Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00826:Cyp2c68'

9984

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp2c68

Ensembl Gene

ENSMUSG00000074882

Gene Name

cytochrome P450, family 2, subfamily c, polypeptide 68

Synonyms

9030012A22Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00826

Quality Score

Status

Chromosome

Chromosomal Location

39677278-39729498 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 39727949 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 68 (Y68H)

Ref Sequence

ENSEMBL: ENSMUSP00000097071 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099472]

AlphaFold

K7N6C2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000099472
AA Change: Y68H

PolyPhen 2 Score 0.869 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000097071
Gene: ENSMUSG00000074882
AA Change: Y68H

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:p450	30	487	2.1e-150	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aars1	T	G	8: 111,766,932 (GRCm39)	S105A	probably damaging	Het
Adamtsl1	C	T	4: 86,075,041 (GRCm39)	P136L	probably damaging	Het
Akap13	C	A	7: 75,327,195 (GRCm39)	N376K	probably damaging	Het
Casp2	T	A	6: 42,246,219 (GRCm39)	Y192*	probably null	Het
Cfap206	C	T	4: 34,721,562 (GRCm39)	S162N	probably damaging	Het
Cyp2j9	A	T	4: 96,474,167 (GRCm39)	I91K	possibly damaging	Het
Diablo	T	C	5: 123,650,751 (GRCm39)	I179M	probably benign	Het
Dnah9	C	T	11: 65,880,768 (GRCm39)	V2610M	probably damaging	Het
Dsc2	C	T	18: 20,168,372 (GRCm39)	A696T	probably damaging	Het
Eaf2	A	T	16: 36,621,038 (GRCm39)	M218K	probably benign	Het
Emc9	G	T	14: 55,822,377 (GRCm39)	L64I	possibly damaging	Het
Epb41l2	T	C	10: 25,317,620 (GRCm39)	S46P	probably benign	Het
Galnt7	A	T	8: 57,993,105 (GRCm39)	Y405*	probably null	Het
Gnl3	A	G	14: 30,734,753 (GRCm39)		probably benign	Het
Map1a	A	G	2: 121,132,757 (GRCm39)	Q1191R	possibly damaging	Het
Map2k2	G	A	10: 80,954,052 (GRCm39)	V173I	probably benign	Het
Nbeal2	A	G	9: 110,455,971 (GRCm39)	V2408A	probably benign	Het
Npepps	T	C	11: 97,126,884 (GRCm39)		probably benign	Het
Osbpl8	A	T	10: 111,108,181 (GRCm39)		probably benign	Het
Phf12	G	T	11: 77,906,332 (GRCm39)	R282L	probably damaging	Het
Phf21a	T	G	2: 92,174,881 (GRCm39)		probably benign	Het
Plin2	T	C	4: 86,582,683 (GRCm39)	N98D	possibly damaging	Het
Prl7a1	A	G	13: 27,824,778 (GRCm39)	V19A	probably damaging	Het
Slfn10-ps	T	C	11: 82,926,085 (GRCm39)		noncoding transcript	Het
Spag11b	T	G	8: 19,191,423 (GRCm39)	V33G	possibly damaging	Het
Trappc13	A	T	13: 104,281,016 (GRCm39)	S349T	probably benign	Het
Trim34a	T	C	7: 103,910,140 (GRCm39)		probably null	Het

