Incidental Mutation 'R1033:Olfr410'
ID95299
Institutional Source Beutler Lab
Gene Symbol Olfr410
Ensembl Gene ENSMUSG00000063116
Gene Nameolfactory receptor 410
SynonymsGA_x6K02T2P1NL-4467421-4466474, MOR255-5
MMRRC Submission 039132-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.212) question?
Stock #R1033 (G1)
Quality Score225
Status Not validated
Chromosome11
Chromosomal Location74330281-74338031 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 74334636 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Lysine at position 198 (N198K)
Ref Sequence ENSEMBL: ENSMUSP00000150291 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052254] [ENSMUST00000213831] [ENSMUST00000214490]
Predicted Effect possibly damaging
Transcript: ENSMUST00000052254
AA Change: N198K

PolyPhen 2 Score 0.480 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000050456
Gene: ENSMUSG00000063116
AA Change: N198K

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 5.4e-53 PFAM
Pfam:7TM_GPCR_Srsx 38 253 5e-6 PFAM
Pfam:7tm_1 44 293 7.7e-27 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213831
AA Change: N198K

PolyPhen 2 Score 0.480 (Sensitivity: 0.89; Specificity: 0.90)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214490
AA Change: N198K

PolyPhen 2 Score 0.480 (Sensitivity: 0.89; Specificity: 0.90)
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.7%
  • 20x: 91.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931408C20Rik G A 1: 26,682,385 P1238L probably benign Het
Aasdh G A 5: 76,876,283 T174M probably damaging Het
Akap6 A C 12: 53,069,222 D1036A probably damaging Het
Alg6 T C 4: 99,762,033 S497P probably benign Het
Arhgap10 T A 8: 77,257,347 I700L possibly damaging Het
Atp11a A G 8: 12,828,555 Y377C probably damaging Het
Atp2b2 A T 6: 113,793,888 probably null Het
Card14 T A 11: 119,338,370 V702D probably damaging Het
Ccdc17 C T 4: 116,596,880 R32* probably null Het
Cdh7 A T 1: 110,085,053 D372V probably damaging Het
Cfap54 A T 10: 92,839,449 I2870N probably benign Het
Cped1 G T 6: 22,016,951 V100F probably damaging Het
Dapk1 T C 13: 60,721,865 probably null Het
Exoc4 G A 6: 33,265,987 G45D probably damaging Het
Fam110b A T 4: 5,799,440 N286I probably benign Het
Fbxo10 A T 4: 45,062,236 C97S probably damaging Het
Frem3 A T 8: 80,695,157 H2062L probably benign Het
Frk T C 10: 34,608,458 C476R probably damaging Het
Gm10471 T C 5: 26,089,127 K18E probably benign Het
Gm10542 A G 18: 44,204,601 T49A probably benign Het
Gm128 A G 3: 95,240,011 V324A possibly damaging Het
Gpr141 C T 13: 19,751,710 M298I probably benign Het
Gxylt1 T C 15: 93,245,077 E369G probably benign Het
Hpse2 A G 19: 42,913,199 V368A probably benign Het
Ice1 A T 13: 70,606,594 S458T probably damaging Het
Itgb7 T A 15: 102,223,554 D198V probably damaging Het
Kcnk10 A G 12: 98,518,670 V72A possibly damaging Het
Magel2 A G 7: 62,380,050 M901V unknown Het
Mgam A T 6: 40,680,624 Y971F probably benign Het
Mib2 C T 4: 155,659,460 G42S probably damaging Het
Mpp6 T C 6: 50,183,736 Y326H probably damaging Het
Mug1 A T 6: 121,880,551 D1078V probably damaging Het
Myom2 G A 8: 15,108,934 R870H probably benign Het
Nek8 A T 11: 78,171,285 L71Q probably null Het
Nox4 T A 7: 87,374,413 D502E probably damaging Het
Nsmaf G A 4: 6,438,054 P73S probably damaging Het
Nup205 C T 6: 35,227,442 A1421V probably benign Het
Nxpe4 T C 9: 48,393,233 F207L probably damaging Het
Olfr1043 A G 2: 86,162,850 I33T possibly damaging Het
Olfr1282 A T 2: 111,335,802 I92N probably damaging Het
Olfr59 A C 11: 74,288,666 T7P probably damaging Het
Prkdc T C 16: 15,767,951 L2451P probably damaging Het
Rad51ap2 C T 12: 11,456,251 S58F probably damaging Het
Rbbp8 A G 18: 11,742,705 R892G probably benign Het
Rock1 A G 18: 10,067,535 S1333P probably benign Het
Rpl7 A G 1: 16,102,504 I197T probably benign Het
Sar1a C A 10: 61,685,616 Q81K probably damaging Het
Shank1 A T 7: 44,356,796 H1979L possibly damaging Het
Slc10a2 C T 8: 5,104,889 V99M probably damaging Het
Slc22a30 G A 19: 8,335,801 Q436* probably null Het
Szt2 C T 4: 118,387,106 R1305H probably damaging Het
Ubash3a G A 17: 31,208,212 G32S probably damaging Het
Vmn1r200 G A 13: 22,395,890 D279N probably damaging Het
Zbtb8a T C 4: 129,354,221 D419G possibly damaging Het
Other mutations in Olfr410
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02103:Olfr410 APN 11 74335036 missense probably damaging 1.00
IGL02885:Olfr410 APN 11 74334693 missense possibly damaging 0.95
R0363:Olfr410 UTSW 11 74335099 missense probably damaging 1.00
R1722:Olfr410 UTSW 11 74334445 missense probably damaging 1.00
R1759:Olfr410 UTSW 11 74334982 missense possibly damaging 0.49
R2007:Olfr410 UTSW 11 74334386 missense possibly damaging 0.57
R2278:Olfr410 UTSW 11 74335165 missense probably benign 0.00
R4756:Olfr410 UTSW 11 74334576 missense probably benign
R5382:Olfr410 UTSW 11 74334980 missense probably benign 0.00
R6026:Olfr410 UTSW 11 74335088 missense probably damaging 0.99
R6048:Olfr410 UTSW 11 74335135 missense probably benign 0.13
X0067:Olfr410 UTSW 11 74334950 missense probably benign 0.00
Z1088:Olfr410 UTSW 11 74334692 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCCAGCACCATAGAATATGGCAAC -3'
(R):5'- TATGGAGACTGCCTCACACAGCTC -3'

Sequencing Primer
(F):5'- CATAGAATATGGCAACCACAGTG -3'
(R):5'- GTTGACTGCTTCCTATTGACAG -3'
Posted On2014-01-05