Incidental Mutation 'R1219:Mapkbp1'
ID 99885
Institutional Source Beutler Lab
Gene Symbol Mapkbp1
Ensembl Gene ENSMUSG00000033902
Gene Name mitogen-activated protein kinase binding protein 1
Synonyms 2810483F24Rik, Jnkbp1
MMRRC Submission 039288-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1219 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 119803180-119857889 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 119849831 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Stop codon at position 768 (G768*)
Ref Sequence ENSEMBL: ENSMUSP00000155163 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000066058] [ENSMUST00000229024]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000066058
AA Change: G762*
SMART Domains Protein: ENSMUSP00000068516
Gene: ENSMUSG00000033902
AA Change: G762*

DomainStartEndE-ValueType
WD40 80 121 8.75e-5 SMART
WD40 124 165 3.64e-2 SMART
WD40 168 205 4.62e-1 SMART
low complexity region 220 234 N/A INTRINSIC
WD40 264 301 2.65e1 SMART
WD40 332 367 1.99e0 SMART
WD40 374 422 1.29e-2 SMART
WD40 463 502 3.9e-2 SMART
WD40 505 547 2.77e-1 SMART
WD40 551 592 2.67e-1 SMART
WD40 599 639 2.21e1 SMART
WD40 642 684 5.75e-1 SMART
WD40 687 726 6.04e-8 SMART
low complexity region 736 747 N/A INTRINSIC
low complexity region 779 795 N/A INTRINSIC
low complexity region 1028 1054 N/A INTRINSIC
coiled coil region 1400 1427 N/A INTRINSIC
low complexity region 1460 1477 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128077
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148161
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184907
Predicted Effect probably null
Transcript: ENSMUST00000229024
AA Change: G768*
Meta Mutation Damage Score 0.9713 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.8%
Validation Efficiency 98% (44/45)
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atad2 A G 15: 57,998,307 (GRCm39) S22P probably benign Het
Atrn A T 2: 130,862,927 (GRCm39) T1336S possibly damaging Het
Bltp1 T A 3: 37,000,619 (GRCm39) L1266* probably null Het
Car9 G T 4: 43,512,439 (GRCm39) probably null Het
Ccdc113 T C 8: 96,264,895 (GRCm39) probably benign Het
Ccdc158 A G 5: 92,802,040 (GRCm39) probably benign Het
Ciao3 T C 17: 25,994,075 (GRCm39) I41T probably damaging Het
Dcun1d3 G T 7: 119,458,631 (GRCm39) Q135K probably damaging Het
Dnah7b A C 1: 46,379,280 (GRCm39) E3671D probably benign Het
Eea1 A G 10: 95,846,623 (GRCm39) probably benign Het
Entrep3 T C 3: 89,091,155 (GRCm39) V42A probably damaging Het
Gdf10 G A 14: 33,654,710 (GRCm39) A406T probably benign Het
Gm5111 A G 6: 48,567,328 (GRCm39) probably benign Het
Golga3 G T 5: 110,332,215 (GRCm39) E50* probably null Het
Junb T C 8: 85,704,268 (GRCm39) E264G probably damaging Het
Kash5 A G 7: 44,838,832 (GRCm39) probably benign Het
Kifc1 G A 17: 34,103,685 (GRCm39) R195C probably benign Het
Krt18 T C 15: 101,939,723 (GRCm39) probably benign Het
Man1a G A 10: 53,795,249 (GRCm39) probably benign Het
Mybpc2 A C 7: 44,165,458 (GRCm39) probably null Het
Nectin3 A T 16: 46,275,042 (GRCm39) C238* probably null Het
Ntf3 G T 6: 126,079,174 (GRCm39) R98S possibly damaging Het
Nup153 T G 13: 46,840,695 (GRCm39) Q971P probably benign Het
