Incidental Mutation 'IGL01642:Olfr715b'
ID93702
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr715b
Ensembl Gene ENSMUSG00000062987
Gene Nameolfactory receptor 715B
SynonymsEG384732, Gm10081
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.124) question?
Stock #IGL01642
Quality Score
Status
Chromosome7
Chromosomal Location107103748-107110369 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 107106822 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Asparagine at position 13 (I13N)
Ref Sequence ENSEMBL: ENSMUSP00000149136 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081044] [ENSMUST00000215713]
Predicted Effect possibly damaging
Transcript: ENSMUST00000081044
AA Change: I13N

PolyPhen 2 Score 0.553 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000079834
Gene: ENSMUSG00000062987
AA Change: I13N

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 7e-57 PFAM
Pfam:7TM_GPCR_Srsx 35 282 1.8e-7 PFAM
Pfam:7tm_1 41 288 2.5e-26 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215713
AA Change: I13N

PolyPhen 2 Score 0.553 (Sensitivity: 0.88; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aanat A G 11: 116,595,688 T18A possibly damaging Het
Abat A T 16: 8,600,919 I126F possibly damaging Het
Adcy6 G A 15: 98,594,509 A958V possibly damaging Het
Ago2 T C 15: 73,123,390 I447V probably benign Het
Arid1a A G 4: 133,681,844 V1784A unknown Het
Atp1b1 A G 1: 164,457,761 F33L probably benign Het
Bpnt1 G A 1: 185,354,041 V198I probably benign Het
C87414 A G 5: 93,636,295 Y437H possibly damaging Het
Clip3 A T 7: 30,297,069 probably benign Het
Clip3 G A 7: 30,298,862 M244I probably benign Het
Cyp2a22 A T 7: 26,938,759 N107K possibly damaging Het
Cyp2c23 A T 19: 44,005,556 L457Q probably damaging Het
Dbr1 A G 9: 99,575,978 Y17C probably damaging Het
Drc7 G A 8: 95,059,139 V208I probably benign Het
Dst T A 1: 34,189,389 L2021Q probably damaging Het
E2f4 C A 8: 105,301,336 P299T probably damaging Het
Eef1b2 T C 1: 63,177,831 L53P probably damaging Het
Enpp3 T C 10: 24,798,269 T378A probably damaging Het
Eps15 A G 4: 109,366,473 N302S probably benign Het
Esrrg G A 1: 188,210,915 V362M probably benign Het
Gcc2 T A 10: 58,280,612 N1014K probably benign Het
Gm3099 T A 14: 4,000,508 M114K possibly damaging Het
Gnptab C T 10: 88,436,132 T928I possibly damaging Het
Gpd2 A T 2: 57,268,071 R31* probably null Het
Impdh1 T C 6: 29,207,166 T60A possibly damaging Het
Kcnab3 A G 11: 69,330,430 E191G probably benign Het
Kcnh5 A G 12: 74,965,169 S659P probably damaging Het
Kl T C 5: 150,980,869 I362T possibly damaging Het
Kpna4 A G 3: 69,085,784 V414A probably damaging Het
Magi1 G A 6: 93,686,624 P1111S possibly damaging Het
Mb21d1 G A 9: 78,437,398 P247L probably damaging Het
Myo18a A G 11: 77,864,732 D1965G probably benign Het
Nadsyn1 G A 7: 143,797,878 P673S probably damaging Het
Naip2 A G 13: 100,160,937 S864P probably damaging Het
Olfr1330 A G 4: 118,893,461 Y126C probably damaging Het
Olfr453 G T 6: 42,744,552 V172L probably benign Het
Paics T A 5: 76,961,510 probably benign Het
Papss1 G T 3: 131,583,235 probably benign Het
Pax3 A G 1: 78,196,663 probably null Het
Pgbd5 T G 8: 124,384,202 Q159P probably benign Het
Pkd1 A G 17: 24,581,292 Y3009C probably damaging Het
Pla2g4d T C 2: 120,280,636 T161A probably damaging Het
Podxl2 T A 6: 88,843,547 Y521F probably damaging Het
Prmt2 C T 10: 76,222,493 G161S probably damaging Het
Rft1 C T 14: 30,676,868 T265I probably damaging Het
Rims2 T A 15: 39,457,796 L736M probably damaging Het
Slf1 C T 13: 77,049,915 A747T probably benign Het
Snx2 A G 18: 53,216,447 K427E probably damaging Het
Tmem131l A T 3: 83,938,050 D424E possibly damaging Het
Tmem2 T A 19: 21,823,901 I794N probably damaging Het
Tnxb A G 17: 34,718,514 T3826A probably damaging Het
Tpp2 T C 1: 43,954,653 Y233H probably damaging Het
Ubl4b C A 3: 107,554,831 E38* probably null Het
Usp5 A T 6: 124,820,453 I486N probably damaging Het
Vmn1r193 A C 13: 22,219,624 L66R probably damaging Het
Vps13b T C 15: 35,792,072 I2162T probably benign Het
Wdr66 T C 5: 123,288,698 V383A possibly damaging Het
Wipf2 T C 11: 98,890,824 V63A probably benign Het
Zfp735 G T 11: 73,710,479 C83F possibly damaging Het
Zfyve26 T C 12: 79,261,574 probably null Het
Other mutations in Olfr715b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00981:Olfr715b APN 7 107106061 nonsense probably null
IGL00981:Olfr715b APN 7 107106062 missense probably benign 0.00
IGL03174:Olfr715b APN 7 107106270 missense probably benign 0.05
R1724:Olfr715b UTSW 7 107106202 missense probably benign 0.00
R2029:Olfr715b UTSW 7 107106436 missense probably benign
R2860:Olfr715b UTSW 7 107106468 missense probably benign 0.10
R2861:Olfr715b UTSW 7 107106468 missense probably benign 0.10
R2862:Olfr715b UTSW 7 107106468 missense probably benign 0.10
R3807:Olfr715b UTSW 7 107106463 missense probably benign 0.01
R4797:Olfr715b UTSW 7 107106027 missense probably benign 0.26
R5008:Olfr715b UTSW 7 107106081 missense probably damaging 0.99
R5918:Olfr715b UTSW 7 107106621 missense probably damaging 1.00
R6090:Olfr715b UTSW 7 107106249 missense possibly damaging 0.52
R6174:Olfr715b UTSW 7 107106507 missense probably damaging 1.00
R6253:Olfr715b UTSW 7 107105938 missense probably benign 0.00
R7408:Olfr715b UTSW 7 107106067 missense probably benign 0.05
R7483:Olfr715b UTSW 7 107106775 missense probably benign 0.00
Posted On2013-12-09