Incidental Mutation 'R1214:Dcdc2c'
ID 99533
Institutional Source Beutler Lab
Gene Symbol Dcdc2c
Ensembl Gene ENSMUSG00000020633
Gene Name doublecortin domain containing 2C
Synonyms 1110015M06Rik
MMRRC Submission 039283-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1214 (G1)
Quality Score 225
Status Not validated
Chromosome 12
Chromosomal Location 28487794-28602398 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 28580429 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 201 (Y201*)
Ref Sequence ENSEMBL: ENSMUSP00000152233 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020963] [ENSMUST00000189735] [ENSMUST00000221349]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000020963
AA Change: Y201*
SMART Domains Protein: ENSMUSP00000020963
Gene: ENSMUSG00000020633
AA Change: Y201*

DomainStartEndE-ValueType
DCX 11 98 2.16e-29 SMART
DCX 131 217 6.18e-7 SMART
low complexity region 302 316 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000185916
AA Change: Y133*
Predicted Effect probably null
Transcript: ENSMUST00000189735
AA Change: Y33*
SMART Domains Protein: ENSMUSP00000140603
Gene: ENSMUSG00000020633
AA Change: Y33*

DomainStartEndE-ValueType
Pfam:DCX 1 44 1.5e-9 PFAM
low complexity region 134 148 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000221349
AA Change: Y201*
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.1%
  • 20x: 92.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 13 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alkbh2 C T 5: 114,262,287 (GRCm39) E148K probably damaging Het
Dock9 C T 14: 121,823,728 (GRCm39) V1395I probably benign Het
Dync1h1 G A 12: 110,602,943 (GRCm39) E2195K probably benign Het
Micall2 T C 5: 139,697,396 (GRCm39) S652G probably damaging Het
Or1j13 G T 2: 36,369,981 (GRCm39) H54N possibly damaging Het
Or2ad1 C T 13: 21,326,337 (GRCm39) V297I probably benign Het
Or4f4b T C 2: 111,314,237 (GRCm39) F154S probably damaging Het
Ptpre A T 7: 135,280,987 (GRCm39) S643C probably damaging Het
Slc26a5 T A 5: 22,019,981 (GRCm39) I530F probably damaging Het
Slfn5 A G 11: 82,850,917 (GRCm39) M405V probably benign Het
Ttc29 A G 8: 79,052,211 (GRCm39) Y364C probably damaging Het
Tut7 A G 13: 59,953,140 (GRCm39) V100A possibly damaging Het
Wasf3 G A 5: 146,407,098 (GRCm39) V473M probably damaging Het
Other mutations in Dcdc2c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02892:Dcdc2c APN 12 28,585,544 (GRCm39) missense probably benign 0.03
R3040:Dcdc2c UTSW 12 28,602,181 (GRCm39) missense probably damaging 1.00
R4937:Dcdc2c UTSW 12 28,580,472 (GRCm39) missense possibly damaging 0.69
R5268:Dcdc2c UTSW 12 28,566,656 (GRCm39) missense possibly damaging 0.83
R5920:Dcdc2c UTSW 12 28,585,536 (GRCm39) missense possibly damaging 0.67
R5921:Dcdc2c UTSW 12 28,574,774 (GRCm39) missense possibly damaging 0.90
R6444:Dcdc2c UTSW 12 28,585,475 (GRCm39) missense probably damaging 1.00
R6939:Dcdc2c UTSW 12 28,591,496 (GRCm39) missense probably benign 0.09
R7044:Dcdc2c UTSW 12 28,520,493 (GRCm39) utr 3 prime probably benign
R7235:Dcdc2c UTSW 12 28,520,718 (GRCm39) missense
R7287:Dcdc2c UTSW 12 28,566,685 (GRCm39) missense probably benign
R7767:Dcdc2c UTSW 12 28,520,256 (GRCm39) missense
R7896:Dcdc2c UTSW 12 28,520,619 (GRCm39) nonsense probably null
R7964:Dcdc2c UTSW 12 28,520,318 (GRCm39) missense
R8802:Dcdc2c UTSW 12 28,576,720 (GRCm39) missense probably benign
R9111:Dcdc2c UTSW 12 28,585,488 (GRCm39) missense probably damaging 1.00
R9545:Dcdc2c UTSW 12 28,602,295 (GRCm39) missense possibly damaging 0.91
R9578:Dcdc2c UTSW 12 28,602,234 (GRCm39) missense probably damaging 1.00
R9694:Dcdc2c UTSW 12 28,585,553 (GRCm39) missense
Z1176:Dcdc2c UTSW 12 28,574,706 (GRCm39) missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- TGCAAAATGGTCACTCAGACCAGAG -3'
(R):5'- TGTGCAGTCCAGGAAGAACAGCTC -3'

Sequencing Primer
(F):5'- agagacagagacagagagacag -3'
(R):5'- AGCTCCCAAAGGCTTCCTG -3'
Posted On 2014-01-15