Nup155 A G 15: 8,146,822 (GRCm39) T221A possibly damaging Het
Ppp2r1b T C 9: 50,778,621 (GRCm39) probably benign Het
Prkd1 A T 12: 50,435,125 (GRCm39) V534E probably damaging Het
Rabep2 A G 7: 126,028,799 (GRCm39) E26G probably damaging Het
Rnf213 C A 11: 119,327,003 (GRCm39) N1663K probably damaging Het
Slc1a1 G A 19: 28,882,146 (GRCm39) probably benign Het
Slc36a4 T C 9: 15,634,832 (GRCm39) Y125H probably damaging Het
Slc6a11 G A 6: 114,202,772 (GRCm39) probably benign Het
Stab1 C T 14: 30,862,578 (GRCm39) probably null Het
Sumf2 G T 5: 129,883,613 (GRCm39) A164S probably benign Het
Sv2b T C 7: 74,786,160 (GRCm39) D420G probably benign Het
Ube2v1 T C 2: 167,459,831 (GRCm39) D56G probably benign Het
Ung A G 5: 114,270,228 (GRCm39) probably benign Het
Vcan T C 13: 89,828,023 (GRCm39) Y2181C probably damaging Het
Vmn1r238 G A 18: 3,123,135 (GRCm39) T93I possibly damaging Het
Vmn2r14 A C 5: 109,372,440 (GRCm39) S17A probably benign Het
Vmn2r25 A G 6: 123,816,282 (GRCm39) V433A probably benign Het
Zfp36l2 A G 17: 84,495,070 (GRCm39) probably null Het
Zfp646 G A 7: 127,482,292 (GRCm39) G1490S probably benign Het
Zfp839 A G 12: 110,834,707 (GRCm39) D654G possibly damaging Het
Other mutations in Mapkbp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01102:Mapkbp1 APN 2 119,852,339 (GRCm39) missense possibly damaging 0.94
IGL01309:Mapkbp1 APN 2 119,849,423 (GRCm39) missense probably damaging 1.00
IGL01728:Mapkbp1 APN 2 119,854,302 (GRCm39) missense probably damaging 1.00
IGL01808:Mapkbp1 APN 2 119,853,650 (GRCm39) splice site probably null
IGL02185:Mapkbp1 APN 2 119,845,144 (GRCm39) missense possibly damaging 0.58
IGL02421:Mapkbp1 APN 2 119,850,136 (GRCm39) missense possibly damaging 0.95
IGL02691:Mapkbp1 APN 2 119,803,655 (GRCm39) splice site probably benign
IGL03146:Mapkbp1 APN 2 119,828,955 (GRCm39) splice site probably benign
IGL03387:Mapkbp1 APN 2 119,828,979 (GRCm39) missense probably damaging 0.99
IGL03054:Mapkbp1 UTSW 2 119,845,881 (GRCm39) missense probably damaging 0.97
R0118:Mapkbp1 UTSW 2 119,855,696 (GRCm39) missense probably benign 0.00
R0393:Mapkbp1 UTSW 2 119,843,384 (GRCm39) splice site probably null
R0463:Mapkbp1 UTSW 2 119,853,632 (GRCm39) missense probably benign 0.01
R0788:Mapkbp1 UTSW 2 119,854,482 (GRCm39) missense probably benign 0.02
R0928:Mapkbp1 UTSW 2 119,845,849 (GRCm39) missense probably benign 0.00
R1104:Mapkbp1 UTSW 2 119,841,554 (GRCm39) splice site probably benign
R1162:Mapkbp1 UTSW 2 119,855,799 (GRCm39) missense possibly damaging 0.87
R1299:Mapkbp1 UTSW 2 119,845,885 (GRCm39) missense probably damaging 1.00
R1300:Mapkbp1 UTSW 2 119,844,136 (GRCm39) missense probably benign 0.25
R1342:Mapkbp1 UTSW 2 119,829,015 (GRCm39) missense possibly damaging 0.95
R1456:Mapkbp1 UTSW 2 119,803,626 (GRCm39) missense probably damaging 1.00
R1464:Mapkbp1 UTSW 2 119,851,742 (GRCm39) missense probably benign
R1464:Mapkbp1 UTSW 2 119,851,742 (GRCm39) missense probably benign
R1470:Mapkbp1 UTSW 2 119,848,301 (GRCm39) missense probably damaging 1.00
R1470:Mapkbp1 UTSW 2 119,848,301 (GRCm39) missense probably damaging 1.00
R1660:Mapkbp1 UTSW 2 119,849,029 (GRCm39) missense possibly damaging 0.83
R2008:Mapkbp1 UTSW 2 119,843,146 (GRCm39) missense probably damaging 1.00
