Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01632:Fyb2'

93498

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fyb2

Ensembl Gene

ENSMUSG00000078612

Gene Name

FYN binding protein 2

Synonyms

1700024P16Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.083) question?

Stock #

IGL01632

Quality Score

Status

Chromosome

Chromosomal Location

104770653-104874060 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 104853008 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Leucine at position 499 (V499L)

Ref Sequence

ENSEMBL: ENSMUSP00000102416 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000106803] [ENSMUST00000106804]

AlphaFold

A2A995

Predicted Effect

probably benign
Transcript: ENSMUST00000106803
AA Change: V563L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000102415
Gene: ENSMUSG00000078612
AA Change: V563L

Domain	Start	End	E-Value	Type
low complexity region	120	132	N/A	INTRINSIC
low complexity region	340	349	N/A	INTRINSIC
low complexity region	442	459	N/A	INTRINSIC
low complexity region	537	549	N/A	INTRINSIC
low complexity region	567	578	N/A	INTRINSIC
low complexity region	682	697	N/A	INTRINSIC
SH3	735	791	3.82e0	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000106804
AA Change: V499L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000102416
Gene: ENSMUSG00000078612
AA Change: V499L

Domain	Start	End	E-Value	Type
low complexity region	56	68	N/A	INTRINSIC
low complexity region	276	285	N/A	INTRINSIC
low complexity region	378	395	N/A	INTRINSIC
low complexity region	473	485	N/A	INTRINSIC
low complexity region	503	514	N/A	INTRINSIC
low complexity region	618	633	N/A	INTRINSIC
SH3	671	727	3.82e0	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgra2	G	A	8: 27,608,761 (GRCm39)	A540T	possibly damaging	Het
Alms1	T	A	6: 85,604,928 (GRCm39)	C1724S	probably benign	Het
Anapc10	T	C	8: 80,439,795 (GRCm39)	M1T	probably null	Het
Antxrl	A	G	14: 33,789,904 (GRCm39)	N332S	probably damaging	Het
Cdkl3	A	G	11: 51,895,899 (GRCm39)	R49G	probably damaging	Het
Chodl	A	G	16: 78,741,452 (GRCm39)		probably benign	Het
Clca3a1	G	T	3: 144,733,202 (GRCm39)	A102D	probably damaging	Het
Clip1	T	C	5: 123,755,559 (GRCm39)	E1029G	probably damaging	Het
Cpeb2	T	A	5: 43,394,765 (GRCm39)	I581N	probably benign	Het
Dmxl1	T	C	18: 49,996,092 (GRCm39)	V406A	probably damaging	Het
Dnah17	C	T	11: 117,924,707 (GRCm39)	R3960Q	probably damaging	Het
Fstl5	A	G	3: 76,615,135 (GRCm39)	D732G	probably benign	Het
Gm43191	A	T	3: 116,445,116 (GRCm39)	H39Q	probably damaging	Het
Hspg2	A	G	4: 137,242,084 (GRCm39)	K606R	probably damaging	Het
Klk1b27	C	T	7: 43,706,097 (GRCm39)		probably benign	Het
Mdga2	T	C	12: 66,676,672 (GRCm39)		probably benign	Het
Mup14	A	T	4: 61,259,383 (GRCm39)	F56L	probably benign	Het
Myh15	A	G	16: 48,881,874 (GRCm39)	K39E	probably benign	Het
Or1j10	A	T	2: 36,267,576 (GRCm39)	N263Y	probably benign	Het
Or5m12	A	G	2: 85,734,714 (GRCm39)	I228T	probably benign	Het
Ppp1r3a	T	A	6: 14,754,810 (GRCm39)	I146F	probably damaging	Het
Ryr2	A	G	13: 11,609,854 (GRCm39)	I759T	probably damaging	Het
Sfmbt1	T	C	14: 30,539,669 (GRCm39)	I819T	probably damaging	Het
Siglec1	A	G	2: 130,925,740 (GRCm39)	V322A	probably benign	Het
Spata3	T	C	1: 85,950,030 (GRCm39)	V87A	possibly damaging	Het
Tacstd2	A	G	6: 67,511,783 (GRCm39)	V303A	possibly damaging	Het
Taok3	T	A	5: 117,403,993 (GRCm39)	F723I	possibly damaging	Het
Tektl1	T	C	10: 78,584,536 (GRCm39)	S329G	probably benign	Het
Vmn1r210	A	T	13: 23,011,366 (GRCm39)	*307R	probably null	Het
Vmn2r70	T	C	7: 85,215,280 (GRCm39)	I85V	probably benign	Het
Zfp384	T	C	6: 125,001,724 (GRCm39)	I123T	probably damaging	Het

