Mutagenetix > Incidental Mutation

Incidental Mutation 'R1101:Fcamr'

98060

Institutional Source

Beutler Lab

Gene Symbol

Fcamr

Ensembl Gene

ENSMUSG00000026415

Gene Name

Fc receptor, IgA, IgM, high affinity

Synonyms

MMRRC Submission

039174-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

R1101 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

130728639-130742477 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 130742223 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000108096 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027670] [ENSMUST00000027670] [ENSMUST00000112477] [ENSMUST00000112477]

AlphaFold

Q2TB54

Predicted Effect

probably null
Transcript: ENSMUST00000027670

SMART Domains

Protein: ENSMUSP00000027670
Gene: ENSMUSG00000026415

Domain	Start	End	E-Value	Type
signal peptide	1	36	N/A	INTRINSIC
IG	87	191	1.19e-5	SMART
low complexity region	208	220	N/A	INTRINSIC
low complexity region	241	253	N/A	INTRINSIC
transmembrane domain	456	475	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000027670

SMART Domains

Protein: ENSMUSP00000027670
Gene: ENSMUSG00000026415

Domain	Start	End	E-Value	Type
signal peptide	1	36	N/A	INTRINSIC
IG	87	191	1.19e-5	SMART
low complexity region	208	220	N/A	INTRINSIC
low complexity region	241	253	N/A	INTRINSIC
transmembrane domain	456	475	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000112477

SMART Domains

Protein: ENSMUSP00000108096
Gene: ENSMUSG00000026415

Domain	Start	End	E-Value	Type
low complexity region	80	87	N/A	INTRINSIC
IG	143	247	1.19e-5	SMART
low complexity region	264	276	N/A	INTRINSIC
low complexity region	297	309	N/A	INTRINSIC
transmembrane domain	512	531	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000112477

SMART Domains

Protein: ENSMUSP00000108096
Gene: ENSMUSG00000026415

Domain	Start	End	E-Value	Type
low complexity region	80	87	N/A	INTRINSIC
IG	143	247	1.19e-5	SMART
low complexity region	264	276	N/A	INTRINSIC
low complexity region	297	309	N/A	INTRINSIC
transmembrane domain	512	531	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000122968

