Incidental Mutation 'R0980:Or8k38'
ID 96936
Institutional Source Beutler Lab
Gene Symbol Or8k38
Ensembl Gene ENSMUSG00000075176
Gene Name olfactory receptor family 8 subfamily K member 38
Synonyms Olfr1085, MOR191-1, GA_x6K02T2Q125-48147264-48146323
MMRRC Submission 039106-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0980 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 86487859-86488800 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 86488209 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 198 (I198L)
Ref Sequence ENSEMBL: ENSMUSP00000150955 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099879] [ENSMUST00000213279] [ENSMUST00000214566]
AlphaFold Q7TR64
Predicted Effect probably benign
Transcript: ENSMUST00000099879
AA Change: I198L

PolyPhen 2 Score 0.391 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000097464
Gene: ENSMUSG00000075176
AA Change: I198L

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 4.6e-49 PFAM
Pfam:7tm_1 41 290 1.1e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213279
AA Change: I198L

PolyPhen 2 Score 0.391 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect probably benign
Transcript: ENSMUST00000214566
AA Change: I198L

PolyPhen 2 Score 0.391 (Sensitivity: 0.90; Specificity: 0.89)
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.0%
  • 10x: 95.1%
  • 20x: 89.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankdd1a T C 9: 65,424,253 (GRCm39) H20R probably damaging Het
Arfgef3 T C 10: 18,467,866 (GRCm39) E1778G possibly damaging Het
Arhgef18 C T 8: 3,439,095 (GRCm39) probably benign Het
Blm A T 7: 80,149,706 (GRCm39) probably null Het
Ccr6 A G 17: 8,474,846 (GRCm39) E17G probably benign Het
Cep126 T C 9: 8,100,720 (GRCm39) T605A probably damaging Het
Cnga4 C A 7: 105,057,213 (GRCm39) P439T probably damaging Het
Col11a1 G A 3: 113,932,414 (GRCm39) R113H unknown Het
Cyp2a5 A G 7: 26,538,431 (GRCm39) probably null Het
D430041D05Rik A G 2: 104,079,690 (GRCm39) V1131A probably damaging Het
Elp3 T C 14: 65,815,402 (GRCm39) T197A probably damaging Het
Etl4 A G 2: 20,806,378 (GRCm39) D1200G probably damaging Het
Gapt G C 13: 110,490,273 (GRCm39) T130R probably damaging Het
Gprin1 T C 13: 54,888,214 (GRCm39) D20G possibly damaging Het
Hltf T C 3: 20,145,665 (GRCm39) S432P probably benign Het
Immt T C 6: 71,851,310 (GRCm39) V54A probably benign Het
Jhy T G 9: 40,856,133 (GRCm39) Y118S possibly damaging Het
Kif23 C A 9: 61,844,046 (GRCm39) K154N possibly damaging Het
Krt79 T C 15: 101,846,442 (GRCm39) T169A probably damaging Het
Llgl2 A G 11: 115,740,827 (GRCm39) E443G probably damaging Het
Ltbp4 A T 7: 27,023,587 (GRCm39) C786S probably damaging Het
Mme A T 3: 63,247,550 (GRCm39) E278D probably benign Het
Nt5c2 G T 19: 46,887,317 (GRCm39) Q162K probably benign Het
Obscn A G 11: 58,888,887 (GRCm39) V2109A possibly damaging Het
Or5p64 GGTAG GG 7: 107,855,229 (GRCm39) probably benign Het
Or8k28 T C 2: 86,285,704 (GRCm39) T304A probably benign Het
Osmr G T 15: 6,881,921 (GRCm39) N74K probably benign Het
Pes1 AGAGGAGGAGGAGGAGGA AGAGGAGGAGGAGGA 11: 3,927,636 (GRCm39) probably benign Het
Pgd A T 4: 149,238,768 (GRCm39) probably null Het
Pld1 T A 3: 28,178,724 (GRCm39) S873T probably damaging Het
Polk A T 13: 96,620,272 (GRCm39) C664S probably benign Het
Proca1 A C 11: 78,095,773 (GRCm39) H135P probably benign Het
Ptgs2 A C 1: 149,980,061 (GRCm39) D333A probably damaging Het
