Incidental Mutation 'R1027:Map9'
ID 96836
Institutional Source Beutler Lab
Gene Symbol Map9
Ensembl Gene ENSMUSG00000033900
Gene Name microtubule-associated protein 9
Synonyms ASAP, 5330427D05Rik, 5033421J10Rik, Mtap9
MMRRC Submission 039129-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.374) question?
Stock # R1027 (G1)
Quality Score 215
Status Validated
Chromosome 3
Chromosomal Location 82265379-82302575 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 82284401 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 325 (D325V)
Ref Sequence ENSEMBL: ENSMUSP00000141282 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091014] [ENSMUST00000192595] [ENSMUST00000193559] [ENSMUST00000195471] [ENSMUST00000195640] [ENSMUST00000195793]
AlphaFold Q3TRR0
Predicted Effect probably damaging
Transcript: ENSMUST00000091014
AA Change: D325V

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000088535
Gene: ENSMUSG00000033900
AA Change: D325V

DomainStartEndE-ValueType
low complexity region 41 52 N/A INTRINSIC
Pfam:DUF4207 340 566 3.6e-10 PFAM
low complexity region 607 622 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000192595
AA Change: D325V

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000141828
Gene: ENSMUSG00000033900
AA Change: D325V

DomainStartEndE-ValueType
low complexity region 41 52 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000193559
AA Change: D325V

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000142014
Gene: ENSMUSG00000033900
AA Change: D325V

DomainStartEndE-ValueType
low complexity region 41 52 N/A INTRINSIC
low complexity region 356 365 N/A INTRINSIC
coiled coil region 476 513 N/A INTRINSIC
low complexity region 516 537 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194622
Predicted Effect probably damaging
Transcript: ENSMUST00000195471
AA Change: D325V

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000141282
Gene: ENSMUSG00000033900
AA Change: D325V

DomainStartEndE-ValueType
low complexity region 41 52 N/A INTRINSIC
low complexity region 356 365 N/A INTRINSIC
coiled coil region 476 513 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000195640
AA Change: D325V

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000142206
Gene: ENSMUSG00000033900
AA Change: D325V

DomainStartEndE-ValueType
low complexity region 41 52 N/A INTRINSIC
Pfam:DUF4207 332 562 4.4e-11 PFAM
low complexity region 564 596 N/A INTRINSIC
low complexity region 607 622 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000195793
SMART Domains Protein: ENSMUSP00000141231
Gene: ENSMUSG00000033900

