Incidental Mutation 'R1056:Oog4'
ID94350
Institutional Source Beutler Lab
Gene Symbol Oog4
Ensembl Gene ENSMUSG00000047799
Gene Nameoogenesin 4
Synonyms
MMRRC Submission 039146-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.074) question?
Stock #R1056 (G1)
Quality Score225
Status Not validated
Chromosome4
Chromosomal Location143437164-143450324 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 143438011 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 245 (T245A)
Ref Sequence ENSEMBL: ENSMUSP00000052217 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061277] [ENSMUST00000073641]
Predicted Effect possibly damaging
Transcript: ENSMUST00000061277
AA Change: T245A

PolyPhen 2 Score 0.716 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000052217
Gene: ENSMUSG00000047799
AA Change: T245A

DomainStartEndE-ValueType
SCOP:d1a4ya_ 195 357 6e-7 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000073641
AA Change: T317A

PolyPhen 2 Score 0.713 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000073325
Gene: ENSMUSG00000047799
AA Change: T317A

DomainStartEndE-ValueType
SCOP:d1a4ya_ 267 429 3e-7 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.1%
  • 20x: 92.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik C A 3: 36,983,453 H2469N possibly damaging Het
4932438A13Rik T A 3: 37,044,680 M1152K probably benign Het
Abca14 A G 7: 120,325,072 Y1649C probably damaging Het
Abcc10 A C 17: 46,303,954 C1459W possibly damaging Het
Amfr A T 8: 93,985,469 F278I probably benign Het
Anks1b G T 10: 90,921,429 probably null Het
Bak1 A G 17: 27,021,273 S147P possibly damaging Het
C7 T C 15: 5,045,778 N144S possibly damaging Het
Casd1 T C 6: 4,641,967 V748A probably benign Het
Ccdc180 T C 4: 45,916,375 S859P probably benign Het
Ccne2 T C 4: 11,192,707 S2P probably damaging Het
Cdc42bpg T A 19: 6,314,021 I541N probably benign Het
Cgnl1 T A 9: 71,725,895 N58I probably damaging Het
Chd7 T C 4: 8,822,402 S832P possibly damaging Het
Chl1 A T 6: 103,675,077 Y318F possibly damaging Het
Coq2 G T 5: 100,657,947 N274K probably benign Het
Crhr2 A T 6: 55,100,735 V214E probably damaging Het
Dgkg G C 16: 22,600,541 P70A probably damaging Het
Dync2h1 T C 9: 7,147,731 I966M probably benign Het
Eif5b C G 1: 38,022,167 R380G unknown Het
Fat4 T A 3: 38,891,392 I1478N probably damaging Het
Gm8251 C T 1: 44,060,927 G337D probably damaging Het
Impact A T 18: 12,976,524 I92L probably benign Het
Ly6c2 A G 15: 75,111,596 probably null Het
Lypd6b G A 2: 49,947,456 V147I possibly damaging Het
Mdga2 T C 12: 66,723,120 D192G probably damaging Het
Mms22l T C 4: 24,586,344 probably null Het
Myo9a C T 9: 59,832,201 T732I possibly damaging Het
Myrf C T 19: 10,223,486 M274I probably benign Het
Nfx1 G A 4: 41,003,057 R686Q probably damaging Het
Ofcc1 C T 13: 40,208,829 G206R probably benign Het
Olfr43 C T 11: 74,206,782 V145I probably benign Het
Olfr594 A T 7: 103,220,418 E233D probably benign Het
Pclo A T 5: 14,540,055 K790* probably null Het
Pcm1 A G 8: 41,321,900 E1668G probably damaging Het
Pkhd1l1 T A 15: 44,591,964 N4040K probably damaging Het
Podnl1 T A 8: 84,129,276 S222T probably benign Het
Ppil4 A G 10: 7,799,632 T182A possibly damaging Het
Prdm13 T C 4: 21,678,544 K649E probably damaging Het
Prob1 A T 18: 35,653,610 H530Q probably benign Het
Rbbp4 A T 4: 129,317,649 M404K probably damaging Het
Rilpl1 A T 5: 124,493,837 F149I probably damaging Het
Sema6c T A 3: 95,171,216 S543T probably benign Het
Sh3rf3 G T 10: 59,007,082 W290L probably damaging Het
Slc2a12 T G 10: 22,665,451 S402A probably benign Het
Tas2r131 T A 6: 132,957,067 I260F possibly damaging Het
Tasp1 A G 2: 140,008,764 I113T possibly damaging Het
Tnrc18 G A 5: 142,773,859 R741* probably null Het
Ube2o G T 11: 116,546,464 D244E probably damaging Het
Vmn1r206 A T 13: 22,620,614 M141K probably benign Het
Zbtb14 C A 17: 69,388,502 F398L probably damaging Het
Zfp747 A G 7: 127,374,588 S137P probably benign Het
Zfp951 A T 5: 104,815,285 H138Q possibly damaging Het
Other mutations in Oog4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01580:Oog4 APN 4 143439112 missense probably benign 0.27
IGL02207:Oog4 APN 4 143438940 missense probably benign 0.20
R0038:Oog4 UTSW 4 143438944 missense probably benign 0.20
R0038:Oog4 UTSW 4 143438944 missense probably benign 0.20
R0326:Oog4 UTSW 4 143439203 missense probably benign 0.03
R0372:Oog4 UTSW 4 143437689 missense probably damaging 1.00
R1598:Oog4 UTSW 4 143438001 missense probably damaging 0.99
R1712:Oog4 UTSW 4 143439914 missense probably damaging 1.00
R4028:Oog4 UTSW 4 143440200 missense probably benign 0.02
R4029:Oog4 UTSW 4 143440200 missense probably benign 0.02
R4030:Oog4 UTSW 4 143440200 missense probably benign 0.02
R4705:Oog4 UTSW 4 143438875 missense probably benign 0.00
R5260:Oog4 UTSW 4 143437854 missense probably benign 0.00
R5945:Oog4 UTSW 4 143437723 missense probably benign 0.01
R6499:Oog4 UTSW 4 143437978 missense probably damaging 0.96
R6614:Oog4 UTSW 4 143437875 missense possibly damaging 0.66
R6852:Oog4 UTSW 4 143439109 missense possibly damaging 0.72
Predicted Primers PCR Primer
(F):5'- GCAGGCAAAATGGCACTGATCTGAG -3'
(R):5'- TGGGTAGTCCTTCTGACATGCACC -3'

Sequencing Primer
(F):5'- ATGGCACTGATCTGAGAGTCC -3'
(R):5'- AGGCTTCCAACTAGAATGCTGTG -3'
Posted On2014-01-05