Incidental Mutation 'IGL00561:Bcl6b'
ID 9254
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Bcl6b
Ensembl Gene ENSMUSG00000000317
Gene Name B cell CLL/lymphoma 6, member B
Synonyms Bazf
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.294) question?
Stock # IGL00561
Quality Score
Status
Chromosome 11
Chromosomal Location 70114954-70120624 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 70119310 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000121365 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000000326] [ENSMUST00000153449]
AlphaFold O88282
Predicted Effect probably benign
Transcript: ENSMUST00000000326
SMART Domains Protein: ENSMUSP00000000326
Gene: ENSMUSG00000000317

DomainStartEndE-ValueType
BTB 38 135 2.17e-25 SMART
low complexity region 143 163 N/A INTRINSIC
ZnF_C2H2 323 345 4.11e-2 SMART
ZnF_C2H2 351 373 2.12e-4 SMART
ZnF_C2H2 379 401 8.34e-3 SMART
ZnF_C2H2 407 429 1.12e-3 SMART
ZnF_C2H2 435 458 1.33e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140542
Predicted Effect probably benign
Transcript: ENSMUST00000153449
SMART Domains Protein: ENSMUSP00000121365
Gene: ENSMUSG00000000317

DomainStartEndE-ValueType
BTB 38 116 2.14e-6 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous null mice display decreased CD4+ and CD8+ cell numbers in the thymus. Homozygous mice for one null allele display decreased secondary responses of memory CD8+ T cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310002L09Rik T A 4: 73,860,956 (GRCm39) T215S possibly damaging Het
C8a G A 4: 104,722,642 (GRCm39) probably benign Het
Cep152 G A 2: 125,405,643 (GRCm39) Q1630* probably null Het
Dnah6 T C 6: 73,172,603 (GRCm39) N285S possibly damaging Het
Elovl5 G A 9: 77,868,256 (GRCm39) R56Q probably benign Het
Fcf1 T C 12: 85,019,835 (GRCm39) V36A probably benign Het
Gdf3 A G 6: 122,584,085 (GRCm39) L94P probably damaging Het
Kcnt2 A T 1: 140,450,836 (GRCm39) H705L probably damaging Het
Ly75 A T 2: 60,206,421 (GRCm39) C83S probably damaging Het
Med12l T A 3: 59,135,245 (GRCm39) S798T probably benign Het
Morc3 G T 16: 93,670,283 (GRCm39) probably null Het
Neb A T 2: 52,096,117 (GRCm39) N1049K probably benign Het
Nlrp6 A G 7: 140,503,037 (GRCm39) D381G probably damaging Het
Pcnx1 A T 12: 82,042,827 (GRCm39) D2303V probably damaging Het
Prss45 A T 9: 110,669,578 (GRCm39) N227I probably damaging Het
Rbbp6 G A 7: 122,570,286 (GRCm39) M34I probably damaging Het
Slc30a7 T C 3: 115,740,369 (GRCm39) probably null Het
Smpdl3a T C 10: 57,684,042 (GRCm39) Y267H probably benign Het
Snw1 A G 12: 87,497,574 (GRCm39) probably null Het
Sp140 G A 1: 85,549,393 (GRCm39) R208K probably benign Het
Tbx19 A G 1: 164,987,968 (GRCm39) V55A probably benign Het
Tmem131 A G 1: 36,850,508 (GRCm39) S1059P probably damaging Het
Tpo G A 12: 30,134,619 (GRCm39) P780S probably damaging Het
Ttn G A 2: 76,570,055 (GRCm39) T26946M probably damaging Het
Vps33b A G 7: 79,935,591 (GRCm39) E372G probably damaging Het
Vwf T C 6: 125,619,684 (GRCm39) V1454A possibly damaging Het
Zbbx C T 3: 74,968,839 (GRCm39) probably null Het
Zfp747l1 T A 7: 126,985,716 (GRCm39) probably benign Het
Other mutations in Bcl6b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01942:Bcl6b APN 11 70,117,569 (GRCm39) missense probably damaging 1.00
IGL02338:Bcl6b APN 11 70,119,918 (GRCm39) missense probably damaging 1.00
IGL02725:Bcl6b APN 11 70,119,344 (GRCm39) missense probably damaging 1.00
IGL02741:Bcl6b APN 11 70,119,942 (GRCm39) missense probably damaging 0.99
R4407:Bcl6b UTSW 11 70,116,929 (GRCm39) missense probably damaging 1.00
R5508:Bcl6b UTSW 11 70,116,919 (GRCm39) missense probably damaging 1.00
R5998:Bcl6b UTSW 11 70,119,009 (GRCm39) missense probably damaging 1.00
R6257:Bcl6b UTSW 11 70,116,878 (GRCm39) missense probably benign
R6600:Bcl6b UTSW 11 70,119,954 (GRCm39) missense probably damaging 1.00
R7107:Bcl6b UTSW 11 70,117,396 (GRCm39) missense probably damaging 1.00
R7896:Bcl6b UTSW 11 70,117,848 (GRCm39) nonsense probably null
R8690:Bcl6b UTSW 11 70,117,447 (GRCm39) missense probably damaging 0.99
R9223:Bcl6b UTSW 11 70,117,400 (GRCm39) nonsense probably null
R9594:Bcl6b UTSW 11 70,118,858 (GRCm39) critical splice donor site probably null
R9733:Bcl6b UTSW 11 70,119,323 (GRCm39) missense probably damaging 0.99
Posted On 2012-12-06