Incidental Mutation 'R1215:Zfp871'
ID 99604
Institutional Source Beutler Lab
Gene Symbol Zfp871
Ensembl Gene ENSMUSG00000024298
Gene Name zinc finger protein 871
Synonyms 9030612M13Rik
MMRRC Submission 039284-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1215 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 32984470-33007261 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 32994946 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 57 (D57E)
Ref Sequence ENSEMBL: ENSMUSP00000050501 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057501] [ENSMUST00000159086]
AlphaFold G5E905
Predicted Effect possibly damaging
Transcript: ENSMUST00000057501
AA Change: D57E

PolyPhen 2 Score 0.705 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000050501
Gene: ENSMUSG00000024298
AA Change: D57E

DomainStartEndE-ValueType
KRAB 1 42 1.32e0 SMART
ZnF_C2H2 174 196 5.9e-3 SMART
ZnF_C2H2 202 224 6.32e-3 SMART
ZnF_C2H2 230 252 1.47e-3 SMART
ZnF_C2H2 258 280 3.63e-3 SMART
ZnF_C2H2 286 308 1.79e-2 SMART
ZnF_C2H2 314 336 4.79e-3 SMART
ZnF_C2H2 342 364 1.69e-3 SMART
ZnF_C2H2 370 392 2.79e-4 SMART
ZnF_C2H2 398 420 1.23e-5 SMART
ZnF_C2H2 426 448 1.2e-3 SMART
ZnF_C2H2 454 476 5.42e-2 SMART
ZnF_C2H2 482 504 8.6e-5 SMART
ZnF_C2H2 510 532 5.21e-4 SMART
ZnF_C2H2 538 560 3.11e-2 SMART
ZnF_C2H2 566 588 2.86e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000159086
AA Change: D76E

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000127178
Gene: ENSMUSG00000024298
AA Change: D76E

