Incidental Mutation 'IGL01632:Anapc10'
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ID93504
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Anapc10
Ensembl Gene ENSMUSG00000036977
Gene Nameanaphase promoting complex subunit 10
SynonymsA830003M23Rik, Apc10, 1500026N15Rik
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.939) question?
Stock #IGL01632
Quality Score
Status
Chromosome8
Chromosomal Location79711820-79779059 bp(+) (GRCm38)
Type of Mutationstart codon destroyed
DNA Base Change (assembly) T to C at 79713166 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Threonine at position 1 (M1T)
Ref Sequence ENSEMBL: ENSMUSP00000148220 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048147] [ENSMUST00000080536] [ENSMUST00000210812]
Predicted Effect probably null
Transcript: ENSMUST00000048147
AA Change: M1T

PolyPhen 2 Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000048244
Gene: ENSMUSG00000036977
AA Change: M1T

DomainStartEndE-ValueType
APC10 22 184 7.76e-96 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000080536
SMART Domains Protein: ENSMUSP00000079379
Gene: ENSMUSG00000058355

DomainStartEndE-ValueType
Pfam:RLI 6 37 6.9e-18 PFAM
Pfam:Fer4 48 71 8e-10 PFAM
AAA 102 293 2.34e-8 SMART
low complexity region 343 358 N/A INTRINSIC
AAA 371 539 2.86e-12 SMART
Predicted Effect probably null
Transcript: ENSMUST00000210812
AA Change: M1T

PolyPhen 2 Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211509
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213842
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgra2 G A 8: 27,118,733 A540T possibly damaging Het
Alms1 T A 6: 85,627,946 C1724S probably benign Het
Antxrl A G 14: 34,067,947 N332S probably damaging Het
Ccdc105 T C 10: 78,748,702 S329G probably benign Het
Cdkl3 A G 11: 52,005,072 R49G probably damaging Het
Chodl A G 16: 78,944,564 probably benign Het
Clca1 G T 3: 145,027,441 A102D probably damaging Het
Clip1 T C 5: 123,617,496 E1029G probably damaging Het
Cpeb2 T A 5: 43,237,422 I581N probably benign Het
Dmxl1 T C 18: 49,863,025 V406A probably damaging Het
Dnah17 C T 11: 118,033,881 R3960Q probably damaging Het
Fstl5 A G 3: 76,707,828 D732G probably benign Het
Fyb2 G T 4: 104,995,811 V499L probably benign Het
Gm43191 A T 3: 116,651,467 H39Q probably damaging Het
Hspg2 A G 4: 137,514,773 K606R probably damaging Het
Klk1b27 C T 7: 44,056,673 probably benign Het
Mdga2 T C 12: 66,629,898 probably benign Het
Mup14 A T 4: 61,303,384 F56L probably benign Het
Myh15 A G 16: 49,061,511 K39E probably benign Het
Olfr1024 A G 2: 85,904,370 I228T probably benign Het
Olfr338 A T 2: 36,377,564 N263Y probably benign Het
Ppp1r3a T A 6: 14,754,811 I146F probably damaging Het
Ryr2 A G 13: 11,594,968 I759T probably damaging Het
Sfmbt1 T C 14: 30,817,712 I819T probably damaging Het
Siglec1 A G 2: 131,083,820 V322A probably benign Het
Spata3 T C 1: 86,022,308 V87A possibly damaging Het
Tacstd2 A G 6: 67,534,799 V303A possibly damaging Het
Taok3 T A 5: 117,265,928 F723I possibly damaging Het
Vmn1r210 A T 13: 22,827,196 *307R probably null Het
Vmn2r70 T C 7: 85,566,072 I85V probably benign Het
Zfp384 T C 6: 125,024,761 I123T probably damaging Het
Other mutations in Anapc10
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0498:Anapc10 UTSW 8 79774981 missense probably benign 0.00
R1586:Anapc10 UTSW 8 79775143 missense probably benign 0.00
R2320:Anapc10 UTSW 8 79775079 missense probably benign
R4885:Anapc10 UTSW 8 79729150 missense probably benign 0.03
R6776:Anapc10 UTSW 8 79719745 missense probably damaging 1.00
Posted On2013-12-09