Incidental Mutation 'R0961:Hyal4'
ID 99133
Institutional Source Beutler Lab
Gene Symbol Hyal4
Ensembl Gene ENSMUSG00000029680
Gene Name hyaluronoglucosaminidase 4
Synonyms 4632428M18Rik
MMRRC Submission 039090-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0961 (G1)
Quality Score 125
Status Validated
Chromosome 6
Chromosomal Location 24748366-24766518 bp(+) (GRCm39)
Type of Mutation utr 5 prime
DNA Base Change (assembly) A to G at 24755745 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000031691 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031691]
AlphaFold Q05A56
Predicted Effect probably benign
Transcript: ENSMUST00000031691
SMART Domains Protein: ENSMUSP00000031691
Gene: ENSMUSG00000029680

DomainStartEndE-ValueType
low complexity region 23 36 N/A INTRINSIC
Pfam:Glyco_hydro_56 41 373 3e-137 PFAM
EGF 375 447 2.81e0 SMART
low complexity region 453 473 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.3%
  • 10x: 95.6%
  • 20x: 89.7%
Validation Efficiency 100% (60/60)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921509C19Rik A C 2: 151,314,686 (GRCm39) S331A probably benign Het
4930433I11Rik A T 7: 40,642,480 (GRCm39) T141S probably benign Het
4933412E24Rik T C 15: 59,887,160 (GRCm39) I427V probably benign Het
Abca15 A T 7: 119,960,208 (GRCm39) K664* probably null Het
Adcy8 A G 15: 64,626,711 (GRCm39) V709A possibly damaging Het
Aox1 T A 1: 58,349,230 (GRCm39) D665E probably benign Het
Arhgap22 C T 14: 33,089,070 (GRCm39) T352M probably damaging Het
Atg9a G A 1: 75,163,390 (GRCm39) L237F probably damaging Het
Ccdc178 T G 18: 22,152,098 (GRCm39) K672T possibly damaging Het
Ccdc63 T G 5: 122,249,009 (GRCm39) K440T possibly damaging Het
Cd55b A T 1: 130,341,813 (GRCm39) W275R probably damaging Het
Col4a3 T C 1: 82,686,297 (GRCm39) probably benign Het
Dmpk C G 7: 18,821,195 (GRCm39) D204E probably damaging Het
Egfr T C 11: 16,812,964 (GRCm39) V148A probably damaging Het
F11 A T 8: 45,694,531 (GRCm39) V610E probably damaging Het
Fam83b A T 9: 76,398,577 (GRCm39) I842N probably damaging Het
Fbxw9 T C 8: 85,788,658 (GRCm39) Y165H probably benign Het
Fzd6 C T 15: 38,889,073 (GRCm39) L64F probably damaging Het
Galntl6 A T 8: 59,364,374 (GRCm39) H45Q probably benign Het
Gbp7 C A 3: 142,247,318 (GRCm39) S276* probably null Het
Gnb5 A T 9: 75,242,933 (GRCm39) I168F probably damaging Het
Gon4l T C 3: 88,805,403 (GRCm39) probably benign Het
Gpat4 C T 8: 23,670,927 (GRCm39) C95Y probably damaging Het
Gstm7 T A 3: 107,834,302 (GRCm39) probably benign Het
Iqca1 C A 1: 90,070,453 (GRCm39) G133V probably null Het
Kank4 G A 4: 98,644,756 (GRCm39) R999W probably benign Het
Kdm2a A G 19: 4,379,219 (GRCm39) V92A probably benign Het
Klhl9 T C 4: 88,639,974 (GRCm39) D89G probably benign Het
Klre1 A G 6: 129,559,378 (GRCm39) T103A probably benign Het
Lamc1 CGCTGGC CGC 1: 153,097,392 (GRCm39) probably null Het
Lamc1 G T 1: 153,097,446 (GRCm39) L1533I probably benign Het
Lca5l T C 16: 95,962,560 (GRCm39) H455R possibly damaging Het
Lmo7 C A 14: 102,031,705 (GRCm39) T33K probably benign Het
Lrig1 A G 6: 94,640,895 (GRCm39) probably benign Het
Mep1b T A 18: 21,221,786 (GRCm39) Y245* probably null Het
Mettl24 A G 10: 40,686,615 (GRCm39) T331A possibly damaging Het
Mycbp2 A C 14: 103,422,271 (GRCm39) D2467E probably damaging Het
Myo15b T C 11: 115,773,280 (GRCm39) S1871P probably benign Het
Ncbp1 T C 4: 46,165,193 (GRCm39) L502P possibly damaging Het
Npr1 T C 3: 90,366,028 (GRCm39) N588D possibly damaging Het
