Incidental Mutation 'R1216:Fyb2'
ID 99630
Institutional Source Beutler Lab
Gene Symbol Fyb2
Ensembl Gene ENSMUSG00000078612
Gene Name FYN binding protein 2
Synonyms 1700024P16Rik
MMRRC Submission 039285-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R1216 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 104770653-104874060 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 104852903 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 528 (V528M)
Ref Sequence ENSEMBL: ENSMUSP00000102415 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106803] [ENSMUST00000106804]
AlphaFold A2A995
Predicted Effect possibly damaging
Transcript: ENSMUST00000106803
AA Change: V528M

PolyPhen 2 Score 0.863 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000102415
Gene: ENSMUSG00000078612
AA Change: V528M

DomainStartEndE-ValueType
low complexity region 120 132 N/A INTRINSIC
low complexity region 340 349 N/A INTRINSIC
low complexity region 442 459 N/A INTRINSIC
low complexity region 537 549 N/A INTRINSIC
low complexity region 567 578 N/A INTRINSIC
low complexity region 682 697 N/A INTRINSIC
SH3 735 791 3.82e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000106804
AA Change: V464M

PolyPhen 2 Score 0.152 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000102416
Gene: ENSMUSG00000078612
AA Change: V464M

DomainStartEndE-ValueType
low complexity region 56 68 N/A INTRINSIC
low complexity region 276 285 N/A INTRINSIC
low complexity region 378 395 N/A INTRINSIC
low complexity region 473 485 N/A INTRINSIC
low complexity region 503 514 N/A INTRINSIC
low complexity region 618 633 N/A INTRINSIC
SH3 671 727 3.82e0 SMART
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.1%
  • 20x: 92.3%
Validation Efficiency 98% (45/46)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A830018L16Rik A T 1: 11,868,716 (GRCm39) D332V probably damaging Het
Akr1c12 T C 13: 4,326,322 (GRCm39) Y53C probably benign Het
Arhgap23 T C 11: 97,383,498 (GRCm39) probably benign Het
AU040320 T C 4: 126,710,276 (GRCm39) probably benign Het
B4galnt2 A G 11: 95,782,767 (GRCm39) L15P probably benign Het
Cadps2 A G 6: 23,583,472 (GRCm39) probably benign Het
Cul9 C G 17: 46,833,101 (GRCm39) A1326P probably damaging Het
Dppa4 T C 16: 48,113,343 (GRCm39) F244S possibly damaging Het
Exoc1 A G 5: 76,702,035 (GRCm39) K445R probably benign Het
Fam47e A G 5: 92,710,343 (GRCm39) E114G probably damaging Het
Fgf12 A T 16: 27,981,202 (GRCm39) N171K possibly damaging Het
Ghr A G 15: 3,349,337 (GRCm39) S614P probably damaging Het
Gm10985 A C 3: 53,752,674 (GRCm39) Y19S probably damaging Het
Gpr152 T A 19: 4,193,554 (GRCm39) V365D possibly damaging Het
Guca1a A G 17: 47,706,637 (GRCm39) probably benign Het
Hivep1 G A 13: 42,310,997 (GRCm39) G1079D probably benign Het
Hnrnpm T C 17: 33,868,687 (GRCm39) D580G probably damaging Het
Ints6 A T 14: 62,945,147 (GRCm39) D394E probably damaging Het
Kat6b T A 14: 21,672,108 (GRCm39) Y339* probably null Het
Kcnj11 C A 7: 45,749,285 (GRCm39) V13L probably benign Het
Lama3 C T 18: 12,554,191 (GRCm39) probably benign Het
Mtrex A G 13: 113,050,876 (GRCm39) probably benign Het
Myo18a A G 11: 77,709,473 (GRCm39) T161A probably benign Het
Ncapg G T 5: 45,857,261 (GRCm39) S991I possibly damaging Het
Nrde2 G A 12: 100,116,069 (GRCm39) probably benign Het
Or4c127 T A 2: 89,832,822 (GRCm39) I24N probably benign Het
Or5d18 T C 2: 87,864,602 (GRCm39) R294G probably damaging Het
Pcdhb7 A T 18: 37,476,927 (GRCm39) T688S probably damaging Het
Pla2g6 T C 15: 79,190,635 (GRCm39) D309G probably benign Het
Plod1 A T 4: 148,005,584 (GRCm39) V404D probably damaging Het
Ppp2r2a G T 14: 67,266,447 (GRCm39) Y71* probably null Het
Prcp A G 7: 92,566,954 (GRCm39) N222S probably benign Het
Rad21 T C 15: 51,833,532 (GRCm39) T316A possibly damaging Het
Ranbp2 T C 10: 58,319,034 (GRCm39) probably benign Het
Rapgef4 C A 2: 72,038,492 (GRCm39) P548T possibly damaging Het
Ric1 G T 19: 29,555,135 (GRCm39) M416I probably benign Het
Slc9a8 T C 2: 167,266,041 (GRCm39) F6S probably benign Het
Smpdl3a T G 10: 57,678,575 (GRCm39) I126S probably null Het
Sphkap A T 1: 83,268,698 (GRCm39) L98Q probably damaging Het
