Incidental Mutation 'R1171:Npr2'
| ID |
99383 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Npr2
|
| Ensembl Gene |
ENSMUSG00000028469 |
| Gene Name |
natriuretic peptide receptor 2 |
| Synonyms |
pwe, guanylyl cyclase-B, cn |
| MMRRC Submission |
039244-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.778)
|
| Stock # |
R1171 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
43631935-43651244 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 43647260 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 772
(D772G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000103506
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030191]
[ENSMUST00000084646]
[ENSMUST00000107870]
[ENSMUST00000107874]
|
| AlphaFold |
Q6VVW5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000030191
AA Change: D772G
PolyPhen 2
Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000030191
Gene: ENSMUSG00000028469
AA Change: D772G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
44 |
399 |
1.9e-45 |
PFAM |
|
Pfam:Pkinase_Tyr
|
518 |
786 |
4.7e-39 |
PFAM |
|
Pfam:Pkinase
|
535 |
785 |
1.2e-32 |
PFAM |
|
CYCc
|
825 |
1019 |
3.28e-111 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000084646
|
| SMART Domains |
Protein: ENSMUSP00000081696
Gene: ENSMUSG00000066196
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
26 |
48 |
N/A |
INTRINSIC |
|
low complexity region
|
121 |
145 |
N/A |
INTRINSIC |
|
low complexity region
|
148 |
175 |
N/A |
INTRINSIC |
|
low complexity region
|
230 |
254 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
316 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107870
|
| SMART Domains |
Protein: ENSMUSP00000103502
Gene: ENSMUSG00000066196
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
26 |
48 |
N/A |
INTRINSIC |
|
low complexity region
|
121 |
145 |
N/A |
INTRINSIC |
|
low complexity region
|
148 |
175 |
N/A |
INTRINSIC |
|
low complexity region
|
230 |
254 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
316 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000107874
AA Change: D772G
PolyPhen 2
Score 0.524 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000103506
Gene: ENSMUSG00000028469
AA Change: D772G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
44 |
399 |
5.7e-56 |
PFAM |
|
Pfam:Pkinase_Tyr
|
518 |
786 |
4.1e-39 |
PFAM |
|
Pfam:Pkinase
|
533 |
785 |
3.8e-34 |
PFAM |
|
CYCc
|
825 |
989 |
4.37e-57 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000123351
|
| SMART Domains |
Protein: ENSMUSP00000117761
Gene: ENSMUSG00000028469
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
28 |
50 |
N/A |
INTRINSIC |
|
Pfam:Pkinase_Tyr
|
71 |
173 |
1.3e-12 |
PFAM |
|
Pfam:Pkinase
|
85 |
170 |
1.2e-10 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000123883
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000128549
AA Change: D337G
|
| SMART Domains |
Protein: ENSMUSP00000114385
Gene: ENSMUSG00000028469
AA Change: D337G
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
21 |
43 |
N/A |
INTRINSIC |
|
Pfam:Pkinase_Tyr
|
84 |
352 |
1e-39 |
PFAM |
|
Pfam:Pkinase
|
101 |
351 |
2.6e-33 |
PFAM |
|
CYCc
|
391 |
585 |
3.28e-111 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000143160
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000130093
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000145817
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000144418
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000151603
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000149575
|
| Coding Region Coverage |
- 1x: 99.6%
- 3x: 98.6%
- 10x: 96.2%
- 20x: 91.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mutations in this gene result in skeletal abnormalities, malocclusion, and reduced viability. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acsm5 |
A |
T |
7: 119,140,075 (GRCm39) |
E492V |
probably damaging |
Het |
| Arid4a |
G |
A |
12: 71,122,112 (GRCm39) |
S509N |
probably benign |
Het |
| Atr |
T |
C |
9: 95,789,376 (GRCm39) |
