Incidental Mutation 'IGL01639:Zfp641'
| ID |
92935 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp641
|
| Ensembl Gene |
ENSMUSG00000022987 |
| Gene Name |
zinc finger protein 641 |
| Synonyms |
9930016F01Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL01639
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
15 |
| Chromosomal Location |
98183466-98194042 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 98189066 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 131
(I131T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133212
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023722]
[ENSMUST00000169721]
|
| AlphaFold |
Q8BZ34 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000023722
AA Change: I117T
PolyPhen 2
Score 0.531 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000023722
Gene: ENSMUSG00000022987
AA Change: I117T
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
91 |
142 |
2.16e-10 |
SMART |
|
ZnF_C2H2
|
236 |
258 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
264 |
286 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
292 |
314 |
1.33e-1 |
SMART |
|
ZnF_C2H2
|
342 |
364 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
370 |
392 |
3.83e-2 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000169721
AA Change: I131T
PolyPhen 2
Score 0.851 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000133212
Gene: ENSMUSG00000022987
AA Change: I131T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
83 |
89 |
N/A |
INTRINSIC |
|
KRAB
|
95 |
156 |
2.56e-21 |
SMART |
|
ZnF_C2H2
|
250 |
272 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
278 |
300 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
306 |
328 |
1.33e-1 |
SMART |
|
ZnF_C2H2
|
356 |
378 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
384 |
406 |
3.83e-2 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 24 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Calm4 |
T |
A |
13: 3,888,302 (GRCm39) |
V136E |
probably damaging |
Het |
| Cnot8 |
A |
T |
11: 58,002,188 (GRCm39) |
I74F |
probably damaging |
Het |
| Coq7 |
A |
T |
7: 118,124,527 (GRCm39) |
V213D |
probably damaging |
Het |
| Itgae |
A |
G |
11: 73,010,204 (GRCm39) |
T565A |
probably benign |
Het |
| Lgi3 |
A |
G |
14: 70,770,825 (GRCm39) |
I155V |
probably benign |
Het |
| Mbd5 |
A |
G |
2: 49,162,320 (GRCm39) |
N42S |
probably damaging |
Het |
| Nherf4 |
T |
A |
9: 44,159,976 (GRCm39) |
E381D |
probably benign |
Het |
| Or13a22 |
A |
G |
7: 140,073,099 (GRCm39) |
I183V |
probably benign |
Het |
| Or2l13 |
T |
C |
16: 19,305,914 (GRCm39) |
S109P |
probably damaging |
Het |
| Pals2 |
T |
C |
6: 50,155,460 (GRCm39) |
I261T |
probably damaging |
Het |
| Pcnx1 |
T |
C |
12: 81,997,094 (GRCm39) |
|
probably null |
Het |
| Plekhg1 |
A |
G |
10: 3,906,751 (GRCm39) |
E556G |
probably damaging |
Het |
| Rab1a |
T |
C |
11: 20,173,185 (GRCm39) |
|
probably benign |
Het |
| Rfx6 |
A |
T |
10: 51,592,002 (GRCm39) |
R133* |
probably null |
Het |
| Spata31d1c |
T |
C |
13: 65,183,903 (GRCm39) |
S482P |
probably damaging |
Het |
| Spire1 |
C |
A |
18: 67,678,738 (GRCm39) |
A68S |
possibly damaging |
Het |
| Tmc1 |
G |
A |
19: 20,793,556 (GRCm39) |
T535M |
probably damaging |
Het |
| Trip10 |
T |
A |
17: 57,561,165 (GRCm39) |
|
probably benign |
Het |
| Trp53bp1 |
A |
C |
2: 121,033,173 (GRCm39) |
V1711G |
possibly damaging |
Het |
| Ubr4 |
G |
T |
4: 139,144,655 (GRCm39) |
R1488L |
probably damaging |
Het |
| Vmn2r84 |
A |
T |
10: 130,225,141 (GRCm39) |
Y456* |
probably null |
Het |
| Zc3h7a |
T |
C |
16: 10,959,572 (GRCm39) |
S794G |
possibly damaging |
Het |
| Zeb2 |
C |
T |
2: 44,887,269 (GRCm39) |
S581N |
probably benign |
Het |
| Zfp292 |
G |
A |
4: 34,809,048 (GRCm39) |
P1332L |
probably benign |
Het |
|
| Other mutations in Zfp641 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL03092:Zfp641
|
APN |
15 |
98,188,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03191:Zfp641
|
APN |
15 |
98,186,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0079:Zfp641
|
UTSW |
15 |
98,186,970 (GRCm39) |
missense |
probably benign |
0.28 |
|
R0243:Zfp641
|
UTSW |
15 |
98,187,008 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R0487:Zfp641
|
UTSW |
15 |
98,187,060 (GRCm39) |
missense |
probably benign |
|
|
R2092:Zfp641
|
UTSW |
15 |
98,191,593 (GRCm39) |
missense |
probably benign |
|
|
R3415:Zfp641
|
UTSW |
15 |
98,188,421 (GRCm39) |
missense |
probably benign |
0.28 |
|
R4834:Zfp641
|
UTSW |
15 |
98,191,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4851:Zfp641
|
UTSW |
15 |
98,186,598 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5776:Zfp641
|
UTSW |
15 |
98,186,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6057:Zfp641
|
UTSW |
15 |
98,190,816 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6896:Zfp641
|
UTSW |
15 |
98,191,684 (GRCm39) |
start codon destroyed |
probably benign |
0.06 |
|
R6958:Zfp641
|
UTSW |
15 |
98,190,832 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6969:Zfp641
|
UTSW |
15 |
98,188,448 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R8117:Zfp641
|
UTSW |
15 |
98,186,856 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8314:Zfp641
|
UTSW |
15 |
98,188,464 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9130:Zfp641
|
UTSW |
15 |
98,186,732 (GRCm39) |
missense |
probably benign |
0.12 |
|
Z1177:Zfp641
|
UTSW |
15 |
98,186,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-12-09 |
Incidental Mutation