Incidental Mutation 'R1171:Tnik'
| ID |
99379 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tnik
|
| Ensembl Gene |
ENSMUSG00000027692 |
| Gene Name |
TRAF2 and NCK interacting kinase |
| Synonyms |
C530008O15Rik, 4831440I19Rik, 1500031A17Rik, C630040K21Rik |
| MMRRC Submission |
039244-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1171 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
28317362-28724734 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 28587089 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Methionine
at position 120
(T120M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125411
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159236]
[ENSMUST00000159308]
[ENSMUST00000159680]
[ENSMUST00000160307]
[ENSMUST00000160518]
[ENSMUST00000160934]
[ENSMUST00000162777]
[ENSMUST00000162485]
[ENSMUST00000161964]
|
| AlphaFold |
P83510 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000159236
AA Change: T120M
PolyPhen 2
Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000124681
Gene: ENSMUSG00000027692
AA Change: T120M
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
793 |
812 |
N/A |
INTRINSIC |
|
low complexity region
|
951 |
958 |
N/A |
INTRINSIC |
|
CNH
|
1005 |
1303 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000159308
AA Change: T120M
|
| SMART Domains |
Protein: ENSMUSP00000125466
Gene: ENSMUSG00000027692
AA Change: T120M
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
746 |
765 |
N/A |
INTRINSIC |
|
low complexity region
|
904 |
911 |
N/A |
INTRINSIC |
|
CNH
|
958 |
1256 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000159680
AA Change: T120M
|
| SMART Domains |
Protein: ENSMUSP00000124876
Gene: ENSMUSG00000027692
AA Change: T120M
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
822 |
841 |
N/A |
INTRINSIC |
|
low complexity region
|
980 |
987 |
N/A |
INTRINSIC |
|
CNH
|
1034 |
1332 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000160307
AA Change: T120M
|
| SMART Domains |
Protein: ENSMUSP00000125081
Gene: ENSMUSG00000027692
AA Change: T120M
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
830 |
849 |
N/A |
INTRINSIC |
|
low complexity region
|
988 |
995 |
N/A |
INTRINSIC |
|
CNH
|
1042 |
1340 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000160518
AA Change: T120M
|
| SMART Domains |
Protein: ENSMUSP00000124011
Gene: ENSMUSG00000027692
AA Change: T120M
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
5.9e-99 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
801 |
820 |
N/A |
INTRINSIC |
|
low complexity region
|
959 |
966 |
N/A |
INTRINSIC |
|
CNH
|
1013 |
1311 |
9.3e-120 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000160934
AA Change: T120M
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000123859
Gene: ENSMUSG00000027692
AA Change: T120M
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase_Tyr
|
25 |
212 |
2.2e-37 |
PFAM |
|
Pfam:Pkinase
|
25 |
219 |
5.9e-52 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000161423
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000162777
AA Change: T120M
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000124726
Gene: ENSMUSG00000027692
AA Change: T120M
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
786 |
N/A |
INTRINSIC |
|
low complexity region
|
925 |
932 |
N/A |
INTRINSIC |
|
CNH
|
979 |
1277 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000162485
AA Change: T120M
|
| SMART Domains |
Protein: ENSMUSP00000124387
Gene: ENSMUSG00000027692
AA Change: T120M
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
794 |
N/A |
INTRINSIC |
|
low complexity region
|
933 |
940 |
N/A |
INTRINSIC |
|
CNH
|
987 |
1285 |
1.92e-117 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162037
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000161964
