Incidental Mutation 'R1217:Zswim4'
ID 99749
Institutional Source Beutler Lab
Gene Symbol Zswim4
Ensembl Gene ENSMUSG00000035671
Gene Name zinc finger SWIM-type containing 4
Synonyms E130119J17Rik
MMRRC Submission 039286-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.202) question?
Stock # R1217 (G1)
Quality Score 98
Status Validated
Chromosome 8
Chromosomal Location 84937571-84963671 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 84946601 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 685 (V685A)
Ref Sequence ENSEMBL: ENSMUSP00000040078 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039480]
AlphaFold Q8C7B8
Predicted Effect possibly damaging
Transcript: ENSMUST00000039480
AA Change: V685A

PolyPhen 2 Score 0.895 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000040078
Gene: ENSMUSG00000035671
AA Change: V685A

DomainStartEndE-ValueType
low complexity region 531 545 N/A INTRINSIC
low complexity region 576 588 N/A INTRINSIC
low complexity region 607 628 N/A INTRINSIC
low complexity region 672 683 N/A INTRINSIC
low complexity region 907 917 N/A INTRINSIC
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.8%
  • 10x: 94.8%
  • 20x: 87.6%
Validation Efficiency 100% (45/45)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adora2a A T 10: 75,169,049 (GRCm39) Y171F probably damaging Het
Agpat4 C T 17: 12,429,203 (GRCm39) R152W probably damaging Het
Aldh1a2 A G 9: 71,188,964 (GRCm39) N293D possibly damaging Het
Ash2l T C 8: 26,312,913 (GRCm39) N441S probably damaging Het
Asrgl1 A T 19: 9,093,864 (GRCm39) probably null Het
Capn3 C A 2: 120,316,902 (GRCm39) S277* probably null Het
Ccdc168 A T 1: 44,096,339 (GRCm39) S1586R possibly damaging Het
Ccp110 T C 7: 118,329,167 (GRCm39) probably benign Het
Cdh17 T C 4: 11,799,676 (GRCm39) V491A probably benign Het
Cep170b T C 12: 112,707,339 (GRCm39) S362P probably damaging Het
Cfap57 A G 4: 118,463,849 (GRCm39) S335P possibly damaging Het
Cmklr1 A T 5: 113,752,107 (GRCm39) L298Q probably damaging Het
Col4a4 A T 1: 82,466,730 (GRCm39) probably null Het
Cul9 C G 17: 46,833,101 (GRCm39) A1326P probably damaging Het
Cyp2d26 A G 15: 82,677,068 (GRCm39) probably benign Het
Cyth3 T C 5: 143,688,575 (GRCm39) Y240H probably damaging Het
Dhx9 G A 1: 153,334,109 (GRCm39) T1017I probably damaging Het
Edar T C 10: 58,464,453 (GRCm39) Y62C probably damaging Het
Esyt3 C T 9: 99,200,097 (GRCm39) G699D possibly damaging Het
Fgb T C 3: 82,950,564 (GRCm39) T397A probably damaging Het
Foxc1 C A 13: 31,992,668 (GRCm39) A493E unknown Het
Grid1 T C 14: 34,542,186 (GRCm39) M1T probably null Het
Ipo4 T C 14: 55,871,816 (GRCm39) K113R probably damaging Het
Kif21b A G 1: 136,080,114 (GRCm39) E550G probably damaging Het
Krt1 T C 15: 101,757,416 (GRCm39) K265E possibly damaging Het
Lmx1a G A 1: 167,618,968 (GRCm39) R109H probably damaging Het
Mcm5 A G 8: 75,852,919 (GRCm39) K677R probably benign Het
Metap1 A T 3: 138,180,791 (GRCm39) L130* probably null Het
Mrgpra4 A G 7: 47,631,085 (GRCm39) L172P probably benign Het
Mylip G A 13: 45,560,178 (GRCm39) E205K probably damaging Het
Myo3b A C 2: 70,161,224 (GRCm39) E1128A probably benign Het
Naip2 T C 13: 100,298,362 (GRCm39) E558G probably benign Het
Naip2 C T 13: 100,298,368 (GRCm39) G556D probably benign Het
Nlrp4d T C 7: 10,098,194 (GRCm39) I823V probably benign Het
Odad1 C T 7: 45,592,182 (GRCm39) probably benign Het
Rec114 A T 9: 58,573,103 (GRCm39) probably benign Het
Rimbp2 C T 5: 128,865,351 (GRCm39) A666T probably benign Het
Siva1 C T 12: 112,613,355 (GRCm39) Q68* probably null Het
Slc22a27 T A 19: 7,904,033 (GRCm39) I35F probably benign Het
Slco1a5 T A 6: 142,200,100 (GRCm39) N228I probably damaging Het
St8sia4 G A 1: 95,581,464 (GRCm39) R93C probably damaging Het
Tprg1 T C 16: 25,231,593 (GRCm39) S190P probably damaging Het
