Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01622:Ficd'

92605

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ficd

Ensembl Gene

ENSMUSG00000053334

Gene Name

FIC domain containing

Synonyms

D5Ertd40e

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01622

Quality Score

Status

Chromosome

Chromosomal Location

113873864-113878661 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 113876622 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Serine at position 266 (G266S)

Ref Sequence

ENSEMBL: ENSMUSP00000071719 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000019118] [ENSMUST00000065698] [ENSMUST00000197041]

AlphaFold

Q8BIX9

Predicted Effect

probably benign
Transcript: ENSMUST00000019118

SMART Domains

Protein: ENSMUSP00000019118
Gene: ENSMUSG00000018974

Domain	Start	End	E-Value	Type
low complexity region	2	10	N/A	INTRINSIC
low complexity region	11	33	N/A	INTRINSIC
low complexity region	42	50	N/A	INTRINSIC
low complexity region	65	93	N/A	INTRINSIC
HAT	127	159	1.76e1	SMART
HAT	165	196	4.82e-1	SMART
HAT	202	238	1.53e-3	SMART
low complexity region	269	281	N/A	INTRINSIC
HAT	325	357	1.78e-4	SMART
HAT	360	392	7.83e-1	SMART
HAT	395	431	7.56e0	SMART
HAT	488	521	7.31e-1	SMART
coiled coil region	554	619	N/A	INTRINSIC
low complexity region	626	640	N/A	INTRINSIC
RRM	705	778	1.87e-14	SMART
RRM	802	874	3.2e-22	SMART
Pfam:LSM_int_assoc	877	937	3.1e-28	PFAM
Pfam:Lsm_interact	944	961	2e-9	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000065698
AA Change: G266S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000071719
Gene: ENSMUSG00000053334
AA Change: G266S

Domain	Start	End	E-Value	Type
transmembrane domain	20	42	N/A	INTRINSIC
SCOP:d1elwa_	105	180	2e-8	SMART
Pfam:Fic	284	381	1.8e-29	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000197041

