Incidental Mutation 'R1106:Or2y14'
ID 98489
Institutional Source Beutler Lab
Gene Symbol Or2y14
Ensembl Gene ENSMUSG00000044170
Gene Name olfactory receptor family 2 subfamily Y member 14
Synonyms Olfr1384, MOR256-23, GA_x6K02T2QP88-5922712-5921756
MMRRC Submission 039179-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R1106 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 49404445-49405478 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 49404519 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 18 (D18G)
Ref Sequence ENSEMBL: ENSMUSP00000149183 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060434] [ENSMUST00000213776]
AlphaFold Q8VFA8
Predicted Effect probably damaging
Transcript: ENSMUST00000060434
AA Change: D18G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000051954
Gene: ENSMUSG00000044170
AA Change: D18G

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 6.9e-48 PFAM
Pfam:7TM_GPCR_Srsx 34 161 4.3e-6 PFAM
Pfam:7tm_1 40 313 2.7e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213776
AA Change: D18G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.3%
  • 20x: 92.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Asic5 C A 3: 81,911,897 (GRCm39) F122L probably damaging Het
Caml A G 13: 55,772,538 (GRCm39) T61A probably benign Het
Cfap20 A T 8: 96,147,873 (GRCm39) I156N probably damaging Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Dio2 A G 12: 90,704,985 (GRCm39) L25P probably damaging Het
Eps8 G A 6: 137,491,322 (GRCm39) P352L probably damaging Het
Gnai2 A G 9: 107,497,385 (GRCm39) I3T probably damaging Het
Hexim2 T C 11: 103,029,319 (GRCm39) S124P probably damaging Het
Klk1b16 C T 7: 43,788,937 (GRCm39) R57C probably damaging Het
Mier3 A T 13: 111,844,763 (GRCm39) D205V probably damaging Het
Or4c102 T C 2: 88,422,355 (GRCm39) V69A probably benign Het
Ptprz1 A G 6: 22,965,748 (GRCm39) D192G probably damaging Het
Samd3 G A 10: 26,147,689 (GRCm39) V455M possibly damaging Het
Slc9c1 C A 16: 45,376,170 (GRCm39) Q419K possibly damaging Het
Syce1 C A 7: 140,359,809 (GRCm39) L83F probably damaging Het
Tas2r139 A G 6: 42,118,479 (GRCm39) T204A probably benign Het
Ush2a G A 1: 188,643,180 (GRCm39) E4181K possibly damaging Het
Vps37a T A 8: 40,965,247 (GRCm39) I33N probably damaging Het
Zfp335 TTGCTGCTGCTGCTGCTGCT TTGCTGCTGCTGCTGCT 2: 164,749,471 (GRCm39) probably benign Het
Zik1 G A 7: 10,224,312 (GRCm39) R262C probably damaging Het
Other mutations in Or2y14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02212:Or2y14 APN 11 49,404,737 (GRCm39) missense probably damaging 0.98
IGL02972:Or2y14 APN 11 49,404,918 (GRCm39) missense probably damaging 1.00
R0157:Or2y14 UTSW 11 49,404,600 (GRCm39) missense probably damaging 1.00
R1213:Or2y14 UTSW 11 49,405,421 (GRCm39) makesense probably null
R3768:Or2y14 UTSW 11 49,404,600 (GRCm39) missense probably damaging 1.00
R4191:Or2y14 UTSW 11 49,404,639 (GRCm39) missense probably damaging 1.00
R4708:Or2y14 UTSW 11 49,405,216 (GRCm39) nonsense probably null
R5443:Or2y14 UTSW 11 49,405,262 (GRCm39) missense probably damaging 0.98
R5770:Or2y14 UTSW 11 49,405,419 (GRCm39) missense unknown
R6245:Or2y14 UTSW 11 49,404,992 (GRCm39) missense possibly damaging 0.94
R6336:Or2y14 UTSW 11 49,405,369 (GRCm39) missense probably damaging 0.99
R7652:Or2y14 UTSW 11 49,404,512 (GRCm39) missense probably damaging 1.00
R8070:Or2y14 UTSW 11 49,404,941 (GRCm39) missense probably damaging 1.00
R8147:Or2y14 UTSW 11 49,405,050 (GRCm39) missense probably benign 0.02
R9289:Or2y14 UTSW 11 49,404,635 (GRCm39) missense probably damaging 1.00
R9551:Or2y14 UTSW 11 49,404,942 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTCTGTGTCTCCAGCCTACAAAACC -3'
(R):5'- CATGCACCCAGCATAGCTGATAGTC -3'

Sequencing Primer
(F):5'- GCAAGGCTGTCATCTAGCTTTAAC -3'
(R):5'- GCATAGCTGATAGTCTGATCACC -3'
Posted On 2014-01-05