Incidental Mutation 'IGL01636:Or7e170'
ID 92978
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or7e170
Ensembl Gene ENSMUSG00000063842
Gene Name olfactory receptor family 7 subfamily E member 170
Synonyms Olfr862, MOR146-1, GA_x6K02T2PVTD-13624132-13623212
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # IGL01636
Quality Score
Status
Chromosome 9
Chromosomal Location 19794679-19795969 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 19795484 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 39 (V39A)
Ref Sequence ENSEMBL: ENSMUSP00000078603 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073765] [ENSMUST00000079660]
AlphaFold Q8VFJ1
Predicted Effect probably benign
Transcript: ENSMUST00000073765
AA Change: V39A

PolyPhen 2 Score 0.135 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000073437
Gene: ENSMUSG00000063842
AA Change: V39A

DomainStartEndE-ValueType
low complexity region 6 17 N/A INTRINSIC
Pfam:7tm_4 31 306 3.1e-52 PFAM
Pfam:7TM_GPCR_Srsx 35 282 1.3e-7 PFAM
Pfam:7tm_1 41 290 5.7e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000079660
AA Change: V39A

PolyPhen 2 Score 0.135 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000078603
Gene: ENSMUSG00000063842
AA Change: V39A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.3e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 303 8.3e-8 PFAM
Pfam:7tm_1 41 290 4.5e-22 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam4 T C 12: 81,466,723 (GRCm39) T633A possibly damaging Het
Adgrd1 G T 5: 129,219,516 (GRCm39) probably benign Het
Bmp7 T C 2: 172,717,001 (GRCm39) probably benign Het
Ccdc54 A G 16: 50,410,277 (GRCm39) *330Q probably null Het
Chd5 A T 4: 152,469,110 (GRCm39) K1812* probably null Het
Cnga3 T A 1: 37,299,874 (GRCm39) I236N possibly damaging Het
Ddost T G 4: 138,036,707 (GRCm39) D135E possibly damaging Het
Dicer1 T C 12: 104,688,500 (GRCm39) D359G probably damaging Het
Dnah17 A C 11: 117,931,882 (GRCm39) S3697A probably benign Het
Dnttip2 G A 3: 122,076,123 (GRCm39) G685D possibly damaging Het
Dst T G 1: 34,254,650 (GRCm39) S4552R probably damaging Het
Ebf2 G A 14: 67,476,927 (GRCm39) E157K probably damaging Het
Ehbp1 C T 11: 22,039,584 (GRCm39) V839M probably benign Het
Ehmt1 G T 2: 24,729,620 (GRCm39) T639K probably damaging Het
Esyt2 T C 12: 116,329,550 (GRCm39) probably null Het
Etv6 T C 6: 134,225,350 (GRCm39) S194P probably benign Het
Fam184b T C 5: 45,741,637 (GRCm39) H198R probably benign Het
Fam210b T C 2: 172,193,460 (GRCm39) F91S probably damaging Het
Fam81a G A 9: 70,006,434 (GRCm39) Q193* probably null Het
Fto A G 8: 92,135,969 (GRCm39) D79G probably damaging Het
Haspin C T 11: 73,028,231 (GRCm39) R286H possibly damaging Het
Hmcn1 C T 1: 150,455,984 (GRCm39) C5312Y probably damaging Het
Ik T A 18: 36,884,254 (GRCm39) D245E possibly damaging Het
Itga1 A G 13: 115,143,484 (GRCm39) V349A possibly damaging Het
Kdm8 T C 7: 125,060,377 (GRCm39) V400A probably damaging Het
Larp1b G T 3: 40,924,913 (GRCm39) R177L probably benign Het
Lifr T G 15: 7,208,499 (GRCm39) probably benign Het
Lrrn2 T C 1: 132,864,959 (GRCm39) L8P possibly damaging Het
Marcksl1 T A 4: 129,408,587 (GRCm39) D55E probably benign Het
