Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01628:Gm8297'

92826

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm8297

Ensembl Gene

ENSMUSG00000090827

Gene Name

predicted gene 8297

Synonyms

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL01628

Quality Score

Status

Chromosome

Chromosomal Location

17477364-17485838 bp(-) (GRCm39)

Type of Mutation

start codon destroyed

DNA Base Change (assembly)

G to A at 16164995 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Isoleucine at position 1 (M1I)

Ref Sequence

ENSEMBL: ENSMUSP00000136942 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171636] [ENSMUST00000171964] [ENSMUST00000178389]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000171636
AA Change: M1I

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000131394
Gene: ENSMUSG00000090827
AA Change: M1I

Domain	Start	End	E-Value	Type
Pfam:Takusan	46	129	4.6e-32	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000171964
AA Change: M1I

PolyPhen 2 Score 0.073 (Sensitivity: 0.93; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000127256
Gene: ENSMUSG00000090827
AA Change: M1I

Domain	Start	End	E-Value	Type
Pfam:Takusan	48	128	2.2e-22	PFAM
transmembrane domain	240	262	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000178389
AA Change: M1I

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000136942
Gene: ENSMUSG00000090827
AA Change: M1I

Domain	Start	End	E-Value	Type
Pfam:Takusan	46	129	4.6e-32	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 23 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A430005L14Rik	T	C	4: 154,045,436 (GRCm39)	V155A	probably damaging	Het
Agtpbp1	T	A	13: 59,655,877 (GRCm39)		probably benign	Het
Bltp1	T	G	3: 37,062,634 (GRCm39)	V3382G	probably damaging	Het
Cd300ld	A	G	11: 114,876,999 (GRCm39)	I144T	probably benign	Het
Cmc1	A	T	9: 117,944,452 (GRCm39)	I22K	probably benign	Het
Cyp3a59	A	G	5: 146,036,629 (GRCm39)	N277S	possibly damaging	Het
Edil3	G	T	13: 89,467,945 (GRCm39)		probably benign	Het
Glipr2	C	A	4: 43,977,565 (GRCm39)	A136E	probably damaging	Het
Insrr	C	A	3: 87,708,099 (GRCm39)	C180*	probably null	Het
Kat2b	A	G	17: 53,917,925 (GRCm39)	N95D	possibly damaging	Het
Mgat4b	A	G	11: 50,124,136 (GRCm39)	I359V	probably benign	Het
Or2h2	A	T	17: 37,396,192 (GRCm39)	Y288*	probably null	Het
Parp9	A	G	16: 35,777,285 (GRCm39)	T177A	possibly damaging	Het
Rmdn2	T	A	17: 79,979,817 (GRCm39)	Y361*	probably null	Het
Rusc2	A	C	4: 43,425,729 (GRCm39)	Q1278P	probably damaging	Het
Setbp1	A	T	18: 78,899,992 (GRCm39)	L1225Q	probably damaging	Het
Slc39a10	A	T	1: 46,874,683 (GRCm39)	H206Q	probably benign	Het
Slc4a10	A	G	2: 62,099,010 (GRCm39)	Y586C	probably damaging	Het
Sos1	C	T	17: 80,730,106 (GRCm39)		probably benign	Het
Tnn	A	G	1: 159,975,172 (GRCm39)	I85T	possibly damaging	Het
Ttn	A	G	2: 76,769,036 (GRCm39)		probably null	Het
Wdr33	G	T	18: 32,021,363 (GRCm39)	G638C	unknown	Het
Zfp976	T	C	7: 42,261,935 (GRCm39)	Y634C	unknown	Het

Other mutations in Gm8297

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R7255:Gm8297	UTSW	14	16,165,868 (GRCm39)	missense	probably damaging	1.00
R7775:Gm8297	UTSW	14	16,167,939 (GRCm39)	missense	possibly damaging	0.92
R7792:Gm8297	UTSW	14	16,165,939 (GRCm39)	missense	possibly damaging	0.62
R7824:Gm8297	UTSW	14	16,167,939 (GRCm39)	missense	possibly damaging	0.92
Z1177:Gm8297	UTSW	14	16,167,810 (GRCm39)	missense	probably benign	0.01

Posted On

2013-12-09