Or2g7 T A 17: 38,378,814 (GRCm39) Y251N probably damaging Het
Or8k16 A T 2: 85,519,790 (GRCm39) T6S probably benign Het
Oxtr C T 6: 112,454,138 (GRCm39) R42Q probably benign Het
Phactr4 A G 4: 132,105,731 (GRCm39) S112P probably benign Het
R3hdm1 C T 1: 128,121,333 (GRCm39) T279I probably benign Het
Rere A G 4: 150,699,829 (GRCm39) probably benign Het
Ryr1 T A 7: 28,709,122 (GRCm39) E4779V unknown Het
Sh2d4b A G 14: 40,596,139 (GRCm39) V81A probably benign Het
Slc10a5 T C 3: 10,399,484 (GRCm39) H392R probably benign Het
Slc26a4 T C 12: 31,585,618 (GRCm39) T477A probably benign Het
Spata31d1b T C 13: 59,865,618 (GRCm39) V922A possibly damaging Het
Sptan1 T A 2: 29,870,075 (GRCm39) probably null Het
Stard9 A G 2: 120,523,920 (GRCm39) D705G probably benign Het
Tdpoz3 T A 3: 93,734,188 (GRCm39) S288T probably benign Het
Tsga10 A G 1: 37,800,509 (GRCm39) probably null Het
Usp18 G A 6: 121,238,452 (GRCm39) A200T probably benign Het
Zfp759 A T 13: 67,287,927 (GRCm39) T493S probably benign Het
Other mutations in Hyal4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01420:Hyal4 APN 6 24,755,871 (GRCm39) missense probably benign 0.03
IGL01791:Hyal4 APN 6 24,763,894 (GRCm39) splice site probably benign
IGL02434:Hyal4 APN 6 24,763,857 (GRCm39) nonsense probably null
IGL02523:Hyal4 APN 6 24,765,968 (GRCm39) missense probably damaging 0.96
IGL03114:Hyal4 APN 6 24,755,964 (GRCm39) missense probably benign 0.00
IGL02835:Hyal4 UTSW 6 24,765,714 (GRCm39) missense probably benign 0.00
PIT4494001:Hyal4 UTSW 6 24,755,833 (GRCm39) missense probably benign 0.05
R0196:Hyal4 UTSW 6 24,756,220 (GRCm39) missense probably damaging 1.00
R0323:Hyal4 UTSW 6 24,756,193 (GRCm39) missense probably benign 0.30
R0398:Hyal4 UTSW 6 24,756,670 (GRCm39) missense probably damaging 0.97
R0946:Hyal4 UTSW 6 24,755,912 (GRCm39) nonsense probably null
R1906:Hyal4 UTSW 6 24,756,110 (GRCm39) missense probably damaging 1.00
R1998:Hyal4 UTSW 6 24,756,310 (GRCm39) missense probably benign 0.00
R2085:Hyal4 UTSW 6 24,755,749 (GRCm39) start gained probably benign
R2483:Hyal4 UTSW 6 24,765,737 (GRCm39) missense probably damaging 0.96
R3622:Hyal4 UTSW 6 24,765,737 (GRCm39) missense probably damaging 0.96
R3623:Hyal4 UTSW 6 24,765,737 (GRCm39) missense probably damaging 0.96
R3624:Hyal4 UTSW 6 24,765,737 (GRCm39) missense probably damaging 0.96
R3712:Hyal4 UTSW 6 24,756,513 (GRCm39) missense probably damaging 1.00
R4031:Hyal4 UTSW 6 24,756,223 (GRCm39) missense probably damaging 1.00
R5762:Hyal4 UTSW 6 24,765,861 (GRCm39) missense possibly damaging 0.93
R6177:Hyal4 UTSW 6 24,766,089 (GRCm39) nonsense probably null
R6442:Hyal4 UTSW 6 24,765,849 (GRCm39) missense probably benign 0.08
R6494:Hyal4 UTSW 6 24,765,745 (GRCm39) missense possibly damaging 0.79
R6901:Hyal4 UTSW 6 24,756,190 (GRCm39) missense probably damaging 0.97
R7565:Hyal4 UTSW 6 24,765,933 (GRCm39) missense possibly damaging 0.77
R7973:Hyal4 UTSW 6 24,755,785 (GRCm39) start codon destroyed probably null 0.99
R7977:Hyal4 UTSW 6 24,763,865 (GRCm39) missense probably damaging 0.99
R7987:Hyal4 UTSW 6 24,763,865 (GRCm39) missense probably damaging 0.99
R8020:Hyal4 UTSW 6 24,755,995 (GRCm39) missense probably benign 0.14
R8676:Hyal4 UTSW 6 24,755,826 (GRCm39) missense probably damaging 0.99
R9331:Hyal4 UTSW 6 24,765,866 (GRCm39) missense probably damaging 1.00
R9573:Hyal4 UTSW 6 24,756,508 (GRCm39) missense possibly damaging 0.62
Z1176:Hyal4 UTSW 6 24,756,627 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2014-01-10