Rexo5 T C 7: 119,423,035 (GRCm39) V289A probably damaging Het
Rnf125 T A 18: 21,112,117 (GRCm39) C49* probably null Het
Rprd2 C A 3: 95,673,216 (GRCm39) R729L probably damaging Het
Sipa1l1 A G 12: 82,388,994 (GRCm39) S407G possibly damaging Het
Slc35a4 C A 18: 36,815,834 (GRCm39) N221K probably damaging Het
Sorcs1 T C 19: 50,220,761 (GRCm39) D563G probably benign Het
Stk39 G T 2: 68,222,515 (GRCm39) T183K probably damaging Het
Tc2n T A 12: 101,644,835 (GRCm39) K264* probably null Het
Trim23 C T 13: 104,324,635 (GRCm39) R238W probably damaging Het
Trim66 C A 7: 109,054,877 (GRCm39) V1240L probably damaging Het
Ttn T C 2: 76,584,389 (GRCm39) T13913A probably damaging Het
Ubap1 T G 4: 41,379,832 (GRCm39) C349G probably damaging Het
Vmn1r170 A T 7: 23,305,759 (GRCm39) I54F possibly damaging Het
Other mutations in Or8k38
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00940:Or8k38 APN 2 86,488,070 (GRCm39) missense probably damaging 0.98
IGL01137:Or8k38 APN 2 86,488,055 (GRCm39) missense possibly damaging 0.92
IGL01329:Or8k38 APN 2 86,488,551 (GRCm39) missense probably benign 0.31
IGL01398:Or8k38 APN 2 86,488,032 (GRCm39) missense probably damaging 1.00
IGL02248:Or8k38 APN 2 86,488,061 (GRCm39) missense probably damaging 1.00
IGL02699:Or8k38 APN 2 86,488,691 (GRCm39) missense probably benign 0.34
IGL02818:Or8k38 APN 2 86,488,128 (GRCm39) missense probably damaging 1.00
IGL03095:Or8k38 APN 2 86,488,775 (GRCm39) missense possibly damaging 0.50
IGL03218:Or8k38 APN 2 86,488,703 (GRCm39) missense probably benign 0.32
R0121:Or8k38 UTSW 2 86,488,163 (GRCm39) missense probably benign 0.42
R0546:Or8k38 UTSW 2 86,488,235 (GRCm39) missense possibly damaging 0.91
R0583:Or8k38 UTSW 2 86,488,704 (GRCm39) missense probably benign 0.20
R2067:Or8k38 UTSW 2 86,488,781 (GRCm39) missense probably damaging 1.00
R2111:Or8k38 UTSW 2 86,488,781 (GRCm39) missense probably damaging 1.00
R3760:Or8k38 UTSW 2 86,488,232 (GRCm39) missense possibly damaging 0.91
R4530:Or8k38 UTSW 2 86,487,905 (GRCm39) missense probably benign 0.00
R4809:Or8k38 UTSW 2 86,488,029 (GRCm39) missense possibly damaging 0.95
R5940:Or8k38 UTSW 2 86,488,394 (GRCm39) missense probably damaging 0.98
R6027:Or8k38 UTSW 2 86,488,148 (GRCm39) missense probably damaging 1.00
R6417:Or8k38 UTSW 2 86,488,510 (GRCm39) nonsense probably null
R6420:Or8k38 UTSW 2 86,488,510 (GRCm39) nonsense probably null
R6619:Or8k38 UTSW 2 86,488,406 (GRCm39) missense probably damaging 1.00
R6762:Or8k38 UTSW 2 86,488,188 (GRCm39) missense probably benign 0.22
R6946:Or8k38 UTSW 2 86,487,932 (GRCm39) missense probably damaging 1.00
R7673:Or8k38 UTSW 2 86,488,070 (GRCm39) missense probably damaging 1.00
R7718:Or8k38 UTSW 2 86,488,373 (GRCm39) missense probably benign 0.26
R8461:Or8k38 UTSW 2 86,487,890 (GRCm39) missense probably benign 0.02
R8506:Or8k38 UTSW 2 86,488,745 (GRCm39) missense probably benign 0.05
R8977:Or8k38 UTSW 2 86,488,472 (GRCm39) missense probably benign 0.02
R9172:Or8k38 UTSW 2 86,487,879 (GRCm39) missense probably benign 0.00
R9211:Or8k38 UTSW 2 86,488,024 (GRCm39) nonsense probably null
R9337:Or8k38 UTSW 2 86,488,476 (GRCm39) missense probably benign 0.01
R9713:Or8k38 UTSW 2 86,488,041 (GRCm39) missense possibly damaging 0.80
Predicted Primers PCR Primer
(F):5'- TTTGACTGGACTTGGGCTGCAC -3'
(R):5'- TGAAAGGCATCACTGACCGTCCTG -3'

Sequencing Primer
(F):5'- CTTGGGCTGCACATACATAAATATC -3'
(R):5'- GTTGCAGAGCATAATTCAGTCTCC -3'
Posted On 2014-01-05