Incidental Mutation 'IGL01643:Gpr65'
| ID |
93586 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Gpr65
|
| Ensembl Gene |
ENSMUSG00000021886 |
| Gene Name |
G-protein coupled receptor 65 |
| Synonyms |
TDAG8, Dig1, Gpcr25 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL01643
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
12 |
| Chromosomal Location |
98234894-98242903 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 98242013 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 222
(E222G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000074581
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000075072]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000075072
AA Change: E222G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000074581
Gene: ENSMUSG00000021886
AA Change: E222G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
33 |
290 |
1.9e-41 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000218404
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000219320
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygous mutant mice have thymocytes and splenocytes that are insensitive to pH-dependent cAMP production. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 29 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933427D14Rik |
C |
T |
11: 72,082,414 (GRCm39) |
R304Q |
probably damaging |
Het |
| Afap1l1 |
T |
A |
18: 61,884,897 (GRCm39) |
E196V |
probably damaging |
Het |
| Bmp5 |
A |
T |
9: 75,746,895 (GRCm39) |
D251V |
probably damaging |
Het |
| Ccser1 |
A |
G |
6: 61,288,839 (GRCm39) |
H334R |
probably benign |
Het |
| Crnkl1 |
A |
G |
2: 145,773,268 (GRCm39) |
M126T |
probably damaging |
Het |
| Ddrgk1 |
T |
C |
2: 130,500,214 (GRCm39) |
|
probably benign |
Het |
| Dpy19l4 |
T |
C |
4: 11,290,184 (GRCm39) |
|
probably benign |
Het |
| Eral1 |
A |
G |
11: 77,965,104 (GRCm39) |
|
probably null |
Het |
| Ereg |
T |
A |
5: 91,234,637 (GRCm39) |
S17T |
probably benign |
Het |
| Fgfr1 |
T |
A |
8: 26,056,751 (GRCm39) |
M280K |
probably benign |
Het |
| Grid1 |
G |
T |
14: 35,045,392 (GRCm39) |
|
probably null |
Het |
| Hspa12b |
A |
G |
2: 130,984,617 (GRCm39) |
T329A |
probably damaging |
Het |
| Inpp4b |
A |
G |
8: 82,798,400 (GRCm39) |
I863V |
probably damaging |
Het |
| Kash5 |
A |
T |
7: 44,849,710 (GRCm39) |
M71K |
probably damaging |
Het |
| Krt8 |
G |
T |
15: 101,905,508 (GRCm39) |
S447Y |
possibly damaging |
Het |
| Lama2 |
T |
A |
10: 26,946,368 (GRCm39) |
|
probably benign |
Het |
| Lama4 |
A |
C |
10: 38,932,846 (GRCm39) |
N574T |
probably benign |
Het |
| Lig3 |
T |
C |
11: 82,689,118 (GRCm39) |
S791P |
probably damaging |
Het |
| Oas2 |
A |
T |
5: 120,874,252 (GRCm39) |
|
probably benign |
Het |
| Or4c12b |
A |
T |
2: 89,647,017 (GRCm39) |
I116F |
probably damaging |
Het |
| Pdk1 |
A |
G |
2: 71,728,049 (GRCm39) |
D370G |
probably damaging |
Het |
| Popdc3 |
T |
A |
10: 45,190,976 (GRCm39) |
I29N |
probably damaging |
Het |
| Rbp3 |
A |
T |
14: 33,678,793 (GRCm39) |
I914F |
probably benign |
Het |
| Rnf207 |
C |
T |
4: 152,402,718 (GRCm39) |
|
probably benign |
Het |
| Ryr2 |
T |
A |
13: 11,707,563 (GRCm39) |
I2825F |
possibly damaging |
Het |
| Slc37a2 |
A |
T |
9: 37,146,849 (GRCm39) |
|
probably benign |
Het |
| Vps8 |
T |
C |
16: 21,336,972 (GRCm39) |
V791A |
possibly damaging |
Het |
| Wdr64 |
T |
C |
1: 175,599,877 (GRCm39) |
L127P |
probably damaging |
Het |
| Whrn |
T |
C |
4: 63,334,672 (GRCm39) |
T368A |
possibly damaging |
Het |
|
| Other mutations in Gpr65 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00435:Gpr65
|
APN |
12 |
98,241,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00717:Gpr65
|
APN |
12 |
98,242,314 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL01942:Gpr65
|
APN |
12 |
98,241,974 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02023:Gpr65
|
APN |
12 |
98,242,127 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02803:Gpr65
|
APN |
12 |
98,241,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1343:Gpr65
|
UTSW |
12 |
98,241,888 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1520:Gpr65
|
UTSW |
12 |
98,241,434 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1771:Gpr65
|
UTSW |
12 |
98,242,259 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1812:Gpr65
|
UTSW |
12 |
98,242,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2261:Gpr65
|
UTSW |
12 |
98,241,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2263:Gpr65
|
UTSW |
12 |
98,241,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5720:Gpr65
|
UTSW |
12 |
98,241,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7458:Gpr65
|
UTSW |
12 |
98,242,324 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8136:Gpr65
|
UTSW |
12 |
98,241,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9376:Gpr65
|
UTSW |
12 |
98,241,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-12-09 |
Incidental Mutation