Incidental Mutation 'IGL01638:Slc22a7'
ID 93155
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Slc22a7
Ensembl Gene ENSMUSG00000067144
Gene Name solute carrier family 22 (organic anion transporter), member 7
Synonyms OAT2, NLT
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # IGL01638
Quality Score
Status
Chromosome 17
Chromosomal Location 46743109-46749383 bp(-) (GRCm39)
Type of Mutation splice site (3 bp from exon)
DNA Base Change (assembly) T to C at 46748920 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000084234 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047034] [ENSMUST00000087012] [ENSMUST00000166852]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000047034
SMART Domains Protein: ENSMUSP00000044580
Gene: ENSMUSG00000015599

DomainStartEndE-ValueType
Pfam:Pkinase_Tyr 34 293 3.4e-21 PFAM
Pfam:Pkinase 34 305 1.7e-33 PFAM
low complexity region 320 334 N/A INTRINSIC
low complexity region 371 395 N/A INTRINSIC
low complexity region 570 593 N/A INTRINSIC
low complexity region 611 624 N/A INTRINSIC
low complexity region 633 653 N/A INTRINSIC
low complexity region 697 709 N/A INTRINSIC
coiled coil region 729 776 N/A INTRINSIC
low complexity region 779 797 N/A INTRINSIC
low complexity region 893 913 N/A INTRINSIC
low complexity region 945 962 N/A INTRINSIC
low complexity region 1090 1115 N/A INTRINSIC
low complexity region 1236 1251 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000087012
SMART Domains Protein: ENSMUSP00000084234
Gene: ENSMUSG00000067144

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
Pfam:MFS_1 82 479 1.2e-32 PFAM
Pfam:Sugar_tr 86 524 2.5e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000166852
SMART Domains Protein: ENSMUSP00000127966
Gene: ENSMUSG00000091742

DomainStartEndE-ValueType
Pfam:Ribosomal_L5 10 59 4.1e-18 PFAM
Pfam:Ribosomal_L5_C 63 161 8.7e-25 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts9 T C 6: 92,849,409 (GRCm39) T436A probably benign Het
Adgrb3 T A 1: 25,598,832 (GRCm39) probably benign Het
Ajap1 A G 4: 153,516,693 (GRCm39) V216A possibly damaging Het
Akap7 T A 10: 25,143,323 (GRCm39) I124F probably damaging Het
Arfgef2 G A 2: 166,715,865 (GRCm39) V1385M probably damaging Het
Arhgap30 A G 1: 171,225,138 (GRCm39) K65E probably damaging Het
Bltp1 A G 3: 37,028,460 (GRCm39) N2377D probably damaging Het
Cacna1a T C 8: 85,298,456 (GRCm39) F1260S probably damaging Het
Cad T A 5: 31,224,958 (GRCm39) C954S probably damaging Het
Fcmr A T 1: 130,802,859 (GRCm39) E157D probably benign Het
Gm4204 A T 1: 135,160,873 (GRCm39) noncoding transcript Het
Gzmn A T 14: 56,406,476 (GRCm39) D16E probably benign Het
Krt86 A C 15: 101,373,353 (GRCm39) probably benign Het
Macc1 T C 12: 119,410,246 (GRCm39) L338P probably benign Het
Ms4a6d A T 19: 11,564,532 (GRCm39) L113Q probably damaging Het
Myh15 T C 16: 48,889,843 (GRCm39) S145P probably damaging Het
Nav3 T C 10: 109,688,724 (GRCm39) K518E probably damaging Het
Or8d6 T C 9: 39,853,816 (GRCm39) S87P probably benign Het
Parp11 T A 6: 127,468,492 (GRCm39) F181I probably benign Het
Ppil1 C A 17: 29,480,766 (GRCm39) K52N probably benign Het
Prl5a1 T A 13: 28,329,422 (GRCm39) C34S possibly damaging Het
Prss55 A G 14: 64,314,636 (GRCm39) V178A probably benign Het
S100a7a A G 3: 90,562,837 (GRCm39) D8G probably benign Het
Sh3glb2 A G 2: 30,235,862 (GRCm39) V310A possibly damaging Het
Slc27a6 A G 18: 58,740,885 (GRCm39) D482G probably damaging Het
Smarcc2 T A 10: 128,323,943 (GRCm39) probably benign Het
Specc1l T A 10: 75,082,039 (GRCm39) Y478* probably null Het
Spryd3 A G 15: 102,038,711 (GRCm39) probably null Het
Tcerg1l G A 7: 137,881,805 (GRCm39) R295C probably damaging Het
Trpv1 T C 11: 73,144,155 (GRCm39) I637T probably damaging Het
Ttc7 A C 17: 87,666,540 (GRCm39) probably null Het
Vmn1r6 C T 6: 56,980,177 (GRCm39) Q280* probably null Het
Other mutations in Slc22a7
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0755:Slc22a7 UTSW 17 46,749,113 (GRCm39) missense possibly damaging 0.93
R0898:Slc22a7 UTSW 17 46,744,075 (GRCm39) missense probably damaging 1.00
R1594:Slc22a7 UTSW 17 46,748,957 (GRCm39) missense possibly damaging 0.94
R1794:Slc22a7 UTSW 17 46,744,079 (GRCm39) missense probably damaging 1.00
R1900:Slc22a7 UTSW 17 46,749,157 (GRCm39) missense probably benign 0.00
R1973:Slc22a7 UTSW 17 46,748,016 (GRCm39) missense probably damaging 1.00
R2117:Slc22a7 UTSW 17 46,744,898 (GRCm39) missense possibly damaging 0.55
R4467:Slc22a7 UTSW 17 46,743,436 (GRCm39) missense probably benign
R4739:Slc22a7 UTSW 17 46,745,923 (GRCm39) missense probably damaging 1.00
R4921:Slc22a7 UTSW 17 46,747,859 (GRCm39) missense probably benign 0.00
R6982:Slc22a7 UTSW 17 46,745,563 (GRCm39) missense probably benign 0.02
R7122:Slc22a7 UTSW 17 46,749,224 (GRCm39) missense probably damaging 1.00
R7412:Slc22a7 UTSW 17 46,745,553 (GRCm39) missense probably benign 0.00
R7634:Slc22a7 UTSW 17 46,749,156 (GRCm39) missense probably benign 0.02
R8112:Slc22a7 UTSW 17 46,747,756 (GRCm39) missense probably benign 0.00
R8703:Slc22a7 UTSW 17 46,744,951 (GRCm39) missense probably damaging 0.98
R9117:Slc22a7 UTSW 17 46,748,029 (GRCm39) missense probably damaging 1.00
R9541:Slc22a7 UTSW 17 46,749,084 (GRCm39) missense probably damaging 1.00
Posted On 2013-12-09