Incidental Mutation 'R1004:Dpp4'
ID 97908
Institutional Source Beutler Lab
Gene Symbol Dpp4
Ensembl Gene ENSMUSG00000035000
Gene Name dipeptidylpeptidase 4
Synonyms Cd26, THAM, Dpp-4
MMRRC Submission 039114-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1004 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 62160417-62242575 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 62162984 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Leucine at position 754 (Q754L)
Ref Sequence ENSEMBL: ENSMUSP00000044050 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047812]
AlphaFold P28843
Predicted Effect probably benign
Transcript: ENSMUST00000047812
AA Change: Q754L

PolyPhen 2 Score 0.078 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000044050
Gene: ENSMUSG00000035000
AA Change: Q754L

DomainStartEndE-ValueType
transmembrane domain 7 29 N/A INTRINSIC
Pfam:DPPIV_N 102 473 5.7e-110 PFAM
Pfam:Abhydrolase_5 545 752 1e-11 PFAM
Pfam:DLH 546 754 4e-7 PFAM
Pfam:Peptidase_S9 551 760 3.4e-61 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156871
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.2%
  • 20x: 92.7%
Validation Efficiency 100% (41/41)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutants show hypoglycemia, hyperinsulinemia, and increased plasma glucagon-like peptide 1 in glucose tolerance tests. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 A G 11: 110,042,780 (GRCm39) I423T possibly damaging Het
Agbl3 A T 6: 34,780,386 (GRCm39) E453V probably damaging Het
Agxt A G 1: 93,063,421 (GRCm39) M108V possibly damaging Het
Akap13 T C 7: 75,337,034 (GRCm39) I831T probably damaging Het
Anpep C T 7: 79,488,004 (GRCm39) E518K probably benign Het
Arid1a A G 4: 133,414,586 (GRCm39) M1215T unknown Het
Cd163 G T 6: 124,302,306 (GRCm39) D957Y probably damaging Het
Ces2e A G 8: 105,656,370 (GRCm39) D200G probably damaging Het
Cfap54 T C 10: 92,902,558 (GRCm39) probably benign Het
Col11a1 A G 3: 113,888,671 (GRCm39) probably benign Het
Dlx6 C T 6: 6,863,665 (GRCm39) Q96* probably null Het
Ece1 A G 4: 137,653,550 (GRCm39) T100A probably benign Het
Gabbr2 C T 4: 46,677,544 (GRCm39) V779M possibly damaging Het
Gatm C T 2: 122,440,141 (GRCm39) probably benign Het
Gpc2 A G 5: 138,276,487 (GRCm39) L213P probably damaging Het
Hook1 A C 4: 95,910,524 (GRCm39) N713H probably benign Het
Kdm5b T A 1: 134,516,642 (GRCm39) I178K possibly damaging Het
Mettl9 G A 7: 120,675,460 (GRCm39) V287I probably benign Het
Mroh2a C A 1: 88,170,142 (GRCm39) A685D possibly damaging Het
Mycbp2 G A 14: 103,378,353 (GRCm39) T3774I probably benign Het
Nup58 C A 14: 60,484,930 (GRCm39) probably benign Het
Nxf1 A T 19: 8,741,681 (GRCm39) T119S probably benign Het
Oaz3 T A 3: 94,342,350 (GRCm39) H102L probably damaging Het
Or8g2b T C 9: 39,751,276 (GRCm39) F182S probably benign Het
Pfpl A T 19: 12,407,789 (GRCm39) Q680L probably benign Het
Poli T A 18: 70,658,509 (GRCm39) Q75L probably benign Het
Ppp2r3d C T 9: 101,075,829 (GRCm39) probably null Het
Prr30 A G 14: 101,436,529 (GRCm39) L11P probably damaging Het
Ptchd4 A T 17: 42,688,493 (GRCm39) Y345F probably benign Het
Ric1 A G 19: 29,579,757 (GRCm39) N1233S probably benign Het
Serpinb9f TA "TTTNA,T" 13: 33,518,225 (GRCm39) probably benign Het
Sh3bgrl2 C T 9: 83,459,684 (GRCm39) probably benign Het
Skp1 G C 11: 52,128,207 (GRCm39) probably benign Het
Slc12a9 T C 5: 137,320,786 (GRCm39) K528R probably damaging Het
Slc22a6 A G 19: 8,595,763 (GRCm39) N35S probably damaging Het
Tcstv2c T A 13: 120,616,558 (GRCm39) D132E probably benign Het
Xrcc5 A G 1: 72,422,937 (GRCm39) probably benign Het
Zfp235 T A 7: 23,840,169 (GRCm39) L266Q probably damaging Het
Zfp600 T A 4: 146,133,103 (GRCm39) probably benign Het
