| 1 |
 |
|
Sgk3
|
0.275
|
|
1 |
9798107-9900845 bp (+)
|
9886104 |
Unknown
|
2017-04-11
Katherine Timer
|
skin/coat/nails
|
| 2 |
|
|
Trpa1
|
0.119
|
|
1 |
14872648-14918862 bp (-)
|
14884116 |
Autosomal Recessive (1;7)
|
2018-07-19
Anne Murray
|
|
| 3 |
|
|
Trpa1
|
0.119
|
|
1 |
14872648-14918862 bp (-)
|
14891303 |
Autosomal Recessive (1;11)
|
2018-07-19
Anne Murray
|
|
| 4 |
|
|
Ly96
|
0.164
|
|
1 |
16688051-16709611 bp (+)
|
16691716 |
Autosomal Recessive (6;33)
|
2018-09-06
Anne Murray
|
LPS-induced Necroptosis - decreased
Macrophage necroptosis: low
NALP3 inflammasome signaling defect
Nlrc4 inflammasome: low response
NLRP3 inflammasome: low response
TLR signaling defect: hyposensitivity to LPS
TLR signaling defect: TNF production by macrophages
|
| 5 |
|
|
Dst
|
0.420
|
|
1 |
33908225-34308661 bp (+)
|
34164167 |
Unknown (2;0)
Autosomal Recessive (4;28)
|
2016-05-13
Anne Murray
|
behavior/neurological
DSS: resistant day 7
TLR signaling defect: hypersensitivity to PAM3CSK4
TLR signaling defect: hypersensitivity to R848
TLR signaling defect: hyposensitivity to R848
TLR signaling defect: TNF production by macrophages
|
| 6 |
|
|
Dst
|
0.420
|
|
1 |
33908225-34308661 bp (+)
|
34165155 |
Autosomal Dominant (1;1)
Autosomal Recessive (4;14)
|
2016-05-13
Anne Murray
|
behavior/neurological
Body Weight - decreased
growth/size
TLR signaling defect: hypersensitivity to CpG + IFNg
TLR signaling defect: hyposensitivity to poly I:C
TLR signaling defect: TNF production by macrophages
|
| 7 |
|
|
Dst
|
0.420
|
|
1 |
33908225-34308661 bp (+)
|
34223795 |
Autosomal Semidominant (1;1)
|
2018-04-25
Anne Murray
|
behavior/neurological
growth/size
|
| 8 |
|
|
Sema4c
|
1.000
|
|
1 |
36548639-36558349 bp (-)
|
36550311 |
Autosomal Recessive (1;3)
|
2018-12-05
Anne Murray
|
pigmentation
skin/coat/nails
|
| 9 |
|
|
Zap70
|
0.296
|
|
1 |
36761798-36782818 bp (+)
|
36770811 |
Unknown (8;0)
|
2017-08-08
Diantha La Vine
|
FACS B:T cells - increased
FACS CD4+ T cells - decreased
FACS CD4+ T cells in CD3+ T cells - decreased
FACS CD8+ T cells - decreased
FACS T cells - decreased
|
| 10 |
|
|
Zap70
|
0.296
|
|
1 |
36761798-36782818 bp (+)
|
36770983 |
Unknown
|
2017-08-08
Diantha La Vine
|
FACS CD4+ T cells - decreased
FACS CD8+ T cells - decreased
T-dependent humoral response defect- decreased antibody response to rSFV
|
| 11 |
|
|
Zap70
|
0.296
|
|
1 |
36761798-36782818 bp (+)
|
36778218 |
Autosomal Recessive (25;438)
Autosomal Semidominant (1;4)
|
2017-08-29
Anne Murray
|
CD8 response - decreased
CTL killing - decreased
CTL killing dominant epitope - decreased
FACS B cells - increased
FACS B:T cells - increased
FACS B1 cells - increased
FACS CD4:CD8 - increased
FACS CD4+ T cells - decreased
FACS CD4+ T cells in CD3+ T cells - decreased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD4 T cells - decreased
FACS CD44+ CD8 MFI - increased
FACS CD44+ CD8 T cells - decreased
FACS CD44+ T cells - decreased
FACS CD8+ T cells - decreased
FACS CD8+ T cells in CD3+ T cells - decreased
FACS central memory CD4 T cells in CD4 T cells - increased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS IgD+ B cell percentage - increased
FACS IgM+ B cells - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
FACS T cells - decreased
OVA-specific IgE - decreased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
|
| 12 |
|
|
Zap70
|
0.296
|
|
1 |
36761798-36782818 bp (+)
|
36779173 |
Autosomal Recessive (4;15)
|
2017-08-08
Diantha La Vine
|
FACS CD44+ CD8 T cells - increased
FACS CD44+ T cells - increased
FACS central memory CD8 T cells in CD8 T cells - increased
T-dependent humoral response defect- decreased antibody response to rSFV
|
| 13 |
 |
|
Zap70
|
0.296
|
|
1 |
36761798-36782818 bp (+)
|
36779704 |
Unknown
|
2017-08-08
Diantha La Vine
|
CD8 response - decreased
FACS CD4+ T cells - decreased
FACS CD8+ T cells - decreased
immune system
|
| 14 |
|
|
Zap70
|
0.296
|
|
1 |
36761798-36782818 bp (+)
|
36781025 |
Unknown
|
2017-08-08
Diantha La Vine
|
FACS CD4+ T cells - decreased
FACS CD8+ T cells - decreased
hematopoietic competition - disadvantage
immune system
|
| 15 |
|
|
Zap70
|
0.296
|
|
1 |
36761798-36782818 bp (+)
|
36781149 |
Unknown
|
2017-08-08
Diantha La Vine
|
CD8 response - decreased
FACS CD4+ T cells - decreased
FACS CD8+ T cells - decreased
immune system
|
| 16 |
|
|
Zap70
|