F1511L |
probably damaging |
Het |
| Bdkrb2 |
G |
T |
12: 105,558,416 (GRCm39) |
R219L |
probably benign |
Het |
| Bhmt2 |
A |
T |
13: 93,798,837 (GRCm39) |
M328K |
probably benign |
Het |
| Btbd3 |
A |
G |
2: 138,125,881 (GRCm39) |
D286G |
probably benign |
Het |
| Bub1b |
T |
G |
2: 118,437,167 (GRCm39) |
L122V |
probably benign |
Het |
| Caml |
T |
C |
13: 55,772,820 (GRCm39) |
S155P |
probably damaging |
Het |
| Cfap43 |
T |
C |
19: 47,824,150 (GRCm39) |
K74E |
probably benign |
Het |
| Chst4 |
A |
G |
8: 110,757,255 (GRCm39) |
S120P |
probably damaging |
Het |
| Col11a1 |
A |
G |
3: 113,860,213 (GRCm39) |
D213G |
unknown |
Het |
| Cripto |
C |
A |
9: 110,772,235 (GRCm39) |
V54L |
probably benign |
Het |
| Cxcl10 |
TACTCAC |
TACTCACTCAC |
5: 92,495,941 (GRCm39) |
|
probably null |
Het |
| Cxcl10 |
CAC |
CACTAAC |
5: 92,495,945 (GRCm39) |
|
probably null |
Het |
| Cyp26b1 |
A |
T |
6: 84,553,653 (GRCm39) |
I167N |
possibly damaging |
Het |
| Dchs1 |
A |
G |
7: 105,406,921 (GRCm39) |
S2195P |
probably benign |
Het |
| Ddx25 |
T |
A |
9: 35,458,142 (GRCm39) |
K326* |
probably null |
Het |
| Dip2c |
A |
T |
13: 9,543,162 (GRCm39) |
Y36F |
possibly damaging |
Het |
| Dock2 |
T |
C |
11: 34,586,068 (GRCm39) |
D538G |
probably damaging |
Het |
| E4f1 |
C |
T |
17: 24,670,523 (GRCm39) |
D55N |
probably damaging |
Het |
| Emp1 |
G |
T |
6: 135,358,077 (GRCm39) |
W141L |
probably damaging |
Het |
| Faim2 |
T |
A |
15: 99,398,135 (GRCm39) |
H271L |
probably benign |
Het |
| Fbxw9 |
T |
C |
8: 85,792,707 (GRCm39) |
M352T |
possibly damaging |
Het |
| Fcrl2 |
A |
T |
3: 87,164,167 (GRCm39) |
F321I |
probably benign |
Het |
| Frzb |
C |
T |
2: 80,268,834 (GRCm39) |
|
probably null |
Het |
| Gal3st1 |
G |
T |
11: 3,948,931 (GRCm39) |
K379N |
probably damaging |
Het |
| Gm5519 |
G |
A |
19: 33,800,372 (GRCm39) |
C22Y |
possibly damaging |
Het |
| Gpn3 |
T |
C |
5: 122,516,583 (GRCm39) |
F71L |
probably benign |
Het |
| H2-M9 |
A |
G |
17: 36,952,545 (GRCm39) |
V167A |
probably benign |
Het |
| Hars1 |
A |
G |
18: 36,904,467 (GRCm39) |
F182L |
possibly damaging |
Het |
| Hid1 |
T |
C |
11: 115,243,543 (GRCm39) |
T502A |
probably benign |
Het |
| Hipk3 |
G |
T |
2: 104,302,021 (GRCm39) |
T57K |
probably benign |
Het |
| Iqsec2 |
A |
G |
X: 150,927,727 (GRCm39) |
S87G |
probably benign |
Het |
| Itpk1 |
G |
A |
12: 102,572,378 (GRCm39) |
L112F |
probably damaging |
Het |
| Klk1b9 |
T |
A |
7: 43,443,817 (GRCm39) |
D110E |
possibly damaging |
Het |
| Lemd3 |
A |
T |
10: 120,785,246 (GRCm39) |
M535K |
possibly damaging |
Het |
| Lipg |
A |
T |
18: 75,078,894 (GRCm39) |
S453T |
possibly damaging |
Het |
| Lrrc75a |
A |
T |
11: 62,500,069 (GRCm39) |
W150R |
probably damaging |
Het |
| Lyg1 |
T |
C |
1: 37,986,305 (GRCm39) |
E143G |
probably damaging |
Het |
| Map3k1 |
A |
G |
13: 111,892,177 (GRCm39) |
V1026A |
probably benign |
Het |
| Mgat3 |
T |
A |
15: 80,095,838 (GRCm39) |
F222I |
probably benign |
Het |
| Mindy4 |
A |
T |
6: 55,232,601 (GRCm39) |
N348I |
possibly damaging |
Het |
| Ms4a20 |
T |
C |
19: 11,089,741 (GRCm39) |
Y48C |
probably damaging |
Het |
| Myo1b |
A |
C |
1: 51,817,684 (GRCm39) |
F532C |
probably damaging |
Het |
| Naif1 |
T |
A |
2: 32,342,558 (GRCm39) |
N36K |
probably damaging |
Het |
| Nkpd1 |
C |
A |
7: 19,258,012 (GRCm39) |
A597E |
possibly damaging |
Het |
| Or52n4 |
T |
G |
7: 104,294,204 (GRCm39) |
D123A |
probably damaging |
Het |
| Or6a2 |
T |
C |
7: 106,600,791 (GRCm39) |
N92S |
probably benign |
Het |
| Pcolce2 |
A |
T |
9: 95,576,793 (GRCm39) |
M355L |
probably benign |
Het |
| Pdgfra |
A |
T |
5: 75,334,108 (GRCm39) |
I394F |
probably damaging |
Het |
| Pdzrn3 |
G |
A |
6: 101,127,838 (GRCm39) |
R943C |
probably damaging |
Het |
| Pml |
A |
G |
9: 58,141,821 (GRCm39) |
V337A |
probably damaging |
Het |
| Pnpla2 |
T |
A |
7: 141,038,794 (GRCm39) |
M321K |
probably benign |
Het |
| Poln |
A |
T |
5: 34,261,284 (GRCm39) |
N546K |
probably damaging |
Het |
| Ppp1r16a |
C |
T |
15: 76,577,869 (GRCm39) |
Q328* |
probably null |
