|Institutional Source||Beutler Lab|
|Gene Name||poly (ADP-ribose) polymerase family, member 14|
|Synonyms||collaborator of Stat6, 1600029O10Rik, CoaSt6|
|Is this an essential gene?||Possibly non essential (E-score: 0.421)|
|Stock #||R1104 (G1)|
|Chromosomal Location||35832874-35871544 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||A to G at 35844415 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000037657 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000042665]|
|Predicted Effect||probably benign
|Meta Mutation Damage Score||0.1096|
|Coding Region Coverage||
|Validation Efficiency||99% (70/71)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit altered B cell subsets and inability to respond to the apoptosis protective affects of IL4. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Parp14||
(F):5'- TGTGCCAATAGCTGGTAGGCAAATG -3'
(R):5'- CCAAAGCAATTTTGGAAGGTGCAGG -3'
(F):5'- GCAAATGGATGAGTAATTCCGTTG -3'
(R):5'- CTCTCTTGGGTAAGGAACAATGC -3'