Incidental Mutation 'R1018:Or4a15'
ID 96537
Institutional Source Beutler Lab
Gene Symbol Or4a15
Ensembl Gene ENSMUSG00000075090
Gene Name olfactory receptor family 4 subfamily A member 15
Synonyms Olfr1234, MOR231-2, GA_x6K02T2Q125-50805620-50804676
MMRRC Submission 039122-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # R1018 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 89190357-89195209 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 89193523 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 83 (L83F)
Ref Sequence ENSEMBL: ENSMUSP00000149303 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099783] [ENSMUST00000111543] [ENSMUST00000137692]
AlphaFold A2AVK5
Predicted Effect possibly damaging
Transcript: ENSMUST00000099783
AA Change: L83F

PolyPhen 2 Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000097371
Gene: ENSMUSG00000075090
AA Change: L83F

DomainStartEndE-ValueType
Pfam:7tm_1 39 285 5.9e-32 PFAM
Pfam:7tm_4 137 278 1.5e-37 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000111543
AA Change: L83F

PolyPhen 2 Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000107168
Gene: ENSMUSG00000075090
AA Change: L83F

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 3.2e-46 PFAM
Pfam:7tm_1 39 285 7.2e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000137692
AA Change: L83F

PolyPhen 2 Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 95.9%
  • 20x: 91.7%
Validation Efficiency 100% (50/50)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 G T 10: 79,837,325 (GRCm39) C403F probably damaging Het
Adam20 C T 8: 41,249,146 (GRCm39) Q419* probably null Het
Ankrd36 C T 11: 5,596,876 (GRCm39) probably benign Het
Arl8b T A 6: 108,795,572 (GRCm39) I170K probably damaging Het
Atp5pb A T 3: 105,861,488 (GRCm39) V78E possibly damaging Het
Car9 G T 4: 43,512,439 (GRCm39) probably null Het
Cgnl1 A G 9: 71,633,340 (GRCm39) Y4H probably damaging Het
Cnn2 T C 10: 79,829,397 (GRCm39) C176R probably damaging Het
Dst A G 1: 34,233,174 (GRCm39) D3392G probably damaging Het
Eed T C 7: 89,617,019 (GRCm39) probably benign Het
Efl1 T A 7: 82,412,221 (GRCm39) V870E possibly damaging Het
Epx T C 11: 87,760,129 (GRCm39) N495S probably benign Het
Fbxw20 T A 9: 109,050,404 (GRCm39) Y407F probably benign Het
Gbp9 T A 5: 105,228,126 (GRCm39) Q552L probably benign Het
Hspa13 C A 16: 75,558,164 (GRCm39) V134L possibly damaging Het
Il16 T C 7: 83,323,746 (GRCm39) N268S probably damaging Het
Kif14 G A 1: 136,423,579 (GRCm39) probably benign Het
Lrig1 G A 6: 94,599,583 (GRCm39) probably benign Het
Myo7a T A 7: 97,756,212 (GRCm39) D29V probably damaging Het
Nsd2 A G 5: 34,000,585 (GRCm39) K34R probably damaging Het
P3h1 C A 4: 119,095,104 (GRCm39) T287K probably damaging Het
Pkhd1 A T 1: 20,271,483 (GRCm39) H3023Q possibly damaging Het
Plxna1 A G 6: 89,319,942 (GRCm39) L535P probably damaging Het
Prom1 A T 5: 44,187,056 (GRCm39) S400R probably benign Het
Psap T G 10: 60,136,590 (GRCm39) L523R probably damaging Het
Psme4 C T 11: 30,754,310 (GRCm39) T189I probably damaging Het
Ptpn12 A T 5: 21,234,867 (GRCm39) S39T possibly damaging Het
