Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00670:Cyp2d26'

9986

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp2d26

Ensembl Gene

ENSMUSG00000022445

Gene Name

cytochrome P450, family 2, subfamily d, polypeptide 26

Synonyms

1300006E06Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.090) question?

Stock #

IGL00670

Quality Score

Status

Chromosome

Chromosomal Location

82674302-82678495 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 82675942 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 257 (M257L)

Ref Sequence

ENSEMBL: ENSMUSP00000006094 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000006094] [ENSMUST00000229387] [ENSMUST00000229512]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000006094
AA Change: M257L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000006094
Gene: ENSMUSG00000022445
AA Change: M257L

Domain	Start	End	E-Value	Type
transmembrane domain	10	27	N/A	INTRINSIC
Pfam:p450	37	497	3.5e-141	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000229387

Predicted Effect

probably benign
Transcript: ENSMUST00000229512

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000230125

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 15 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc9	A	T	6: 142,633,007 (GRCm39)	L245Q	probably damaging	Het
Abcd3	A	T	3: 121,569,333 (GRCm39)	V333D	probably damaging	Het
Aff2	T	A	X: 68,588,199 (GRCm39)	M122K	possibly damaging	Het
Car10	C	T	11: 93,195,483 (GRCm39)		probably benign	Het
Cyp2j5	T	G	4: 96,522,512 (GRCm39)	D354A	probably benign	Het
Fam228b	T	C	12: 4,814,081 (GRCm39)	K59E	probably damaging	Het
Fndc3c1	T	C	X: 105,489,383 (GRCm39)	D346G	probably benign	Het
Med14	G	A	X: 12,620,428 (GRCm39)	A95V	probably damaging	Het
Med23	T	C	10: 24,764,482 (GRCm39)	L155P	probably damaging	Het
Mrps31	A	G	8: 22,919,206 (GRCm39)	D312G	probably damaging	Het
Ppp1r3a	A	T	6: 14,719,059 (GRCm39)	N618K	probably benign	Het
Prb1a	A	T	6: 132,184,109 (GRCm39)		probably benign	Het
Slc5a4a	A	T	10: 75,999,567 (GRCm39)	I210F	probably damaging	Het
Tasor2	A	T	13: 3,635,241 (GRCm39)	I522N	probably benign	Het
Ttn	A	T	2: 76,657,335 (GRCm39)		probably benign	Het

Other mutations in Cyp2d26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00559:Cyp2d26	APN	15	82,675,244 (GRCm39)	missense	probably benign	0.31
IGL01646:Cyp2d26	APN	15	82,675,619 (GRCm39)	missense	probably benign	0.00
IGL01915:Cyp2d26	APN	15	82,674,450 (GRCm39)	missense	probably benign	0.06
IGL01940:Cyp2d26	APN	15	82,676,758 (GRCm39)	missense	probably benign	0.00
IGL02127:Cyp2d26	APN	15	82,675,307 (GRCm39)	missense	probably benign	0.09
IGL02452:Cyp2d26	APN	15	82,676,827 (GRCm39)	missense	probably benign	0.00
IGL03216:Cyp2d26	APN	15	82,677,462 (GRCm39)	missense	probably benign
IGL03377:Cyp2d26	APN	15	82,674,755 (GRCm39)	missense	possibly damaging	0.47
R0149:Cyp2d26	UTSW	15	82,676,968 (GRCm39)	missense	probably damaging	1.00
R0848:Cyp2d26	UTSW	15	82,674,434 (GRCm39)	missense	probably benign	0.00
R1165:Cyp2d26	UTSW	15	82,678,242 (GRCm39)	missense	probably damaging	1.00
R1217:Cyp2d26	UTSW	15	82,677,068 (GRCm39)	splice site	probably benign
R1780:Cyp2d26	UTSW	15	82,678,208 (GRCm39)	missense	probably damaging	1.00
R2048:Cyp2d26	UTSW	15	82,676,928 (GRCm39)	utr 3 prime	probably benign
R2152:Cyp2d26	UTSW	15	82,676,907 (GRCm39)	critical splice donor site	probably null
R2397:Cyp2d26	UTSW	15	82,678,236 (GRCm39)	missense	probably damaging	1.00
R4702:Cyp2d26	UTSW	15	82,676,648 (GRCm39)	intron	probably benign
R5157:Cyp2d26	UTSW	15	82,675,190 (GRCm39)	missense	probably benign	0.01
R5444:Cyp2d26	UTSW	15	82,676,739 (GRCm39)	missense	probably benign	0.18
R6017:Cyp2d26	UTSW	15	82,674,774 (GRCm39)	missense	possibly damaging	0.68
R6223:Cyp2d26	UTSW	15	82,675,918 (GRCm39)	missense	probably benign	0.04
R6390:Cyp2d26	UTSW	15	82,676,825 (GRCm39)	missense	possibly damaging	0.68
R6473:Cyp2d26	UTSW	15	82,675,968 (GRCm39)	missense	probably benign	0.02
R6858:Cyp2d26	UTSW	15	82,678,284 (GRCm39)	missense	probably damaging	1.00
R6912:Cyp2d26	UTSW	15	82,675,320 (GRCm39)	missense	probably benign	0.16
R6936:Cyp2d26	UTSW	15	82,676,741 (GRCm39)	missense	probably benign	0.14
R6960:Cyp2d26	UTSW	15	82,674,446 (GRCm39)	missense	probably damaging	0.98
R7053:Cyp2d26	UTSW	15	82,676,801 (GRCm39)	missense	probably benign	0.00
R7113:Cyp2d26	UTSW	15	82,674,403 (GRCm39)	missense	probably benign	0.02
R7126:Cyp2d26	UTSW	15	82,678,209 (GRCm39)	missense	probably benign	0.00
R7272:Cyp2d26	UTSW	15	82,676,764 (GRCm39)	missense	probably benign
R7771:Cyp2d26	UTSW	15	82,675,947 (GRCm39)	missense	probably benign
R8695:Cyp2d26	UTSW	15	82,676,907 (GRCm39)	critical splice donor site	probably benign
R9466:Cyp2d26	UTSW	15	82,674,424 (GRCm39)	missense	probably benign	0.01
R9489:Cyp2d26	UTSW	15	82,674,672 (GRCm39)	missense	probably benign	0.00
R9605:Cyp2d26	UTSW	15	82,674,672 (GRCm39)	missense	probably benign	0.00
R9656:Cyp2d26	UTSW	15	82,677,059 (GRCm39)	missense	probably benign	0.03
X0021:Cyp2d26	UTSW	15	82,674,718 (GRCm39)	missense	probably benign	0.04

Posted On

2012-12-06