R2083:Mapkbp1 UTSW 2 119,845,963 (GRCm39) missense possibly damaging 0.96
R2371:Mapkbp1 UTSW 2 119,841,261 (GRCm39) missense probably damaging 1.00
R2423:Mapkbp1 UTSW 2 119,855,071 (GRCm39) missense probably benign 0.00
R3976:Mapkbp1 UTSW 2 119,852,339 (GRCm39) missense possibly damaging 0.94
R4009:Mapkbp1 UTSW 2 119,854,086 (GRCm39) missense probably benign 0.00
R4183:Mapkbp1 UTSW 2 119,848,346 (GRCm39) missense probably damaging 1.00
R4246:Mapkbp1 UTSW 2 119,843,508 (GRCm39) missense probably damaging 1.00
R4503:Mapkbp1 UTSW 2 119,846,187 (GRCm39) missense probably damaging 1.00
R4513:Mapkbp1 UTSW 2 119,854,174 (GRCm39) missense possibly damaging 0.63
R4517:Mapkbp1 UTSW 2 119,855,545 (GRCm39) intron probably benign
R4742:Mapkbp1 UTSW 2 119,847,299 (GRCm39) missense probably damaging 1.00
R5049:Mapkbp1 UTSW 2 119,845,982 (GRCm39) splice site probably benign
R5079:Mapkbp1 UTSW 2 119,844,214 (GRCm39) missense probably damaging 0.99
R5137:Mapkbp1 UTSW 2 119,852,662 (GRCm39) missense probably damaging 1.00
R5255:Mapkbp1 UTSW 2 119,847,735 (GRCm39) missense probably damaging 1.00
R5530:Mapkbp1 UTSW 2 119,845,836 (GRCm39) missense probably benign
R5546:Mapkbp1 UTSW 2 119,849,724 (GRCm39) missense probably damaging 1.00
R5634:Mapkbp1 UTSW 2 119,803,576 (GRCm39) missense probably damaging 1.00
R5696:Mapkbp1 UTSW 2 119,852,201 (GRCm39) splice site probably null
R5891:Mapkbp1 UTSW 2 119,854,413 (GRCm39) nonsense probably null
R6263:Mapkbp1 UTSW 2 119,853,772 (GRCm39) missense probably damaging 1.00
R6807:Mapkbp1 UTSW 2 119,851,640 (GRCm39) missense probably damaging 0.99
R6890:Mapkbp1 UTSW 2 119,846,283 (GRCm39) missense probably damaging 1.00
R7159:Mapkbp1 UTSW 2 119,855,613 (GRCm39) missense possibly damaging 0.72
R7467:Mapkbp1 UTSW 2 119,852,669 (GRCm39) missense probably damaging 1.00
R7536:Mapkbp1 UTSW 2 119,849,066 (GRCm39) missense probably damaging 1.00
R7564:Mapkbp1 UTSW 2 119,844,232 (GRCm39) missense probably benign 0.09
R7801:Mapkbp1 UTSW 2 119,842,554 (GRCm39) missense probably damaging 1.00
R7886:Mapkbp1 UTSW 2 119,843,128 (GRCm39) missense possibly damaging 0.90
R8095:Mapkbp1 UTSW 2 119,848,131 (GRCm39) missense probably benign 0.11
R8421:Mapkbp1 UTSW 2 119,849,431 (GRCm39) missense probably damaging 0.99
R8548:Mapkbp1 UTSW 2 119,854,572 (GRCm39) missense probably benign 0.33
R8856:Mapkbp1 UTSW 2 119,845,109 (GRCm39) missense probably damaging 1.00
R8971:Mapkbp1 UTSW 2 119,850,050 (GRCm39) missense probably benign
R9007:Mapkbp1 UTSW 2 119,850,143 (GRCm39) missense probably damaging 0.99
R9251:Mapkbp1 UTSW 2 119,853,671 (GRCm39) missense probably benign 0.00
R9255:Mapkbp1 UTSW 2 119,843,556 (GRCm39) missense probably damaging 1.00
R9361:Mapkbp1 UTSW 2 119,845,252 (GRCm39) missense probably benign 0.02
R9587:Mapkbp1 UTSW 2 119,847,277 (GRCm39) missense possibly damaging 0.80
R9685:Mapkbp1 UTSW 2 119,851,664 (GRCm39) missense probably benign 0.35
R9803:Mapkbp1 UTSW 2 119,841,256 (GRCm39) missense probably benign 0.11
Predicted Primers PCR Primer
(F):5'- TGAGACAATTCTTCTCTGTGCCACC -3'
(R):5'- ACTCACTGGGCAAGAAGGCAAC -3'

Sequencing Primer
(F):5'- CCTTGCCAATTCGTGGGAAG -3'
(R):5'- AGGCAACACTGATGGGC -3'
Posted On 2014-01-15