Other mutations in Dpp4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00492:Dpp4 APN 2 62,209,646 (GRCm39) missense probably damaging 1.00
IGL02205:Dpp4 APN 2 62,182,601 (GRCm39) missense probably damaging 1.00
IGL02276:Dpp4 APN 2 62,187,295 (GRCm39) splice site probably benign
IGL02335:Dpp4 APN 2 62,164,988 (GRCm39) missense probably benign 0.03
IGL02615:Dpp4 APN 2 62,189,672 (GRCm39) missense probably damaging 1.00
IGL02639:Dpp4 APN 2 62,182,584 (GRCm39) missense probably benign
IGL02972:Dpp4 APN 2 62,182,569 (GRCm39) missense probably damaging 1.00
IGL03366:Dpp4 APN 2 62,187,301 (GRCm39) splice site probably null
caribou UTSW 2 62,178,245 (GRCm39) missense possibly damaging 0.69
PIT4449001:Dpp4 UTSW 2 62,186,988 (GRCm39) missense probably benign 0.00
R0502:Dpp4 UTSW 2 62,195,332 (GRCm39) missense probably damaging 0.99
R0581:Dpp4 UTSW 2 62,187,020 (GRCm39) missense probably benign
R1075:Dpp4 UTSW 2 62,182,630 (GRCm39) missense probably benign 0.39
R1476:Dpp4 UTSW 2 62,178,245 (GRCm39) missense possibly damaging 0.69
R1702:Dpp4 UTSW 2 62,216,773 (GRCm39) critical splice donor site probably null
R1707:Dpp4 UTSW 2 62,189,679 (GRCm39) splice site probably benign
R1733:Dpp4 UTSW 2 62,203,213 (GRCm39) critical splice acceptor site probably null
R1899:Dpp4 UTSW 2 62,175,394 (GRCm39) splice site probably benign
R2264:Dpp4 UTSW 2 62,208,583 (GRCm39) missense possibly damaging 0.71
R2496:Dpp4 UTSW 2 62,217,477 (GRCm39) missense possibly damaging 0.90
R3765:Dpp4 UTSW 2 62,216,780 (GRCm39) missense probably benign 0.17
R4278:Dpp4 UTSW 2 62,209,667 (GRCm39) missense probably damaging 1.00
R4413:Dpp4 UTSW 2 62,217,484 (GRCm39) missense possibly damaging 0.89
R4432:Dpp4 UTSW 2 62,175,456 (GRCm39) missense probably damaging 1.00
R4647:Dpp4 UTSW 2 62,164,949 (GRCm39) missense probably damaging 1.00
R4710:Dpp4 UTSW 2 62,190,659 (GRCm39) missense probably benign 0.04
R4914:Dpp4 UTSW 2 62,178,236 (GRCm39) missense probably benign 0.20
R5173:Dpp4 UTSW 2 62,217,474 (GRCm39) missense probably damaging 1.00
R5283:Dpp4 UTSW 2 62,190,680 (GRCm39) missense probably damaging 1.00
R5698:Dpp4 UTSW 2 62,164,655 (GRCm39) missense probably damaging 1.00
R6621:Dpp4 UTSW 2 62,182,484 (GRCm39) missense probably damaging 1.00
R6681:Dpp4 UTSW 2 62,178,893 (GRCm39) missense probably benign 0.01
R6739:Dpp4 UTSW 2 62,217,439 (GRCm39) missense probably benign
R6962:Dpp4 UTSW 2 62,203,174 (GRCm39) missense probably benign 0.11
R7249:Dpp4 UTSW 2 62,215,547 (GRCm39) missense probably benign 0.14
R7268:Dpp4 UTSW 2 62,178,186 (GRCm39) missense probably damaging 1.00
R7343:Dpp4 UTSW 2 62,189,245 (GRCm39) nonsense probably null
R7357:Dpp4 UTSW 2 62,217,421 (GRCm39) missense probably benign
R7366:Dpp4 UTSW 2 62,184,943 (GRCm39) missense probably damaging 1.00
R7413:Dpp4 UTSW 2 62,187,333 (GRCm39) missense probably damaging 1.00
R7431:Dpp4 UTSW 2 62,182,582 (GRCm39) missense probably benign 0.01
R7642:Dpp4 UTSW 2 62,190,627 (GRCm39) critical splice donor site probably null
R8004:Dpp4 UTSW 2 62,189,172 (GRCm39) missense probably benign 0.00
R8197:Dpp4 UTSW 2 62,203,171 (GRCm39) missense probably benign 0.31
R8341:Dpp4 UTSW 2 62,178,234 (GRCm39) missense probably benign 0.10
R8706:Dpp4 UTSW 2 62,208,647 (GRCm39) missense probably benign 0.00
R8977:Dpp4 UTSW 2 62,204,747 (GRCm39) missense probably benign 0.29
R8997:Dpp4 UTSW 2 62,164,958 (GRCm39) missense probably damaging 0.99
R9100:Dpp4 UTSW 2 62,204,733 (GRCm39) missense possibly damaging 0.51
R9616:Dpp4 UTSW 2 62,217,429 (GRCm39) missense probably damaging 1.00
R9777:Dpp4 UTSW 2 62,195,340 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- GTCTGGCAGTGAACAGCTCTTCTC -3'
(R):5'- ACATGTCTTGAACAGCTCTGGTGG -3'

Sequencing Primer
(F):5'- TGGGGACAGGCATCCTTAG -3'
(R):5'- AGGCTTATAAACCATTCCCGTTG -3'
Posted On 2014-01-05