0.296
|
|
1 |
36761798-36782818 bp (+)
|
36781365 |
Autosomal Recessive (25;386)
|
2017-08-09
Anne Murray
|
CD8 response - decreased
CTL killing - decreased
CTL killing dominant epitope - decreased
FACS B cells - increased
FACS B:T cells - increased
FACS B1 cells - increased
FACS CD4:CD8 - increased
FACS CD4+ T cells - decreased
FACS CD4+ T cells in CD3+ T cells - decreased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD4 T cells - decreased
FACS CD44+ CD8 MFI - increased
FACS CD44+ CD8 T cells - decreased
FACS CD44+ T cells - decreased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - decreased
FACS CD8+ T cells in CD3+ T cells - decreased
FACS central memory CD4 T cells in CD4 T cells - increased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS IgD+ B cell percentage - increased
FACS IgM+ B cells - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
FACS T cells - decreased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
|
| 17 |
|
|
Zap70
|
0.296
|
|
1 |
36761798-36782818 bp (+)
|
36781412 |
Unknown (11;0)
Autosomal Dominant (3;6)
Autosomal Recessive (9;86)
|
2017-08-08
Diantha La Vine
|
30 min GTT hypoglycemic
dsDNA induced type I IFN production - increased
FACS B:T cells - decreased
FACS CD4:CD8 - decreased
FACS CD4+ T cells - decreased
FACS CD4+ T cells in CD3+ T cells - decreased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD8 MFI - increased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - increased
FACS CD8+ T cells in CD3+ T cells - increased
FACS central memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS T cells - decreased
impaired response to dsDNA- type I IFN production by macrophages
T-dependent humoral response defect- decreased antibody response to rSFV
T-dependent humoral response defect- increased antibody response to OVA+ alum immunization
TLR signaling defect: hypersensitivity to LPS
TLR signaling defect: hypersensitivity to PAM3CSK4
TLR signaling defect: hypersensitivity to R848
TLR signaling defect: TNF production by macrophages
|
| 18 |
|
|
Col3a1
|
0.842
|
|
1 |
45311538-45349706 bp (+)
|
45327866 |
Autosomal Recessive (2;7)
Autosomal Semidominant (3;12)
|
2019-01-18
Anne Murray
|
DSS: sensitive day 10
DSS: sensitive day 7
FACS CD4+ T cells - increased
FACS CD8+ T cells - increased
FACS T cells - increased
|
| 19 |
|
|
Stat1
|
0.000
|
|
1 |
52119440-52161865 bp (+)
|
52123209 |
Autosomal Recessive (11;109)
|
2018-03-29
Diantha La Vine
|
CD8 response - decreased
CTL killing - decreased
CTL killing dominant epitope - decreased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD4 T cells - increased
FACS CD44+ CD8 MFI - increased
FACS CD44+ T cells - increased
FACS CD44+ T MFI - increased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
|
| 20 |
|
|
Stat1
|
0.000
|
|
1 |
52119440-52161865 bp (+)
|
52139264 |
Autosomal Dominant (7;44)
Autosomal Recessive (17;202)
Autosomal Semidominant (3;33)
|
2018-04-04
Anne Murray
|
CTL killing - increased
CTL killing dominant epitope - increased
FACS B cells - decreased
FACS B:T cells - decreased
FACS B1 cells - decreased
FACS CD4:CD8 - increased
FACS CD4+ T cells in CD3+ T cells - increased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD4 T cells - increased
FACS CD44+ CD8 MFI - increased
FACS CD44+ CD8 T cells - increased
FACS CD44+ T cells - increased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - decreased
FACS CD8+ T cells in CD3+ T cells - decreased
FACS central memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
FACS NK cells - decreased
FACS NK T cells - increased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
total IgE level - decreased
|
| 21 |
|
|
Stat1
|
0.000
|
|
1 |
52119440-52161865 bp (+)
|
52140588 |
Unknown (3;0)
|
2018-03-29
Diantha La Vine
|
immune system
MCMV proliferation in macrophages - increased
MCMV susceptibility
NK cell response - decreased
response to injected CpG DNA - decreased
RVFV susceptibility
|
| 22 |
|
|
Stat1
|
0.000
|
|
1 |
52119440-52161865 bp (+)
|
52151225 |
Unknown (2;0)
|
2018-03-29
Diantha La Vine
|
immune system
MCMV susceptibility
NK cell response - decreased
|
| 23 |
|
|
Stat1
|
0.000
|
|
1 |
52119440-52161865 bp (+)
|
52153923 |
Autosomal Recessive (2;16)
|
2018-03-29
Diantha La Vine
|
fasting hyperglycemia (female)
NK cell response - decreased
NK killing - decreased
|
| 24 |
|
|
Casp8
