Incidental Mutation 'IGL01627:Zyg11b'
| ID |
92804 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zyg11b
|
| Ensembl Gene |
ENSMUSG00000034636 |
| Gene Name |
zyg-ll family member B, cell cycle regulator |
| Synonyms |
1110046I03Rik, 2810482G21Rik, D4Mgi23, LOC242610 |
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.725)
|
| Stock # |
IGL01627
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
4 |
| Chromosomal Location |
108086921-108158293 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 108107985 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 474
(I474V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000043844
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000043616]
|
| AlphaFold |
Q3UFS0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000043616
AA Change: I474V
PolyPhen 2
Score 0.191 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000043844
Gene: ENSMUSG00000034636
AA Change: I474V
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1jdha_
|
370 |
722 |
3e-16 |
SMART |
|
Blast:ARM
|
480 |
526 |
1e-17 |
BLAST |
|
Blast:ARM
|
528 |
570 |
3e-19 |
BLAST |
|
Blast:ARM
|
638 |
679 |
3e-10 |
BLAST |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 35 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgra2 |
G |
A |
8: 27,608,761 (GRCm39) |
A540T |
possibly damaging |
Het |
| Casp9 |
T |
C |
4: 141,532,853 (GRCm39) |
|
probably benign |
Het |
| Ccdc186 |
G |
A |
19: 56,780,452 (GRCm39) |
T864I |
probably damaging |
Het |
| Cgas |
A |
T |
9: 78,349,996 (GRCm39) |
V57E |
possibly damaging |
Het |
| Chek1 |
T |
A |
9: 36,635,191 (GRCm39) |
H64L |
probably damaging |
Het |
| Chsy3 |
T |
C |
18: 59,309,367 (GRCm39) |
S207P |
probably damaging |
Het |
| Clec4n |
A |
G |
6: 123,221,433 (GRCm39) |
|
probably benign |
Het |
| Col9a1 |
G |
A |
1: 24,218,689 (GRCm39) |
|
probably null |
Het |
| Dgkd |
A |
G |
1: 87,808,150 (GRCm39) |
R73G |
probably damaging |
Het |
| Dmbt1 |
A |
T |
7: 130,682,915 (GRCm39) |
T562S |
probably benign |
Het |
| Epb42 |
T |
C |
2: 120,856,324 (GRCm39) |
T407A |
probably benign |
Het |
| Eps8l3 |
A |
G |
3: 107,788,487 (GRCm39) |
D58G |
probably damaging |
Het |
| Fuca1 |
A |
T |
4: 135,652,862 (GRCm39) |
N162I |
possibly damaging |
Het |
| Gramd1a |
T |
C |
7: 30,839,221 (GRCm39) |
D229G |
probably damaging |
Het |
| Grin1 |
A |
G |
2: 25,208,709 (GRCm39) |
S64P |
probably damaging |
Het |
| Hgd |
T |
G |
16: 37,442,287 (GRCm39) |
V243G |
probably damaging |
Het |
| Il23r |
A |
T |
6: 67,400,412 (GRCm39) |
N639K |
probably benign |
Het |
| Il33 |
A |
G |
19: 29,929,390 (GRCm39) |
T38A |
possibly damaging |
Het |
| Mycbpap |
T |
C |
11: 94,405,430 (GRCm39) |
E33G |
probably damaging |
Het |
| Npas1 |
C |
T |
7: 16,199,111 (GRCm39) |
G148D |
probably damaging |
Het |
| Ntan1 |
C |
T |
16: 13,652,603 (GRCm39) |
T233M |
probably benign |
Het |
| Or6c5 |
A |
T |
10: 129,074,138 (GRCm39) |
N40I |
probably damaging |
Het |
| Plscr1l1 |
A |
T |
9: 92,229,864 (GRCm39) |
I23F |
probably damaging |
Het |
| Pou2f1 |
A |
T |
1: 165,708,002 (GRCm39) |
|
probably benign |
Het |
| Rims4 |
T |
C |
2: 163,706,022 (GRCm39) |
Y204C |
probably damaging |
Het |
| Selp |
A |
G |
1: 163,971,461 (GRCm39) |
|
probably null |
Het |
| Senp7 |
A |
G |
16: 55,992,219 (GRCm39) |
E725G |
probably damaging |
Het |
| Snx31 |
A |
T |
15: 36,517,818 (GRCm39) |
F366Y |
probably damaging |
Het |
| Spats2l |
A |
G |
1: 57,941,241 (GRCm39) |
|
probably benign |
Het |
| Tssk4 |
T |
C |
14: 55,888,010 (GRCm39) |
F69L |
probably damaging |
Het |
| Ugt3a1 |
T |
C |
15: 9,335,806 (GRCm39) |
L9P |
probably damaging |
Het |
| Vmn2r76 |
A |
T |
7: 85,874,871 (GRCm39) |
I702N |
probably damaging |
Het |
| Vps18 |
C |
A |
2: 119,127,672 (GRCm39) |
R832S |
probably benign |
Het |
| Xpo6 |
A |
G |
7: 125,748,506 (GRCm39) |
L375P |
probably damaging |
Het |
| Zfp462 |
C |
A |
4: 55,008,912 (GRCm39) |
P293T |
possibly damaging |
Het |
|
| Other mutations in Zyg11b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01080:Zyg11b
|
APN |
4 |
108,094,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01143:Zyg11b
|
APN |
4 |
108,102,191 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02517:Zyg11b
|
APN |
4 |
108,123,515 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03166:Zyg11b
|
APN |
4 |
108,123,086 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0326:Zyg11b
|
UTSW |
4 |
108,129,450 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0345:Zyg11b
|
UTSW |
4 |
108,123,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0396:Zyg11b
|
UTSW |
4 |
108,112,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0571:Zyg11b
|
UTSW |
4 |
108,117,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0718:Zyg11b
|
UTSW |
4 |
108,099,273 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1426:Zyg11b
|
UTSW |
4 |
108,108,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1495:Zyg11b
|
UTSW |
4 |
108,123,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1829:Zyg11b
|
UTSW |
4 |
108,123,290 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R1907:Zyg11b
|
UTSW |
4 |
108,112,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1916:Zyg11b
|
UTSW |
4 |
108,129,480 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1980:Zyg11b
|
UTSW |
4 |
108,123,127 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2070:Zyg11b
|
UTSW |
4 |
108,108,016 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2495:Zyg11b
|
UTSW |
4 |
108,101,921 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4717:Zyg11b
|
UTSW |
4 |
108,099,069 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5889:Zyg11b
|
UTSW |
4 |
108,094,577 (GRCm39) |
nonsense |
probably null |
|
|
R5957:Zyg11b
|
UTSW |
4 |
108,102,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6606:Zyg11b
|
UTSW |
4 |
108,093,286 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7151:Zyg11b
|
UTSW |
4 |
108,102,119 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7316:Zyg11b
|
UTSW |
4 |
108,107,699 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7488:Zyg11b
|
UTSW |
4 |
108,123,655 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R8936:Zyg11b
|
UTSW |
4 |
108,109,356 (GRCm39) |
missense |
|
|
|
R9291:Zyg11b
|
UTSW |
4 |
108,108,014 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9642:Zyg11b
|
UTSW |
4 |
108,117,185 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0022:Zyg11b
|
UTSW |
4 |
108,093,298 (GRCm39) |
missense |
probably benign |
|
|
X0067:Zyg11b
|
UTSW |
4 |
108,112,543 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Zyg11b
|
UTSW |
4 |
108,112,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-12-09 |
Incidental Mutation