Incidental Mutation 'R1114:Or5m5'
ID 96992
Institutional Source Beutler Lab
Gene Symbol Or5m5
Ensembl Gene ENSMUSG00000044923
Gene Name olfactory receptor family 5 subfamily M member 5
Synonyms MOR196-2, Olfr1030, GA_x6K02T2Q125-47462755-47463693
MMRRC Submission 039187-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R1114 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 85809656-85815142 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 85814651 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 156 (I156F)
Ref Sequence ENSEMBL: ENSMUSP00000053309 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056849]
AlphaFold Q8VFL5
Predicted Effect probably benign
Transcript: ENSMUST00000056849
AA Change: I156F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000053309
Gene: ENSMUSG00000044923
AA Change: I156F

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 2.4e-58 PFAM
Pfam:7tm_1 47 296 3.2e-27 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.7%
  • 3x: 97.5%
  • 10x: 93.5%
  • 20x: 84.2%
Validation Efficiency 100% (47/47)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700128F08Rik T A 9: 8,222,179 (GRCm39) noncoding transcript Het
Acss3 T A 10: 106,824,740 (GRCm39) R422S possibly damaging Het
Asb15 G A 6: 24,567,176 (GRCm39) R499H probably damaging Het
Aspm C T 1: 139,389,662 (GRCm39) probably benign Het
Camk2d G A 3: 126,633,941 (GRCm39) V488M probably damaging Het
Cd247 A G 1: 165,616,407 (GRCm39) K4E probably benign Het
Cdh20 A G 1: 104,906,739 (GRCm39) D522G probably damaging Het
Cse1l T A 2: 166,783,123 (GRCm39) probably benign Het
Dctn2 T A 10: 127,114,011 (GRCm39) probably null Het
Dpy19l1 A T 9: 24,336,072 (GRCm39) F545I probably benign Het
Dpy19l4 A G 4: 11,287,643 (GRCm39) probably benign Het
Dsg4 A T 18: 20,599,540 (GRCm39) T719S possibly damaging Het
Dusp12 A C 1: 170,708,586 (GRCm39) V48G probably damaging Het
Efcab7 A T 4: 99,735,452 (GRCm39) R159* probably null Het
Fabp3 C T 4: 130,206,180 (GRCm39) T57I probably benign Het
Fbxw20 A G 9: 109,052,550 (GRCm39) V261A probably damaging Het
Gtf3c3 C T 1: 54,456,937 (GRCm39) A488T probably damaging Het
Inpp5j C A 11: 3,444,814 (GRCm39) R953L possibly damaging Het
Itprid2 A G 2: 79,487,873 (GRCm39) E652G probably damaging Het
Lrrk2 C T 15: 91,584,671 (GRCm39) R363* probably null Het
Ltbp1 A G 17: 75,667,770 (GRCm39) D1089G probably benign Het
Luc7l T C 17: 26,494,832 (GRCm39) probably benign Het
Mdn1 G A 4: 32,746,568 (GRCm39) probably null Het
Mgat4a A T 1: 37,503,487 (GRCm39) probably benign Het
Mmp12 A G 9: 7,358,289 (GRCm39) T392A possibly damaging Het
Nlrp12 A G 7: 3,277,166 (GRCm39) V921A probably benign Het
Or5t7 G A 2: 86,507,629 (GRCm39) T16I possibly damaging Het
Or6c8b T A 10: 128,882,711 (GRCm39) I74F possibly damaging Het
Pkd2l1 T C 19: 44,179,983 (GRCm39) probably benign Het
Pramel24 A G 4: 143,453,425 (GRCm39) I178V probably benign Het
Rictor C A 15: 6,823,486 (GRCm39) C1554* probably null Het
Ryr2 A G 13: 11,960,867 (GRCm39) C24R probably damaging Het
Scamp2 T A 9: 57,488,863 (GRCm39) I188N probably damaging Het
Smg1 A T 7: 117,759,013 (GRCm39) probably benign Het
Sned1 G A 1: 93,209,376 (GRCm39) V830M possibly damaging Het
Synrg C A 11: 83,914,262 (GRCm39) probably benign Het
Syt9 G T 7: 107,024,562 (GRCm39) V152F possibly damaging Het
Trmt2a A G 16: 18,068,304 (GRCm39) probably benign Het
Vmn2r100 T C 17: 19,752,261 (GRCm39) I831T probably damaging Het
Vps13a G T 19: 16,727,515 (GRCm39) H196N probably benign Het
Xdh T C 17: 74,248,144 (GRCm39) probably benign Het
Other mutations in Or5m5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01775:Or5m5 APN 2 85,815,014 (GRCm39) missense probably damaging 0.99
IGL01795:Or5m5 APN 2 85,814,478 (GRCm39) missense probably damaging 1.00
IGL02395:Or5m5 APN 2 85,814,426 (GRCm39) missense possibly damaging 0.76
IGL03277:Or5m5 APN 2 85,814,517 (GRCm39) missense probably damaging 0.99
PIT4468001:Or5m5 UTSW 2 85,814,792 (GRCm39) missense probably benign 0.10
R0458:Or5m5 UTSW 2 85,814,600 (GRCm39) missense probably benign 0.00
R1642:Or5m5 UTSW 2 85,814,201 (GRCm39) missense probably benign 0.00
R2189:Or5m5 UTSW 2 85,814,412 (GRCm39) missense probably damaging 1.00
R4094:Or5m5 UTSW 2 85,814,562 (GRCm39) missense probably damaging 1.00
R4246:Or5m5 UTSW 2 85,814,624 (GRCm39) missense possibly damaging 0.90
R4677:Or5m5 UTSW 2 85,814,315 (GRCm39) missense possibly damaging 0.61
R5537:Or5m5 UTSW 2 85,814,570 (GRCm39) missense possibly damaging 0.83
R6018:Or5m5 UTSW 2 85,815,148 (GRCm39) utr 3 prime probably benign
R6531:Or5m5 UTSW 2 85,814,651 (GRCm39) missense probably benign
R7367:Or5m5 UTSW 2 85,814,687 (GRCm39) missense possibly damaging 0.68
R7611:Or5m5 UTSW 2 85,814,407 (GRCm39) nonsense probably null
R7693:Or5m5 UTSW 2 85,814,979 (GRCm39) missense probably damaging 1.00
R7753:Or5m5 UTSW 2 85,815,060 (GRCm39) missense possibly damaging 0.75
R8940:Or5m5 UTSW 2 85,814,543 (GRCm39) missense probably benign
R8961:Or5m5 UTSW 2 85,814,610 (GRCm39) missense probably damaging 1.00
R9049:Or5m5 UTSW 2 85,814,235 (GRCm39) missense possibly damaging 0.49
R9202:Or5m5 UTSW 2 85,814,801 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- GTGACTCCCAAGATGCTGGTGAAC -3'
(R):5'- AGAACGCATCCTCAAGATGGCAATG -3'

Sequencing Primer
(F):5'- GAAAACCATTTCATATGCTGCG -3'
(R):5'- CATCCTCAAGATGGCAATGAGAATG -3'
Posted On 2014-01-05