Other mutations in Fyb2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00664:Fyb2	APN	4	104,872,913 (GRCm39)	missense	probably damaging	1.00
IGL01155:Fyb2	APN	4	104,856,583 (GRCm39)	missense	probably benign	0.00
IGL01746:Fyb2	APN	4	104,802,404 (GRCm39)	missense	probably benign	0.01
IGL02381:Fyb2	APN	4	104,805,863 (GRCm39)	splice site	probably benign
IGL02590:Fyb2	APN	4	104,836,250 (GRCm39)	missense	probably damaging	1.00
IGL02885:Fyb2	APN	4	104,861,118 (GRCm39)	missense	probably damaging	0.99
IGL03114:Fyb2	APN	4	104,852,975 (GRCm39)	missense	probably damaging	0.97
IGL03189:Fyb2	APN	4	104,872,939 (GRCm39)	missense	probably damaging	1.00
IGL03231:Fyb2	APN	4	104,843,460 (GRCm39)	nonsense	probably null
R0076:Fyb2	UTSW	4	104,802,661 (GRCm39)	missense	possibly damaging	0.46
R0662:Fyb2	UTSW	4	104,852,895 (GRCm39)	missense	possibly damaging	0.46
R0723:Fyb2	UTSW	4	104,873,063 (GRCm39)	missense	probably benign	0.00
R1216:Fyb2	UTSW	4	104,852,903 (GRCm39)	missense	possibly damaging	0.86
R1672:Fyb2	UTSW	4	104,808,059 (GRCm39)	missense	probably benign	0.10
R1710:Fyb2	UTSW	4	104,861,113 (GRCm39)	missense	probably damaging	1.00
R1900:Fyb2	UTSW	4	104,802,652 (GRCm39)	missense	probably benign	0.06
R1965:Fyb2	UTSW	4	104,770,846 (GRCm39)	missense	probably benign	0.00
R2106:Fyb2	UTSW	4	104,802,769 (GRCm39)	missense	probably benign	0.01
R5191:Fyb2	UTSW	4	104,852,994 (GRCm39)	missense	possibly damaging	0.88
R5236:Fyb2	UTSW	4	104,805,957 (GRCm39)	missense	probably benign	0.00
R5277:Fyb2	UTSW	4	104,872,876 (GRCm39)	missense	probably damaging	1.00
R5502:Fyb2	UTSW	4	104,802,521 (GRCm39)	missense	probably damaging	1.00
R5769:Fyb2	UTSW	4	104,872,841 (GRCm39)	missense	probably damaging	1.00
R5769:Fyb2	UTSW	4	104,870,518 (GRCm39)	missense	probably damaging	1.00
R6167:Fyb2	UTSW	4	104,802,661 (GRCm39)	missense	possibly damaging	0.46
R6169:Fyb2	UTSW	4	104,857,713 (GRCm39)	missense	probably benign	0.16
R6371:Fyb2	UTSW	4	104,852,975 (GRCm39)	missense	probably damaging	0.97
R6582:Fyb2	UTSW	4	104,802,739 (GRCm39)	missense	probably benign	0.00
R6713:Fyb2	UTSW	4	104,847,432 (GRCm39)	missense	probably benign	0.16
R6719:Fyb2	UTSW	4	104,867,656 (GRCm39)	missense	probably benign	0.07
R7484:Fyb2	UTSW	4	104,870,499 (GRCm39)	missense	probably benign	0.01
R7534:Fyb2	UTSW	4	104,856,545 (GRCm39)	nonsense	probably null
R7590:Fyb2	UTSW	4	104,802,443 (GRCm39)	missense	probably benign	0.01
R7699:Fyb2	UTSW	4	104,867,651 (GRCm39)	missense	probably benign	0.07
R7700:Fyb2	UTSW	4	104,867,651 (GRCm39)	missense	probably benign	0.07
R8041:Fyb2	UTSW	4	104,857,681 (GRCm39)	missense	possibly damaging	0.82
R8298:Fyb2	UTSW	4	104,806,028 (GRCm39)	missense	probably damaging	0.99
R8300:Fyb2	UTSW	4	104,857,689 (GRCm39)	missense	probably damaging	1.00
R8755:Fyb2	UTSW	4	104,861,086 (GRCm39)	missense	unknown
R8817:Fyb2	UTSW	4	104,802,652 (GRCm39)	missense	probably benign	0.06
R8873:Fyb2	UTSW	4	104,856,538 (GRCm39)	missense	probably damaging	1.00
R8914:Fyb2	UTSW	4	104,857,700 (GRCm39)	missense	probably benign	0.09
R9224:Fyb2	UTSW	4	104,853,105 (GRCm39)	missense	probably benign	0.44
R9434:Fyb2	UTSW	4	104,847,534 (GRCm39)	missense	probably damaging	0.99
R9512:Fyb2	UTSW	4	104,853,100 (GRCm39)	missense	probably benign	0.00
R9589:Fyb2	UTSW	4	104,872,833 (GRCm39)	missense	probably damaging	1.00
R9634:Fyb2	UTSW	4	104,856,579 (GRCm39)	nonsense	probably null
R9758:Fyb2	UTSW	4	104,802,961 (GRCm39)	missense	probably benign	0.01
X0018:Fyb2	UTSW	4	104,802,407 (GRCm39)	missense	probably benign	0.04
Z1176:Fyb2	UTSW	4	104,770,857 (GRCm39)	missense	probably damaging	0.98

Posted On

2013-12-09