Qtrt2 T A 16: 43,698,363 (GRCm39) H98L possibly damaging Het
Rad54l2 C A 9: 106,589,589 (GRCm39) C601F probably benign Het
Saxo4 A T 19: 10,456,824 (GRCm39) probably benign Het
Sfswap A G 5: 129,631,640 (GRCm39) K756R possibly damaging Het
Slc24a5 T C 2: 124,910,827 (GRCm39) V86A probably damaging Het
Srrm2 T C 17: 24,041,514 (GRCm39) S2575P probably damaging Het
Stam T C 2: 14,122,185 (GRCm39) probably benign Het
Tbx6 T A 7: 126,382,364 (GRCm39) probably benign Het
Tmem131 A C 1: 36,833,900 (GRCm39) F1727V probably damaging Het
Tpr T A 1: 150,317,934 (GRCm39) H2147Q possibly damaging Het
Trio T A 15: 27,871,257 (GRCm39) H620L probably damaging Het
Uba5 T C 9: 103,927,102 (GRCm39) T292A probably benign Het
Unc5a T A 13: 55,138,765 (GRCm39) V48E possibly damaging Het
Upf1 G T 8: 70,791,556 (GRCm39) H514Q possibly damaging Het
Usp9y A G Y: 1,341,414 (GRCm39) probably benign Het
Vmn2r6 T A 3: 64,464,261 (GRCm39) D191V probably benign Het
Wapl T C 14: 34,413,863 (GRCm39) Y242H possibly damaging Het
Zfp341 A T 2: 154,487,972 (GRCm39) N812Y probably damaging Het
Zfp358 C A 8: 3,546,843 (GRCm39) S475* probably null Het
Zfp957 C A 14: 79,450,182 (GRCm39) C539F probably damaging Het
Other mutations in Or4a15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02134:Or4a15 APN 2 89,193,172 (GRCm39) missense probably damaging 0.97
R0945:Or4a15 UTSW 2 89,193,599 (GRCm39) missense probably damaging 0.98
R1419:Or4a15 UTSW 2 89,193,666 (GRCm39) missense probably damaging 1.00
R1872:Or4a15 UTSW 2 89,192,933 (GRCm39) missense probably damaging 1.00
R1929:Or4a15 UTSW 2 89,193,353 (GRCm39) missense probably benign 0.01
R2143:Or4a15 UTSW 2 89,193,447 (GRCm39) missense probably damaging 1.00
R3499:Or4a15 UTSW 2 89,193,294 (GRCm39) missense probably benign 0.07
R3776:Or4a15 UTSW 2 89,193,108 (GRCm39) missense possibly damaging 0.69
R4595:Or4a15 UTSW 2 89,193,669 (GRCm39) missense probably damaging 0.98
R6287:Or4a15 UTSW 2 89,193,363 (GRCm39) nonsense probably null
R7256:Or4a15 UTSW 2 89,192,838 (GRCm39) missense probably benign 0.21
R7516:Or4a15 UTSW 2 89,193,719 (GRCm39) missense probably benign 0.01
R7636:Or4a15 UTSW 2 89,193,583 (GRCm39) nonsense probably null
R7975:Or4a15 UTSW 2 89,193,413 (GRCm39) missense probably benign 0.23
R8240:Or4a15 UTSW 2 89,192,896 (GRCm39) missense probably benign 0.01
R8514:Or4a15 UTSW 2 89,193,573 (GRCm39) missense probably benign 0.06
R8680:Or4a15 UTSW 2 89,193,065 (GRCm39) missense probably benign 0.00
R8780:Or4a15 UTSW 2 89,193,652 (GRCm39) missense probably damaging 1.00
R8898:Or4a15 UTSW 2 89,192,957 (GRCm39) missense possibly damaging 0.56
R9402:Or4a15 UTSW 2 89,193,123 (GRCm39) nonsense probably null
R9434:Or4a15 UTSW 2 89,193,692 (GRCm39) missense probably benign 0.02
R9451:Or4a15 UTSW 2 89,193,243 (GRCm39) missense probably damaging 1.00
R9632:Or4a15 UTSW 2 89,193,065 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- AAGGTGACGGTACAAATTGCTCCTC -3'
(R):5'- TGGGCCTCACTCAGAATCCAGAAG -3'

Sequencing Primer
(F):5'- GTGCAAGCCAGTTTTAGCAG -3'
(R):5'- GCCAAAAGGTTCTGTTTGTCAC -3'
Posted On 2014-01-05