Incidental Mutation 'R1216:Nrde2'
ID 99663
Institutional Source Beutler Lab
Gene Symbol Nrde2
Ensembl Gene ENSMUSG00000021179
Gene Name nrde-2 necessary for RNA interference, domain containing
Synonyms BC002230, 6720454P05Rik
MMRRC Submission 039285-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1216 (G1)
Quality Score 225
Status Validated
Chromosome 12
Chromosomal Location 100091711-100125912 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) G to A at 100116069 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000152698 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021596] [ENSMUST00000221954]
AlphaFold Q80XC6
Predicted Effect probably benign
Transcript: ENSMUST00000021596
SMART Domains Protein: ENSMUSP00000021596
Gene: ENSMUSG00000021179

DomainStartEndE-ValueType
low complexity region 85 107 N/A INTRINSIC
low complexity region 146 154 N/A INTRINSIC
Pfam:NRDE-2 318 658 1.2e-107 PFAM
Blast:HAT 765 800 2e-10 BLAST
Blast:HAT 802 841 3e-16 BLAST
Blast:HAT 986 1018 3e-10 BLAST
Blast:HAT 1075 1109 1e-14 BLAST
Blast:HAT 1111 1143 8e-15 BLAST
low complexity region 1154 1171 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000221954
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.1%
  • 20x: 92.3%
Validation Efficiency 98% (45/46)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A830018L16Rik A T 1: 11,868,716 (GRCm39) D332V probably damaging Het
Akr1c12 T C 13: 4,326,322 (GRCm39) Y53C probably benign Het
Arhgap23 T C 11: 97,383,498 (GRCm39) probably benign Het
AU040320 T C 4: 126,710,276 (GRCm39) probably benign Het
B4galnt2 A G 11: 95,782,767 (GRCm39) L15P probably benign Het
Cadps2 A G 6: 23,583,472 (GRCm39) probably benign Het
Cul9 C G 17: 46,833,101 (GRCm39) A1326P probably damaging Het
Dppa4 T C 16: 48,113,343 (GRCm39) F244S possibly damaging Het
Exoc1 A G 5: 76,702,035 (GRCm39) K445R probably benign Het
Fam47e A G 5: 92,710,343 (GRCm39) E114G probably damaging Het
Fgf12 A T 16: 27,981,202 (GRCm39) N171K possibly damaging Het
Fyb2 G A 4: 104,852,903 (GRCm39) V528M possibly damaging Het
Ghr A G 15: 3,349,337 (GRCm39) S614P probably damaging Het
Gm10985 A C 3: 53,752,674 (GRCm39) Y19S probably damaging Het
Gpr152 T A 19: 4,193,554 (GRCm39) V365D possibly damaging Het
Guca1a A G 17: 47,706,637 (GRCm39) probably benign Het
Hivep1 G A 13: 42,310,997 (GRCm39) G1079D probably benign Het
Hnrnpm T C 17: 33,868,687 (GRCm39) D580G probably damaging Het
Ints6 A T 14: 62,945,147 (GRCm39) D394E probably damaging Het
Kat6b T A 14: 21,672,108 (GRCm39) Y339* probably null Het
Kcnj11 C A 7: 45,749,285 (GRCm39) V13L probably benign Het
Lama3 C T 18: 12,554,191 (GRCm39) probably benign Het
Mtrex A G 13: 113,050,876 (GRCm39) probably benign Het
Myo18a A G 11: 77,709,473 (GRCm39) T161A probably benign Het
Ncapg G T 5: 45,857,261 (GRCm39) S991I possibly damaging Het
Or4c127 T A 2: 89,832,822 (GRCm39) I24N probably benign Het
Or5d18 T C 2: 87,864,602 (GRCm39) R294G probably damaging Het
Pcdhb7 A T 18: 37,476,927 (GRCm39) T688S probably damaging Het
Pla2g6 T C 15: 79,190,635 (GRCm39) D309G probably benign Het
Plod1 A T 4: 148,005,584 (GRCm39) V404D probably damaging Het
Ppp2r2a G T 14: 67,266,447 (GRCm39) Y71* probably null Het
Prcp A G 7: 92,566,954 (GRCm39) N222S probably benign Het
Rad21 T C 15: 51,833,532 (GRCm39) T316A possibly damaging Het
Ranbp2 T C 10: 58,319,034 (GRCm39) probably benign Het
Rapgef4 C A 2: 72,038,492 (GRCm39) P548T possibly damaging Het
Ric1 G T 19: 29,555,135 (GRCm39) M416I probably benign Het
Slc9a8 T C 2: 167,266,041 (GRCm39) F6S probably benign Het
Smpdl3a T G 10: 57,678,575 (GRCm39) I126S probably null Het
