Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01619:Prss29'

92538

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prss29

Ensembl Gene

ENSMUSG00000034039

Gene Name

serine protease 29

Synonyms

mISP-2, Isp2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

IGL01619

Quality Score

Status

Chromosome

Chromosomal Location

25537628-25541658 bp(+) (GRCm39)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

T to C at 25540113 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000024993 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000024993]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000024993

SMART Domains

Protein: ENSMUSP00000024993
Gene: ENSMUSG00000034039

Domain	Start	End	E-Value	Type
signal peptide	1	17	N/A	INTRINSIC
Tryp_SPc	30	271	7.11e-89	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankrd46	T	C	15: 36,486,113 (GRCm39)	T47A	possibly damaging	Het
Asxl3	T	G	18: 22,656,385 (GRCm39)	V1465G	probably damaging	Het
Celsr3	A	T	9: 108,711,756 (GRCm39)	D1657V	probably damaging	Het
Celsr3	A	G	9: 108,714,603 (GRCm39)	H1995R	probably benign	Het
Cimip2b	G	A	4: 43,427,814 (GRCm39)	T170I	possibly damaging	Het
Cntn6	G	A	6: 104,705,335 (GRCm39)		probably benign	Het
Def6	C	T	17: 28,426,838 (GRCm39)	L8F	probably damaging	Het
Dnah9	T	A	11: 65,722,441 (GRCm39)	K1940*	probably null	Het
Dock10	A	G	1: 80,612,015 (GRCm39)		probably benign	Het
Fam72a	A	G	1: 131,461,650 (GRCm39)	I112V	probably benign	Het
Fgl1	A	T	8: 41,650,008 (GRCm39)	W258R	probably damaging	Het
Ints6l	G	T	X: 55,542,104 (GRCm39)		probably benign	Het
Lifr	A	T	15: 7,220,643 (GRCm39)	N1091I	probably damaging	Het
Mga	T	C	2: 119,762,309 (GRCm39)	I1100T	possibly damaging	Het
Mrpl40	T	A	16: 18,691,294 (GRCm39)	M139L	probably benign	Het
Myom1	T	C	17: 71,351,471 (GRCm39)		probably benign	Het
Or2m12	T	A	16: 19,104,909 (GRCm39)	T195S	probably damaging	Het
Pcdhb5	T	C	18: 37,455,992 (GRCm39)	F791L	probably damaging	Het
Ranbp2	A	G	10: 58,299,900 (GRCm39)		probably null	Het
Serpinb9e	A	G	13: 33,439,108 (GRCm39)	K178R	probably damaging	Het
Shtn1	A	G	19: 59,016,601 (GRCm39)	S233P	probably damaging	Het
Smpd1	G	A	7: 105,204,549 (GRCm39)	V143M	possibly damaging	Het
Terb1	G	A	8: 105,199,646 (GRCm39)	H433Y	probably benign	Het
Traf6	C	T	2: 101,520,443 (GRCm39)	Q164*	probably null	Het
Trip12	C	A	1: 84,792,631 (GRCm39)	R4L	probably damaging	Het
Ttn	G	A	2: 76,693,879 (GRCm39)	P208S	possibly damaging	Het
Ube2c	T	C	2: 164,613,232 (GRCm39)	I50T	probably damaging	Het
Uggt1	T	C	1: 36,200,775 (GRCm39)	D1174G	probably damaging	Het
Vmn2r121	T	G	X: 123,041,997 (GRCm39)	M387L	probably benign	Het
Vmn2r18	T	A	5: 151,510,229 (GRCm39)	N48I	probably benign	Het
Zc3h15	T	C	2: 83,490,517 (GRCm39)	L217P	probably damaging	Het
Zyg11a	T	A	4: 108,062,414 (GRCm39)	E129V	probably damaging	Het

Other mutations in Prss29

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01120:Prss29	APN	17	25,541,107 (GRCm39)	missense	probably benign	0.05
IGL01670:Prss29	APN	17	25,541,437 (GRCm39)	missense	probably benign	0.03
IGL02516:Prss29	APN	17	25,539,875 (GRCm39)	missense	probably damaging	1.00
R1538:Prss29	UTSW	17	25,539,257 (GRCm39)	start codon destroyed	possibly damaging	0.93
R4285:Prss29	UTSW	17	25,541,231 (GRCm39)	missense	probably damaging	1.00
R5148:Prss29	UTSW	17	25,539,881 (GRCm39)	missense	probably benign	0.00
R5468:Prss29	UTSW	17	25,540,020 (GRCm39)	missense	possibly damaging	0.95
R5483:Prss29	UTSW	17	25,541,177 (GRCm39)	missense	probably benign	0.00
R5852:Prss29	UTSW	17	25,541,408 (GRCm39)	missense	probably benign	0.01
R6226:Prss29	UTSW	17	25,539,513 (GRCm39)	missense	possibly damaging	0.74
R6346:Prss29	UTSW	17	25,540,084 (GRCm39)	missense	possibly damaging	0.83
R7430:Prss29	UTSW	17	25,540,113 (GRCm39)	critical splice donor site	probably null
R7547:Prss29	UTSW	17	25,539,896 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-12-09