AA Change: T120M
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000125411
Gene: ENSMUSG00000027692
AA Change: T120M
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
738 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
903 |
N/A |
INTRINSIC |
|
CNH
|
950 |
1248 |
1.92e-117 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.6%
- 3x: 98.6%
- 10x: 96.2%
- 20x: 91.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired postsynaptic signaling and cognitive function. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acsm5 |
A |
T |
7: 119,140,075 (GRCm39) |
E492V |
probably damaging |
Het |
| Arid4a |
G |
A |
12: 71,122,112 (GRCm39) |
S509N |
probably benign |
Het |
| Atr |
T |
C |
9: 95,789,376 (GRCm39) |
F1511L |
probably damaging |
Het |
| Bdkrb2 |
G |
T |
12: 105,558,416 (GRCm39) |
R219L |
probably benign |
Het |
| Bhmt2 |
A |
T |
13: 93,798,837 (GRCm39) |
M328K |
probably benign |
Het |
| Btbd3 |
A |
G |
2: 138,125,881 (GRCm39) |
D286G |
probably benign |
Het |
| Bub1b |
T |
G |
2: 118,437,167 (GRCm39) |
L122V |
probably benign |
Het |
| Caml |
T |
C |
13: 55,772,820 (GRCm39) |
S155P |
probably damaging |
Het |
| Cfap43 |
T |
C |
19: 47,824,150 (GRCm39) |
K74E |
probably benign |
Het |
| Chst4 |
A |
G |
8: 110,757,255 (GRCm39) |
S120P |
probably damaging |
Het |
| Col11a1 |
A |
G |
3: 113,860,213 (GRCm39) |
D213G |
unknown |
Het |
| Cripto |
C |
A |
9: 110,772,235 (GRCm39) |
V54L |
probably benign |
Het |
| Cxcl10 |
TACTCAC |
TACTCACTCAC |
5: 92,495,941 (GRCm39) |
|
probably null |
Het |
| Cxcl10 |
CAC |
CACTAAC |
5: 92,495,945 (GRCm39) |
|
probably null |
Het |
| Cyp26b1 |
A |
T |
6: 84,553,653 (GRCm39) |
I167N |
possibly damaging |
Het |
| Dchs1 |
A |
G |
7: 105,406,921 (GRCm39) |
S2195P |
probably benign |
Het |
| Ddx25 |
T |
A |
9: 35,458,142 (GRCm39) |
K326* |
probably null |
Het |
| Dip2c |
A |
T |
13: 9,543,162 (GRCm39) |
Y36F |
possibly damaging |
Het |
| Dock2 |
T |
C |
11: 34,586,068 (GRCm39) |
D538G |
probably damaging |
Het |
| E4f1 |
C |
T |
17: 24,670,523 (GRCm39) |
D55N |
probably damaging |
Het |
| Emp1 |
G |
T |
6: 135,358,077 (GRCm39) |
W141L |
probably damaging |
Het |
| Faim2 |
T |
A |
15: 99,398,135 (GRCm39) |
H271L |
probably benign |
Het |
| Fbxw9 |
T |
C |
8: 85,792,707 (GRCm39) |
M352T |
possibly damaging |
Het |
| Fcrl2 |
A |
T |
3: 87,164,167 (GRCm39) |
F321I |
probably benign |
Het |
| Frzb |
C |
T |
2: 80,268,834 (GRCm39) |
|
probably null |
Het |
| Gal3st1 |
G |
T |
11: 3,948,931 (GRCm39) |
K379N |
probably damaging |
Het |
| Gm5519 |
G |
A |
19: 33,800,372 (GRCm39) |
C22Y |
possibly damaging |
Het |
| Gpn3 |
T |
C |
5: 122,516,583 (GRCm39) |
F71L |
probably benign |
Het |
| H2-M9 |
A |
G |
17: 36,952,545 (GRCm39) |
V167A |
probably benign |
Het |
| Hars1 |
A |
G |
18: 36,904,467 (GRCm39) |
F182L |
possibly damaging |
Het |
| Hid1 |
T |
C |
11: 115,243,543 (GRCm39) |
T502A |
probably benign |
Het |
| Hipk3 |
G |
T |
2: 104,302,021 (GRCm39) |
T57K |
probably benign |
Het |
| Iqsec2 |
A |
G |
X: 150,927,727 (GRCm39) |
S87G |
probably benign |
Het |
| Itpk1 |
G |
A |
12: 102,572,378 (GRCm39) |
L112F |
probably damaging |
Het |
| Klk1b9 |
T |
A |
7: 43,443,817 (GRCm39) |
D110E |
possibly damaging |
Het |
| Lemd3 |
A |
T |
10: 120,785,246 (GRCm39) |
M535K |
possibly damaging |
Het |
| Lipg |
A |
T |
18: 75,078,894 (GRCm39) |
S453T |
possibly damaging |
Het |
| Lrrc75a |
A |
T |
11: 62,500,069 (GRCm39) |
W150R |
probably damaging |
Het |
| Lyg1 |
T |
C |
1: 37,986,305 (GRCm39) |
E143G |
probably damaging |
Het |
| Map3k1 |
A |
G |
13: 111,892,177 (GRCm39) |
V1026A |
probably benign |
Het |
| Mgat3 |
T |
A |
15: 80,095,838 (GRCm39) |
F222I |
probably benign |
Het |
| Mindy4 |
A |
T |
6: 55,232,601 (GRCm39) |
N348I |
possibly damaging |
Het |
| Ms4a20 |
