Incidental Mutation 'R1101:Or5k1'
ID 98137
Institutional Source Beutler Lab
Gene Symbol Or5k1
Ensembl Gene ENSMUSG00000049362
Gene Name olfactory receptor family 5 subfamily K member 1
Synonyms MOR184-3, GA_x54KRFPKG5P-54960233-54959268, Olfr173
MMRRC Submission 039174-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R1101 (G1)
Quality Score 225
Status Not validated
Chromosome 16
Chromosomal Location 58617142-58618305 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 58617615 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 198 (V198A)
Ref Sequence ENSEMBL: ENSMUSP00000145946 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049940] [ENSMUST00000206205]
AlphaFold E9QAT7
Predicted Effect probably benign
Transcript: ENSMUST00000049940
AA Change: V198A

PolyPhen 2 Score 0.273 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000052798
Gene: ENSMUSG00000049362
AA Change: V198A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 5.7e-52 PFAM
Pfam:7tm_1 41 290 9.7e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000206205
AA Change: V198A

PolyPhen 2 Score 0.273 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.5%
  • 20x: 91.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700034J05Rik T C 6: 146,853,909 (GRCm39) I249M possibly damaging Het
2610021A01Rik C A 7: 41,276,783 (GRCm39) H829N probably damaging Het
4930433I11Rik A T 7: 40,642,480 (GRCm39) T141S probably benign Het
Abi3bp G T 16: 56,426,521 (GRCm39) R512L probably damaging Het
Acot2 T G 12: 84,039,624 (GRCm39) S378A probably benign Het
Akap9 T C 5: 4,096,205 (GRCm39) I2360T probably benign Het
Bank1 T C 3: 135,989,625 (GRCm39) D155G probably benign Het
Bsn A G 9: 107,993,610 (GRCm39) V714A probably damaging Het
Cdh15 G A 8: 123,587,585 (GRCm39) V170I possibly damaging Het
Clcn2 G A 16: 20,522,345 (GRCm39) T787I probably damaging Het
Dapk1 A G 13: 60,864,599 (GRCm39) H131R probably damaging Het
Dct T G 14: 118,274,034 (GRCm39) D291A probably damaging Het
Dhx37 A G 5: 125,492,216 (GRCm39) Y1128H probably damaging Het
Dip2c A T 13: 9,684,780 (GRCm39) I1174F probably damaging Het
Eif3l A G 15: 78,959,467 (GRCm39) Y3C probably damaging Het
Enpp5 A G 17: 44,392,258 (GRCm39) N229S possibly damaging Het
Fam83b A T 9: 76,452,952 (GRCm39) H38Q possibly damaging Het
Fcamr T A 1: 130,742,223 (GRCm39) probably null Het
Hdac2 G A 10: 36,867,805 (GRCm39) V184I probably damaging Het
Igf2bp2 A T 16: 21,981,700 (GRCm39) L5Q probably damaging Het
Iqca1 C A 1: 90,070,453 (GRCm39) G133V probably null Het
Ireb2 T A 9: 54,816,986 (GRCm39) H951Q probably benign Het
Lman1 T A 18: 66,120,969 (GRCm39) M418L probably benign Het
Lrrfip2 C T 9: 111,019,293 (GRCm39) R275W probably damaging Het
Mast3 T A 8: 71,239,307 (GRCm39) I424F probably damaging Het
Mep1a T C 17: 43,802,584 (GRCm39) D147G probably benign Het
Mtr C A 13: 12,204,411 (GRCm39) E1128D possibly damaging Het
Ogfod1 C A 8: 94,790,932 (GRCm39) S534R probably benign Het
Or4c107 A T 2: 88,789,328 (GRCm39) I173F possibly damaging Het
Or4k42 T C 2: 111,319,787 (GRCm39) T239A probably damaging Het
Oxtr C T 6: 112,454,138 (GRCm39) R42Q probably benign Het
Pcdh18 T A 3: 49,707,828 (GRCm39) D882V probably damaging Het
Pik3cg C T 12: 32,245,645 (GRCm39) G868S probably null Het
Plppr5 T G 3: 117,456,172 (GRCm39) M231R probably damaging Het
Polr2a T C 11: 69,638,897 (GRCm39) T46A probably benign Het
Ppp4r3a C A 12: 101,017,830 (GRCm39) R440L probably damaging Het
Serpinb9e A T 13: 33,444,071 (GRCm39) T364S probably benign Het
Sirt3 A G 7: 140,449,541 (GRCm39) V135A possibly damaging Het
Supt16 T C 14: 52,408,896 (GRCm39) N826S probably null Het
Tbr1 T C 2: 61,635,083 (GRCm39) I11T probably benign Het
Trim72 A G 7: 127,609,419 (GRCm39) E407G possibly damaging Het
Vps72 C A 3: 95,026,487 (GRCm39) T144K probably damaging Het
Other mutations in Or5k1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02649:Or5k1 APN 16 58,617,713 (GRCm39) missense probably damaging 1.00
IGL02728:Or5k1 APN 16 58,617,843 (GRCm39) missense probably benign 0.07
IGL02893:Or5k1 APN 16 58,618,020 (GRCm39) missense probably damaging 1.00
R0035:Or5k1 UTSW 16 58,617,485 (GRCm39) nonsense probably null
R0480:Or5k1 UTSW 16 58,617,684 (GRCm39) missense probably benign 0.05
R1434:Or5k1 UTSW 16 58,617,811 (GRCm39) missense probably benign 0.06
R1992:Or5k1 UTSW 16 58,617,309 (GRCm39) missense probably benign
R2220:Or5k1 UTSW 16 58,617,987 (GRCm39) missense possibly damaging 0.69
R2436:Or5k1 UTSW 16 58,617,607 (GRCm39) missense probably benign 0.00
R4212:Or5k1 UTSW 16 58,617,732 (GRCm39) missense possibly damaging 0.67
R4910:Or5k1 UTSW 16 58,617,805 (GRCm39) missense probably benign 0.03
R5666:Or5k1 UTSW 16 58,617,424 (GRCm39) missense possibly damaging 0.75
R5670:Or5k1 UTSW 16 58,617,424 (GRCm39) missense possibly damaging 0.75
R5896:Or5k1 UTSW 16 58,618,095 (GRCm39) missense probably damaging 1.00
R6182:Or5k1 UTSW 16 58,617,655 (GRCm39) missense probably damaging 1.00
R6613:Or5k1 UTSW 16 58,617,894 (GRCm39) missense probably damaging 0.99
R6723:Or5k1 UTSW 16 58,617,795 (GRCm39) missense probably benign 0.06
R7051:Or5k1 UTSW 16 58,617,538 (GRCm39) missense probably benign 0.21
R7141:Or5k1 UTSW 16 58,617,771 (GRCm39) missense probably benign 0.05
R7179:Or5k1 UTSW 16 58,617,250 (GRCm39) missense probably benign 0.00
R7602:Or5k1 UTSW 16 58,617,343 (GRCm39) missense possibly damaging 0.62
R8425:Or5k1 UTSW 16 58,617,966 (GRCm39) missense probably benign 0.11
Z1176:Or5k1 UTSW 16 58,618,036 (GRCm39) missense probably damaging 0.99
Z1176:Or5k1 UTSW 16 58,617,786 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAATGACGTGAGACTGGTAGCAGAC -3'
(R):5'- GAAGCTCTGCCTTCAGATGACGAC -3'

Sequencing Primer
(F):5'- GGTTTAGTAAGGGAACCACTATTG -3'
(R):5'- CTTCAGATGACGACGGGAGC -3'
Posted On 2014-01-05