Mutagenetix > Incidental Mutation

Incidental Mutation 'R1069:Ncapg'

99191

Institutional Source

Beutler Lab

Gene Symbol

Ncapg

Ensembl Gene

ENSMUSG00000015880

Gene Name

non-SMC condensin I complex, subunit G

Synonyms

MFT.M05.13, Hcapg, 5730507H05Rik

MMRRC Submission

039155-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.955) question?

Stock #

R1069 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

45827261-45857888 bp(+) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

T to A at 45833272 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000112871 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000117396]

AlphaFold

E9PWG6

Predicted Effect

probably benign
Transcript: ENSMUST00000117396

SMART Domains

Protein: ENSMUSP00000112871
Gene: ENSMUSG00000015880

Domain	Start	End	E-Value	Type
Pfam:Cnd3	557	863	7.4e-87	PFAM
low complexity region	864	874	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129562

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134309

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000198274

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.4%
3x: 98.8%
10x: 97.5%
20x: 95.4%

Validation Efficiency

100% (33/33)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921524L21Rik	A	G	18: 6,624,037 (GRCm39)	N106S	probably benign	Het
Akr1c21	C	A	13: 4,625,333 (GRCm39)		probably benign	Het
Alpk2	G	A	18: 65,438,085 (GRCm39)	R1570C	probably benign	Het
Atp8b3	G	A	10: 80,366,852 (GRCm39)	R249C	probably damaging	Het
Cacnb4	C	A	2: 52,345,623 (GRCm39)	R252I	probably damaging	Het
Cars1	T	C	7: 143,123,844 (GRCm39)	T480A	probably benign	Het
Ccnf	A	T	17: 24,442,971 (GRCm39)	C745*	probably null	Het
Ccr8	A	G	9: 119,923,283 (GRCm39)	I133V	probably benign	Het
Cndp1	G	A	18: 84,652,777 (GRCm39)		probably benign	Het
Dgkq	T	C	5: 108,803,903 (GRCm39)		probably benign	Het
Ecd	A	G	14: 20,383,504 (GRCm39)	C312R	probably damaging	Het
Eddm13	A	T	7: 6,258,921 (GRCm39)		probably null	Het
Gstm1	T	C	3: 107,920,064 (GRCm39)	S226G	probably damaging	Het
Gtf3c3	C	T	1: 54,456,937 (GRCm39)	A488T	probably damaging	Het
Hacd4	T	A	4: 88,355,739 (GRCm39)	I49L	probably damaging	Het
Hid1	T	C	11: 115,247,591 (GRCm39)	N269S	probably damaging	Het
Ifitm3	A	T	7: 140,589,813 (GRCm39)		probably benign	Het
Kctd9	C	T	14: 67,966,869 (GRCm39)		probably benign	Het
Kif20b	T	C	19: 34,928,251 (GRCm39)	L1131P	probably damaging	Het
Kif2c	T	C	4: 117,035,350 (GRCm39)	T33A	probably damaging	Het
Lipc	T	C	9: 70,730,819 (GRCm39)	T38A	probably benign	Het
Lrguk	A	C	6: 34,025,818 (GRCm39)	I205L	possibly damaging	Het
Mir100hg	G	A	9: 41,501,594 (GRCm39)	R151H	possibly damaging	Het
Ptprd	A	G	4: 75,916,724 (GRCm39)		probably benign	Het
Ptprd	T	A	4: 76,018,870 (GRCm39)	K635*	probably null	Het
Sap130	G	A	18: 31,844,682 (GRCm39)	V898I	probably damaging	Het
Sned1	G	A	1: 93,209,376 (GRCm39)	V830M	possibly damaging	Het
Svep1	C	T	4: 58,070,239 (GRCm39)	G2516R	probably damaging	Het
Tas2r131	C	T	6: 132,934,788 (GRCm39)	R7K	probably benign	Het
Tfpi	A	G	2: 84,284,136 (GRCm39)		probably benign	Het
Trim80	T	C	11: 115,338,909 (GRCm39)	C580R	probably damaging	Het
Ttn	T	A	2: 76,800,273 (GRCm39)	I312F	unknown	Het

