW 1 74,180,208 (GRCm39) missense probably benign 0.04
X0025:Rufy4 UTSW 1 74,172,178 (GRCm39) missense probably benign
Posted On 2013-12-09