Incidental Mutation 'R1104:Ptgir'
ID 98360
Institutional Source Beutler Lab
Gene Symbol Ptgir
Ensembl Gene ENSMUSG00000043017
Gene Name prostaglandin I receptor (IP)
Synonyms IP, prostacyclin receptor
MMRRC Submission 039177-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R1104 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 16640442-16644828 bp(+) (GRCm39)
Type of Mutation splice site (220 bp from exon)
DNA Base Change (assembly) G to A at 16641055 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000083270 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086101] [ENSMUST00000144408]
AlphaFold P43252
Predicted Effect probably null
Transcript: ENSMUST00000086101
SMART Domains Protein: ENSMUSP00000083270
Gene: ENSMUSG00000043017

DomainStartEndE-ValueType
transmembrane domain 63 85 N/A INTRINSIC
transmembrane domain 100 119 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000144408
AA Change: G116R

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000122080
Gene: ENSMUSG00000043017
AA Change: G116R

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 49 291 2.6e-11 PFAM
Pfam:7tm_1 58 319 1.2e-21 PFAM
Meta Mutation Damage Score 0.3465 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.3%
Validation Efficiency 99% (70/71)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit increased susceptibility to thrombosis and injury-induced vascular proliferation, and decreased inflammatory and pain responses. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700056E22Rik C T 1: 183,765,702 (GRCm39) S119N probably benign Het
4930550C14Rik A G 9: 53,332,917 (GRCm39) I93V probably benign Het
Abcg5 A C 17: 84,989,477 (GRCm39) I77S possibly damaging Het
Adam3 T C 8: 25,171,545 (GRCm39) Y762C probably benign Het
Agap1 T C 1: 89,716,962 (GRCm39) S26P probably damaging Het
Ago1 T C 4: 126,347,426 (GRCm39) Y441C probably damaging Het
B3gnt3 A G 8: 72,146,481 (GRCm39) L16S possibly damaging Het
Btaf1 T A 19: 36,982,002 (GRCm39) D1677E probably damaging Het
Cd5l T A 3: 87,268,206 (GRCm39) S18T probably benign Het
Cdca2 T A 14: 67,931,131 (GRCm39) R521W probably damaging Het
Cfap61 C A 2: 145,792,981 (GRCm39) S64* probably null Het
Cryzl2 T A 1: 157,298,174 (GRCm39) probably benign Het
Cul7 T A 17: 46,974,116 (GRCm39) L1467H probably damaging Het
Dhrs1 T C 14: 55,981,162 (GRCm39) K83E probably benign Het
Dmrt2 T A 19: 25,655,980 (GRCm39) F526L probably benign Het
Dnajb14 T A 3: 137,614,115 (GRCm39) M342K possibly damaging Het
Dpf3 A G 12: 83,378,761 (GRCm39) V101A probably benign Het
Dthd1 A C 5: 62,979,302 (GRCm39) T321P probably damaging Het
Flt4 C T 11: 49,527,166 (GRCm39) probably benign Het
Fras1 G A 5: 96,856,530 (GRCm39) R1971Q probably benign Het
Fry A G 5: 150,419,754 (GRCm39) N608S probably damaging Het
Gabrr3 T A 16: 59,281,998 (GRCm39) V451D probably damaging Het
Glg1 A G 8: 111,924,235 (GRCm39) L251P probably benign Het
Gli2 T A 1: 118,781,080 (GRCm39) S222C probably damaging Het
Gsr A G 8: 34,159,949 (GRCm39) E99G probably damaging Het
H1f5 T C 13: 21,964,451 (GRCm39) T92A possibly damaging Het
Hlx G T 1: 184,464,184 (GRCm39) A52D probably damaging Het
Hus1b T C 13: 31,131,679 (GRCm39) probably benign Het
Igf1r T A 7: 67,844,774 (GRCm39) I849N possibly damaging Het
Itih5 A G 2: 10,256,323 (GRCm39) T930A probably benign Het
Ivns1abp T A 1: 151,235,860 (GRCm39) M309K probably benign Het
Kdm3b T A 18: 34,952,864 (GRCm39) F1078Y probably damaging Het
Krt12 C A 11: 99,312,792 (GRCm39) G84V unknown Het
Krt40 T G 11: 99,431,059 (GRCm39) E150A probably damaging Het
Lcn11 G T 2: 25,669,115 (GRCm39) probably benign Het
Lcor G T 19: 41,574,502 (GRCm39) G1086C probably damaging Het
Liph A G 16: 21,802,898 (GRCm39) I57T possibly damaging Het
Lrrc46 C T 11: 96,926,997 (GRCm39) V107M probably damaging Het
Ltb4r1 T C 14: 56,004,832 (GRCm39) I45T probably damaging Het
Mapkbp1 A G 2: 119,841,554 (GRCm39) probably benign Het
Mark3 C T 12: 111,584,831 (GRCm39) probably benign Het
Mug2 C T 6: 122,036,014 (GRCm39) A642V probably benign Het
Myh11 A G 16: 14,019,991 (GRCm39) S1814P possibly damaging Het
Ndst1 T A 18: 60,830,218 (GRCm39) S631C probably damaging Het