Trpc6 A G 9: 8,658,287 (GRCm39) probably null Het
Vmn2r70 C T 7: 85,208,269 (GRCm39) C736Y probably damaging Het
Zfp629 C T 7: 127,211,916 (GRCm39) probably benign Het
Other mutations in Zswim4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00493:Zswim4 APN 8 84,938,769 (GRCm39) missense probably damaging 1.00
IGL03048:Zswim4 UTSW 8 84,938,604 (GRCm39) missense possibly damaging 0.95
R0217:Zswim4 UTSW 8 84,939,293 (GRCm39) missense probably damaging 1.00
R0688:Zswim4 UTSW 8 84,955,517 (GRCm39) missense possibly damaging 0.93
R1853:Zswim4 UTSW 8 84,950,829 (GRCm39) missense probably damaging 1.00
R1878:Zswim4 UTSW 8 84,939,405 (GRCm39) missense possibly damaging 0.55
R2205:Zswim4 UTSW 8 84,952,498 (GRCm39) missense possibly damaging 0.70
R2940:Zswim4 UTSW 8 84,950,377 (GRCm39) missense probably damaging 1.00
R3747:Zswim4 UTSW 8 84,938,676 (GRCm39) missense possibly damaging 0.86
R3748:Zswim4 UTSW 8 84,938,676 (GRCm39) missense possibly damaging 0.86
R3750:Zswim4 UTSW 8 84,938,676 (GRCm39) missense possibly damaging 0.86
R4777:Zswim4 UTSW 8 84,963,586 (GRCm39) missense probably benign
R4831:Zswim4 UTSW 8 84,938,948 (GRCm39) missense probably damaging 1.00
R4959:Zswim4 UTSW 8 84,938,852 (GRCm39) missense probably benign 0.22
R4968:Zswim4 UTSW 8 84,944,001 (GRCm39) missense probably benign 0.37
R4973:Zswim4 UTSW 8 84,938,852 (GRCm39) missense probably benign 0.22
R4977:Zswim4 UTSW 8 84,953,296 (GRCm39) splice site probably null
R4978:Zswim4 UTSW 8 84,953,296 (GRCm39) splice site probably null
R4980:Zswim4 UTSW 8 84,953,296 (GRCm39) splice site probably null
R4981:Zswim4 UTSW 8 84,953,296 (GRCm39) splice site probably null
R4982:Zswim4 UTSW 8 84,953,296 (GRCm39) splice site probably null
R4983:Zswim4 UTSW 8 84,953,296 (GRCm39) splice site probably null
R5248:Zswim4 UTSW 8 84,946,561 (GRCm39) missense probably benign 0.13
R5337:Zswim4 UTSW 8 84,961,708 (GRCm39) missense probably damaging 1.00
R5366:Zswim4 UTSW 8 84,939,419 (GRCm39) missense probably benign 0.39
R5646:Zswim4 UTSW 8 84,957,739 (GRCm39) splice site probably null
R5845:Zswim4 UTSW 8 84,943,871 (GRCm39) splice site probably null
R6193:Zswim4 UTSW 8 84,952,774 (GRCm39) missense probably benign
R6270:Zswim4 UTSW 8 84,957,580 (GRCm39) missense probably damaging 1.00
R6648:Zswim4 UTSW 8 84,957,543 (GRCm39) missense probably benign 0.22
R6920:Zswim4 UTSW 8 84,940,714 (GRCm39) missense probably benign 0.01
R7117:Zswim4 UTSW 8 84,940,681 (GRCm39) missense probably damaging 1.00
R7155:Zswim4 UTSW 8 84,946,556 (GRCm39) missense probably damaging 1.00
R7344:Zswim4 UTSW 8 84,950,327 (GRCm39) nonsense probably null
R7354:Zswim4 UTSW 8 84,955,478 (GRCm39) missense probably damaging 1.00
R8036:Zswim4 UTSW 8 84,949,918 (GRCm39) missense probably benign 0.22
R8408:Zswim4 UTSW 8 84,939,014 (GRCm39) missense possibly damaging 0.82
R8518:Zswim4 UTSW 8 84,938,586 (GRCm39) missense probably damaging 1.00
R8750:Zswim4 UTSW 8 84,939,313 (GRCm39) missense possibly damaging 0.82
R8830:Zswim4 UTSW 8 84,949,945 (GRCm39) missense possibly damaging 0.92
R8838:Zswim4 UTSW 8 84,940,699 (GRCm39) missense probably damaging 1.00
R8840:Zswim4 UTSW 8 84,940,699 (GRCm39) missense probably damaging 1.00
R8842:Zswim4 UTSW 8 84,940,699 (GRCm39) missense probably damaging 1.00
R9185:Zswim4 UTSW 8 84,963,633 (GRCm39) start codon destroyed probably null 0.94
R9355:Zswim4 UTSW 8 84,955,687 (GRCm39) missense probably damaging 1.00
R9432:Zswim4 UTSW 8 84,963,539 (GRCm39) missense probably damaging 1.00
R9635:Zswim4 UTSW 8 84,939,354 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CACCTTTGGCAGCCGTCAGCAT -3'
(R):5'- TGCAGCTCGACGAGTTCCCCTT -3'

Sequencing Primer
(F):5'- CCGTCAGCATGGTGGAG -3'
(R):5'- AAATTCCAGCTCTTCTtttgataagg -3'
Posted On 2014-01-15