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125056

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136015

Coding Region Coverage

1x: 98.9%
3x: 98.0%
10x: 95.5%
20x: 91.2%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous null mice have enhanced germinal center formation, affinity maturation and memory induction of IgG3 producing B cells after immunization with T cell-independent antigens. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700034J05Rik	T	C	6: 146,853,909 (GRCm39)	I249M	possibly damaging	Het
2610021A01Rik	C	A	7: 41,276,783 (GRCm39)	H829N	probably damaging	Het
4930433I11Rik	A	T	7: 40,642,480 (GRCm39)	T141S	probably benign	Het
Abi3bp	G	T	16: 56,426,521 (GRCm39)	R512L	probably damaging	Het
Acot2	T	G	12: 84,039,624 (GRCm39)	S378A	probably benign	Het
Akap9	T	C	5: 4,096,205 (GRCm39)	I2360T	probably benign	Het
Bank1	T	C	3: 135,989,625 (GRCm39)	D155G	probably benign	Het
Bsn	A	G	9: 107,993,610 (GRCm39)	V714A	probably damaging	Het
Cdh15	G	A	8: 123,587,585 (GRCm39)	V170I	possibly damaging	Het
Clcn2	G	A	16: 20,522,345 (GRCm39)	T787I	probably damaging	Het
Dapk1	A	G	13: 60,864,599 (GRCm39)	H131R	probably damaging	Het
Dct	T	G	14: 118,274,034 (GRCm39)	D291A	probably damaging	Het
Dhx37	A	G	5: 125,492,216 (GRCm39)	Y1128H	probably damaging	Het
Dip2c	A	T	13: 9,684,780 (GRCm39)	I1174F	probably damaging	Het
Eif3l	A	G	15: 78,959,467 (GRCm39)	Y3C	probably damaging	Het
Enpp5	A	G	17: 44,392,258 (GRCm39)	N229S	possibly damaging	Het
Fam83b	A	T	9: 76,452,952 (GRCm39)	H38Q	possibly damaging	Het
Hdac2	G	A	10: 36,867,805 (GRCm39)	V184I	probably damaging	Het
Igf2bp2	A	T	16: 21,981,700 (GRCm39)	L5Q	probably damaging	Het
Iqca1	C	A	1: 90,070,453 (GRCm39)	G133V	probably null	Het
Ireb2	T	A	9: 54,816,986 (GRCm39)	H951Q	probably benign	Het
Lman1	T	A	18: 66,120,969 (GRCm39)	M418L	probably benign	Het
Lrrfip2	C	T	9: 111,019,293 (GRCm39)	R275W	probably damaging	Het
Mast3	T	A	8: 71,239,307 (GRCm39)	I424F	probably damaging	Het
Mep1a	T	C	17: 43,802,584 (GRCm39)	D147G	probably benign	Het
Mtr	C	A	13: 12,204,411 (GRCm39)	E1128D	possibly damaging	Het
Ogfod1	C	A	8: 94,790,932 (GRCm39)	S534R	probably benign	Het
Or4c107	A	T	2: 88,789,328 (GRCm39)	I173F	possibly damaging	Het
Or4k42	T	C	2: 111,319,787 (GRCm39)	T239A	probably damaging	Het
Or5k1	A	G	16: 58,617,615 (GRCm39)	V198A	probably benign	Het
Oxtr	C	T	6: 112,454,138 (GRCm39)	R42Q	probably benign	Het
Pcdh18	T	A	3: 49,707,828 (GRCm39)	D882V	probably damaging	Het
Pik3cg	C	T	12: 32,245,645 (GRCm39)	G868S	probably null	Het
Plppr5	T	G	3: 117,456,172 (GRCm39)	M231R	probably damaging	Het
Polr2a	T	C	11: 69,638,897 (GRCm39)	T46A	probably benign	Het
Ppp4r3a	C	A	12: 101,017,830 (GRCm39)	R440L	probably damaging	Het
Serpinb9e	A	T	13: 33,444,071 (GRCm39)	T364S	probably benign	Het
Sirt3	A	G	7: 140,449,541 (GRCm39)	V135A	possibly damaging	Het
Supt16	T	C	14: 52,408,896 (GRCm39)	N826S	probably null	Het
Tbr1	T	C	2: 61,635,083 (GRCm39)	I11T	probably benign	Het
Trim72	A	G	7: 127,609,419 (GRCm39)	E407G	possibly damaging	Het
Vps72	C	A	3: 95,026,487 (GRCm39)	T144K	probably damaging	Het

