Incidental Mutation 'R1055:Or5b3'
ID 94321
Institutional Source Beutler Lab
Gene Symbol Or5b3
Ensembl Gene ENSMUSG00000063777
Gene Name olfactory receptor family 5 subfamily B member 3
Synonyms MOR202-11, Olfr1469, GA_x6K02T2RE5P-3743369-3744289
MMRRC Submission 039145-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # R1055 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 13387935-13388864 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 13388754 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 274 (A274T)
Ref Sequence ENSEMBL: ENSMUSP00000150006 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077538] [ENSMUST00000216910]
AlphaFold Q8VFW5
Predicted Effect probably benign
Transcript: ENSMUST00000077538
AA Change: A274T

PolyPhen 2 Score 0.098 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000076741
Gene: ENSMUSG00000063777
AA Change: A274T

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 2e-47 PFAM
Pfam:7tm_1 42 290 2.3e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216910
AA Change: A274T

PolyPhen 2 Score 0.098 (Sensitivity: 0.93; Specificity: 0.85)
Meta Mutation Damage Score 0.4386 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.3%
  • 10x: 95.3%
  • 20x: 87.5%
Validation Efficiency 100% (58/58)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930578I06Rik A G 14: 64,210,724 (GRCm39) V168A possibly damaging Het
A1cf C A 19: 31,909,919 (GRCm39) T237N probably benign Het
Actl10 A T 2: 154,394,588 (GRCm39) Q180L probably benign Het
Adcy1 T C 11: 7,059,075 (GRCm39) L327P probably damaging Het
Adcy7 T C 8: 89,044,685 (GRCm39) probably benign Het
Ahctf1 G A 1: 179,591,051 (GRCm39) T1243I possibly damaging Het
Akap6 C T 12: 52,927,455 (GRCm39) Q122* probably null Het
Apob G A 12: 8,044,963 (GRCm39) G861D probably damaging Het
Arhgef11 A C 3: 87,624,425 (GRCm39) T539P probably benign Het
Cd244a T A 1: 171,404,844 (GRCm39) V232E probably damaging Het
Chia1 A C 3: 106,038,199 (GRCm39) D365A probably damaging Het
Clpsl2 C T 17: 28,768,500 (GRCm39) Q5* probably null Het
Clrn1 T A 3: 58,772,531 (GRCm39) I117F probably benign Het
Csmd3 A G 15: 47,744,933 (GRCm39) L1354P probably damaging Het
Csn2 G A 5: 87,842,596 (GRCm39) P144S possibly damaging Het
Dcdc2a T A 13: 25,286,593 (GRCm39) M172K probably damaging Het
Dnah9 A T 11: 66,050,837 (GRCm39) W152R probably damaging Het
Dnmt3a T A 12: 3,922,864 (GRCm39) S82T probably benign Het
Ebf1 A G 11: 44,523,602 (GRCm39) K146E probably damaging Het
Gfpt2 A C 11: 49,718,038 (GRCm39) R504S probably damaging Het
Gpank1 T A 17: 35,343,284 (GRCm39) S255T probably damaging Het
Greb1 T C 12: 16,732,252 (GRCm39) M1570V probably damaging Het
Gtf2i A T 5: 134,292,478 (GRCm39) I403K probably damaging Het
Hoxc11 T A 15: 102,863,270 (GRCm39) C104S probably damaging Het
Hsh2d G A 8: 72,954,304 (GRCm39) D229N probably benign Het
Ilrun T C 17: 27,986,910 (GRCm39) N272S probably damaging Het
Khdrbs2 A T 1: 32,683,238 (GRCm39) probably benign Het
Lix1l G T 3: 96,528,626 (GRCm39) G200V probably damaging Het
Lrrc23 T C 6: 124,755,114 (GRCm39) N141S probably damaging Het
Marchf11 A T 15: 26,309,748 (GRCm39) D134V probably damaging Het
Myo9a A T 9: 59,762,653 (GRCm39) T795S probably benign Het
Nhsl1 T A 10: 18,401,223 (GRCm39) D782E probably benign Het
Nptxr T C 15: 79,674,456 (GRCm39) probably benign Het
Nrp1 A G 8: 129,195,079 (GRCm39) M512V possibly damaging Het
Ofcc1 C T 13: 40,362,305 (GRCm39) G206R probably benign Het
Or12e7 ATTGCTACTC A 2: 87,287,781 (GRCm39) probably benign Het
Pard3 T C 8: 128,104,761 (GRCm39) F267S probably benign Het
Pomt2 G A 12: 87,194,254 (GRCm39) T50M possibly damaging Het
Qsox2 A G 2: 26,104,137 (GRCm39) Y298H probably damaging Het
Rabgap1 A G 2: 37,382,080 (GRCm39) K450E possibly damaging Het
