Mutagenetix > Incidental Mutation

Incidental Mutation 'R1004:Zfp600'

97936

Institutional Source

Beutler Lab

Gene Symbol

Zfp600

Ensembl Gene

ENSMUSG00000066007

Gene Name

zinc finger protein 600

Synonyms

Gm13164

MMRRC Submission

039114-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.397) question?

Stock #

R1004 (G1)

Quality Score

190

Status

Validated

Chromosome

Chromosomal Location

146093397-146135326 bp(+) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

T to A at 146133103 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000117892 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000092750] [ENSMUST00000131932] [ENSMUST00000168483]

AlphaFold

A2A7V0

Predicted Effect

unknown
Transcript: ENSMUST00000092750
AA Change: S590R

SMART Domains

Protein: ENSMUSP00000090425
Gene: ENSMUSG00000066007
AA Change: S590R

Domain	Start	End	E-Value	Type
KRAB	28	90	1.29e-17	SMART
ZnF_C2H2	251	273	7.9e-4	SMART
ZnF_C2H2	279	301	7.9e-4	SMART
ZnF_C2H2	307	329	3.49e-5	SMART
ZnF_C2H2	335	357	1.95e-3	SMART
ZnF_C2H2	363	385	7.9e-4	SMART
ZnF_C2H2	391	413	7.9e-4	SMART
ZnF_C2H2	419	441	3.49e-5	SMART
ZnF_C2H2	447	469	3.89e-3	SMART
ZnF_C2H2	475	497	2.75e-3	SMART
ZnF_C2H2	503	525	3.04e-5	SMART
ZnF_C2H2	531	553	8.34e-3	SMART
ZnF_C2H2	559	581	5.67e-5	SMART
ZnF_C2H2	587	609	1.98e-4	SMART
ZnF_C2H2	615	637	5.29e-5	SMART
ZnF_C2H2	643	665	1.58e-3	SMART
ZnF_C2H2	671	693	1.28e-3	SMART
ZnF_C2H2	699	721	1.6e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000131932

SMART Domains

Protein: ENSMUSP00000117892
Gene: ENSMUSG00000066007

Domain	Start	End	E-Value	Type
KRAB	28	90	1.29e-17	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000152923

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000153595

Predicted Effect

unknown
Transcript: ENSMUST00000168483
AA Change: S590R

SMART Domains

Protein: ENSMUSP00000126879
Gene: ENSMUSG00000066007
AA Change: S590R

Domain	Start	End	E-Value	Type
KRAB	28	90	1.29e-17	SMART
ZnF_C2H2	251	273	7.9e-4	SMART
ZnF_C2H2	279	301	7.9e-4	SMART
ZnF_C2H2	307	329	3.49e-5	SMART
ZnF_C2H2	335	357	1.95e-3	SMART
ZnF_C2H2	363	385	7.9e-4	SMART
ZnF_C2H2	391	413	7.9e-4	SMART
ZnF_C2H2	419	441	3.49e-5	SMART
ZnF_C2H2	447	469	3.89e-3	SMART
ZnF_C2H2	475	497	2.75e-3	SMART
ZnF_C2H2	503	525	3.04e-5	SMART
ZnF_C2H2	531	553	8.34e-3	SMART
ZnF_C2H2	559	581	5.67e-5	SMART
ZnF_C2H2	587	609	1.98e-4	SMART
ZnF_C2H2	615	637	5.29e-5	SMART
ZnF_C2H2	643	665	1.58e-3	SMART
ZnF_C2H2	671	693	1.28e-3	SMART
ZnF_C2H2	699	721	1.6e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000181199

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.2%
20x: 92.7%

Validation Efficiency

100% (41/41)

