Incidental Mutation 'R1054:Spata31e4'
ID |
94217 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Spata31e4
|
Ensembl Gene |
ENSMUSG00000094918 |
Gene Name |
spermatogenesis associated 31 subfamily E member 4 |
Synonyms |
Gm8765 |
MMRRC Submission |
039144-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.062)
|
Stock # |
R1054 (G1)
|
Quality Score |
117 |
Status
|
Not validated
|
Chromosome |
13 |
Chromosomal Location |
50852348-50857471 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 50856432 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Alanine
at position 690
(V690A)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000097118
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000099518]
|
AlphaFold |
B7ZWJ3 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000099518
AA Change: V690A
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
SMART Domains |
Protein: ENSMUSP00000097118 Gene: ENSMUSG00000094918 AA Change: V690A
Domain | Start | End | E-Value | Type |
low complexity region
|
69 |
82 |
N/A |
INTRINSIC |
Pfam:FAM75
|
95 |
418 |
1.1e-15 |
PFAM |
SCOP:d1i5pa1
|
811 |
874 |
9e-3 |
SMART |
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.7%
- 20x: 93.9%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 46 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Arhgap39 |
T |
C |
15: 76,635,759 (GRCm39) |
T159A |
probably benign |
Het |
Arhgef38 |
T |
C |
3: 132,822,226 (GRCm39) |
Y763C |
probably damaging |
Het |
Arv1 |
T |
A |
8: 125,458,611 (GRCm39) |
F245Y |
probably benign |
Het |
Ccdc175 |
A |
G |
12: 72,225,318 (GRCm39) |
I113T |
possibly damaging |
Het |
Cdc42bpb |
A |
T |
12: 111,279,787 (GRCm39) |
M932K |
probably benign |
Het |
Cdh15 |
T |
C |
8: 123,591,076 (GRCm39) |
F442L |
possibly damaging |
Het |
Col28a1 |
C |
T |
6: 8,175,534 (GRCm39) |
D105N |
probably damaging |
Het |
Cpne4 |
A |
G |
9: 104,899,600 (GRCm39) |
T428A |
probably benign |
Het |
Cramp1 |
T |
A |
17: 25,202,151 (GRCm39) |
I444F |
probably damaging |
Het |
Dhx32 |
T |
A |
7: 133,327,001 (GRCm39) |
K360M |
probably damaging |
Het |
Dna2 |
T |
A |
10: 62,799,602 (GRCm39) |
C669S |
possibly damaging |
Het |
Dusp8 |
ACTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGC |
ACTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGC |
7: 141,635,804 (GRCm39) |
|
probably benign |
Het |
Eif3f |
G |
A |
7: 108,537,024 (GRCm39) |
|
probably null |
Het |
Elmod1 |
T |
C |
9: 53,820,058 (GRCm39) |
D310G |
probably benign |
Het |
Fn1 |
A |
G |
1: 71,625,373 (GRCm39) |
*2272Q |
probably null |
Het |
Gnat1 |
A |
G |
9: 107,554,638 (GRCm39) |
S76P |
probably damaging |
Het |
Gtf2f2 |
T |
C |
14: 76,232,885 (GRCm39) |
T94A |
probably benign |
Het |
Hacd4 |
A |
T |
4: 88,341,264 (GRCm39) |
W152R |
probably damaging |
Het |
Kcnh8 |
A |
G |
17: 53,110,512 (GRCm39) |
Y241C |
probably damaging |
Het |
Lepr |
T |
C |