|
1.000
|
|
1 |
58795374-58847503 bp (+)
|
58844770 |
Autosomal Recessive (9;57)
|
2018-09-24
Anne Murray
|
FACS B1 cells - decreased
FACS CD44+ CD4 MFI - decreased
FACS CD44+ CD4 T cells - decreased
FACS CD44+ CD8 MFI - increased
FACS effector memory CD8 T cells in CD8 T cells - increased
|
| 25 |
|
|
Ctla4
|
1.000
|
|
1 |
60887000-60915832 bp (+)
|
60912491 |
Autosomal Dominant (2;8)
Autosomal Recessive (3;44)
Autosomal Semidominant (5;27)
|
2018-09-07
Anne Murray
|
Body Weight (Female) - increased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD4 T cells - increased
FACS CD44+ CD8 MFI - increased
FACS CD44+ T cells - increased
FACS CD44+ T MFI - increased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
|
| 26 |
|
|
Crygd
|
0.304
|
|
1 |
65061872-65063452 bp (-)
|
65063084 |
Unknown
|
2016-05-13
Stephen Lyon
|
vision/eye
|
| 27 |
|
|
Crygb
|
0.000
|
|
1 |
65080219-65082288 bp (-)
|
65082157 |
Unknown
|
2017-03-30
Katherine Timer
|
vision/eye
|
| 28 |
|
|
Epha4
|
0.781
|
|
1 |
77367185-77515088 bp (-)
|
77481076 |
Unknown
|
2018-05-22
Anne Murray
|
behavior/neurological
|
| 29 |
|
|
Pax3
|
0.720
|
|
1 |
78101267-78197134 bp (-)
|
78122590 |
Unknown (1;0)
|
2016-05-13
Peter Jurek
|
pigmentation
skin/coat/nails
|
| 30 |
|
|
Pax3
|
0.720
|
|
1 |
78101267-78197134 bp (-)
|
78132232 |
Autosomal Dominant (1;6)
|
2017-12-19
Anne Murray
|
pigmentation
skin/coat/nails
|
| 31 |
|
|
Irs1
|
0.401
|
|
1 |
82233101-82291416 bp (-)
|
82286967 |
Autosomal Recessive (6;32)
|
2018-10-24
Anne Murray
|
Body Weight - decreased
Body Weight (DSS Female) - decreased
Body Weight (DSS Male) - decreased
Body Weight (DSS) - decreased
Body Weight (Female) - decreased
Body Weight (Male) - decreased
|
| 32 |
|
|
Irs1
|
0.401
|
|
1 |
82233101-82291416 bp (-)
|
82287732 |
Unknown (1;0)
Autosomal Recessive (6;24)
|
2018-10-24
Anne Murray
|
Body Weight - decreased
Body Weight (Male) - decreased
Fasting Insulin - increased
Fasting Insulin (Male) - increased
|
| 33 |
|
|
Col4a4
|
0.289
|
|
1 |
82448423-82586849 bp (-)
|
82535740 |
Unknown (1;0)
|
2016-05-13
Stephen Lyon
|
digestive/alimentary
hearing/vestibular/ear
renal/urinary system
|
| 34 |
|
|
Pde6d
|
0.212
|
|
1 |
86542994-86582629 bp (-)
|
86547526 |
Unknown (2;0)
Autosomal Recessive (3;16)
|
2018-09-05
Anne Murray
|
Body Weight - decreased
Body Weight (Female) - decreased
Body Weight (Male) - decreased
|
| 35 |
|
|
Inpp5d
|
0.914
|
|
1 |
87620312-87720507 bp (+)
|
87669784 |
Unknown (1;0)
|
2018-01-05
Eva Marie Y. Moresco
|
CTL killing - decreased
growth/size
hematopoietic system
homeostasis/metabolism
immune system
life span-post-weaning/aging
respiratory system
|
| 36 |
|
|
Inpp5d
|
0.914
|
|
1 |
87620312-87720507 bp (+)
|
87697546 |
Autosomal Dominant (3;10)
Autosomal Semidominant (5;25)
|
2018-05-10
Anne Murray
|
FACS B cells - decreased
FACS B:T cells - decreased
FACS B1a cells - increased
FACS B2 cells - decreased
FACS CD11c+ DCs - increased
FACS CD44+ CD4 T cells - decreased
FACS IgD+ B cell percentage - decreased
FACS IgM+ B cells - decreased
|
| 37 |
|
|
Inpp5d
|
0.914
|
|
1 |
87620312-87720507 bp (+)
|
87705964 |
Autosomal Dominant (2;10)
Autosomal Recessive (3;21)
|
2017-10-20
Anne Murray
|
125-03 Response - increased
FACS IgM MFI - decreased
FACS NK cells - decreased
LPS-induced Necroptosis - decreased
Macrophage necroptosis: low
TLR signaling defect: hypersensitivity to PAM3CSK4
TLR signaling defect: TNF production by macrophages
|
| 38 |
|
|
Mlph
|
0.121
|
|
1 |
90915085-90951142 bp (+)
|
90928122 |
Autosomal Recessive (1;4)
|
2016-12-07
Anne Murray
|
pigmentation
skin/coat/nails
|
| 39 |
|
|
Mlph
|
0.121
|
|
1 |
90915085-90951142 bp (+)
|
90933301 |
Unknown
|
2016-05-13
Anne Murray
|
pigmentation
skin/coat/nails
|
| 40 |
|
|
Per2
|
0.236
|
|
1 |
91415982-91459324 bp (-)
|
91423829 |
Autosomal Recessive (2;24)
Autosomal Semidominant (2;33)
|
2017-05-09
Eva Marie Y. Moresco
|
|
| 41 |
|
|
Mdm4
|
1.000
|
|
1 |
132959484-133030561 bp (-)
|
133012651 |
Autosomal Dominant (7;60)
|
2018-10-25
Anne Murray
|
FACS CD4:CD8 - increased
FACS CD4+ T cells in CD3+ T cells - increased
FACS CD8+ T cells - decreased
FACS CD8+ T cells in CD3+ T cells - decreased
post-MCMV FACS CD4:CD8 - increased
post-MCMV FACS CD4+ T cells in CD3+ T cells - increased
post-MCMV FACS CD8+ T cells in CD3+ T cells - decreased
|
| 42 |
|
|
Syt2
|