Rpa1 A T 11: 75,193,558 (GRCm39) V591D probably damaging Het
Sall3 A C 18: 81,013,007 (GRCm39) M1143R probably benign Het
Scgb1b19 G T 7: 32,986,768 (GRCm39) A13S unknown Het
Scn1a T C 2: 66,168,340 (GRCm39) T89A probably benign Het
Sdk2 C T 11: 113,729,472 (GRCm39) silent Het
Sdr42e1 T G 8: 118,390,323 (GRCm39) N106T probably damaging Het
Shpk A T 11: 73,105,945 (GRCm39) M266L probably benign Het
Slc34a1 G T 13: 55,550,846 (GRCm39) R139L probably benign Het
Smbd1 C A 16: 32,627,088 (GRCm39) D67Y probably damaging Het
Srd5a3 A G 5: 76,301,485 (GRCm39) N238S probably benign Het
Tmprss2 T C 16: 97,377,462 (GRCm39) N212D probably damaging Het
Uap1 G T 1: 169,984,480 (GRCm39) probably benign Het
Ugt1a6a A G 1: 88,066,736 (GRCm39) M181V probably benign Het
Vmn2r32 C T 7: 7,477,326 (GRCm39) W355* probably null Het
Vmn2r86 T A 10: 130,282,226 (GRCm39) S797C probably damaging Het
Wiz A G 17: 32,606,616 (GRCm39) S40P probably damaging Het
Zfand6 A G 7: 84,265,181 (GRCm39) probably benign Het
Zfp280d G A 9: 72,236,449 (GRCm39) probably null Het
Other mutations in Or5b3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01064:Or5b3 APN 19 13,388,590 (GRCm39) missense probably benign 0.01
IGL01520:Or5b3 APN 19 13,388,114 (GRCm39) missense probably damaging 0.97
IGL01671:Or5b3 APN 19 13,388,255 (GRCm39) missense probably benign 0.29
IGL02247:Or5b3 APN 19 13,388,831 (GRCm39) missense probably benign 0.01
IGL02297:Or5b3 APN 19 13,388,839 (GRCm39) missense probably benign 0.00
IGL02417:Or5b3 APN 19 13,388,259 (GRCm39) missense possibly damaging 0.52
IGL02442:Or5b3 APN 19 13,388,351 (GRCm39) missense probably benign 0.00
IGL02989:Or5b3 APN 19 13,388,850 (GRCm39) missense probably benign
IGL03269:Or5b3 APN 19 13,388,792 (GRCm39) missense probably damaging 0.99
IGL02988:Or5b3 UTSW 19 13,388,826 (GRCm39) missense possibly damaging 0.75
R0707:Or5b3 UTSW 19 13,388,784 (GRCm39) missense probably benign 0.22
R1102:Or5b3 UTSW 19 13,388,454 (GRCm39) missense probably damaging 1.00
R1946:Or5b3 UTSW 19 13,388,143 (GRCm39) missense possibly damaging 0.64
R2111:Or5b3 UTSW 19 13,388,307 (GRCm39) missense probably damaging 0.99
R4072:Or5b3 UTSW 19 13,388,299 (GRCm39) missense possibly damaging 0.49
R4073:Or5b3 UTSW 19 13,388,299 (GRCm39) missense possibly damaging 0.49
R4076:Or5b3 UTSW 19 13,388,299 (GRCm39) missense possibly damaging 0.49
R4726:Or5b3 UTSW 19 13,388,469 (GRCm39) missense probably damaging 1.00
R4939:Or5b3 UTSW 19 13,388,219 (GRCm39) missense probably benign 0.10
R5914:Or5b3 UTSW 19 13,388,326 (GRCm39) missense probably benign 0.31
R6003:Or5b3 UTSW 19 13,388,403 (GRCm39) missense probably benign 0.34
R6743:Or5b3 UTSW 19 13,387,957 (GRCm39) missense probably damaging 1.00
R6825:Or5b3 UTSW 19 13,388,514 (GRCm39) missense probably benign 0.01
R6826:Or5b3 UTSW 19 13,388,452 (GRCm39) missense probably benign 0.05
R6970:Or5b3 UTSW 19 13,388,792 (GRCm39) missense probably damaging 0.99
R7558:Or5b3 UTSW 19 13,388,355 (GRCm39) missense probably damaging 1.00
R7596:Or5b3 UTSW 19 13,388,511 (GRCm39) missense probably benign 0.01
R7923:Or5b3 UTSW 19 13,388,182 (GRCm39) missense probably benign 0.17
R8014:Or5b3 UTSW 19 13,388,175 (GRCm39) missense not run
R8506:Or5b3 UTSW 19 13,388,604 (GRCm39) missense possibly damaging 0.49
R8746:Or5b3 UTSW 19 13,388,092 (GRCm39) missense probably benign 0.44
R8803:Or5b3 UTSW 19 13,388,037 (GRCm39) missense probably damaging 0.99
R9112:Or5b3 UTSW 19 13,388,475 (GRCm39) missense probably benign 0.05
R9721:Or5b3 UTSW 19 13,388,334 (GRCm39) missense probably benign 0.17
Z1177:Or5b3 UTSW 19 13,388,083 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- GCATCACTTCTTCTGTGATATTCCAGCA -3'
(R):5'- CACTGACCAGTCAAAGCAAGAGTCAA -3'

Sequencing Primer
(F):5'- GGTTCTCTCTTGCTCTGACAGAC -3'
(R):5'- GGTTGTTCTGTAGCAGTCAACTAAC -3'
Posted On 2014-01-05