Incidental Mutation 'R1110:Tcl1b1'
ID 96678
Institutional Source Beutler Lab
Gene Symbol Tcl1b1
Ensembl Gene ENSMUSG00000066359
Gene Name T cell leukemia/lymphoma 1B, 1
Synonyms
MMRRC Submission 039183-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R1110 (G1)
Quality Score 225
Status Validated
Chromosome 12
Chromosomal Location 105125963-105132884 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 105126074 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Phenylalanine at position 19 (V19F)
Ref Sequence ENSEMBL: ENSMUSP00000152806 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081379] [ENSMUST00000085043] [ENSMUST00000142230] [ENSMUST00000146174] [ENSMUST00000222342]
AlphaFold P56840
Predicted Effect probably benign
Transcript: ENSMUST00000081379
SMART Domains Protein: ENSMUSP00000080115
Gene: ENSMUSG00000060863

DomainStartEndE-ValueType
Pfam:TCL1_MTCP1 1 117 4.5e-37 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000085043
AA Change: V19F

PolyPhen 2 Score 0.951 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000082118
Gene: ENSMUSG00000066359
AA Change: V19F

DomainStartEndE-ValueType
Pfam:TCL1_MTCP1 1 115 4.1e-38 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000142230
SMART Domains Protein: ENSMUSP00000120367
Gene: ENSMUSG00000060863

DomainStartEndE-ValueType
Pfam:TCL1_MTCP1 1 85 5.9e-35 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000146174
SMART Domains Protein: ENSMUSP00000121354
Gene: ENSMUSG00000060863

DomainStartEndE-ValueType
Pfam:TCL1_MTCP1 1 117 3.1e-44 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000222342
AA Change: V19F

