Incidental Mutation 'R1029:Taar7a'
| ID |
95157 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Taar7a
|
| Ensembl Gene |
ENSMUSG00000095647 |
| Gene Name |
trace amine-associated receptor 7A |
| Synonyms |
Taar7a, LOC215856 |
| MMRRC Submission |
039131-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.084)
|
| Stock # |
R1029 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
23868303-23869379 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 23868439 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 314
(I314T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000077616
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000078532]
|
| AlphaFold |
Q5QD12 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000078532
AA Change: I314T
PolyPhen 2
Score 0.651 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000077616
Gene: ENSMUSG00000095647
AA Change: I314T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
54 |
344 |
9.2e-10 |
PFAM |
|
Pfam:7TM_GPCR_Srx
|
56 |
261 |
5.2e-9 |
PFAM |
|
Pfam:7tm_1
|
64 |
326 |
3.2e-58 |
PFAM |
|
| Meta Mutation Damage Score |
0.1795 |
| Coding Region Coverage |
- 1x: 99.7%
- 3x: 99.0%
- 10x: 97.2%
- 20x: 94.5%
|
| Validation Efficiency |
92% (36/39) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 36 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930505A04Rik |
A |
G |
11: 30,376,177 (GRCm39) |
L230S |
probably damaging |
Het |
| 4930505A04Rik |
A |
G |
11: 30,396,389 (GRCm39) |
|
probably benign |
Het |
| Atg2b |
A |
G |
12: 105,602,032 (GRCm39) |
I1648T |
probably damaging |
Het |
| Ccdc110 |
T |
C |
8: 46,394,817 (GRCm39) |
F236S |
probably damaging |
Het |
| Ccdc178 |
T |
C |
18: 22,230,782 (GRCm39) |
D363G |
possibly damaging |
Het |
| Cntn5 |
T |
A |
9: 9,831,577 (GRCm39) |
D601V |
probably damaging |
Het |
| Cog7 |
C |
T |
7: 121,529,752 (GRCm39) |
|
probably null |
Het |
| Dnah7c |
A |
G |
1: 46,651,881 (GRCm39) |
K1365E |
probably damaging |
Het |
| Dock9 |
T |
C |
14: 121,837,096 (GRCm39) |
|
probably null |
Het |
| Ehd3 |
T |
A |
17: 74,123,321 (GRCm39) |
I108N |
probably benign |
Het |
| Erbb4 |
A |
G |
1: 68,348,773 (GRCm39) |
S535P |
probably damaging |
Het |
| Fam170a |
T |
C |
18: 50,414,741 (GRCm39) |
V129A |
probably damaging |
Het |
| Gfra3 |
T |
C |
18: 34,823,892 (GRCm39) |
T361A |
probably benign |
Het |
| Gm10295 |
A |
T |
7: 71,000,448 (GRCm39) |
I44K |
unknown |
Het |
| Gm10553 |
T |
C |
1: 85,078,170 (GRCm39) |
S96P |
probably benign |
Het |
| Gm21738 |
T |
A |
14: 19,415,957 (GRCm38) |
Y194F |
probably benign |
Het |
| Hspa13 |
A |
T |
16: 75,562,125 (GRCm39) |
Y25N |
probably damaging |
Het |
| Lrfn3 |
G |
A |
7: 30,055,347 (GRCm39) |
P533S |
probably damaging |
Het |
| Lrp4 |
A |
G |
2: 91,317,372 (GRCm39) |
|
probably benign |
Het |
| Mical3 |
T |
C |
6: 120,911,639 (GRCm39) |
D1991G |
probably benign |
Het |
| Myoz1 |
A |
G |
14: 20,700,600 (GRCm39) |
Y206H |
probably damaging |
Het |
| Or2at1 |
A |
T |
7: 99,416,431 (GRCm39) |
I21F |
probably benign |
Het |
| Otog |
A |
G |
7: 45,924,019 (GRCm39) |
E1126G |
probably damaging |
Het |
| Pak3 |
TTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC |
TTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC |
X: 142,526,889 (GRCm39) |
|
probably benign |
Het |
| Prkdc |
A |
G |
16: 15,472,613 (GRCm39) |
|
probably benign |