0.303
|
|
1 |
134646677-134762593 bp (+)
|
134747620 |
Autosomal Recessive (1;3)
Autosomal Semidominant (1;1)
|
2018-05-22
Anne Murray
|
behavior/neurological
Body Weight - decreased
growth/size
lethality-postnatal
nervous system
|
| 43 |
|
|
Ptprc
|
0.243
|
|
1 |
138062861-138175708 bp (-)
|
138067890 |
Autosomal Recessive (3;15)
Autosomal Semidominant (4;29)
|
2018-10-05
Diantha La Vine
|
FACS B1 cells - increased
FACS B1a cells in B1 cells - decreased
FACS B1b cells - decreased
FACS B220 MFI - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
|
| 44 |
|
|
Ptprc
|
0.243
|
|
1 |
138062861-138175708 bp (-)
|
138068401 |
Autosomal Recessive (48;482)
Autosomal Semidominant (7;48)
|
2018-10-05
Diantha La Vine
|
30 min GTT hypoglycemic
30 min GTT hypoglycemic (male)
FACS B cells - decreased
FACS B:T cells - decreased
FACS B1 cells - increased
FACS B1a cells in B1 cells - decreased
FACS B1b cells - increased
FACS B2 cells - decreased
FACS CD11c+ DCs - increased
FACS CD4:CD8 - increased
FACS CD4+ T cells - decreased
FACS CD4+ T cells in CD3+ T cells - increased
FACS CD44+ CD4 T cells - decreased
FACS CD44+ CD8 MFI - decreased
FACS CD44+ CD8 MFI - increased
FACS CD44+ CD8 T cells - decreased
FACS CD44+ T cells - decreased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - decreased
FACS CD8+ T cells in CD3+ T cells - decreased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS IgD+ B cell percentage - decreased
FACS IgM MFI - increased
FACS IgM+ B cells - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
FACS neutrophils - increased
FACS NK T cells - decreased
FACS T cells - decreased
post-MCMV FACS B cells - decreased
post-MCMV FACS B:T cells - decreased
post-MCMV FACS B1 cells - increased
post-MCMV FACS B1a cells in B1 cells - decreased
post-MCMV FACS B1b cells in B1 cells - increased
post-MCMV FACS B220 MFI - decreased
post-MCMV FACS CD11b+ DCs (gated in CD11c+ cells) - increased
post-MCMV FACS CD4:CD8 - increased
post-MCMV FACS CD4+ T cells - decreased
post-MCMV FACS CD44+ CD8 MFI - increased
post-MCMV FACS CD44+ T MFI - increased
post-MCMV FACS CD8+ T cells - decreased
post-MCMV FACS CD8+ T cells in CD3+ T cells - decreased
post-MCMV FACS central memory CD8 T cells in CD8 T cells - increased
post-MCMV FACS IgD MFI - decreased
post-MCMV FACS IgD+ B cell percentage - decreased
post-MCMV FACS IgM MFI - increased
post-MCMV FACS IgM+ B cells - decreased
post-MCMV FACS macrophages - decreased
post-MCMV FACS naive CD8 T cells in CD8 T cells - decreased
post-MCMV FACS neutrophils - increased
post-MCMV FACS pDCs - decreased
post-MCMV FACS T cells - decreased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
total IgE level - decreased
|
| 45 |
|
|
Ptprc
|
0.243
|
|
1 |
138062861-138175708 bp (-)
|
138071249 |
Autosomal Dominant (2;8)
|
2018-10-05
Diantha La Vine
|
Blood Pressure: SBP Day 2 - increased
|
| 46 |
|
|
Ptprc
|
0.243
|
|
1 |
138062861-138175708 bp (-)
|
138078451 |
Autosomal Semidominant (1;5)
|
2018-10-10
Anne Murray
|
Body Weight (BP Male) - increased
|
| 47 |
|
|
Ptprc
|
0.243
|
|
1 |
138062861-138175708 bp (-)
|
138083790 |
Unknown
|
2018-10-05
Diantha La Vine
|
FACS B cells - decreased
FACS CD4+ T cells - decreased
FACS CD8+ T cells - decreased
hematopoietic system
immune system
|
| 48 |
|
|
Ptprc
|
0.243
|
|
1 |
138062861-138175708 bp (-)
|
138094299 |
Autosomal Recessive (1;4)
Autosomal Semidominant (1;4)
|
2018-10-05
Diantha La Vine
|
FACS B1b cells in B1 cells - decreased
NALP3 inflammasome signaling defect
NLRP3 inflammasome: high response
|
| 49 |
|
|
Ptprc
|
0.243
|
|
1 |
138062861-138175708 bp (-)
|
138101041 |
Autosomal Recessive (17;235)
Autosomal Semidominant (1;17)
|
2018-10-05
Diantha La Vine
|
FACS B cells - decreased
FACS B:T cells - decreased
FACS B1 cells - increased
FACS B220 MFI - decreased
FACS CD4+ T cells - decreased
FACS CD4+ T cells in CD3+ T cells - increased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD8 MFI - increased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - decreased
FACS CD8+ T cells in CD3+ T cells - decreased
FACS central memory CD4 T cells in CD4 T cells - increased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
FACS T cells - decreased
|
| 50 |
|
|
Ptprc
|
0.243
|
|
1 |
138062861-138175708 bp (-)
|
138113678 |
Autosomal Dominant (1;14)
Autosomal Recessive (18;122)
Autosomal Semidominant (2;12)
