Incidental Mutation 'R0750:Garin4'
ID 99086
Institutional Source Beutler Lab
Gene Symbol Garin4
Ensembl Gene ENSMUSG00000091017
Gene Name golgi associated RAB2 interactor family member 4
Synonyms 4933417M04Rik, Fam71a
MMRRC Submission 038930-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R0750 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 190894781-190897014 bp(-) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) G to A at 190896682 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000127945 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171798]
AlphaFold B7XG49
Predicted Effect probably benign
Transcript: ENSMUST00000171798
SMART Domains Protein: ENSMUSP00000127945
Gene: ENSMUSG00000091017

DomainStartEndE-ValueType
Pfam:DUF3699 120 193 3.6e-31 PFAM
low complexity region 214 227 N/A INTRINSIC
low complexity region 505 513 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 93.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that interacts with the Rab2B small GTPase and may be important for integrity of the Golgi body. A knockdown of this gene induces fragmentation of the Golgi, similar to the effect seen with a knockdown of the Rab2B small GTPase. The encoded protein has an N-terminal Rab-binding domain specific for Rab2B. [provided by RefSeq, Feb 2017]
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agrn A T 4: 156,251,394 (GRCm39) L1974* probably null Het
Brd4 T C 17: 32,439,226 (GRCm39) E418G probably benign Het
Brip1 G A 11: 85,952,325 (GRCm39) S1152L possibly damaging Het
Btrc T G 19: 45,491,585 (GRCm39) F81C probably damaging Het
Cep85l A G 10: 53,157,642 (GRCm39) L585P probably damaging Het
Cfap46 T G 7: 139,234,586 (GRCm39) E671D probably damaging Het
Dsg1a T C 18: 20,473,210 (GRCm39) L761P probably benign Het
Ece2 G T 16: 20,451,800 (GRCm39) V396L probably benign Het
Hs6st3 CGGAGGAGGAGGAGGAGGA CGGAGGAGGAGGAGGA 14: 119,376,119 (GRCm39) probably benign Het
Id2 A G 12: 25,145,670 (GRCm39) S114P probably damaging Het
Igf1r T C 7: 67,861,839 (GRCm39) F1133S probably damaging Het
Izumo1 T C 7: 45,275,707 (GRCm39) probably null Het
Krt35 A G 11: 99,986,979 (GRCm39) S12P possibly damaging Het
Or5a1 T C 19: 12,098,077 (GRCm39) probably null Het
Pkdrej G T 15: 85,702,275 (GRCm39) D1220E probably benign Het
Pramel32 A G 4: 88,545,905 (GRCm39) F479S probably benign Het
Sema3a G A 5: 13,607,092 (GRCm39) probably null Het
Tmed6 T C 8: 107,788,401 (GRCm39) Y182C possibly damaging Het
Tmem174 G T 13: 98,773,787 (GRCm39) N14K probably damaging Het
Tmem87b T C 2: 128,660,356 (GRCm39) L33P possibly damaging Het
Vmn1r16 T C 6: 57,299,812 (GRCm39) Y270C probably benign Het
Vps37d A T 5: 135,103,294 (GRCm39) L116Q possibly damaging Het
Zfp592 A G 7: 80,674,493 (GRCm39) S486G probably benign Het
Other mutations in Garin4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01065:Garin4 APN 1 190,895,224 (GRCm39) missense probably benign 0.00
IGL01541:Garin4 APN 1 190,896,606 (GRCm39) nonsense probably null
IGL02364:Garin4 APN 1 190,895,713 (GRCm39) missense probably benign 0.03
IGL02573:Garin4 APN 1 190,896,067 (GRCm39) missense probably damaging 1.00
IGL02705:Garin4 APN 1 190,896,499 (GRCm39) missense probably damaging 1.00
IGL03057:Garin4 APN 1 190,895,141 (GRCm39) missense probably benign 0.01
IGL03283:Garin4 APN 1 190,895,029 (GRCm39) missense probably benign 0.08
R0234:Garin4 UTSW 1 190,895,105 (GRCm39) missense probably benign 0.00
R0234:Garin4 UTSW 1 190,895,105 (GRCm39) missense probably benign 0.00
R0402:Garin4 UTSW 1 190,896,637 (GRCm39) missense probably benign 0.03
R0635:Garin4 UTSW 1 190,895,924 (GRCm39) missense probably benign
R1118:Garin4 UTSW 1 190,896,682 (GRCm39) start gained probably benign
R1521:Garin4 UTSW 1 190,896,219 (GRCm39) missense probably benign 0.00
R1573:Garin4 UTSW 1 190,896,682 (GRCm39) start gained probably benign
R1654:Garin4 UTSW 1 190,895,678 (GRCm39) missense probably benign 0.00
R1699:Garin4 UTSW 1 190,896,018 (GRCm39) missense probably benign 0.01
R1900:Garin4 UTSW 1 190,896,631 (GRCm39) missense possibly damaging 0.76
R2912:Garin4 UTSW 1 190,895,425 (GRCm39) missense probably benign 0.00
R2939:Garin4 UTSW 1 190,896,103 (GRCm39) missense possibly damaging 0.54
R3747:Garin4 UTSW 1 190,896,207 (GRCm39) missense probably damaging 1.00
R4133:Garin4 UTSW 1 190,895,205 (GRCm39) missense probably benign 0.05
R6038:Garin4 UTSW 1 190,894,919 (GRCm39) missense probably damaging 0.98
R6038:Garin4 UTSW 1 190,894,919 (GRCm39) missense probably damaging 0.98
R7179:Garin4 UTSW 1 190,896,218 (GRCm39) missense probably damaging 1.00
R7182:Garin4 UTSW 1 190,895,548 (GRCm39) missense probably damaging 0.99
R7261:Garin4 UTSW 1 190,896,308 (GRCm39) missense unknown
R7326:Garin4 UTSW 1 190,896,550 (GRCm39) missense probably benign 0.00
R7363:Garin4 UTSW 1 190,895,910 (GRCm39) missense probably damaging 0.99
R7960:Garin4 UTSW 1 190,895,645 (GRCm39) missense probably benign 0.02
R8120:Garin4 UTSW 1 190,895,022 (GRCm39) missense probably damaging 0.99
R8916:Garin4 UTSW 1 190,895,857 (GRCm39) missense probably benign 0.00
R9011:Garin4 UTSW 1 190,895,258 (GRCm39) missense probably benign 0.08
R9090:Garin4 UTSW 1 190,895,153 (GRCm39) missense probably damaging 1.00
R9165:Garin4 UTSW 1 190,895,258 (GRCm39) missense probably benign 0.04
R9189:Garin4 UTSW 1 190,894,900 (GRCm39) missense possibly damaging 0.65
R9271:Garin4 UTSW 1 190,895,153 (GRCm39) missense probably damaging 1.00
Z1176:Garin4 UTSW 1 190,895,942 (GRCm39) missense probably benign 0.03
Predicted Primers
Posted On 2014-01-10