Other mutations in Fcamr

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00840:Fcamr	APN	1	130,740,951 (GRCm39)	missense	probably benign	0.01
IGL02880:Fcamr	APN	1	130,741,071 (GRCm39)	missense	probably benign	0.00
IGL03199:Fcamr	APN	1	130,740,655 (GRCm39)	missense	probably damaging	1.00
IGL03392:Fcamr	APN	1	130,728,685 (GRCm39)	utr 5 prime	probably benign
IGL03398:Fcamr	APN	1	130,730,985 (GRCm39)	missense	probably damaging	0.97
R1312:Fcamr	UTSW	1	130,739,224 (GRCm39)	missense	probably damaging	1.00
R1351:Fcamr	UTSW	1	130,740,757 (GRCm39)	missense	possibly damaging	0.83
R1387:Fcamr	UTSW	1	130,732,379 (GRCm39)	missense	possibly damaging	0.85
R1475:Fcamr	UTSW	1	130,742,221 (GRCm39)	splice site	probably null
R1728:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1728:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1728:Fcamr	UTSW	1	130,732,306 (GRCm39)	missense	probably benign	0.06
R1728:Fcamr	UTSW	1	130,732,364 (GRCm39)	missense	probably benign	0.00
R1728:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1728:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1728:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1728:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1728:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1729:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1729:Fcamr	UTSW	1	130,732,364 (GRCm39)	missense	probably benign	0.00
R1729:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1729:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1729:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1729:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1729:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1729:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1730:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1730:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1730:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1730:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1730:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1730:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1730:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1739:Fcamr	UTSW	1	130,732,364 (GRCm39)	missense	probably benign	0.00
R1739:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1739:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1739:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1739:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1739:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1739:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1739:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1762:Fcamr	UTSW	1	130,732,364 (GRCm39)	missense	probably benign	0.00
R1762:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1762:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1762:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1762:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1762:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1762:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1762:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1783:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1783:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1783:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1783:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1783:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1783:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1783:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1783:Fcamr	UTSW	1	130,732,364 (GRCm39)	missense	probably benign	0.00
R1784:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1784:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1784:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1784:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1784:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1784:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1784:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1784:Fcamr	UTSW	1	130,732,364 (GRCm39)	missense	probably benign	0.00
R1785:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1785:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1785:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1785:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1785:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1785:Fcamr	UTSW	1	130,732,364 (GRCm39)	missense	probably benign	0.00
R1785:Fcamr	UTSW	1	130,732,306 (GRCm39)	missense	probably benign	0.06
R1785:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1785:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1793:Fcamr	UTSW	1	130,739,284 (GRCm39)	missense	probably benign	0.03
R2085:Fcamr	UTSW	1	130,739,335 (GRCm39)	missense	probably damaging	1.00
R3937:Fcamr	UTSW	1	130,732,313 (GRCm39)	missense	probably damaging	0.97
R4529:Fcamr	UTSW	1	130,732,313 (GRCm39)	missense	probably damaging	0.99
R4624:Fcamr	UTSW	1	130,730,999 (GRCm39)	missense	probably damaging	0.99
R4822:Fcamr	UTSW	1	130,740,423 (GRCm39)	missense	possibly damaging	0.82
R5055:Fcamr	UTSW	1	130,739,174 (GRCm39)	missense	probably damaging	1.00
R5514:Fcamr	UTSW	1	130,741,793 (GRCm39)	missense	probably damaging	1.00
R5807:Fcamr	UTSW	1	130,739,263 (GRCm39)	missense	probably damaging	1.00
R6077:Fcamr	UTSW	1	130,740,663 (GRCm39)	missense	probably damaging	1.00
R6200:Fcamr	UTSW	1	130,730,927 (GRCm39)	missense	probably benign	0.16
R6653:Fcamr	UTSW	1	130,740,939 (GRCm39)	missense	possibly damaging	0.89
R7081:Fcamr	UTSW	1	130,740,949 (GRCm39)	missense	probably damaging	1.00
R7362:Fcamr	UTSW	1	130,741,760 (GRCm39)	missense	possibly damaging	0.52
R7828:Fcamr	UTSW	1	130,739,443 (GRCm39)	missense	probably damaging	1.00
R7861:Fcamr	UTSW	1	130,742,375 (GRCm39)	missense	probably benign
R8188:Fcamr	UTSW	1	130,730,665 (GRCm39)	splice site	probably null
R8869:Fcamr	UTSW	1	130,739,335 (GRCm39)	missense	probably damaging	1.00
R8907:Fcamr	UTSW	1	130,740,328 (GRCm39)	missense	probably damaging	1.00
R9568:Fcamr	UTSW	1	130,732,356 (GRCm39)	missense	probably damaging	0.99
X0012:Fcamr	UTSW	1	130,740,471 (GRCm39)	missense	probably benign	0.09

Predicted Primers

PCR Primer
(F):5'- TTTTCCACCCGATAGCCTCAGGAC -3'
(R):5'- TAGCTTCAGAGAATGCCTGGCCTC -3'

Sequencing Primer
(F):5'- GTCCTACAGGTACAGACTCTTGATG -3'
(R):5'- TGAGGCCCAAGCTGGTATG -3'

Posted On

2014-01-05