|
2018-10-05
Diantha La Vine
|
FACS B cells - decreased
FACS B:T cells - decreased
FACS B1 cells - increased
FACS B220 MFI - decreased
FACS CD4:CD8 - increased
FACS CD4+ T cells - decreased
FACS CD4+ T cells in CD3+ T cells - increased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD4 T cells - decreased
FACS CD44+ CD8 MFI - increased
FACS CD44+ CD8 T cells - decreased
FACS CD44+ T cells - decreased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - decreased
FACS CD8+ T cells in CD3+ T cells - decreased
FACS central memory CD4 T cells in CD4 T cells - increased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
FACS T cells - decreased
|
| 51 |
|
|
Ptprc
|
0.243
|
|
1 |
138062861-138175708 bp (-)
|
138137493 |
Unknown
|
2018-10-05
Diantha La Vine
|
FACS CD4+ T cells - decreased
FACS CD8+ T cells - decreased
hematopoietic system
immune system
|
| 52 |
|
|
Nek7
|
1.000
|
|
1 |
138482875-138620141 bp (-)
|
138544242 |
Autosomal Semidominant (2;10)
|
2018-05-21
Anne Murray
|
NALP3 inflammasome signaling defect
NLRP3 inflammasome: low response
|
| 53 |
|
|
Pappa2
|
0.000
|
|
1 |
158711727-158980490 bp (-)
|
158716990 |
Autosomal Semidominant (2;11)
|
2019-01-15
Diantha La Vine
|
Body Weight - decreased
Body Weight (Male) - decreased
growth/size
|
| 54 |
|
|
Pappa2
|
0.000
|
|
1 |
158711727-158980490 bp (-)
|
158782403 |
Autosomal Recessive (2;10)
|
2019-01-15
Diantha La Vine
|
Body Weight - decreased
Body Weight (BP) - decreased
|
| 55 |
|
|
Pappa2
|
0.000
|
|
1 |
158711727-158980490 bp (-)
|
158834918 |
Unknown (2;0)
Autosomal Dominant (1;4)
Autosomal Recessive (1;1)
Autosomal Semidominant (1;5)
|
2019-01-15
Diantha La Vine
|
Body Weight (Female) - decreased
FACS B1b cells - decreased
growth/size
|
| 56 |
|
|
Pappa2
|
0.000
|
|
1 |
158711727-158980490 bp (-)
|
158956645 |
Autosomal Dominant (1;4)
|
2019-01-18
Anne Murray
|
Body Weight (BP Female) - decreased
|
| 57 |
|
|
Rc3h1
|
0.299
|
|
1 |
160906418-160974978 bp (+)
|
160940830 |
Unknown
|
2016-05-13
Peter Jurek
|
autoimmunity
immune system
|
| 58 |
|
|
Rc3h1
|
0.299
|
|
1 |
160906418-160974978 bp (+)
|
160959399 |
Unknown (1;0)
Autosomal Recessive (3;16)
Autosomal Semidominant (4;17)
|
2016-05-13
Anne Murray
|
Body Weight - decreased
Body Weight (Female) - decreased
Body Weight (Male) - decreased
FACS central memory CD8 T cells in CD8 T cells - decreased
FACS effector memory CD8 T cells in CD8 T cells - increased
growth/size
limbs/digits/tail phenotype
T-independent B cell response defect- increased TNP-specific IgM to TNP-Ficoll immunization
|
| 59 |
|
|
Fasl
|
0.355
|
|
1 |
161780689-161788495 bp (-)
|
161787138 |
Autosomal Recessive (1;6)
|
2016-05-13
Anne Murray
|
T-dependent humoral response defect- decreased antibody response to rSFV
|
| 60 |
|
|
Sell
|
0.000
|
|
1 |
164061982-164084181 bp (+)
|
164065661 |
Autosomal Recessive (4;54)
|
2016-05-17
Anne Murray
|
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
|
| 61 |
|
|
Sell
|
0.000
|
|
1 |
164061982-164084181 bp (+)
|
164066201 |
Autosomal Dominant (1;4)
Autosomal Recessive (6;41)
|
2016-05-13
Peter Jurek
|
FACS central memory CD4 T cells in CD4 T cells - decreased
FACS central memory CD8 T cells in CD8 T cells - decreased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
|
| 62 |
|
|
Cd247
|
0.069
|
|
1 |
165788681-165877277 bp (+)
|
165855214 |
Unknown
|
2016-05-13
Stephen Lyon
|
hematopoietic competition - disadvantage
immune system
|
| 63 |
|
|
Mpz
|
0.183
|
|
1 |
171150711-171161130 bp (+)
|
171158810 |
Autosomal Recessive (1;4)
|
2018-05-22
Anne Murray
|
behavior/neurological
|
| 64 |
|
|
Cr2
|
0.174
|
|
1 |
195136811-195176716 bp (-)
|
195155888 |
Autosomal Semidominant (1;4)
|
2018-10-16
Anne Murray
|
T-dependent humoral response defect- decreased antibody response to rSFV
|
| 65 |
|
|
a
|
0.149
|
|
2 |
154791402-155051012 bp (+)
|
|
Unknown
|
2016-05-13
Anne Murray
|
pigmentation
skin/coat/nails
|
| 66 |
|
|
a
|
0.149
|
|
2 |
154791402-155051012 bp (+)
|
|
Unknown
|
2016-05-13
Stephen Lyon
|
pigmentation
skin/coat/nails
|
| 67 |
|
|
a
|
0.149
|
|
2 |
154791402-155051012 bp (+)
|
|
Unknown
|
2016-05-13
Anne Murray
|
pigmentation
skin/coat/nails
|
| 68 |
|
|
Dclre1c
|
0.655
|
|
2 |
3424131-3464130 bp (+)
|
3436475 |
Autosomal Recessive (22;213)
|
2018-06-15
Diantha La Vine
|
FACS B cells - decreased