Nrbf2 A T 10: 67,103,691 (GRCm39) D137E possibly damaging Het
Or2ag16 A T 7: 106,351,989 (GRCm39) M202K probably benign Het
Or51l4 A G 7: 103,404,183 (GRCm39) V203A probably benign Het
Or6c208 T A 10: 129,224,090 (GRCm39) M196K probably benign Het
Parn A G 16: 13,485,449 (GRCm39) Y16H probably damaging Het
Parp14 A G 16: 35,664,785 (GRCm39) probably benign Het
Prl3d1 C T 13: 27,283,992 (GRCm39) T187I probably benign Het
Rabgap1l C T 1: 160,059,445 (GRCm39) probably benign Het
Rims4 C T 2: 163,705,849 (GRCm39) V262M possibly damaging Het
Rnf213 T C 11: 119,368,055 (GRCm39) Y4697H probably benign Het
Rps6ka4 T A 19: 6,808,364 (GRCm39) I598F probably damaging Het
Ryr2 C T 13: 11,684,855 (GRCm39) V3029M probably damaging Het
Slc34a1 T C 13: 24,003,920 (GRCm39) F335S probably damaging Het
Spata6l T C 19: 28,945,032 (GRCm39) M1V probably null Het
Stau2 A T 1: 16,510,585 (GRCm39) Y124* probably null Het
Tbl3 A G 17: 24,920,580 (GRCm39) I652T probably benign Het
Trappc3 C T 4: 126,166,759 (GRCm39) probably benign Het
Trim60 A T 8: 65,454,071 (GRCm39) F59L probably benign Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Ush2a T C 1: 188,648,453 (GRCm39) F4686S probably benign Het
Vcan T C 13: 89,840,529 (GRCm39) T1672A probably damaging Het
Vmn1r215 T A 13: 23,260,758 (GRCm39) I266N possibly damaging Het
Vmn2r6 A T 3: 64,445,487 (GRCm39) V657E possibly damaging Het
Wdr95 G T 5: 149,529,802 (GRCm39) A548S probably benign Het
Zfp12 A G 5: 143,231,500 (GRCm39) Y609C probably damaging Het
Znfx1 C A 2: 166,897,560 (GRCm39) E455* probably null Het
Other mutations in Ptgir
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02496:Ptgir APN 7 16,641,409 (GRCm39) missense possibly damaging 0.76
IGL02928:Ptgir APN 7 16,642,923 (GRCm39) missense possibly damaging 0.74
IGL02950:Ptgir APN 7 16,641,526 (GRCm39) missense probably damaging 1.00
R2159:Ptgir UTSW 7 16,640,794 (GRCm39) missense possibly damaging 0.88
R2161:Ptgir UTSW 7 16,640,794 (GRCm39) missense possibly damaging 0.88
R2162:Ptgir UTSW 7 16,640,794 (GRCm39) missense possibly damaging 0.88
R2184:Ptgir UTSW 7 16,642,708 (GRCm39) missense probably damaging 1.00
R2866:Ptgir UTSW 7 16,640,794 (GRCm39) missense possibly damaging 0.88
R3845:Ptgir UTSW 7 16,641,311 (GRCm39) missense probably damaging 0.99
R3953:Ptgir UTSW 7 16,640,794 (GRCm39) missense possibly damaging 0.88
R3955:Ptgir UTSW 7 16,640,794 (GRCm39) missense possibly damaging 0.88
R3956:Ptgir UTSW 7 16,640,794 (GRCm39) missense possibly damaging 0.88
R3957:Ptgir UTSW 7 16,640,794 (GRCm39) missense possibly damaging 0.88
R4092:Ptgir UTSW 7 16,640,932 (GRCm39) missense probably damaging 1.00
R4245:Ptgir UTSW 7 16,640,794 (GRCm39) missense possibly damaging 0.88
R4354:Ptgir UTSW 7 16,640,794 (GRCm39) missense possibly damaging 0.88
R4551:Ptgir UTSW 7 16,640,794 (GRCm39) missense possibly damaging 0.88
R4563:Ptgir UTSW 7 16,640,794 (GRCm39) missense possibly damaging 0.88
R4564:Ptgir UTSW 7 16,640,794 (GRCm39) missense possibly damaging 0.88
R4657:Ptgir UTSW 7 16,641,071 (GRCm39) missense probably benign 0.00
R4670:Ptgir UTSW 7 16,640,794 (GRCm39) missense possibly damaging 0.88
R4671:Ptgir UTSW 7 16,640,794 (GRCm39) missense possibly damaging 0.88
R4825:Ptgir UTSW 7 16,642,768 (GRCm39) missense probably damaging 1.00
R4835:Ptgir UTSW 7 16,640,794 (GRCm39) missense possibly damaging 0.88
R5179:Ptgir UTSW 7 16,641,253 (GRCm39) missense probably damaging 1.00
R5226:Ptgir UTSW 7 16,642,645 (GRCm39) missense probably damaging 1.00
R6039:Ptgir UTSW 7 16,640,815 (GRCm39) missense possibly damaging 0.64
R6039:Ptgir UTSW 7 16,640,815 (GRCm39) missense possibly damaging 0.64
R7311:Ptgir UTSW 7 16,640,973 (GRCm39) missense probably damaging 1.00
R7650:Ptgir UTSW 7 16,640,876 (GRCm39) missense possibly damaging 0.95
R8673:Ptgir UTSW 7 16,641,287 (GRCm39) missense probably damaging 0.99
R8992:Ptgir UTSW 7 16,641,220 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- TGGCAGATCCCAGATCCTATGAAGATG -3'
(R):5'- AATACTGCTGATGCTCGCCCAG -3'

Sequencing Primer
(F):5'- AGGCTCCTGCTGGAATATCAC -3'
(R):5'- CCAGCAGGGGCAGTGAG -3'
Posted On 2014-01-05