Med12 C A X: 100,318,795 (GRCm39) S74R probably damaging Het
Mtarc2 T C 1: 184,564,838 (GRCm39) K231E probably benign Het
Or52s1 C A 7: 102,861,384 (GRCm39) R95S probably benign Het
Or6c35 A T 10: 129,168,752 (GRCm39) M1L probably damaging Het
Or8k39 G A 2: 86,563,945 (GRCm39) Q4* probably null Het
Orc3 A C 4: 34,595,096 (GRCm39) L233R probably damaging Het
Pik3cd A G 4: 149,738,772 (GRCm39) M715T possibly damaging Het
Prss43 T A 9: 110,656,505 (GRCm39) L64Q possibly damaging Het
Pyroxd2 C A 19: 42,726,771 (GRCm39) G209V probably benign Het
Rab3b A G 4: 108,797,916 (GRCm39) D198G possibly damaging Het
Rrbp1 A T 2: 143,789,815 (GRCm39) probably benign Het
Smg6 T C 11: 74,825,929 (GRCm39) probably null Het
Ssrp1 T C 2: 84,871,443 (GRCm39) probably benign Het
Strip2 C A 6: 29,931,192 (GRCm39) T381K probably benign Het
Svep1 A T 4: 58,116,622 (GRCm39) L876Q possibly damaging Het
Tle4 T C 19: 14,429,897 (GRCm39) I625V probably damaging Het
Tnfrsf23 T C 7: 143,233,736 (GRCm39) T81A probably damaging Het
Ttc41 A G 10: 86,612,542 (GRCm39) K1272E probably benign Het
Usp3 A G 9: 66,469,834 (GRCm39) probably null Het
Vmn1r121 C T 7: 20,832,282 (GRCm39) V53M probably benign Het
Vmn1r65 A T 7: 6,011,720 (GRCm39) S171R probably benign Het
Vmn2r4 A T 3: 64,313,657 (GRCm39) D441E probably benign Het
Vps13d A T 4: 144,801,618 (GRCm39) H2353Q probably damaging Het
Vwa8 T C 14: 79,435,794 (GRCm39) S1835P possibly damaging Het
Other mutations in Or7e170
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01114:Or7e170 APN 9 19,794,844 (GRCm39) nonsense probably null
IGL01765:Or7e170 APN 9 19,795,247 (GRCm39) missense possibly damaging 0.71
IGL01967:Or7e170 APN 9 19,794,885 (GRCm39) missense probably damaging 0.97
IGL03145:Or7e170 APN 9 19,794,735 (GRCm39) missense possibly damaging 0.93
IGL03222:Or7e170 APN 9 19,795,495 (GRCm39) nonsense probably null
R0117:Or7e170 UTSW 9 19,795,595 (GRCm39) missense probably damaging 0.96
R0662:Or7e170 UTSW 9 19,795,248 (GRCm39) missense probably benign 0.32
R2399:Or7e170 UTSW 9 19,795,220 (GRCm39) missense probably damaging 0.98
R4224:Or7e170 UTSW 9 19,794,896 (GRCm39) missense probably benign 0.44
R4572:Or7e170 UTSW 9 19,795,275 (GRCm39) missense probably benign
R5607:Or7e170 UTSW 9 19,795,272 (GRCm39) missense probably benign 0.16
R5741:Or7e170 UTSW 9 19,794,857 (GRCm39) missense possibly damaging 0.92
R5759:Or7e170 UTSW 9 19,795,484 (GRCm39) missense probably benign 0.14
R6237:Or7e170 UTSW 9 19,795,365 (GRCm39) missense probably damaging 1.00
R6434:Or7e170 UTSW 9 19,795,141 (GRCm39) nonsense probably null
R7075:Or7e170 UTSW 9 19,795,359 (GRCm39) missense probably benign 0.16
R7534:Or7e170 UTSW 9 19,795,472 (GRCm39) missense probably benign 0.16
R7735:Or7e170 UTSW 9 19,795,410 (GRCm39) missense probably damaging 0.99
R8415:Or7e170 UTSW 9 19,795,409 (GRCm39) missense possibly damaging 0.95
R9246:Or7e170 UTSW 9 19,795,686 (GRCm39) start gained probably benign
R9438:Or7e170 UTSW 9 19,795,083 (GRCm39) missense probably benign
R9795:Or7e170 UTSW 9 19,795,347 (GRCm39) missense probably benign
Z1177:Or7e170 UTSW 9 19,794,963 (GRCm39) missense probably damaging 1.00
Posted On 2013-12-09