FACS B:T cells - increased
FACS B1a cells - decreased
FACS B1b cells - increased
FACS B2 cells - decreased
FACS B220 MFI - decreased
FACS CD11c+ DCs - increased
FACS CD4+ T cells - decreased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD8 MFI - increased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - decreased
FACS IgD MFI - decreased
FACS IgD+ B cell percentage - decreased
FACS IgM+ B cells - decreased
FACS macrophages - increased
FACS neutrophils - increased
FACS NK cells - increased
FACS T cells - decreased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
|
| 69 |
|
|
Dclre1c
|
0.655
|
|
2 |
3424131-3464130 bp (+)
|
3437705 |
Autosomal Recessive (35;533)
|
2018-06-15
Anne Murray
|
Blood Pressure: HR Average - decreased
Blood Pressure: HR Day 3 - decreased
Blood Pressure: SBP Average - decreased
Body Weight - decreased
Body Weight (BP Female) - decreased
Body Weight (BP Male) - decreased
Body Weight (BP) - decreased
Body Weight (Male) - decreased
FACS B cells - decreased
FACS B:T cells - decreased
FACS B1 cells - decreased
FACS B220 MFI - decreased
FACS CD4:CD8 - decreased
FACS CD4+ T cells - decreased
FACS CD4+ T cells in CD3+ T cells - decreased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD4 T cells - increased
FACS CD44+ CD8 MFI - increased
FACS CD44+ CD8 T cells - increased
FACS CD44+ T cells - increased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - decreased
FACS CD8+ T cells in CD3+ T cells - increased
FACS central memory CD4 T cells in CD4 T cells - increased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
FACS NK T cells - decreased
FACS T cells - decreased
growth/size
skin/coat/nails
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
total IgE level - increased
|
| 70 |
|
|
Dclre1c
|
0.655
|
|
2 |
3424131-3464130 bp (+)
|
3452863 |
Autosomal Dominant (1;4)
Autosomal Recessive (4;19)
Autosomal Semidominant (3;12)
|
2018-06-15
Anne Murray
|
Body Weight - increased
Body Weight (Female) - increased
FACS CD44+ CD4 MFI - increased
FACS CD44+ T MFI - increased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS naive CD8 T cells in CD8 T cells - decreased
|
| 71 |
|
|
Prkcq
|
0.000
|
|
2 |
11172108-11301222 bp (+)
|
11226986 |
Unknown
|
2016-11-08
Anne Murray
|
|
| 72 |
|
|
Prkcq
|
0.000
|
|
2 |
11172108-11301222 bp (+)
|
11283849 |
Autosomal Recessive (1;6)
|
2018-01-18
Anne Murray
|
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
|
| 73 |
|
|
Rxra
|
1.000
|
|
2 |
27676440-27762957 bp (+)
|
27752334 |
Unknown
|
2017-04-11
Katherine Timer
|
hematopoietic system
immune system
pigmentation
skeleton phenotype
skin/coat/nails
vision/eye
|
| 74 |
|
|
Ntmt1
|
0.283
|
|
2 |
30807826-30823033 bp (+)
|
30822365 |
Unknown (1;0)
Autosomal Recessive (7;49)
|
2018-08-08
Anne Murray
|
Body Weight - decreased
Body Weight (DSS Female) - increased
Body Weight (DSS Male) - decreased
Body Weight (DSS) - decreased
Body Weight (Female) - decreased
Body Weight (Male) - decreased
FACS IgD MFI - decreased
Nlrc4 inflammasome: high response
|
| 75 |
|
|
Ttc21b
|
1.000
|
|
2 |
66184327-66256617 bp (-)
|
66242679 |
Autosomal Recessive (2;18)
|
2018-07-27
Anne Murray
|
Body Weight - increased
Body Weight (Female) - increased
|
| 76 |
|
|
Neurod1
|
0.736
|
|
2 |
79452521-79456751 bp (-)
|
79454595 |
Autosomal Recessive (4;17)
|
2018-02-02
Anne Murray
|
behavior/neurological
hearing/vestibular/ear
|
| 77 |
|
|
Alx4
|
0.579
|
|
2 |
93642384-93681339 bp (+)
|
93675369 |
Unknown
|
2016-05-13
Stephen Lyon
|
craniofacial
limbs/digits/tail phenotype
|
| 78 |
|
|
Rag2
|
0.295
|
|
2 |
101624718-101632529 bp (+)
|
101630603 |
Autosomal Recessive (5;28)
Autosomal Semidominant (1;4)
|
2017-05-17
Anne Murray
|
FACS B1b cells - increased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD8 MFI - increased
FACS neutrophils - increased
NALP3 inflammasome signaling defect
NLRP3 inflammasome: high response
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
|
| 79 |
|
|
Rag1
|
0.504
|
|
2 |
101638282-101649501 bp (-)
|
101641223 |
Unknown
|
2016-05-13
Stephen Lyon
|
FACS B cells - decreased
FACS CD4+ T cells - decreased
FACS CD8+ T cells - decreased
immune system
|
| 80 |
|
|
Rag1
|
0.504
|
|
2 |
101638282-101649501 bp (-)
|
101645647 |
Unknown (1;0)
|
2016-05-13
Stephen Lyon
|
FACS B cells - decreased
FACS CD4+ T cells - decreased
FACS CD8+ T cells - decreased