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.7%
  • 20x: 94.3%
Validation Efficiency 97% (63/65)
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acap3 T A 4: 155,989,856 (GRCm39) probably null Het
Acp2 A G 2: 91,038,767 (GRCm39) probably null Het
Akap13 T G 7: 75,261,125 (GRCm39) S447A possibly damaging Het
Alk G A 17: 72,291,740 (GRCm39) probably benign Het
Arhgef39 T C 4: 43,496,834 (GRCm39) T327A probably benign Het
Calhm5 T G 10: 33,972,013 (GRCm39) I141L probably benign Het
Cdan1 G A 2: 120,551,083 (GRCm39) A1103V probably damaging Het
Cdh18 A G 15: 23,474,403 (GRCm39) T758A probably benign Het
Cdk17 T A 10: 93,074,895 (GRCm39) Y3* probably null Het
Cdon T C 9: 35,367,733 (GRCm39) probably benign Het
Cntn3 T A 6: 102,222,119 (GRCm39) N460I probably benign Het
Cntrl T A 2: 35,050,639 (GRCm39) C985S possibly damaging Het
Col6a2 T C 10: 76,443,574 (GRCm39) E497G probably benign Het
Crybg1 A G 10: 43,875,089 (GRCm39) M673T possibly damaging Het
Cyp2u1 A G 3: 131,087,258 (GRCm39) I441T possibly damaging Het
Disp2 T C 2: 118,620,920 (GRCm39) S551P probably damaging Het
Dock2 A T 11: 34,206,535 (GRCm39) F1354I possibly damaging Het
Dstyk A G 1: 132,381,063 (GRCm39) probably benign Het
Dzip1 T C 14: 119,126,717 (GRCm39) N527S probably benign Het
Eomes A G 9: 118,313,667 (GRCm39) I571V probably benign Het
Fbxl13 T C 5: 21,689,034 (GRCm39) D758G probably benign Het
Frem1 T C 4: 82,868,557 (GRCm39) S1457G probably damaging Het
Gabbr2 C T 4: 46,718,838 (GRCm39) C613Y probably damaging Het
Gm9755 A T 8: 67,967,710 (GRCm39) noncoding transcript Het
Hnrnpul2 A G 19: 8,804,110 (GRCm39) R570G probably damaging Het
Ift70a1 A T 2: 75,810,320 (GRCm39) C588S probably damaging Het
Igdcc4 A G 9: 65,034,208 (GRCm39) H674R possibly damaging Het
Kdm5d T A Y: 910,539 (GRCm39) L250H probably damaging Het
Kif1a T C 1: 92,951,175 (GRCm39) probably benign Het
Kmt2c T C 5: 25,519,360 (GRCm39) N2250S probably benign Het
Kmt2e C T 5: 23,707,653 (GRCm39) H1739Y probably damaging Het
Lmtk3 T A 7: 45,444,427 (GRCm39) probably benign Het
Lpin3 A G 2: 160,735,999 (GRCm39) D93G probably benign Het
Myh10 T C 11: 68,682,676 (GRCm39) probably benign Het
Myom2 G A 8: 15,172,413 (GRCm39) E1171K probably benign Het
Ncoa6 A T 2: 155,253,440 (GRCm39) probably benign Het
Nup160 A G 2: 90,563,563 (GRCm39) probably benign Het
Oit3 G A 10: 59,264,016 (GRCm39) R373C probably damaging Het
Olfml2a A T 2: 38,849,765 (GRCm39) I494L probably damaging Het
Or11g27 T C 14: 50,771,159 (GRCm39) S97P possibly damaging Het
Or9r7 A G 10: 129,962,522 (GRCm39) Y135H probably damaging Het
Parp6 G T 9: 59,556,847 (GRCm39) C584F probably damaging Het
Pcgf2 A G 11: 97,582,676 (GRCm39) probably benign Het
Pde3a T C 6: 141,405,042 (GRCm39) probably benign Het
Pibf1 C T 14: 99,350,409 (GRCm39) R186C probably damaging Het
Pitrm1 A G 13: 6,608,280 (GRCm39) D335G probably benign Het
Pkp4 T C 2: 59,169,109 (GRCm39) L752P probably damaging Het
Plcb3 C A 19: 6,939,281 (GRCm39) E566* probably null Het
Prune2 T C 19: 17,102,586 (GRCm39) S2582P probably benign Het
Reln A T 5: 22,239,773 (GRCm39) D831E probably benign Het
Samd9l T A 6: 3,374,267 (GRCm39) D998V probably benign Het
Sardh G A 2: 27,081,931 (GRCm39) T865I possibly damaging Het
Setbp1 G A 18: 78,901,075 (GRCm39) T864I probably damaging Het
Slc9a1 T A 4: 133,097,859 (GRCm39) M2K probably benign Het
Sorbs2 A G 8: 46,248,767 (GRCm39) T593A probably benign Het
Spata31e3 A T 13: 50,402,296 (GRCm39) D83E possibly damaging Het
Svs5 A T 2: 164,175,507 (GRCm39) I120L probably benign Het
Urgcp T C 11: 5,666,004 (GRCm39) N778S probably benign Het
Vnn1 A T 10: 23,775,499 (GRCm39) I250F possibly damaging Het
Xntrpc A G 7: 101,732,181 (GRCm39) R365G possibly damaging Het
Zfp84 T A 7: 29,470,797 (GRCm39) M1K probably null Het
Zfyve26 G A 12: 79,326,841 (GRCm39) R761C probably damaging Het
Zp3r A G 1: 130,505,621 (GRCm39) probably null Het
Other mutations in Tcl1b1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01016:Tcl1b1 APN 12 105,130,663 (GRCm39) nonsense probably null
R0781:Tcl1b1 UTSW 12 105,126,074 (GRCm39) missense probably damaging 0.97
R1962:Tcl1b1 UTSW 12 105,130,727 (GRCm39) missense probably benign 0.24
R2300:Tcl1b1 UTSW 12 105,130,783 (GRCm39) missense probably benign 0.13
R6548:Tcl1b1 UTSW 12 105,130,663 (GRCm39) missense probably benign 0.01
R7068:Tcl1b1 UTSW 12 105,125,952 (GRCm39) unclassified probably benign
R7257:Tcl1b1 UTSW 12 105,130,790 (GRCm39) missense probably damaging 1.00
R9493:Tcl1b1 UTSW 12 105,130,823 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- CCACAGGGTCAGGTTTCAGGAAAG -3'
(R):5'- CTGTAACGGAGTTCTCAATGCTAGGG -3'

Sequencing Primer
(F):5'- GGTGGTGTCCAAAATAATTCCCTG -3'
(R):5'- CTacacacaacacacacacacac -3'
Posted On 2014-01-05