T |
C |
19: 11,089,741 (GRCm39) |
Y48C |
probably damaging |
Het |
| Myo1b |
A |
C |
1: 51,817,684 (GRCm39) |
F532C |
probably damaging |
Het |
| Naif1 |
T |
A |
2: 32,342,558 (GRCm39) |
N36K |
probably damaging |
Het |
| Nkpd1 |
C |
A |
7: 19,258,012 (GRCm39) |
A597E |
possibly damaging |
Het |
| Npr2 |
A |
G |
4: 43,647,260 (GRCm39) |
D772G |
possibly damaging |
Het |
| Or52n4 |
T |
G |
7: 104,294,204 (GRCm39) |
D123A |
probably damaging |
Het |
| Or6a2 |
T |
C |
7: 106,600,791 (GRCm39) |
N92S |
probably benign |
Het |
| Pcolce2 |
A |
T |
9: 95,576,793 (GRCm39) |
M355L |
probably benign |
Het |
| Pdgfra |
A |
T |
5: 75,334,108 (GRCm39) |
I394F |
probably damaging |
Het |
| Pdzrn3 |
G |
A |
6: 101,127,838 (GRCm39) |
R943C |
probably damaging |
Het |
| Pml |
A |
G |
9: 58,141,821 (GRCm39) |
V337A |
probably damaging |
Het |
| Pnpla2 |
T |
A |
7: 141,038,794 (GRCm39) |
M321K |
probably benign |
Het |
| Poln |
A |
T |
5: 34,261,284 (GRCm39) |
N546K |
probably damaging |
Het |
| Ppp1r16a |
C |
T |
15: 76,577,869 (GRCm39) |
Q328* |
probably null |
Het |
| Prss28 |
T |
A |
17: 25,529,029 (GRCm39) |
F123L |
possibly damaging |
Het |
| Psg18 |
A |
G |
7: 18,080,004 (GRCm39) |
V399A |
probably benign |
Het |
| Rab5a |
T |
C |
17: 53,813,443 (GRCm39) |
C212R |
probably damaging |
Het |
| Ranbp6 |
A |
T |
19: 29,789,679 (GRCm39) |
D224E |
probably benign |
Het |
| Recql4 |
T |
C |
15: 76,588,239 (GRCm39) |
I1104M |
possibly damaging |
Het |
| Rev1 |
A |
T |
1: 38,127,581 (GRCm39) |
N226K |
possibly damaging |
Het |
| Rhbdl3 |
T |
A |
11: 80,244,418 (GRCm39) |
V375E |
possibly damaging |
Het |
| Senp6 |
T |
A |
9: 80,024,007 (GRCm39) |
N423K |
possibly damaging |
Het |
| Sertad2 |
C |
G |
11: 20,598,091 (GRCm39) |
L96V |
probably benign |
Het |
| Slc33a1 |
T |
A |
3: 63,861,315 (GRCm39) |
T296S |
probably benign |
Het |
| Smurf2 |
G |
A |
11: 106,743,444 (GRCm39) |
P188S |
possibly damaging |
Het |
| Spta1 |
T |
A |
1: 174,039,180 (GRCm39) |
Y1174* |
probably null |
Het |
| Stra6l |
A |
T |
4: 45,864,982 (GRCm39) |
T103S |
probably benign |
Het |
| Swt1 |
C |
T |
1: 151,281,272 (GRCm39) |
A352T |
probably damaging |
Het |
| Thoc2l |
T |
C |
5: 104,668,769 (GRCm39) |
V1097A |
possibly damaging |
Het |
| Tigd2 |
T |
A |
6: 59,188,361 (GRCm39) |
N409K |
possibly damaging |
Het |
| Tlr6 |
G |
T |
5: 65,112,593 (GRCm39) |
H105N |
probably benign |
Het |
| Tmprss9 |
A |
C |
10: 80,715,692 (GRCm39) |
T15P |
possibly damaging |
Het |
| Tnr |
T |
A |
1: 159,685,780 (GRCm39) |
I337N |
probably damaging |
Het |
| Top3a |
A |
G |
11: 60,641,419 (GRCm39) |
Y422H |
probably benign |
Het |
| Trim67 |
A |
G |
8: 125,555,820 (GRCm39) |
N768S |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,536,310 (GRCm39) |
V35016A |
probably benign |
Het |
| Utrn |
A |
C |
10: 12,357,052 (GRCm39) |
S312R |
probably damaging |
Het |
| Vdac2 |
A |
G |
14: 21,887,879 (GRCm39) |
Y62C |
probably damaging |
Het |
| Vwa5b2 |
A |
G |
16: 20,423,734 (GRCm39) |
T1216A |
probably benign |
Het |
| Wfdc16 |
T |
C |
2: 164,480,403 (GRCm39) |
K31E |
possibly damaging |
Het |
| Wtip |
C |
T |
7: 33,824,921 (GRCm39) |
C221Y |
probably damaging |
Het |
| Xrn1 |
A |
G |
9: 95,873,064 (GRCm39) |
D640G |
possibly damaging |
Het |
| Zdhhc5 |
T |
C |
2: 84,522,685 (GRCm39) |
R293G |
probably benign |
Het |
| Zfp536 |
T |
C |
7: 37,269,059 (GRCm39) |
D119G |
probably damaging |
Het |
| Zfp81 |
T |
C |
17: 33,554,254 (GRCm39) |
T187A |
probably benign |
Het |
| Zfp810 |
C |
T |
9: 22,190,122 (GRCm39) |
G262D |
possibly damaging |
Het |
| Zfp963 |
A |
C |
8: 70,195,669 (GRCm39) |
I203M |
possibly damaging |
Het |
| Zfpm2 |
T |
C |
15: 40,965,075 (GRCm39) |
M520T |
probably damaging |
Het |
| Zswim8 |
G |
A |
14: 20,763,181 (GRCm39) |
R360Q |
possibly damaging |
Het |
| Zwilch |