hematopoietic system
immune system
RVFV susceptibility
|
| 81 |
|
|
Cd44
|
0.344
|
|
2 |
102811141-102901665 bp (-)
|
102865370 |
Autosomal Dominant (2;30)
Autosomal Semidominant (7;62)
|
2018-09-18
Anne Murray
|
FACS CD44+ CD4 MFI - decreased
FACS CD44+ CD4 T cells - decreased
FACS CD44+ CD8 MFI - decreased
FACS CD44+ CD8 T cells - decreased
FACS CD44+ T cells - decreased
FACS CD44+ T MFI - decreased
FACS central memory CD4 T cells in CD4 T cells - decreased
FACS central memory CD8 T cells in CD8 T cells - decreased
FACS effector memory CD4 T cells in CD4 T cells - decreased
|
| 82 |
|
|
Rasgrp1
|
0.285
|
|
2 |
117279993-117343001 bp (-)
|
117284929 |
Autosomal Recessive (18;323)
Autosomal Semidominant (1;11)
|
2018-10-12
Diantha La Vine
|
FACS B:T cells - increased
FACS CD4:CD8 - decreased
FACS CD4+ T cells - decreased
FACS CD4+ T cells in CD3+ T cells - decreased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD4 T cells - increased
FACS CD44+ CD8 MFI - increased
FACS CD44+ T cells - increased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - decreased
FACS CD8+ T cells in CD3+ T cells - increased
FACS central memory CD4 T cells in CD4 T cells - increased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
FACS NK cells - increased
FACS T cells - decreased
|
| 83 |
|
|
Rasgrp1
|
0.285
|
|
2 |
117279993-117343001 bp (-)
|
117291792 |
Autosomal Recessive (26;515)
Autosomal Semidominant (2;8)
|
2019-01-10
Anne Murray
|
FACS B:T cells - increased
FACS B1b cells - increased
FACS CD4+ T cells - decreased
FACS CD4+ T cells in CD3+ T cells - decreased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD8 MFI - increased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - decreased
FACS central memory CD4 T cells in CD4 T cells - increased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS IgM MFI - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
FACS neutrophils - increased
FACS NK cells - increased
FACS T cells - decreased
|
| 84 |
|
|
Rasgrp1
|
0.285
|
|
2 |
117279993-117343001 bp (-)
|
117291895 |
Autosomal Dominant (2;17)
|
2018-10-16
Anne Murray
|
FACS CD44+ CD4 MFI - increased
FACS CD44+ T MFI - increased
|
| 85 |
|
|
Rasgrp1
|
0.285
|
|
2 |
117279993-117343001 bp (-)
|
117302004 |
Autosomal Recessive (17;95)
Autosomal Semidominant (2;8)
|
2018-10-12
Diantha La Vine
|
FACS B:T cells - increased
FACS CD4+ T cells in CD3+ T cells - decreased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD8 MFI - increased
FACS CD8+ T cells in CD3+ T cells - increased
FACS central memory CD4 T cells in CD4 T cells - increased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
FACS NK cells - increased
IgA response to 2nd OVA/Alum Challenge (day 7) - increased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
total IgE level - increased
|
| 86 |
|
|
Eif2ak4
|
0.000
|
|
2 |
118388618-118475234 bp (+)
|
118400653 |
Unknown (2;0)
|
2016-05-13
Stephen Lyon
|
adenovirus infection of macrophages - increased
immune system
MCMV proliferation in macrophages - increased
|
| 87 |
|
|
Trp53bp1
|
0.000
|
|
2 |
121193281-121271407 bp (-)
|
121207887 |
Autosomal Recessive (8;62)
|
2017-09-04
Diantha La Vine
|
FACS CD44+ CD8 MFI - increased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS IgD MFI - decreased
FACS IgD+ B cell percentage - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
|
| 88 |
|
|
Trp53bp1
|
0.000
|
|
2 |
121193281-121271407 bp (-)
|
121211313 |
Autosomal Recessive (1;6)
Autosomal Semidominant (1;4)
|
2017-09-15
Anne Murray
|
FACS B2 cells - increased
FACS IgD MFI - decreased
|
| 89 |
|
|
Trp53bp1
|
0.000
|
|
2 |
121193281-121271407 bp (-)
|
121251868 |
Autosomal Recessive (3;14)
|
2018-03-08
Diantha La Vine
|
FACS B:T cells - increased
FACS CD44+ T cells - increased
FACS CD44+ T MFI - increased
FACS IgD MFI - decreased
FACS T cells - decreased
|
| 90 |
|
|
Trp53bp1
|
0.000
|
|
2 |
121193281-121271407 bp (-)
|
121270319 |
Autosomal Dominant (1;4)
Autosomal Recessive (1;4)
|
2017-09-15
Anne Murray
|
30 Min. Insulin (Male) - decreased
FACS IgD MFI - decreased
|
| 91 |
|
|
Gatm
|
0.000
|
|
2 |
122594467-122611303 bp (-)
|
122600744 |
Autosomal Recessive (3;23)
Autosomal Semidominant (1;7)
|
2017-03-16
Katherine Timer
|
Body Weight - decreased
Body Weight (Male) - decreased
DSS: sensitive day 10
DSS: sensitive day 7
|
| 92 |
|
|
Sppl2a
|