DomainStartEndE-ValueType
KRAB 4 61 2.18e-15 SMART
ZnF_C2H2 193 215 5.9e-3 SMART
ZnF_C2H2 221 243 6.32e-3 SMART
ZnF_C2H2 249 271 1.47e-3 SMART
ZnF_C2H2 277 299 3.63e-3 SMART
ZnF_C2H2 305 327 1.79e-2 SMART
ZnF_C2H2 333 355 4.79e-3 SMART
ZnF_C2H2 361 383 1.69e-3 SMART
ZnF_C2H2 389 411 2.79e-4 SMART
ZnF_C2H2 417 439 1.23e-5 SMART
ZnF_C2H2 445 467 1.2e-3 SMART
ZnF_C2H2 473 495 5.42e-2 SMART
ZnF_C2H2 501 523 8.6e-5 SMART
ZnF_C2H2 529 551 5.21e-4 SMART
ZnF_C2H2 557 579 3.11e-2 SMART
ZnF_C2H2 585 607 2.86e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000168337
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.7%
  • 20x: 90.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alkbh2 C T 5: 114,262,287 (GRCm39) E148K probably damaging Het
Art5 C T 7: 101,747,116 (GRCm39) R123H probably damaging Het
Azin2 A G 4: 128,843,489 (GRCm39) S66P probably damaging Het
Cep295 T C 9: 15,239,178 (GRCm39) E1865G probably benign Het
Ces1a A G 8: 93,759,318 (GRCm39) C273R probably damaging Het
Cfap44 A G 16: 44,239,666 (GRCm39) Y571C probably damaging Het
Cntfr C A 4: 41,662,064 (GRCm39) W226L probably damaging Het
Csmd3 A T 15: 47,868,227 (GRCm39) probably null Het
Cyp2a4 C T 7: 26,014,226 (GRCm39) P468S possibly damaging Het
Dync1h1 G A 12: 110,602,943 (GRCm39) E2195K probably benign Het
E130308A19Rik T A 4: 59,690,743 (GRCm39) D192E probably benign Het
Fam184b C T 5: 45,741,520 (GRCm39) R237H probably damaging Het
Fmn1 T A 2: 113,523,375 (GRCm39) Y1247* probably null Het
Grb14 T C 2: 64,747,608 (GRCm39) S18G probably benign Het
Hs2st1 G A 3: 144,170,902 (GRCm39) T90I possibly damaging Het
Mcc A T 18: 44,601,561 (GRCm39) N589K possibly damaging Het
Mff T A 1: 82,719,609 (GRCm39) S196T probably benign Het
Nyap1 C T 5: 137,733,395 (GRCm39) W546* probably null Het
Or13p10 A T 4: 118,523,496 (GRCm39) M261L possibly damaging Het
Ppp2r3d A G 9: 101,089,883 (GRCm39) S147P probably benign Het
Rsph14 T C 10: 74,860,898 (GRCm39) H134R probably benign Het
Slc25a3 G A 10: 90,953,170 (GRCm39) A274V possibly damaging Het
Slc43a2 T A 11: 75,453,688 (GRCm39) W229R probably damaging Het
Slco4c1 C A 1: 96,756,596 (GRCm39) L575F probably damaging Het
Smyd4 T A 11: 75,281,121 (GRCm39) I198N possibly damaging Het
Trpm6 A G 19: 18,773,862 (GRCm39) D413G probably damaging Het
Ush2a A G 1: 188,689,479 (GRCm39) T33A possibly damaging Het
Zfyve9 T C 4: 108,507,426 (GRCm39) Q1176R probably benign Het
Other mutations in Zfp871
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00849:Zfp871 APN 17 32,994,873 (GRCm39) missense probably benign
IGL00963:Zfp871 APN 17 32,993,726 (GRCm39) missense probably benign 0.25
IGL01687:Zfp871 APN 17 32,994,618 (GRCm39) missense probably benign 0.00
IGL02170:Zfp871 APN 17 32,994,662 (GRCm39) missense possibly damaging 0.72
IGL02399:Zfp871 APN 17 32,993,329 (GRCm39) missense probably benign 0.18
R0304:Zfp871 UTSW 17 32,993,408 (GRCm39) missense probably damaging 0.99
R1444:Zfp871 UTSW 17 32,993,900 (GRCm39) missense possibly damaging 0.85
R1754:Zfp871 UTSW 17 32,994,308 (GRCm39) missense probably damaging 1.00
R1913:Zfp871 UTSW 17 32,994,891 (GRCm39) missense possibly damaging 0.53
R2018:Zfp871 UTSW 17 32,993,751 (GRCm39) missense probably damaging 1.00
R2180:Zfp871 UTSW 17 32,994,275 (GRCm39) missense probably damaging 1.00
R2881:Zfp871 UTSW 17 32,994,407 (GRCm39) missense probably damaging 1.00
R4422:Zfp871 UTSW 17 32,993,808 (GRCm39) missense probably benign 0.37
R4422:Zfp871 UTSW 17 32,993,807 (GRCm39) missense probably benign 0.39
R4979:Zfp871 UTSW 17 32,994,829 (GRCm39) missense probably damaging 0.99
R5564:Zfp871 UTSW 17 32,994,842 (GRCm39) missense possibly damaging 0.70
R6228:Zfp871 UTSW 17 32,994,858 (GRCm39) missense possibly damaging 0.50
R6232:Zfp871 UTSW 17 32,994,494 (GRCm39) frame shift probably null
R6233:Zfp871 UTSW 17 32,994,494 (GRCm39) frame shift probably null
R6234:Zfp871 UTSW 17 32,994,494 (GRCm39) frame shift probably null
R6474:Zfp871 UTSW 17 32,994,647 (GRCm39) missense possibly damaging 0.85
R7237:Zfp871 UTSW 17 32,994,289 (GRCm39) missense probably damaging 1.00
R7809:Zfp871 UTSW 17 32,993,826 (GRCm39) missense probably damaging 1.00
R8830:Zfp871 UTSW 17 32,993,901 (GRCm39) missense probably benign 0.03
R9219:Zfp871 UTSW 17 32,993,914 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- GATCTTCGCACGATTCATGCTTTGG -3'
(R):5'- ACAGCAGCCTCTGAGACAAAACTTG -3'

Sequencing Primer
(F):5'- CTTTGGGTCAGGTTTAAGAAGTACAC -3'
(R):5'- GTGTAGGTGATATAACAGCCACCC -3'
Posted On 2014-01-15