Incidental Mutation 'R1126:Rmdn3'
ID 96130
Institutional Source Beutler Lab
Gene Symbol Rmdn3
Ensembl Gene ENSMUSG00000070730
Gene Name regulator of microtubule dynamics 3
Synonyms Fam82a2, 1200015F23Rik
MMRRC Submission 039199-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1126 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 118967482-118987515 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 118984476 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 92 (D92G)
Ref Sequence ENSEMBL: ENSMUSP00000092283 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094695] [ENSMUST00000129351] [ENSMUST00000135419] [ENSMUST00000139519]
AlphaFold Q3UJU9
Predicted Effect probably benign
Transcript: ENSMUST00000094695
AA Change: D92G

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000092283
Gene: ENSMUSG00000070730
AA Change: D92G

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
coiled coil region 91 122 N/A INTRINSIC
low complexity region 135 148 N/A INTRINSIC
low complexity region 216 234 N/A INTRINSIC
SCOP:d1hxia_ 354 445 1e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000129351
SMART Domains Protein: ENSMUSP00000119498
Gene: ENSMUSG00000070730

DomainStartEndE-ValueType
transmembrane domain 10 32 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000135419
SMART Domains Protein: ENSMUSP00000123373
Gene: ENSMUSG00000070730

DomainStartEndE-ValueType
transmembrane domain 10 32 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000139519
SMART Domains Protein: ENSMUSP00000115973
Gene: ENSMUSG00000070730

DomainStartEndE-ValueType
transmembrane domain 10 32 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.6%
Validation Efficiency
MGI Phenotype PHENOTYPE: Phenotypic analysis of mice homozygous for a gene trap allele indicates this mutation has no notable phenotype in any parameter tested. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc8 T C 7: 45,759,062 (GRCm39) E1226G probably damaging Het
Arhgef40 G T 14: 52,234,583 (GRCm39) S962I probably damaging Het
Atp9b A T 18: 80,822,169 (GRCm39) M477K probably damaging Het
Enpp2 C T 15: 54,770,222 (GRCm39) probably null Het
Ephb3 T A 16: 21,041,226 (GRCm39) M727K possibly damaging Het
Exo5 A T 4: 120,779,322 (GRCm39) I181N probably damaging Het
Fbn1 T C 2: 125,163,112 (GRCm39) probably null Het
Gas6 T C 8: 13,533,700 (GRCm39) N103S probably benign Het
Gm11596 A T 11: 99,683,699 (GRCm39) C140* probably null Het
Il6st T C 13: 112,640,266 (GRCm39) Y681H probably damaging Het
Itih4 T C 14: 30,611,918 (GRCm39) probably null Het
Kdm5b C T 1: 134,541,729 (GRCm39) A768V possibly damaging Het
Krt87 A T 15: 101,385,363 (GRCm39) N336K probably damaging Het
Mfsd6 A G 1: 52,748,670 (GRCm39) V65A probably benign Het
Nipsnap1 A G 11: 4,834,081 (GRCm39) N90S probably benign Het
Nlrp9a C A 7: 26,260,166 (GRCm39) D640E probably benign Het
Or11h4b C T 14: 50,918,720 (GRCm39) A124T possibly damaging Het
Or1l4 A T 2: 37,092,113 (GRCm39) M287L probably benign Het
Or2j3 A G 17: 38,615,579 (GRCm39) C258R probably damaging Het
Or5p53 A C 7: 107,533,578 (GRCm39) M284L possibly damaging Het
Parp9 G A 16: 35,768,110 (GRCm39) V97I possibly damaging Het
Pdzd2 T C 15: 12,458,306 (GRCm39) T12A possibly damaging Het
Penk T C 4: 4,138,119 (GRCm39) T9A probably benign Het
Pilrb2 T C 5: 137,869,222 (GRCm39) D126G probably damaging Het
Pkdrej A T 15: 85,700,515 (GRCm39) V1807E probably damaging Het
Ppp1r9a A G 6: 4,906,795 (GRCm39) E450G possibly damaging Het
Rag1 T C 2: 101,473,034 (GRCm39) R703G probably damaging Het
Rem1 G A 2: 152,476,455 (GRCm39) V238M probably damaging Het
Rp1l1 G A 14: 64,267,918 (GRCm39) G1168D probably damaging Het
Saxo1 T A 4: 86,397,224 (GRCm39) T105S probably benign Het
Slc39a2 G A 14: 52,131,602 (GRCm39) G58R probably damaging Het
Tbx6 C T 7: 126,383,891 (GRCm39) T315I probably damaging Het
Tcf12 A G 9: 71,907,715 (GRCm39) M99T probably benign Het
Tdrd3 A G 14: 87,718,210 (GRCm39) D197G probably damaging Het
Tnc T C 4: 63,936,357 (GRCm39) N193S probably damaging Het
Ttn A G 2: 76,680,347 (GRCm39) probably benign Het
Vmn1r225 A G 17: 20,722,588 (GRCm39) I10V probably benign Het
Zp3r A G 1: 130,546,079 (GRCm39) L77P probably damaging Het
Other mutations in Rmdn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01374:Rmdn3 APN 2 118,984,428 (GRCm39) missense probably damaging 1.00
IGL01684:Rmdn3 APN 2 118,978,055 (GRCm39) missense probably damaging 1.00
IGL02892:Rmdn3 APN 2 118,984,561 (GRCm39) missense probably benign 0.00
R0534:Rmdn3 UTSW 2 118,976,851 (GRCm39) missense probably benign 0.00
R2332:Rmdn3 UTSW 2 118,984,008 (GRCm39) unclassified probably benign
R3850:Rmdn3 UTSW 2 118,986,903 (GRCm39) missense possibly damaging 0.65
R5034:Rmdn3 UTSW 2 118,978,058 (GRCm39) missense probably damaging 1.00
R5221:Rmdn3 UTSW 2 118,986,935 (GRCm39) missense probably damaging 1.00
R5942:Rmdn3 UTSW 2 118,978,058 (GRCm39) missense probably damaging 1.00
R6049:Rmdn3 UTSW 2 118,983,906 (GRCm39) missense probably damaging 1.00
R6188:Rmdn3 UTSW 2 118,969,831 (GRCm39) critical splice donor site probably null
R7011:Rmdn3 UTSW 2 118,968,904 (GRCm39) missense probably damaging 1.00
R7181:Rmdn3 UTSW 2 118,969,849 (GRCm39) missense probably damaging 1.00
R8277:Rmdn3 UTSW 2 118,976,905 (GRCm39) missense probably damaging 1.00
R8721:Rmdn3 UTSW 2 118,969,846 (GRCm39) missense possibly damaging 0.87
R9144:Rmdn3 UTSW 2 118,969,847 (GRCm39) missense probably benign 0.21
R9172:Rmdn3 UTSW 2 118,968,863 (GRCm39) missense probably benign 0.00
R9317:Rmdn3 UTSW 2 118,986,991 (GRCm39) missense unknown
R9727:Rmdn3 UTSW 2 118,968,827 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- TCAATAGGCCAAAGGGCACAGC -3'
(R):5'- AGGAAATGGCCCAGCTCATGTCTC -3'

Sequencing Primer
(F):5'- TGGGCTTGTTTAGAACCACAAAG -3'
(R):5'- gtccaatcccagccccc -3'
Posted On 2014-01-05