DomainStartEndE-ValueType
low complexity region 72 90 N/A INTRINSIC
Meta Mutation Damage Score 0.2694 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 95.0%
  • 20x: 89.0%
Validation Efficiency 94% (31/33)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] ASAP is a microtubule-associated protein required for spindle function, mitotic progression, and cytokinesis (Saffin et al., 2005 [PubMed 16049101]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts10 G T 17: 33,762,737 (GRCm39) R572L probably benign Het
Adamts16 A T 13: 70,915,921 (GRCm39) V838E probably damaging Het
Arfgef3 T C 10: 18,467,123 (GRCm39) R2026G probably benign Het
Arl16 G A 11: 120,356,522 (GRCm39) A159V probably benign Het
Astn1 G T 1: 158,407,849 (GRCm39) R602L probably damaging Het
Dennd1b T C 1: 138,969,700 (GRCm39) V72A probably damaging Het
Filip1l A G 16: 57,390,051 (GRCm39) E213G probably benign Het
Gm10985 A C 3: 53,752,674 (GRCm39) Y19S probably damaging Het
Gm4076 T C 13: 85,275,508 (GRCm39) noncoding transcript Het
Herc1 T C 9: 66,363,250 (GRCm39) V2691A probably benign Het
Hid1 A C 11: 115,246,251 (GRCm39) F340V probably damaging Het
Itga10 C T 3: 96,559,054 (GRCm39) probably benign Het
Kif16b T C 2: 142,696,458 (GRCm39) probably benign Het
Mtor A G 4: 148,624,456 (GRCm39) M2079V probably benign Het
Nop14 A G 5: 34,801,348 (GRCm39) S608P probably damaging Het
Or5p62 A T 7: 107,771,348 (GRCm39) V201D probably damaging Het
Pcm1 T C 8: 41,746,482 (GRCm39) probably benign Het
Pigs T C 11: 78,227,651 (GRCm39) S272P probably damaging Het
Plekhh1 T C 12: 79,101,256 (GRCm39) probably benign Het
Prkdc A G 16: 15,468,576 (GRCm39) D129G possibly damaging Het
Rab33b T C 3: 51,391,876 (GRCm39) S42P probably damaging Het
Rnf214 C T 9: 45,811,187 (GRCm39) V159I probably benign Het
Sel1l3 A T 5: 53,302,820 (GRCm39) M683K possibly damaging Het
Sntb2 A G 8: 107,718,203 (GRCm39) K304E probably benign Het
Svep1 C A 4: 58,094,084 (GRCm39) S1518I possibly damaging Het
Tg T C 15: 66,544,258 (GRCm39) S76P possibly damaging Het
Ttn A G 2: 76,697,777 (GRCm39) probably benign Het
Zbtb12 CTTCAT CTTCATTCAT 17: 35,115,284 (GRCm39) probably null Het
Other mutations in Map9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00742:Map9 APN 3 82,270,727 (GRCm39) missense probably benign 0.37
IGL01520:Map9 APN 3 82,286,272 (GRCm39) missense probably damaging 0.99
IGL02281:Map9 APN 3 82,298,453 (GRCm39) missense possibly damaging 0.53
IGL02931:Map9 APN 3 82,284,428 (GRCm39) missense possibly damaging 0.86
IGL02937:Map9 APN 3 82,270,819 (GRCm39) missense possibly damaging 0.95
IGL02985:Map9 APN 3 82,267,209 (GRCm39) nonsense probably null
IGL03113:Map9 APN 3 82,267,285 (GRCm39) splice site probably benign
R0134:Map9 UTSW 3 82,267,290 (GRCm39) splice site probably benign
R0225:Map9 UTSW 3 82,267,290 (GRCm39) splice site probably benign
R0468:Map9 UTSW 3 82,281,510 (GRCm39) critical splice donor site probably null
R1794:Map9 UTSW 3 82,287,528 (GRCm39) missense probably damaging 1.00
R4008:Map9 UTSW 3 82,266,390 (GRCm39) missense probably damaging 1.00
R5728:Map9 UTSW 3 82,270,642 (GRCm39) missense probably benign 0.00
R5905:Map9 UTSW 3 82,287,555 (GRCm39) critical splice donor site probably null
R6028:Map9 UTSW 3 82,287,555 (GRCm39) critical splice donor site probably null
R6334:Map9 UTSW 3 82,290,612 (GRCm39) missense probably damaging 1.00
R6798:Map9 UTSW 3 82,287,471 (GRCm39) missense probably damaging 1.00
R7135:Map9 UTSW 3 82,270,765 (GRCm39) missense probably benign 0.03
R7443:Map9 UTSW 3 82,278,663 (GRCm39) missense possibly damaging 0.72
R7694:Map9 UTSW 3 82,266,290 (GRCm39) start gained probably benign
R8224:Map9 UTSW 3 82,266,370 (GRCm39) missense probably benign 0.33
R8237:Map9 UTSW 3 82,284,467 (GRCm39) missense probably damaging 0.97
R8395:Map9 UTSW 3 82,289,276 (GRCm39) missense probably benign 0.06
R8504:Map9 UTSW 3 82,284,476 (GRCm39) critical splice donor site probably null
R8696:Map9 UTSW 3 82,270,668 (GRCm39) missense possibly damaging 0.53
R8818:Map9 UTSW 3 82,291,270 (GRCm39) missense possibly damaging 0.86
R8957:Map9 UTSW 3 82,278,687 (GRCm39) missense probably benign
R9044:Map9 UTSW 3 82,287,525 (GRCm39) missense possibly damaging 0.92
R9266:Map9 UTSW 3 82,278,594 (GRCm39) missense possibly damaging 0.48
R9695:Map9 UTSW 3 82,284,292 (GRCm39) missense probably benign 0.18
Predicted Primers PCR Primer
(F):5'- TCTGCCATGCACTGAGTGGAAC -3'
(R):5'- CTCACTATGCAGCCAGAGTGTCATC -3'

Sequencing Primer
(F):5'- GTGCTCTGCCTCCAAACAG -3'
(R):5'- AGTTTCCAGTGAACACTCGG -3'
Posted On 2014-01-05