Incidental Mutation 'R1037:Or5d38'
ID 93839
Institutional Source Beutler Lab
Gene Symbol Or5d38
Ensembl Gene ENSMUSG00000101078
Gene Name olfactory receptor family 5 subfamily D member 38
Synonyms GA_x6K02T2Q125-49616865-49615915, MOR174-6, Olfr1166
MMRRC Submission 039136-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R1037 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 87953704-87955337 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 87954573 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 252 (I252T)
Ref Sequence ENSEMBL: ENSMUSP00000149099 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099833] [ENSMUST00000217575]
AlphaFold Q7TR27
Predicted Effect probably damaging
Transcript: ENSMUST00000099833
AA Change: I252T

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000097421
Gene: ENSMUSG00000101078
AA Change: I252T

DomainStartEndE-ValueType
Pfam:7tm_4 33 310 6e-51 PFAM
Pfam:7tm_1 43 292 3e-14 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217575
AA Change: I252T

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.1%
  • 10x: 94.3%
  • 20x: 85.9%
Validation Efficiency 100% (58/58)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933405L10Rik A G 8: 106,436,144 (GRCm39) S139G probably benign Het
Abca2 T A 2: 25,328,240 (GRCm39) probably benign Het
Abcb1b A T 5: 8,875,657 (GRCm39) N610I probably benign Het
Ahnak T C 19: 8,984,982 (GRCm39) F2089L probably benign Het
Cacnb1 T C 11: 97,895,843 (GRCm39) probably benign Het
Cep57 T C 9: 13,730,275 (GRCm39) I61V possibly damaging Het
Ckap5 T C 2: 91,380,974 (GRCm39) I110T probably benign Het
Clasp2 T C 9: 113,725,702 (GRCm39) probably benign Het
Col11a1 A C 3: 113,987,801 (GRCm39) E265A probably damaging Het
Cst13 A G 2: 148,672,251 (GRCm39) probably benign Het
Cyp24a1 G A 2: 170,333,537 (GRCm39) T272M probably damaging Het
Cyp4a14 A C 4: 115,347,193 (GRCm39) L415R probably damaging Het
Dbnl T C 11: 5,746,807 (GRCm39) F179S probably damaging Het
Eepd1 T C 9: 25,498,079 (GRCm39) L388P possibly damaging Het
Exosc8 G T 3: 54,640,159 (GRCm39) A55E probably damaging Het
Fam72a G A 1: 131,461,557 (GRCm39) V81I probably damaging Het
Fasn C T 11: 120,700,277 (GRCm39) M2182I probably benign Het
Fras1 C T 5: 96,862,322 (GRCm39) P2234S probably damaging Het
Grn C A 11: 102,323,896 (GRCm39) D33E possibly damaging Het
Gsap A G 5: 21,456,163 (GRCm39) probably benign Het
H2bc15 T A 13: 21,938,417 (GRCm39) V42E probably damaging Het
Hook3 T C 8: 26,562,378 (GRCm39) Q229R possibly damaging Het
Itgb6 T C 2: 60,480,412 (GRCm39) E308G probably damaging Het
Kmo C T 1: 175,479,184 (GRCm39) P240L possibly damaging Het
Lrrc4c A G 2: 97,460,330 (GRCm39) M319V probably benign Het
Mia3 T C 1: 183,138,698 (GRCm39) I672M probably benign Het
Mib2 C T 4: 155,743,917 (GRCm39) G42S probably damaging Het
Mlc1 A G 15: 88,849,664 (GRCm39) L223P probably damaging Het
Mmp21 T C 7: 133,276,182 (GRCm39) K554E probably benign Het