Sphkap A T 1: 83,268,698 (GRCm39) L98Q probably damaging Het
Spink4 T G 4: 40,924,974 (GRCm39) probably benign Het
Taar5 A T 10: 23,847,605 (GRCm39) L334F probably damaging Het
Tecta A T 9: 42,289,203 (GRCm39) I454K probably benign Het
Ttc7 C T 17: 87,654,006 (GRCm39) T561M possibly damaging Het
Vmn2r9 G T 5: 108,995,440 (GRCm39) H403N probably damaging Het
Zdbf2 G A 1: 63,342,161 (GRCm39) C180Y possibly damaging Het
Other mutations in Nrde2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02207:Nrde2 APN 12 100,097,190 (GRCm39) missense probably benign 0.01
IGL02697:Nrde2 APN 12 100,097,466 (GRCm39) missense probably damaging 1.00
IGL02798:Nrde2 APN 12 100,110,081 (GRCm39) nonsense probably null
IGL02810:Nrde2 APN 12 100,110,017 (GRCm39) missense possibly damaging 0.81
IGL02814:Nrde2 APN 12 100,110,394 (GRCm39) missense probably null 0.80
IGL02990:Nrde2 APN 12 100,108,355 (GRCm39) missense probably damaging 1.00
kurtz UTSW 12 100,100,664 (GRCm39) missense possibly damaging 0.92
R0090:Nrde2 UTSW 12 100,095,545 (GRCm39) splice site probably benign
R0576:Nrde2 UTSW 12 100,098,492 (GRCm39) missense possibly damaging 0.82
R0646:Nrde2 UTSW 12 100,110,105 (GRCm39) nonsense probably null
R1130:Nrde2 UTSW 12 100,091,929 (GRCm39) missense probably damaging 0.97
R1661:Nrde2 UTSW 12 100,116,119 (GRCm39) missense probably benign 0.19
R2069:Nrde2 UTSW 12 100,108,491 (GRCm39) missense probably damaging 1.00
R4405:Nrde2 UTSW 12 100,096,843 (GRCm39) missense probably benign 0.01
R4422:Nrde2 UTSW 12 100,112,286 (GRCm39) nonsense probably null
R5169:Nrde2 UTSW 12 100,095,552 (GRCm39) critical splice donor site probably null
R5200:Nrde2 UTSW 12 100,096,756 (GRCm39) missense possibly damaging 0.77
R5338:Nrde2 UTSW 12 100,097,037 (GRCm39) missense probably damaging 1.00
R5512:Nrde2 UTSW 12 100,108,509 (GRCm39) missense probably benign 0.20
R5820:Nrde2 UTSW 12 100,098,546 (GRCm39) missense probably benign 0.00
R6019:Nrde2 UTSW 12 100,098,501 (GRCm39) missense probably benign 0.04
R6346:Nrde2 UTSW 12 100,098,565 (GRCm39) missense probably benign 0.01
R6378:Nrde2 UTSW 12 100,097,016 (GRCm39) missense probably damaging 0.99
R6479:Nrde2 UTSW 12 100,110,207 (GRCm39) missense probably benign 0.00
R6523:Nrde2 UTSW 12 100,100,664 (GRCm39) missense possibly damaging 0.92
R7073:Nrde2 UTSW 12 100,098,747 (GRCm39) missense probably benign 0.00
R7220:Nrde2 UTSW 12 100,097,178 (GRCm39) missense probably benign 0.05
R7412:Nrde2 UTSW 12 100,108,509 (GRCm39) nonsense probably null
R7505:Nrde2 UTSW 12 100,098,757 (GRCm39) missense probably benign 0.15
R7699:Nrde2 UTSW 12 100,097,094 (GRCm39) missense probably benign 0.16
R7700:Nrde2 UTSW 12 100,097,094 (GRCm39) missense probably benign 0.16
R7733:Nrde2 UTSW 12 100,110,399 (GRCm39) missense possibly damaging 0.92
R7868:Nrde2 UTSW 12 100,097,446 (GRCm39) missense possibly damaging 0.65
R7963:Nrde2 UTSW 12 100,116,127 (GRCm39) missense probably damaging 0.99
R8131:Nrde2 UTSW 12 100,108,502 (GRCm39) missense probably benign 0.02
R8213:Nrde2 UTSW 12 100,097,262 (GRCm39) missense probably benign
R9061:Nrde2 UTSW 12 100,110,123 (GRCm39) missense probably benign 0.00
R9142:Nrde2 UTSW 12 100,117,518 (GRCm39) missense probably benign 0.15
R9371:Nrde2 UTSW 12 100,092,477 (GRCm39) missense probably benign 0.09
R9412:Nrde2 UTSW 12 100,096,681 (GRCm39) nonsense probably null
R9468:Nrde2 UTSW 12 100,106,268 (GRCm39) missense probably benign 0.00
R9542:Nrde2 UTSW 12 100,110,426 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- ACATGTGCCGTCTCCCAGAATCAG -3'
(R):5'- TCTCAGGTGAGAGCAACACTAGCG -3'

Sequencing Primer
(F):5'- cacaccaacaatcctagcac -3'
(R):5'- CAAGCAGgaagaagaagaaggag -3'
Posted On 2014-01-15