Incidental Mutation 'IGL00161:Rnase10'
ID 968
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rnase10
Ensembl Gene ENSMUSG00000021872
Gene Name ribonuclease, RNase A family, 10 (non-active)
Synonyms 4930474F22Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL00161
Quality Score
Status
Chromosome 14
Chromosomal Location 51245208-51248215 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 51247238 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 168 (D168E)
Ref Sequence ENSEMBL: ENSMUSP00000131065 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022424] [ENSMUST00000164632]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000022424
AA Change: D205E

PolyPhen 2 Score 0.060 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000022424
Gene: ENSMUSG00000021872
AA Change: D205E

DomainStartEndE-ValueType
transmembrane domain 40 62 N/A INTRINSIC
low complexity region 87 98 N/A INTRINSIC
Pfam:RnaseA 132 244 2.2e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000164632
AA Change: D168E

PolyPhen 2 Score 0.910 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000131065
Gene: ENSMUSG00000021872
AA Change: D168E

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
low complexity region 50 61 N/A INTRINSIC
Pfam:RnaseA 91 208 1.4e-21 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous disruption of this gene leads to decreased bone mineral density, alterations in B cell, T cell and NK cell number, and abnormal circulating glucose, creatinine, chloride and serum albumin levels. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap13 T A 7: 75,375,719 (GRCm39) V1932E probably damaging Het
Alg3 A G 16: 20,426,608 (GRCm39) V211A probably damaging Het
Bsn T C 9: 107,992,309 (GRCm39) T1148A probably benign Het
Dmbt1 G T 7: 130,711,357 (GRCm39) D1538Y probably damaging Het
Fbxl20 C T 11: 97,981,500 (GRCm39) G396D possibly damaging Het
Gsto2 A G 19: 47,863,406 (GRCm39) D94G probably damaging Het
Igf2r T C 17: 12,932,877 (GRCm39) I882V probably benign Het
Ltbp1 C T 17: 75,617,147 (GRCm39) probably benign Het
Men1 G A 19: 6,387,237 (GRCm39) probably null Het
Nlrp1b A C 11: 71,072,007 (GRCm39) probably benign Het
Notch3 A T 17: 32,377,088 (GRCm39) C272* probably null Het
Or4c123 A G 2: 89,126,799 (GRCm39) C272R probably benign Het
Or8g26 A G 9: 39,096,388 (GRCm39) K305E possibly damaging Het
Pard3 A G 8: 128,086,299 (GRCm39) probably benign Het
Pcsk4 A G 10: 80,158,657 (GRCm39) Y532H probably damaging Het
Pkd1l1 A G 11: 8,879,353 (GRCm39) probably null Het
Potefam3e T C 8: 19,799,499 (GRCm39) probably benign Het
Prex1 A G 2: 166,480,321 (GRCm39) Y140H probably damaging Het
Ptpdc1 C T 13: 48,740,534 (GRCm39) R238Q possibly damaging Het
Rdx A G 9: 51,997,646 (GRCm39) D540G probably damaging Het
Slc30a5 A C 13: 100,943,174 (GRCm39) D561E probably damaging Het
Spag1 C T 15: 36,195,562 (GRCm39) R252* probably null Het
Spata31g1 A T 4: 42,973,982 (GRCm39) H1105L probably benign Het
Stox1 T C 10: 62,503,692 (GRCm39) E121G probably damaging Het
Synm T C 7: 67,384,663 (GRCm39) M558V probably benign Het
Tenm2 C T 11: 36,097,726 (GRCm39) probably benign Het
Vmn1r64 T C 7: 5,886,827 (GRCm39) T239A probably damaging Het
Other mutations in Rnase10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01534:Rnase10 APN 14 51,245,436 (GRCm39) missense probably benign 0.00
IGL02082:Rnase10 APN 14 51,246,856 (GRCm39) missense probably damaging 1.00
IGL02661:Rnase10 APN 14 51,247,273 (GRCm39) missense probably damaging 1.00
R1254:Rnase10 UTSW 14 51,247,083 (GRCm39) missense probably damaging 0.99
R1989:Rnase10 UTSW 14 51,247,095 (GRCm39) missense probably benign 0.03
R3878:Rnase10 UTSW 14 51,246,889 (GRCm39) missense probably damaging 0.97
R5405:Rnase10 UTSW 14 51,247,317 (GRCm39) missense probably damaging 1.00
R5942:Rnase10 UTSW 14 51,246,735 (GRCm39) missense probably benign 0.08
R6107:Rnase10 UTSW 14 51,246,751 (GRCm39) missense possibly damaging 0.89
R6994:Rnase10 UTSW 14 51,247,138 (GRCm39) missense probably damaging 1.00
R7138:Rnase10 UTSW 14 51,247,167 (GRCm39) missense probably damaging 1.00
R7186:Rnase10 UTSW 14 51,247,242 (GRCm39) missense probably damaging 1.00
R7848:Rnase10 UTSW 14 51,246,970 (GRCm39) missense possibly damaging 0.75
Posted On 2011-07-12