Spink4 T G 4: 40,924,974 (GRCm39) probably benign Het
Taar5 A T 10: 23,847,605 (GRCm39) L334F probably damaging Het
Tecta A T 9: 42,289,203 (GRCm39) I454K probably benign Het
Ttc7 C T 17: 87,654,006 (GRCm39) T561M possibly damaging Het
Vmn2r9 G T 5: 108,995,440 (GRCm39) H403N probably damaging Het
Zdbf2 G A 1: 63,342,161 (GRCm39) C180Y possibly damaging Het
Other mutations in Fyb2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00664:Fyb2 APN 4 104,872,913 (GRCm39) missense probably damaging 1.00
IGL01155:Fyb2 APN 4 104,856,583 (GRCm39) missense probably benign 0.00
IGL01632:Fyb2 APN 4 104,853,008 (GRCm39) missense probably benign
IGL01746:Fyb2 APN 4 104,802,404 (GRCm39) missense probably benign 0.01
IGL02381:Fyb2 APN 4 104,805,863 (GRCm39) splice site probably benign
IGL02590:Fyb2 APN 4 104,836,250 (GRCm39) missense probably damaging 1.00
IGL02885:Fyb2 APN 4 104,861,118 (GRCm39) missense probably damaging 0.99
IGL03114:Fyb2 APN 4 104,852,975 (GRCm39) missense probably damaging 0.97
IGL03189:Fyb2 APN 4 104,872,939 (GRCm39) missense probably damaging 1.00
IGL03231:Fyb2 APN 4 104,843,460 (GRCm39) nonsense probably null
R0076:Fyb2 UTSW 4 104,802,661 (GRCm39) missense possibly damaging 0.46
R0662:Fyb2 UTSW 4 104,852,895 (GRCm39) missense possibly damaging 0.46
R0723:Fyb2 UTSW 4 104,873,063 (GRCm39) missense probably benign 0.00
R1672:Fyb2 UTSW 4 104,808,059 (GRCm39) missense probably benign 0.10
R1710:Fyb2 UTSW 4 104,861,113 (GRCm39) missense probably damaging 1.00
R1900:Fyb2 UTSW 4 104,802,652 (GRCm39) missense probably benign 0.06
R1965:Fyb2 UTSW 4 104,770,846 (GRCm39) missense probably benign 0.00
R2106:Fyb2 UTSW 4 104,802,769 (GRCm39) missense probably benign 0.01
R5191:Fyb2 UTSW 4 104,852,994 (GRCm39) missense possibly damaging 0.88
R5236:Fyb2 UTSW 4 104,805,957 (GRCm39) missense probably benign 0.00
R5277:Fyb2 UTSW 4 104,872,876 (GRCm39) missense probably damaging 1.00
R5502:Fyb2 UTSW 4 104,802,521 (GRCm39) missense probably damaging 1.00
R5769:Fyb2 UTSW 4 104,872,841 (GRCm39) missense probably damaging 1.00
R5769:Fyb2 UTSW 4 104,870,518 (GRCm39) missense probably damaging 1.00
R6167:Fyb2 UTSW 4 104,802,661 (GRCm39) missense possibly damaging 0.46
R6169:Fyb2 UTSW 4 104,857,713 (GRCm39) missense probably benign 0.16
R6371:Fyb2 UTSW 4 104,852,975 (GRCm39) missense probably damaging 0.97
R6582:Fyb2 UTSW 4 104,802,739 (GRCm39) missense probably benign 0.00
R6713:Fyb2 UTSW 4 104,847,432 (GRCm39) missense probably benign 0.16
R6719:Fyb2 UTSW 4 104,867,656 (GRCm39) missense probably benign 0.07
R7484:Fyb2 UTSW 4 104,870,499 (GRCm39) missense probably benign 0.01
R7534:Fyb2 UTSW 4 104,856,545 (GRCm39) nonsense probably null
R7590:Fyb2 UTSW 4 104,802,443 (GRCm39) missense probably benign 0.01
R7699:Fyb2 UTSW 4 104,867,651 (GRCm39) missense probably benign 0.07
R7700:Fyb2 UTSW 4 104,867,651 (GRCm39) missense probably benign 0.07
R8041:Fyb2 UTSW 4 104,857,681 (GRCm39) missense possibly damaging 0.82
R8298:Fyb2 UTSW 4 104,806,028 (GRCm39) missense probably damaging 0.99
R8300:Fyb2 UTSW 4 104,857,689 (GRCm39) missense probably damaging 1.00
R8755:Fyb2 UTSW 4 104,861,086 (GRCm39) missense unknown
R8817:Fyb2 UTSW 4 104,802,652 (GRCm39) missense probably benign 0.06
R8873:Fyb2 UTSW 4 104,856,538 (GRCm39) missense probably damaging 1.00
R8914:Fyb2 UTSW 4 104,857,700 (GRCm39) missense probably benign 0.09
R9224:Fyb2 UTSW 4 104,853,105 (GRCm39) missense probably benign 0.44
R9434:Fyb2 UTSW 4 104,847,534 (GRCm39) missense probably damaging 0.99
R9512:Fyb2 UTSW 4 104,853,100 (GRCm39) missense probably benign 0.00
R9589:Fyb2 UTSW 4 104,872,833 (GRCm39) missense probably damaging 1.00
R9634:Fyb2 UTSW 4 104,856,579 (GRCm39) nonsense probably null
R9758:Fyb2 UTSW 4 104,802,961 (GRCm39) missense probably benign 0.01
X0018:Fyb2 UTSW 4 104,802,407 (GRCm39) missense probably benign 0.04
Z1176:Fyb2 UTSW 4 104,770,857 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TGGCTTATCCAAGACCGTGCAGAC -3'
(R):5'- AGCTGGAGAAGTCCCACTTTCGTC -3'

Sequencing Primer
(F):5'- gagaggaaagaagggataaggg -3'
(R):5'- TAGAAAGATCATTAGCCTCCTGTGC -3'
Posted On 2014-01-15