T |
A |
9: 64,065,999 (GRCm39) |
H254L |
possibly damaging |
Het |
|
| Other mutations in Tnik |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00516:Tnik
|
APN |
3 |
28,708,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00726:Tnik
|
APN |
3 |
28,587,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01022:Tnik
|
APN |
3 |
28,679,377 (GRCm39) |
splice site |
probably null |
|
|
IGL01145:Tnik
|
APN |
3 |
28,658,316 (GRCm39) |
intron |
probably benign |
|
|
IGL01664:Tnik
|
APN |
3 |
28,692,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01843:Tnik
|
APN |
3 |
28,625,007 (GRCm39) |
splice site |
probably null |
|
|
IGL02378:Tnik
|
APN |
3 |
28,692,608 (GRCm39) |
nonsense |
probably null |
|
|
IGL02448:Tnik
|
APN |
3 |
28,675,226 (GRCm39) |
missense |
probably null |
0.01 |
|
IGL02756:Tnik
|
APN |
3 |
28,596,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03332:Tnik
|
APN |
3 |
28,720,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
delightful
|
UTSW |
3 |
28,658,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Hottie
|
UTSW |
3 |
28,317,792 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
|
Knockout
|
UTSW |
3 |
28,715,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Looker
|
UTSW |
3 |
28,715,853 (GRCm39) |
nonsense |
probably null |
|
|
Lovely
|
UTSW |
3 |
28,666,119 (GRCm39) |
critical splice donor site |
probably null |
|
|
Usher
|
UTSW |
3 |
28,618,246 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R0135:Tnik
|
UTSW |
3 |
28,661,394 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R0418:Tnik
|
UTSW |
3 |
28,625,029 (GRCm39) |
nonsense |
probably null |
|
|
R0540:Tnik
|
UTSW |
3 |
28,704,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0549:Tnik
|
UTSW |
3 |
28,625,069 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0556:Tnik
|
UTSW |
3 |
28,679,367 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0586:Tnik
|
UTSW |
3 |
28,631,510 (GRCm39) |
splice site |
probably benign |
|
|
R0607:Tnik
|
UTSW |
3 |
28,704,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0842:Tnik
|
UTSW |
3 |
28,648,235 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R1068:Tnik
|
UTSW |
3 |
28,587,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1597:Tnik
|
UTSW |
3 |
28,658,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1638:Tnik
|
UTSW |
3 |
28,719,889 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1652:Tnik
|
UTSW |
3 |
28,658,442 (GRCm39) |
missense |
probably benign |
0.22 |
|
R1996:Tnik
|
UTSW |
3 |
28,719,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2333:Tnik
|
UTSW |
3 |
28,587,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2426:Tnik
|
UTSW |
3 |
28,700,830 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2509:Tnik
|
UTSW |
3 |
28,722,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3774:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3775:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4007:Tnik
|
UTSW |
3 |
28,658,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4119:Tnik
|
UTSW |
3 |
28,720,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4209:Tnik
|
UTSW |
3 |
28,413,214 (GRCm39) |
splice site |
probably benign |
|
|
R4441:Tnik
|
UTSW |
3 |
28,618,246 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4611:Tnik
|
UTSW |
3 |
28,596,249 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4714:Tnik
|
UTSW |
3 |
28,648,226 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4772:Tnik
|
UTSW |
3 |
28,661,359 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4829:Tnik
|
UTSW |
3 |
28,593,690 (GRCm39) |
intron |
probably benign |
|
|
R4839:Tnik
|
UTSW |
3 |
28,650,224 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4898:Tnik
|
UTSW |
3 |
28,704,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5029:Tnik