Other mutations in Cyp2c68

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00514:Cyp2c68	APN	19	39,700,939 (GRCm39)	missense	probably damaging	0.98
IGL01363:Cyp2c68	APN	19	39,691,871 (GRCm39)	missense	probably benign	0.01
IGL01892:Cyp2c68	APN	19	39,722,788 (GRCm39)	missense	probably benign	0.00
IGL02088:Cyp2c68	APN	19	39,691,965 (GRCm39)	splice site	probably benign
IGL02422:Cyp2c68	APN	19	39,722,896 (GRCm39)	missense	probably damaging	1.00
IGL03047:Cyp2c68	UTSW	19	39,722,904 (GRCm39)	missense	probably benign	0.00
R0523:Cyp2c68	UTSW	19	39,727,873 (GRCm39)	missense	probably benign	0.08
R0729:Cyp2c68	UTSW	19	39,727,994 (GRCm39)	splice site	probably benign
R0975:Cyp2c68	UTSW	19	39,691,802 (GRCm39)	missense	possibly damaging	0.85
R1117:Cyp2c68	UTSW	19	39,700,903 (GRCm39)	missense	probably damaging	1.00
R1355:Cyp2c68	UTSW	19	39,729,400 (GRCm39)	missense	probably damaging	1.00
R1370:Cyp2c68	UTSW	19	39,729,400 (GRCm39)	missense	probably damaging	1.00
R1436:Cyp2c68	UTSW	19	39,729,484 (GRCm39)	start codon destroyed	probably null	1.00
R1564:Cyp2c68	UTSW	19	39,724,024 (GRCm39)	nonsense	probably null
R1730:Cyp2c68	UTSW	19	39,687,719 (GRCm39)	missense	possibly damaging	0.87
R1865:Cyp2c68	UTSW	19	39,722,733 (GRCm39)	missense	probably benign	0.04
R1905:Cyp2c68	UTSW	19	39,724,026 (GRCm39)	missense	probably benign	0.01
R1951:Cyp2c68	UTSW	19	39,700,972 (GRCm39)	missense	probably benign	0.22
R1952:Cyp2c68	UTSW	19	39,700,972 (GRCm39)	missense	probably benign	0.22
R2224:Cyp2c68	UTSW	19	39,724,026 (GRCm39)	missense	probably benign	0.34
R2230:Cyp2c68	UTSW	19	39,687,804 (GRCm39)	missense	probably benign	0.07
R2231:Cyp2c68	UTSW	19	39,687,804 (GRCm39)	missense	probably benign	0.07
R2866:Cyp2c68	UTSW	19	39,677,589 (GRCm39)	missense	probably damaging	1.00
R3104:Cyp2c68	UTSW	19	39,722,757 (GRCm39)	missense	probably benign
R4409:Cyp2c68	UTSW	19	39,727,896 (GRCm39)	missense	probably damaging	0.98
R4575:Cyp2c68	UTSW	19	39,722,805 (GRCm39)	missense	probably benign	0.21
R4620:Cyp2c68	UTSW	19	39,701,006 (GRCm39)	splice site	probably null
R4684:Cyp2c68	UTSW	19	39,687,779 (GRCm39)	missense	possibly damaging	0.48
R5023:Cyp2c68	UTSW	19	39,700,951 (GRCm39)	missense	probably benign	0.01
R5410:Cyp2c68	UTSW	19	39,687,728 (GRCm39)	missense	possibly damaging	0.65
R5513:Cyp2c68	UTSW	19	39,691,850 (GRCm39)	missense	probably damaging	1.00
R5568:Cyp2c68	UTSW	19	39,677,526 (GRCm39)	missense	probably benign	0.19
R5706:Cyp2c68	UTSW	19	39,722,762 (GRCm39)	missense	possibly damaging	0.95
R5890:Cyp2c68	UTSW	19	39,700,936 (GRCm39)	missense	probably damaging	1.00
R5897:Cyp2c68	UTSW	19	39,700,975 (GRCm39)	missense	probably benign	0.01
R6007:Cyp2c68	UTSW	19	39,722,780 (GRCm39)	missense	probably damaging	1.00
R6132:Cyp2c68	UTSW	19	39,691,858 (GRCm39)	missense	possibly damaging	0.90
R6187:Cyp2c68	UTSW	19	39,729,452 (GRCm39)	missense	probably benign	0.32
R6229:Cyp2c68	UTSW	19	39,727,622 (GRCm39)	missense	probably benign	0.02
R6341:Cyp2c68	UTSW	19	39,700,933 (GRCm39)	missense	possibly damaging	0.54
R7209:Cyp2c68	UTSW	19	39,677,649 (GRCm39)	missense	probably damaging	1.00
R7330:Cyp2c68	UTSW	19	39,677,634 (GRCm39)	missense	probably damaging	1.00
R7374:Cyp2c68	UTSW	19	39,727,648 (GRCm39)	critical splice acceptor site	probably null
R7402:Cyp2c68	UTSW	19	39,729,318 (GRCm39)	missense	probably benign	0.02
R7483:Cyp2c68	UTSW	19	39,677,581 (GRCm39)	missense	probably benign	0.02
R9103:Cyp2c68	UTSW	19	39,727,625 (GRCm39)	missense	possibly damaging	0.95
R9204:Cyp2c68	UTSW	19	39,727,571 (GRCm39)	missense	probably damaging	1.00
R9452:Cyp2c68	UTSW	19	39,687,833 (GRCm39)	missense	possibly damaging	0.75
Z1088:Cyp2c68	UTSW	19	39,727,907 (GRCm39)	missense	probably damaging	0.96

Posted On

2012-12-06