Nup160 C T 2: 90,524,246 (GRCm39) T383I probably damaging Het
Opcml T A 9: 28,814,595 (GRCm39) D290E probably damaging Het
Or10a3b T A 7: 108,445,191 (GRCm39) T9S probably benign Het
Or4a27 T A 2: 88,559,376 (GRCm39) D189V probably damaging Het
Or5ac19 C T 16: 59,089,307 (GRCm39) C241Y probably damaging Het
Or5k14 T C 16: 58,693,333 (GRCm39) Y60C probably damaging Het
Palm3 C A 8: 84,755,901 (GRCm39) T471K probably benign Het
Prl2c5 T A 13: 13,360,492 (GRCm39) L50* probably null Het
Pzp T C 6: 128,496,389 (GRCm39) N281S probably benign Het
Qser1 T C 2: 104,590,900 (GRCm39) Y1722C probably damaging Het
Ryr3 A G 2: 112,699,453 (GRCm39) V879A probably benign Het
Sbno1 A G 5: 124,531,975 (GRCm39) S736P possibly damaging Het
Septin5 G A 16: 18,441,844 (GRCm39) probably benign Het
Slc17a6 A G 7: 51,298,996 (GRCm39) probably benign Het
Spag17 A T 3: 100,010,433 (GRCm39) T1976S probably benign Het
Swt1 A T 1: 151,246,320 (GRCm39) probably benign Het
Tenm4 T C 7: 96,446,688 (GRCm39) W853R probably damaging Het
Thbs1 A T 2: 117,953,532 (GRCm39) Q983L probably damaging Het
Tmem191 A G 16: 17,094,347 (GRCm39) probably benign Het
Tmprss11g A T 5: 86,638,606 (GRCm39) V294D probably damaging Het
Tor1aip2 A G 1: 155,941,082 (GRCm39) S463G probably benign Het
Trim36 A G 18: 46,329,385 (GRCm39) probably benign Het
Ttc1 A G 11: 43,621,326 (GRCm39) V285A possibly damaging Het
Uckl1 C T 2: 181,214,278 (GRCm39) R303H possibly damaging Het
Vwa8 C A 14: 79,324,094 (GRCm39) C1132* probably null Het
Other mutations in Or5d38
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01109:Or5d38 APN 2 87,955,023 (GRCm39) missense probably damaging 1.00
R1452:Or5d38 UTSW 2 87,954,655 (GRCm39) missense probably benign 0.01
R1842:Or5d38 UTSW 2 87,954,471 (GRCm39) missense probably damaging 1.00
R2005:Or5d38 UTSW 2 87,954,891 (GRCm39) missense probably damaging 1.00
R4106:Or5d38 UTSW 2 87,954,817 (GRCm39) missense possibly damaging 0.67
R4930:Or5d38 UTSW 2 87,954,684 (GRCm39) missense probably benign 0.08
R5473:Or5d38 UTSW 2 87,954,981 (GRCm39) missense possibly damaging 0.94
R5911:Or5d38 UTSW 2 87,955,027 (GRCm39) missense probably benign
R6596:Or5d38 UTSW 2 87,954,543 (GRCm39) missense probably damaging 1.00
R7842:Or5d38 UTSW 2 87,955,330 (GRCm39) start gained probably benign
R8902:Or5d38 UTSW 2 87,954,778 (GRCm39) missense probably damaging 1.00
R8943:Or5d38 UTSW 2 87,954,718 (GRCm39) missense probably damaging 0.98
R9120:Or5d38 UTSW 2 87,955,123 (GRCm39) missense probably damaging 1.00
R9240:Or5d38 UTSW 2 87,955,231 (GRCm39) missense probably benign 0.26
R9733:Or5d38 UTSW 2 87,955,000 (GRCm39) missense probably damaging 0.99
R9783:Or5d38 UTSW 2 87,954,610 (GRCm39) missense probably benign 0.07
Predicted Primers PCR Primer
(F):5'- AGCTGATAAGTCTCCTGACTGTGTCC -3'
(R):5'- GGCATCATCAATCACTTTGGCTGTG -3'

Sequencing Primer
(F):5'- GTCCTTCACATCTTTATTTCTAAGGC -3'
(R):5'- AGTACTCCGCTGTCATCTCTG -3'
Posted On 2014-01-05