|
UTSW |
3 |
28,719,993 (GRCm39) |
splice site |
probably null |
|
|
R5278:Tnik
|
UTSW |
3 |
28,704,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5307:Tnik
|
UTSW |
3 |
28,596,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5330:Tnik
|
UTSW |
3 |
28,596,167 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5375:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5459:Tnik
|
UTSW |
3 |
28,715,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5708:Tnik
|
UTSW |
3 |
28,666,120 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5749:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5751:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5780:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5837:Tnik
|
UTSW |
3 |
28,722,202 (GRCm39) |
unclassified |
probably benign |
|
|
R5969:Tnik
|
UTSW |
3 |
28,675,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6244:Tnik
|
UTSW |
3 |
28,704,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6273:Tnik
|
UTSW |
3 |
28,631,649 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6457:Tnik
|
UTSW |
3 |
28,593,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6464:Tnik
|
UTSW |
3 |
28,666,119 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6473:Tnik
|
UTSW |
3 |
28,317,792 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
|
R6737:Tnik
|
UTSW |
3 |
28,650,235 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7049:Tnik
|
UTSW |
3 |
28,715,853 (GRCm39) |
nonsense |
probably null |
|
|
R7237:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7267:Tnik
|
UTSW |
3 |
28,700,776 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7445:Tnik
|
UTSW |
3 |
28,718,058 (GRCm39) |
splice site |
probably null |
|
|
R7499:Tnik
|
UTSW |
3 |
28,684,743 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7629:Tnik
|
UTSW |
3 |
28,715,877 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7654:Tnik
|
UTSW |
3 |
28,658,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7886:Tnik
|
UTSW |
3 |
28,720,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8096:Tnik
|
UTSW |
3 |
28,715,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8210:Tnik
|
UTSW |
3 |
28,658,482 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8233:Tnik
|
UTSW |
3 |
28,609,086 (GRCm39) |
missense |
unknown |
|
|
R8386:Tnik
|
UTSW |
3 |
28,317,823 (GRCm39) |
missense |
unknown |
|
|
R8399:Tnik
|
UTSW |
3 |
28,548,159 (GRCm39) |
missense |
unknown |
|
|
R8490:Tnik
|
UTSW |
3 |
28,650,321 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8539:Tnik
|
UTSW |
3 |
28,596,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8751:Tnik
|
UTSW |
3 |
28,666,057 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8804:Tnik
|
UTSW |
3 |
28,648,202 (GRCm39) |
missense |
unknown |
|
|
R8966:Tnik
|
UTSW |
3 |
28,587,044 (GRCm39) |
missense |
unknown |
|
|
R8998:Tnik
|
UTSW |
3 |
28,719,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8999:Tnik
|
UTSW |
3 |
28,719,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9016:Tnik
|
UTSW |
3 |
28,692,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9154:Tnik
|
UTSW |
3 |
28,704,235 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9284:Tnik
|
UTSW |
3 |
28,593,570 (GRCm39) |
missense |
unknown |
|
|
R9290:Tnik
|
UTSW |
3 |
28,675,124 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9411:Tnik
|
UTSW |
3 |
28,684,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9484:Tnik
|
UTSW |
3 |
28,649,093 (GRCm39) |
missense |
unknown |
|
|
X0022:Tnik
|
UTSW |
3 |
28,722,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tnik
|
UTSW |
3 |
28,661,477 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1176:Tnik
|
UTSW |
3 |
28,658,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
|
| Posted On |
2014-01-15 |
Incidental Mutation