Other mutations in Ncapg

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00662:Ncapg	APN	5	45,850,502 (GRCm39)	missense	possibly damaging	0.53
IGL00777:Ncapg	APN	5	45,853,107 (GRCm39)	missense	possibly damaging	0.93
IGL00857:Ncapg	APN	5	45,833,927 (GRCm39)	splice site	probably null
IGL00916:Ncapg	APN	5	45,828,534 (GRCm39)	missense	probably benign	0.37
IGL01293:Ncapg	APN	5	45,839,196 (GRCm39)	missense	probably benign	0.01
IGL01360:Ncapg	APN	5	45,831,727 (GRCm39)	nonsense	probably null
IGL01462:Ncapg	APN	5	45,828,477 (GRCm39)	missense	probably benign	0.02
IGL01527:Ncapg	APN	5	45,829,726 (GRCm39)	missense	possibly damaging	0.71
IGL01732:Ncapg	APN	5	45,851,195 (GRCm39)	missense	probably damaging	1.00
IGL01788:Ncapg	APN	5	45,828,423 (GRCm39)	missense	probably damaging	0.97
IGL01871:Ncapg	APN	5	45,845,923 (GRCm39)	missense	probably benign	0.09
IGL03106:Ncapg	APN	5	45,853,010 (GRCm39)	missense	probably damaging	1.00
IGL03124:Ncapg	APN	5	45,828,551 (GRCm39)	missense	probably benign
R0086:Ncapg	UTSW	5	45,834,086 (GRCm39)	splice site	probably null
R0109:Ncapg	UTSW	5	45,851,090 (GRCm39)	splice site	probably null
R0110:Ncapg	UTSW	5	45,850,489 (GRCm39)	unclassified	probably benign
R0377:Ncapg	UTSW	5	45,851,159 (GRCm39)	missense	probably benign
R0432:Ncapg	UTSW	5	45,829,770 (GRCm39)	missense	probably damaging	0.99
R0637:Ncapg	UTSW	5	45,844,666 (GRCm39)	missense	probably damaging	1.00
R0835:Ncapg	UTSW	5	45,838,790 (GRCm39)	missense	probably damaging	0.96
R0894:Ncapg	UTSW	5	45,837,236 (GRCm39)	missense	probably null	0.24
R1216:Ncapg	UTSW	5	45,857,261 (GRCm39)	missense	possibly damaging	0.68
R1967:Ncapg	UTSW	5	45,857,252 (GRCm39)	missense	probably damaging	0.99
R2396:Ncapg	UTSW	5	45,835,715 (GRCm39)	missense	probably benign	0.00
R3157:Ncapg	UTSW	5	45,833,400 (GRCm39)	missense	probably benign
R3735:Ncapg	UTSW	5	45,853,469 (GRCm39)	missense	probably benign	0.00
R3736:Ncapg	UTSW	5	45,853,469 (GRCm39)	missense	probably benign	0.00
R3887:Ncapg	UTSW	5	45,831,705 (GRCm39)	missense	probably benign
R4371:Ncapg	UTSW	5	45,835,797 (GRCm39)	missense	probably benign
R4545:Ncapg	UTSW	5	45,828,554 (GRCm39)	missense	probably damaging	1.00
R4546:Ncapg	UTSW	5	45,828,554 (GRCm39)	missense	probably damaging	1.00
R4558:Ncapg	UTSW	5	45,833,986 (GRCm39)	missense	probably benign	0.00
R4615:Ncapg	UTSW	5	45,844,741 (GRCm39)	missense	probably benign	0.00
R4938:Ncapg	UTSW	5	45,828,551 (GRCm39)	missense	probably benign
R5839:Ncapg	UTSW	5	45,829,620 (GRCm39)	missense	probably damaging	0.99
R5871:Ncapg	UTSW	5	45,853,039 (GRCm39)	missense	probably damaging	1.00
R6086:Ncapg	UTSW	5	45,850,578 (GRCm39)	missense	probably damaging	1.00
R6418:Ncapg	UTSW	5	45,839,158 (GRCm39)	missense	probably damaging	1.00
R6617:Ncapg	UTSW	5	45,827,474 (GRCm39)	missense	probably benign	0.03
R7145:Ncapg	UTSW	5	45,827,372 (GRCm39)	missense	possibly damaging	0.82
R7408:Ncapg	UTSW	5	45,853,135 (GRCm39)	missense	probably benign	0.00
R7443:Ncapg	UTSW	5	45,829,652 (GRCm39)	missense	probably benign	0.31
R7463:Ncapg	UTSW	5	45,851,434 (GRCm39)	splice site	probably null
R7509:Ncapg	UTSW	5	45,853,450 (GRCm39)	missense	probably benign	0.01
R7687:Ncapg	UTSW	5	45,857,227 (GRCm39)	missense	probably benign	0.03
R7919:Ncapg	UTSW	5	45,853,390 (GRCm39)	missense	probably benign	0.00
R8022:Ncapg	UTSW	5	45,839,136 (GRCm39)	missense	probably damaging	1.00
R8177:Ncapg	UTSW	5	45,851,095 (GRCm39)	missense	probably benign	0.00
R8261:Ncapg	UTSW	5	45,844,730 (GRCm39)	missense	possibly damaging	0.90
R8263:Ncapg	UTSW	5	45,849,134 (GRCm39)	missense	probably benign	0.44
R8324:Ncapg	UTSW	5	45,853,010 (GRCm39)	missense	probably damaging	1.00
R8333:Ncapg	UTSW	5	45,831,805 (GRCm39)	missense	probably damaging	0.96
R8742:Ncapg	UTSW	5	45,851,216 (GRCm39)	missense	probably damaging	1.00
R9026:Ncapg	UTSW	5	45,853,115 (GRCm39)	missense	probably benign	0.00
R9051:Ncapg	UTSW	5	45,853,140 (GRCm39)	missense	probably damaging	1.00
R9076:Ncapg	UTSW	5	45,833,983 (GRCm39)	missense	probably benign
R9122:Ncapg	UTSW	5	45,846,015 (GRCm39)	missense	possibly damaging	0.95
R9751:Ncapg	UTSW	5	45,851,195 (GRCm39)	missense	probably damaging	1.00
R9776:Ncapg	UTSW	5	45,829,834 (GRCm39)	missense	probably damaging	0.96
RF019:Ncapg	UTSW	5	45,856,198 (GRCm39)	missense	probably benign	0.00
Z1088:Ncapg	UTSW	5	45,837,222 (GRCm39)	missense	probably damaging	1.00
Z1177:Ncapg	UTSW	5	45,829,844 (GRCm39)	critical splice donor site	probably null

Predicted Primers

Posted On

2014-01-10