Het |
| Pttg1ip2 |
C |
T |
5: 5,505,919 (GRCm39) |
A121T |
probably benign |
Het |
| Rab7 |
A |
G |
6: 87,990,624 (GRCm39) |
S17P |
probably damaging |
Het |
| Slc35e1 |
T |
C |
8: 73,246,415 (GRCm39) |
|
probably benign |
Het |
| Sppl2a |
A |
G |
2: 126,765,514 (GRCm39) |
S203P |
probably benign |
Het |
| Tgs1 |
T |
C |
4: 3,593,471 (GRCm39) |
I453T |
probably damaging |
Het |
| Tmem117 |
C |
A |
15: 94,909,217 (GRCm39) |
T210N |
probably benign |
Het |
| Trim55 |
A |
G |
3: 19,698,906 (GRCm39) |
N45S |
probably damaging |
Het |
| Ugt2b34 |
G |
C |
5: 87,052,246 (GRCm39) |
S250* |
probably null |
Het |
| Vmn2r67 |
G |
A |
7: 84,785,974 (GRCm39) |
T677I |
probably damaging |
Het |
| Zfp335 |
C |
G |
2: 164,734,598 (GRCm39) |
|
probably benign |
Het |
| Znrf1 |
T |
A |
8: 112,263,986 (GRCm39) |
Y72N |
probably damaging |
Het |
|
| Other mutations in Taar7a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00476:Taar7a
|
APN |
10 |
23,868,294 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02408:Taar7a
|
APN |
10 |
23,868,500 (GRCm39) |
missense |
probably benign |
|
|
PIT4434001:Taar7a
|
UTSW |
10 |
23,869,319 (GRCm39) |
missense |
probably benign |
|
|
R0422:Taar7a
|
UTSW |
10 |
23,869,172 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1742:Taar7a
|
UTSW |
10 |
23,869,117 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2104:Taar7a
|
UTSW |
10 |
23,868,959 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2421:Taar7a
|
UTSW |
10 |
23,868,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3907:Taar7a
|
UTSW |
10 |
23,868,457 (GRCm39) |
missense |
probably benign |
0.25 |
|
R4021:Taar7a
|
UTSW |
10 |
23,869,284 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5180:Taar7a
|
UTSW |
10 |
23,869,046 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5486:Taar7a
|
UTSW |
10 |
23,868,356 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5507:Taar7a
|
UTSW |
10 |
23,868,529 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5587:Taar7a
|
UTSW |
10 |
23,868,726 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5766:Taar7a
|
UTSW |
10 |
23,869,260 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5861:Taar7a
|
UTSW |
10 |
23,868,337 (GRCm39) |
missense |
probably benign |
|
|
R7201:Taar7a
|
UTSW |
10 |
23,868,358 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7506:Taar7a
|
UTSW |
10 |
23,868,892 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R8810:Taar7a
|
UTSW |
10 |
23,869,279 (GRCm39) |
missense |
probably benign |
0.20 |
|
R9015:Taar7a
|
UTSW |
10 |
23,868,733 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9172:Taar7a
|
UTSW |
10 |
23,868,677 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9686:Taar7a
|
UTSW |
10 |
23,869,309 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9717:Taar7a
|
UTSW |
10 |
23,868,799 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9720:Taar7a
|
UTSW |
10 |
23,868,733 (GRCm39) |
missense |
probably benign |
0.10 |
|
X0064:Taar7a
|
UTSW |
10 |
23,868,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Taar7a
|
UTSW |
10 |
23,868,790 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCTGTGATCCTGTCGTACTGAAACC -3'
(R):5'- ACTGCCAGGGCATCAGAAAGCTAC -3'
Sequencing Primer
(F):5'- ATGCTTGGATCACAGCTCG -3'
(R):5'- GCATCAGAAAGCTACAAGGAC -3'
|
| Posted On |
2014-01-05 |
Incidental Mutation