4: 101,639,793 (GRCm39) |
I753T |
probably damaging |
Het |
Med12l |
C |
T |
3: 59,156,072 (GRCm39) |
H1162Y |
probably damaging |
Het |
Med25 |
C |
T |
7: 44,529,804 (GRCm39) |
A485T |
probably benign |
Het |
Mup5 |
A |
T |
4: 61,750,871 (GRCm39) |
S145R |
probably benign |
Het |
Myo1g |
A |
G |
11: 6,468,987 (GRCm39) |
V105A |
probably damaging |
Het |
Npc2 |
A |
G |
12: 84,807,492 (GRCm39) |
|
probably null |
Het |
Or52h1 |
A |
G |
7: 103,829,498 (GRCm39) |
I39T |
probably benign |
Het |
Or6p1 |
A |
G |
1: 174,258,419 (GRCm39) |
T142A |
probably benign |
Het |
Otulinl |
T |
C |
15: 27,664,635 (GRCm39) |
R79G |
probably damaging |
Het |
Pdzd2 |
A |
G |
15: 12,371,725 (GRCm39) |
S2557P |
probably damaging |
Het |
Pop1 |
T |
C |
15: 34,509,955 (GRCm39) |
V353A |
probably benign |
Het |
Pou3f2 |
A |
G |
4: 22,487,536 (GRCm39) |
V199A |
possibly damaging |
Het |
Pramel18 |
A |
G |
4: 101,766,361 (GRCm39) |
E15G |
probably benign |
Het |
Ptprm |
A |
T |
17: 67,349,313 (GRCm39) |
N43K |
probably damaging |
Het |
Qrsl1 |
C |
T |
10: 43,758,077 (GRCm39) |
D339N |
probably damaging |
Het |
Rpl13-ps3 |
C |
A |
14: 59,131,394 (GRCm39) |
|
noncoding transcript |
Het |
Sdk2 |
C |
T |
11: 113,729,472 (GRCm39) |
|
silent |
Het |
Sdr16c6 |
A |
G |
4: 4,069,908 (GRCm39) |
V144A |
probably damaging |
Het |
Spata31d1b |
C |
A |
13: 59,865,332 (GRCm39) |
H827N |
probably damaging |
Het |
Taf4b |
T |
A |
18: 14,954,530 (GRCm39) |
H535Q |
probably benign |
Het |
Timmdc1 |
A |
G |
16: 38,342,790 (GRCm39) |
V36A |
probably benign |
Het |
Tmem74b |
C |
T |
2: 151,548,339 (GRCm39) |
A22V |
probably benign |
Het |
Txnrd3 |
T |
A |
6: 89,627,543 (GRCm39) |
Y65* |
probably null |
Het |
Vmn1r200 |
T |
A |
13: 22,579,624 (GRCm39) |
S133R |
probably damaging |
Het |
Vwf |
G |
A |
6: 125,567,190 (GRCm39) |
C311Y |
probably damaging |
Het |
Wipf2 |
G |
A |
11: 98,787,141 (GRCm39) |
R390H |
possibly damaging |
Het |
Zfp282 |
T |
A |
6: 47,881,533 (GRCm39) |
S407T |
probably benign |
Het |
|
Other mutations in Spata31e4 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01548:Spata31e4
|
APN |
13 |
50,854,414 (GRCm39) |
missense |
probably benign |
0.18 |
IGL02452:Spata31e4
|
APN |
13 |
50,857,113 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02610:Spata31e4
|
APN |
13 |
50,855,748 (GRCm39) |
missense |
possibly damaging |
0.91 |
IGL03171:Spata31e4
|
APN |
13 |
50,856,388 (GRCm39) |
missense |
probably benign |
0.23 |
IGL03369:Spata31e4
|
APN |
13 |
50,857,200 (GRCm39) |
missense |
possibly damaging |
0.74 |
PIT4382001:Spata31e4
|
UTSW |
13 |
50,855,007 (GRCm39) |
missense |
probably damaging |
0.99 |
R0346:Spata31e4
|
UTSW |
13 |
50,857,346 (GRCm39) |
missense |
probably benign |
0.12 |
R1015:Spata31e4
|
UTSW |
13 |
50,855,664 (GRCm39) |
missense |
possibly damaging |
0.92 |
R1102:Spata31e4
|
UTSW |
13 |
50,857,118 (GRCm39) |
missense |