Het |
| Prss28 |
T |
A |
17: 25,529,029 (GRCm39) |
F123L |
possibly damaging |
Het |
| Psg18 |
A |
G |
7: 18,080,004 (GRCm39) |
V399A |
probably benign |
Het |
| Rab5a |
T |
C |
17: 53,813,443 (GRCm39) |
C212R |
probably damaging |
Het |
| Ranbp6 |
A |
T |
19: 29,789,679 (GRCm39) |
D224E |
probably benign |
Het |
| Recql4 |
T |
C |
15: 76,588,239 (GRCm39) |
I1104M |
possibly damaging |
Het |
| Rev1 |
A |
T |
1: 38,127,581 (GRCm39) |
N226K |
possibly damaging |
Het |
| Rhbdl3 |
T |
A |
11: 80,244,418 (GRCm39) |
V375E |
possibly damaging |
Het |
| Senp6 |
T |
A |
9: 80,024,007 (GRCm39) |
N423K |
possibly damaging |
Het |
| Sertad2 |
C |
G |
11: 20,598,091 (GRCm39) |
L96V |
probably benign |
Het |
| Slc33a1 |
T |
A |
3: 63,861,315 (GRCm39) |
T296S |
probably benign |
Het |
| Smurf2 |
G |
A |
11: 106,743,444 (GRCm39) |
P188S |
possibly damaging |
Het |
| Spta1 |
T |
A |
1: 174,039,180 (GRCm39) |
Y1174* |
probably null |
Het |
| Stra6l |
A |
T |
4: 45,864,982 (GRCm39) |
T103S |
probably benign |
Het |
| Swt1 |
C |
T |
1: 151,281,272 (GRCm39) |
A352T |
probably damaging |
Het |
| Thoc2l |
T |
C |
5: 104,668,769 (GRCm39) |
V1097A |
possibly damaging |
Het |
| Tigd2 |
T |
A |
6: 59,188,361 (GRCm39) |
N409K |
possibly damaging |
Het |
| Tlr6 |
G |
T |
5: 65,112,593 (GRCm39) |
H105N |
probably benign |
Het |
| Tmprss9 |
A |
C |
10: 80,715,692 (GRCm39) |
T15P |
possibly damaging |
Het |
| Tnik |
C |
T |
3: 28,587,089 (GRCm39) |
T120M |
probably damaging |
Het |
| Tnr |
T |
A |
1: 159,685,780 (GRCm39) |
I337N |
probably damaging |
Het |
| Top3a |
A |
G |
11: 60,641,419 (GRCm39) |
Y422H |
probably benign |
Het |
| Trim67 |
A |
G |
8: 125,555,820 (GRCm39) |
N768S |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,536,310 (GRCm39) |
V35016A |
probably benign |
Het |
| Utrn |
A |
C |
10: 12,357,052 (GRCm39) |
S312R |
probably damaging |
Het |
| Vdac2 |
A |
G |
14: 21,887,879 (GRCm39) |
Y62C |
probably damaging |
Het |
| Vwa5b2 |
A |
G |
16: 20,423,734 (GRCm39) |
T1216A |
probably benign |
Het |
| Wfdc16 |
T |
C |
2: 164,480,403 (GRCm39) |
K31E |
possibly damaging |
Het |
| Wtip |
C |
T |
7: 33,824,921 (GRCm39) |
C221Y |
probably damaging |
Het |
| Xrn1 |
A |
G |
9: 95,873,064 (GRCm39) |
D640G |
possibly damaging |
Het |
| Zdhhc5 |
T |
C |
2: 84,522,685 (GRCm39) |
R293G |
probably benign |
Het |
| Zfp536 |
T |
C |
7: 37,269,059 (GRCm39) |
D119G |
probably damaging |
Het |
| Zfp81 |
T |
C |
17: 33,554,254 (GRCm39) |
T187A |
probably benign |
Het |
| Zfp810 |
C |
T |
9: 22,190,122 (GRCm39) |
G262D |
possibly damaging |
Het |
| Zfp963 |
A |
C |
8: 70,195,669 (GRCm39) |
I203M |
possibly damaging |
Het |
| Zfpm2 |
T |
C |
15: 40,965,075 (GRCm39) |
M520T |
probably damaging |
Het |
| Zswim8 |
G |
A |
14: 20,763,181 (GRCm39) |
R360Q |
possibly damaging |
Het |
| Zwilch |
T |
A |
9: 64,065,999 (GRCm39) |
H254L |
possibly damaging |
Het |
|
| Other mutations in Npr2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00790:Npr2
|
APN |
4 |
43,641,612 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL01116:Npr2
|
APN |
4 |
43,640,248 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01447:Npr2
|
APN |
4 |
43,640,554 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02412:Npr2
|
APN |
4 |
43,647,005 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02449:Npr2
|
APN |
4 |
43,646,641 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03120:Npr2
|
APN |
4 |
43,643,133 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03351:Npr2
|
APN |
4 |
43,640,652 (GRCm39) |
missense |
probably benign |
0.36 |
|
Anterior
|
UTSW |
4 |
43,643,622 (GRCm39) |
missense |
probably damaging |
1.00 |
|
palmar
|
UTSW |
4 |
43,647,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Plantar
|
UTSW |
4 |
43,640,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Ventral
|
UTSW |
4 |
43,641,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0066:Npr2
|
UTSW |
4 |
43,632,329 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0201:Npr2
|
UTSW |
4 |