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca9	A	G	11: 110,042,780 (GRCm39)	I423T	possibly damaging	Het
Agbl3	A	T	6: 34,780,386 (GRCm39)	E453V	probably damaging	Het
Agxt	A	G	1: 93,063,421 (GRCm39)	M108V	possibly damaging	Het
Akap13	T	C	7: 75,337,034 (GRCm39)	I831T	probably damaging	Het
Anpep	C	T	7: 79,488,004 (GRCm39)	E518K	probably benign	Het
Arid1a	A	G	4: 133,414,586 (GRCm39)	M1215T	unknown	Het
Cd163	G	T	6: 124,302,306 (GRCm39)	D957Y	probably damaging	Het
Ces2e	A	G	8: 105,656,370 (GRCm39)	D200G	probably damaging	Het
Cfap54	T	C	10: 92,902,558 (GRCm39)		probably benign	Het
Col11a1	A	G	3: 113,888,671 (GRCm39)		probably benign	Het
Dlx6	C	T	6: 6,863,665 (GRCm39)	Q96*	probably null	Het
Dpp4	T	A	2: 62,162,984 (GRCm39)	Q754L	probably benign	Het
Ece1	A	G	4: 137,653,550 (GRCm39)	T100A	probably benign	Het
Gabbr2	C	T	4: 46,677,544 (GRCm39)	V779M	possibly damaging	Het
Gatm	C	T	2: 122,440,141 (GRCm39)		probably benign	Het
Gpc2	A	G	5: 138,276,487 (GRCm39)	L213P	probably damaging	Het
Hook1	A	C	4: 95,910,524 (GRCm39)	N713H	probably benign	Het
Kdm5b	T	A	1: 134,516,642 (GRCm39)	I178K	possibly damaging	Het
Mettl9	G	A	7: 120,675,460 (GRCm39)	V287I	probably benign	Het
Mroh2a	C	A	1: 88,170,142 (GRCm39)	A685D	possibly damaging	Het
Mycbp2	G	A	14: 103,378,353 (GRCm39)	T3774I	probably benign	Het
Nup58	C	A	14: 60,484,930 (GRCm39)		probably benign	Het
Nxf1	A	T	19: 8,741,681 (GRCm39)	T119S	probably benign	Het
Oaz3	T	A	3: 94,342,350 (GRCm39)	H102L	probably damaging	Het
Or8g2b	T	C	9: 39,751,276 (GRCm39)	F182S	probably benign	Het
Pfpl	A	T	19: 12,407,789 (GRCm39)	Q680L	probably benign	Het
Poli	T	A	18: 70,658,509 (GRCm39)	Q75L	probably benign	Het
Ppp2r3d	C	T	9: 101,075,829 (GRCm39)		probably null	Het
Prr30	A	G	14: 101,436,529 (GRCm39)	L11P	probably damaging	Het
Ptchd4	A	T	17: 42,688,493 (GRCm39)	Y345F	probably benign	Het
Ric1	A	G	19: 29,579,757 (GRCm39)	N1233S	probably benign	Het
Serpinb9f	TA	"TTTNA,T"	13: 33,518,225 (GRCm39)		probably benign	Het
Sh3bgrl2	C	T	9: 83,459,684 (GRCm39)		probably benign	Het
Skp1	G	C	11: 52,128,207 (GRCm39)		probably benign	Het
Slc12a9	T	C	5: 137,320,786 (GRCm39)	K528R	probably damaging	Het
Slc22a6	A	G	19: 8,595,763 (GRCm39)	N35S	probably damaging	Het
Tcstv2c	T	A	13: 120,616,558 (GRCm39)	D132E	probably benign	Het
Xrcc5	A	G	1: 72,422,937 (GRCm39)		probably benign	Het
Zfp235	T	A	7: 23,840,169 (GRCm39)	L266Q	probably damaging	Het

Other mutations in Zfp600

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
PIT4131001:Zfp600	UTSW	4	146,131,802 (GRCm39)	frame shift	probably null
R1323:Zfp600	UTSW	4	146,133,261 (GRCm39)	missense	probably damaging	1.00
R1323:Zfp600	UTSW	4	146,133,261 (GRCm39)	missense	probably damaging	1.00
R1702:Zfp600	UTSW	4	146,133,497 (GRCm39)	missense	probably benign	0.04
R2165:Zfp600	UTSW	4	146,133,488 (GRCm39)	nonsense	probably null
R5238:Zfp600	UTSW	4	146,131,741 (GRCm39)	splice site	probably null
R5548:Zfp600	UTSW	4	146,133,019 (GRCm39)	missense	possibly damaging	0.86
R5646:Zfp600	UTSW	4	146,131,670 (GRCm39)	missense	probably damaging	1.00
R5948:Zfp600	UTSW	4	146,131,645 (GRCm39)	missense	probably damaging	0.96
R6112:Zfp600	UTSW	4	146,131,701 (GRCm39)	missense	probably benign	0.41
R7044:Zfp600	UTSW	4	146,131,892 (GRCm39)	nonsense	probably null
R7836:Zfp600	UTSW	4	146,133,523 (GRCm39)	missense	probably benign
R8080:Zfp600	UTSW	4	146,133,182 (GRCm39)	missense	unknown
R8749:Zfp600	UTSW	4	146,133,151 (GRCm39)	missense	unknown
R9255:Zfp600	UTSW	4	146,131,673 (GRCm39)	missense	possibly damaging	0.70
Z1176:Zfp600	UTSW	4	146,133,209 (GRCm39)	missense	unknown
Z1177:Zfp600	UTSW	4	146,133,333 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

Posted On

2014-01-05