probably benign |
0.00 |
R1519:Spata31e4
|
UTSW |
13 |
50,854,443 (GRCm39) |
critical splice donor site |
probably null |
|
R1628:Spata31e4
|
UTSW |
13 |
50,856,324 (GRCm39) |
missense |
probably benign |
0.25 |
R1754:Spata31e4
|
UTSW |
13 |
50,855,123 (GRCm39) |
missense |
probably damaging |
0.98 |
R4212:Spata31e4
|
UTSW |
13 |
50,854,388 (GRCm39) |
missense |
possibly damaging |
0.94 |
R4672:Spata31e4
|
UTSW |
13 |
50,857,208 (GRCm39) |
missense |
probably benign |
|
R4780:Spata31e4
|
UTSW |
13 |
50,855,116 (GRCm39) |
missense |
probably damaging |
0.97 |
R4794:Spata31e4
|
UTSW |
13 |
50,857,275 (GRCm39) |
missense |
probably benign |
0.07 |
R5171:Spata31e4
|
UTSW |
13 |
50,854,414 (GRCm39) |
missense |
possibly damaging |
0.85 |
R6240:Spata31e4
|
UTSW |
13 |
50,855,453 (GRCm39) |
missense |
probably damaging |
0.97 |
R6366:Spata31e4
|
UTSW |
13 |
50,855,972 (GRCm39) |
missense |
probably benign |
0.01 |
R6421:Spata31e4
|
UTSW |
13 |
50,855,987 (GRCm39) |
missense |
probably benign |
0.35 |
R6644:Spata31e4
|
UTSW |
13 |
50,856,071 (GRCm39) |
missense |
possibly damaging |
0.54 |
R6678:Spata31e4
|
UTSW |
13 |
50,855,946 (GRCm39) |
missense |
probably benign |
0.14 |
R6788:Spata31e4
|
UTSW |
13 |
50,857,131 (GRCm39) |
missense |
probably damaging |
0.99 |
R7030:Spata31e4
|
UTSW |
13 |
50,857,019 (GRCm39) |
missense |
possibly damaging |
0.52 |
R7513:Spata31e4
|
UTSW |
13 |
50,856,909 (GRCm39) |
missense |
probably benign |
0.01 |
R7681:Spata31e4
|
UTSW |
13 |
50,856,290 (GRCm39) |
missense |
possibly damaging |
0.70 |
R7753:Spata31e4
|
UTSW |
13 |
50,855,817 (GRCm39) |
missense |
probably damaging |
1.00 |
R7794:Spata31e4
|
UTSW |
13 |
50,856,344 (GRCm39) |
missense |
probably damaging |
0.98 |
R7994:Spata31e4
|
UTSW |
13 |
50,856,900 (GRCm39) |
missense |
probably benign |
0.04 |
R8021:Spata31e4
|
UTSW |
13 |
50,855,130 (GRCm39) |
missense |
possibly damaging |
0.50 |
R8858:Spata31e4
|
UTSW |
13 |
50,855,423 (GRCm39) |
missense |
probably benign |
0.07 |
R9027:Spata31e4
|
UTSW |
13 |
50,857,007 (GRCm39) |
nonsense |
probably null |
|
R9037:Spata31e4
|
UTSW |
13 |
50,856,944 (GRCm39) |
missense |
probably benign |
0.09 |
R9047:Spata31e4
|
UTSW |
13 |
50,856,128 (GRCm39) |
nonsense |
probably null |
|
R9065:Spata31e4
|
UTSW |
13 |
50,856,276 (GRCm39) |
missense |
probably benign |
0.01 |
R9476:Spata31e4
|
UTSW |
13 |
50,856,149 (GRCm39) |
missense |
possibly damaging |
0.70 |
R9495:Spata31e4
|
UTSW |
13 |
50,855,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
R9510:Spata31e4
|
UTSW |
13 |
50,856,149 (GRCm39) |
missense |
possibly damaging |
0.70 |
Z1177:Spata31e4
|
UTSW |
13 |
50,856,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- GTATGACAATGGAAGGCCCTGGAC -3'
(R):5'- ACTCTGGCTCTCTACATGGGGATG -3'
Sequencing Primer
(F):5'- TCCAGTGAGAGTCACATTGGTAAG -3'
(R):5'- CACAAACTTTGATCTTATCAGCTAGG -3'
|
Posted On |
2014-01-05 |