43,641,617 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0309:Npr2
|
UTSW |
4 |
43,640,904 (GRCm39) |
unclassified |
probably benign |
|
|
R0437:Npr2
|
UTSW |
4 |
43,648,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0440:Npr2
|
UTSW |
4 |
43,650,315 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0464:Npr2
|
UTSW |
4 |
43,640,597 (GRCm39) |
splice site |
probably null |
|
|
R0511:Npr2
|
UTSW |
4 |
43,632,801 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0576:Npr2
|
UTSW |
4 |
43,640,947 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0630:Npr2
|
UTSW |
4 |
43,641,219 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0690:Npr2
|
UTSW |
4 |
43,646,991 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1079:Npr2
|
UTSW |
4 |
43,643,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1140:Npr2
|
UTSW |
4 |
43,648,353 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1741:Npr2
|
UTSW |
4 |
43,643,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1848:Npr2
|
UTSW |
4 |
43,632,384 (GRCm39) |
missense |
probably benign |
|
|
R1864:Npr2
|
UTSW |
4 |
43,641,258 (GRCm39) |
missense |
probably benign |
0.30 |
|
R1919:Npr2
|
UTSW |
4 |
43,640,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2054:Npr2
|
UTSW |
4 |
43,646,560 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2106:Npr2
|
UTSW |
4 |
43,644,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2143:Npr2
|
UTSW |
4 |
43,648,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2306:Npr2
|
UTSW |
4 |
43,633,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2372:Npr2
|
UTSW |
4 |
43,650,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2889:Npr2
|
UTSW |
4 |
43,641,600 (GRCm39) |
missense |
probably benign |
0.26 |
|
R3076:Npr2
|
UTSW |
4 |
43,640,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3078:Npr2
|
UTSW |
4 |
43,640,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3711:Npr2
|
UTSW |
4 |
43,643,378 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3730:Npr2
|
UTSW |
4 |
43,640,999 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4301:Npr2
|
UTSW |
4 |
43,641,332 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4352:Npr2
|
UTSW |
4 |
43,646,592 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4412:Npr2
|
UTSW |
4 |
43,644,150 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4583:Npr2
|
UTSW |
4 |
43,633,522 (GRCm39) |
splice site |
probably null |
|
|
R4593:Npr2
|
UTSW |
4 |
43,647,323 (GRCm39) |
unclassified |
probably benign |
|
|
R5042:Npr2
|
UTSW |
4 |
43,647,002 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5213:Npr2
|
UTSW |
4 |
43,640,673 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5546:Npr2
|
UTSW |
4 |
43,650,150 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5784:Npr2
|
UTSW |
4 |
43,632,801 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5787:Npr2
|
UTSW |
4 |
43,633,593 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6364:Npr2
|
UTSW |
4 |
43,643,622 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6925:Npr2
|
UTSW |
4 |
43,647,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6949:Npr2
|
UTSW |
4 |
43,640,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7380:Npr2
|
UTSW |
4 |
43,641,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7432:Npr2
|
UTSW |
4 |
43,647,155 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7500:Npr2
|
UTSW |
4 |
43,650,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8235:Npr2
|
UTSW |
4 |
43,641,603 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8292:Npr2
|
UTSW |
4 |
43,643,086 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R9310:Npr2
|
UTSW |
4 |
43,632,404 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9684:Npr2
|
UTSW |
4 |
43,632,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9746:Npr2
|
UTSW |
4 |
43,633,527 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
Z1176:Npr2
|
UTSW |
4 |
43,650,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
|
| Posted On |
2014-01-15 |
Incidental Mutation