SMART Domains

Protein: ENSMUSP00000143778
Gene: ENSMUSG00000018974

Domain	Start	End	E-Value	Type
low complexity region	2	10	N/A	INTRINSIC
low complexity region	11	33	N/A	INTRINSIC
low complexity region	42	50	N/A	INTRINSIC
low complexity region	65	93	N/A	INTRINSIC
HAT	127	159	1.76e1	SMART
HAT	165	196	4.82e-1	SMART
HAT	202	238	1.53e-3	SMART
low complexity region	269	281	N/A	INTRINSIC
Blast:HAT	292	323	1e-5	BLAST
HAT	325	357	1.33e-3	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930596D02Rik	G	A	14: 35,532,024 (GRCm39)	Q184*	probably null	Het
A1bg	A	C	15: 60,789,742 (GRCm39)	I502S	possibly damaging	Het
Actl11	T	C	9: 107,805,775 (GRCm39)	S33P	probably benign	Het
Aftph	G	T	11: 20,659,632 (GRCm39)	D730E	probably damaging	Het
Arhgap29	A	G	3: 121,767,773 (GRCm39)		probably benign	Het
Brf1	T	G	12: 112,924,795 (GRCm39)	E643A	probably benign	Het
Caskin1	G	T	17: 24,722,914 (GRCm39)		probably null	Het
Ccnjl	T	C	11: 43,476,154 (GRCm39)	V259A	probably benign	Het
Ccser2	G	T	14: 36,662,920 (GRCm39)	T88K	probably benign	Het
Cdk17	T	C	10: 93,074,824 (GRCm39)		probably benign	Het
Clec16a	G	A	16: 10,395,774 (GRCm39)	S309N	possibly damaging	Het
Cpxm1	C	A	2: 130,233,191 (GRCm39)	A633S	probably benign	Het
Ctnnbl1	A	T	2: 157,661,468 (GRCm39)	N326I	probably damaging	Het
Cyp46a1	T	C	12: 108,318,234 (GRCm39)	V215A	possibly damaging	Het
Daxx	A	G	17: 34,132,454 (GRCm39)	D528G	probably benign	Het
Dnah6	T	C	6: 73,121,701 (GRCm39)	Y1427C	probably damaging	Het
Dpy19l3	G	A	7: 35,422,169 (GRCm39)	T228I	probably damaging	Het
Fam131c	C	T	4: 141,109,761 (GRCm39)	A131V	possibly damaging	Het
Fat1	A	G	8: 45,482,592 (GRCm39)	T3061A	possibly damaging	Het
Fgl2	T	A	5: 21,578,175 (GRCm39)	L154H	possibly damaging	Het
Fhod3	T	A	18: 25,155,924 (GRCm39)	I514K	probably benign	Het
Frem3	A	G	8: 81,340,544 (GRCm39)	T946A	probably benign	Het
Gan	T	A	8: 117,913,917 (GRCm39)	V105D	probably damaging	Het
Garin5b	A	G	7: 4,761,722 (GRCm39)	V330A	probably benign	Het
Gramd1c	A	G	16: 43,811,061 (GRCm39)	V221A	probably damaging	Het
Hacd1	A	G	2: 14,040,667 (GRCm39)	V196A	probably benign	Het
Kcna6	C	A	6: 126,715,576 (GRCm39)	V438L	probably damaging	Het
Kif14	T	C	1: 136,425,094 (GRCm39)		probably benign	Het
Klhl41	T	C	2: 69,508,582 (GRCm39)	V512A	probably benign	Het
Lrfn1	A	G	7: 28,166,111 (GRCm39)	T502A	probably damaging	Het
Notch3	A	T	17: 32,377,844 (GRCm39)	F105I	possibly damaging	Het
Or4b13	T	G	2: 90,082,953 (GRCm39)	K126N	probably damaging	Het
Or5m10	A	T	2: 85,717,306 (GRCm39)	H54L	probably benign	Het
P3h1	C	T	4: 119,092,480 (GRCm39)	T171I	probably damaging	Het
Pcdhb1	A	G	18: 37,399,366 (GRCm39)	E439G	possibly damaging	Het
Pik3c3	A	T	18: 30,423,578 (GRCm39)	K225*	probably null	Het
Pik3c3	A	G	18: 30,426,102 (GRCm39)		probably benign	Het
Pik3r5	T	A	11: 68,377,452 (GRCm39)		probably null	Het
Pnpt1	A	C	11: 29,098,272 (GRCm39)		probably benign	Het
Ppp2r1b	T	A	9: 50,789,422 (GRCm39)	V495D	probably damaging	Het
Rbfox3	C	A	11: 118,396,440 (GRCm39)		probably benign	Het
Sec14l2	G	A	11: 4,053,966 (GRCm39)	P234S	possibly damaging	Het
Sec16a	A	C	2: 26,328,915 (GRCm39)	D1033E	probably benign	Het
Septin14	A	G	5: 129,763,019 (GRCm39)	V357A	probably damaging	Het
Sf3a3	C	T	4: 124,612,136 (GRCm39)	T131I	possibly damaging	Het
Snrpa	A	T	7: 26,892,395 (GRCm39)	M55K	probably benign	Het
Swt1	G	T	1: 151,286,760 (GRCm39)	T244N	probably benign	Het
Tbl1xr1	A	G	3: 22,246,238 (GRCm39)	T253A	probably benign	Het
Tst	G	T	15: 78,283,964 (GRCm39)	R288S	probably benign	Het
Vmn2r60	A	G	7: 41,785,910 (GRCm39)	I238V	probably benign	Het
Zbtb14	A	G	17: 69,695,184 (GRCm39)	K294R	probably benign	Het
Zfp710	T	A	7: 79,730,871 (GRCm39)	V16E	probably damaging	Het
Zfpm2	A	G	15: 40,965,320 (GRCm39)	T602A	probably benign	Het
Zfr2	G	A	10: 81,087,193 (GRCm39)	M850I	probably benign	Het

Other mutations in Ficd

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01774:Ficd	APN	5	113,877,073 (GRCm39)	missense	probably damaging	0.98
IGL01899:Ficd	APN	5	113,875,158 (GRCm39)	missense	probably benign
IGL02237:Ficd	APN	5	113,876,373 (GRCm39)	missense	probably damaging	0.98
IGL02527:Ficd	APN	5	113,875,027 (GRCm39)	missense	probably benign	0.04
IGL03030:Ficd	APN	5	113,874,990 (GRCm39)	missense	probably benign
IGL03062:Ficd	APN	5	113,876,314 (GRCm39)	missense	probably damaging	1.00
IGL03339:Ficd	APN	5	113,876,800 (GRCm39)	missense	probably benign	0.00
R0145:Ficd	UTSW	5	113,876,880 (GRCm39)	missense	probably damaging	1.00
R5207:Ficd	UTSW	5	113,875,072 (GRCm39)	missense	probably benign	0.15
R5530:Ficd	UTSW	5	113,876,986 (GRCm39)	missense	probably damaging	1.00
R6730:Ficd	UTSW	5	113,876,773 (GRCm39)	missense	probably damaging	1.00
R7256:Ficd	UTSW	5	113,876,880 (GRCm39)	missense	probably damaging	1.00
R7624:Ficd	UTSW	5	113,876,751 (GRCm39)	missense	probably benign	0.03
R7960:Ficd	UTSW	5	113,877,020 (GRCm39)	missense	probably benign	0.00
R8757:Ficd	UTSW	5	113,876,575 (GRCm39)	missense	probably damaging	0.99
R8759:Ficd	UTSW	5	113,876,575 (GRCm39)	missense	probably damaging	0.99
R8870:Ficd	UTSW	5	113,876,248 (GRCm39)	missense	probably damaging	0.98
R9224:Ficd	UTSW	5	113,875,196 (GRCm39)	missense	probably benign

Posted On

2013-12-09