0.368
|
|
2 |
126890391-126933235 bp (-)
|
126920313 |
Autosomal Recessive (5;44)
Autosomal Semidominant (1;4)
|
2016-10-28
Anne Murray
|
FACS central memory CD8 T cells in CD8 T cells - increased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
Total IgE After 2nd OVA/Alum Challenge (day 7) - decreased
total IgE level - decreased
|
| 93 |
|
|
Sppl2a
|
0.368
|
|
2 |
126890391-126933235 bp (-)
|
126923594 |
Unknown
|
2016-12-08
Katherine Timer
|
|
| 94 |
|
|
Tgm3
|
0.088
|
|
2 |
130012349-130050399 bp (+)
|
130024585 |
Unknown (1;0)
|
2016-05-13
Stephen Lyon
|
immune system
RVFV susceptibility
skin/coat/nails
|
| 95 |
|
|
Pax1
|
0.449
|
|
2 |
147361925-147393295 bp (+)
|
147365802 |
Unknown (1;0)
Autosomal Semidominant (3;12)
|
2016-05-13
Anne Murray
|
Body Weight - decreased
Body Weight (DSS Female) - decreased
Body Weight (Female) - decreased
limbs/digits/tail phenotype
|
| 96 |
|
|
Rims4
|
0.074
|
|
2 |
163859751-163918683 bp (-)
|
163864120 |
Autosomal Recessive (1;6)
|
2018-02-06
Anne Murray
|
Body Weight - decreased
growth/size
|
| 97 |
|
|
Rims4
|
0.074
|
|
2 |
163859751-163918683 bp (-)
|
163864865 |
Autosomal Recessive (2;13)
|
2018-02-06
Anne Murray
|
Body Weight - decreased
Body Weight (Male) - decreased
growth/size
|
| 98 |
|
|
Stk4
|
0.000
|
|
2 |
164070322-164155524 bp (+)
|
164079566 |
Autosomal Recessive (4;21)
|
2018-08-15
Anne Murray
|
FACS B:T cells - increased
FACS B1a cells in B1 cells - decreased
FACS B1b cells in B1 cells - increased
FACS B220 MFI - decreased
FACS CD4:CD8 - increased
FACS CD4+ T cells - decreased
FACS CD4+ T cells in CD3+ T cells - increased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD8 MFI - increased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - decreased
FACS CD8+ T cells in CD3+ T cells - decreased
FACS central memory CD4 T cells in CD4 T cells - increased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS IgD MFI - decreased
FACS macrophages - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
FACS neutrophils - increased
FACS NK cells - increased
FACS T cells - decreased
Fasting Insulin (Female) - increased
T-dependent humoral response defect- decreased antibody response to rSFV
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
Total IgE After 2nd OVA/Alum Challenge (day 7) - increased
|
| 99 |
|
|
Stk4
|
0.000
|
|
2 |
164070322-164155524 bp (+)
|
164083688 |
Autosomal Recessive (22;210)
|
2018-09-21
Anne Murray
|
FACS B:T cells - increased
FACS B1a cells in B1 cells - decreased
FACS B1b cells in B1 cells - increased
FACS B220 MFI - decreased
FACS CD4:CD8 - increased
FACS CD4+ T cells - decreased
FACS CD4+ T cells in CD3+ T cells - increased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD8 MFI - increased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - decreased
FACS CD8+ T cells in CD3+ T cells - decreased
FACS central memory CD4 T cells in CD4 T cells - increased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS IgD MFI - decreased
FACS macrophages - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
FACS neutrophils - increased
FACS NK cells - increased
FACS T cells - decreased
Fasting Insulin (Female) - increased
T-dependent humoral response defect- decreased antibody response to rSFV
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
Total IgE After 2nd OVA/Alum Challenge (day 7) - increased
|
| 100 |
|
|
Stk4
|
0.000
|
|
2 |
164070322-164155524 bp (+)
|
164099827 |
Autosomal Recessive (27;309)
|
2018-10-29
Diantha La Vine
|
FACS B:T cells - increased
FACS B1a cells in B1 cells - decreased
FACS B1b cells in B1 cells - increased
FACS B220 MFI - decreased
FACS CD4:CD8 - increased
FACS CD4+ T cells - decreased
FACS CD4+ T cells in CD3+ T cells - increased
FACS CD44+ CD4 MFI - increased
FACS CD44+ CD8 MFI - increased
FACS CD44+ T MFI - increased
FACS CD8+ T cells - decreased
FACS CD8+ T cells in CD3+ T cells - decreased
FACS central memory CD4 T cells in CD4 T cells - increased
FACS central memory CD8 T cells in CD8 T cells - increased
FACS effector memory CD4 T cells in CD4 T cells - increased
FACS effector memory CD8 T cells in CD8 T cells - increased
FACS IgD MFI - decreased
FACS macrophages - increased
FACS naive CD4 T cells in CD4 T cells - decreased
FACS naive CD8 T cells in CD8 T cells - decreased
FACS neutrophils - increased
FACS NK cells - increased
FACS T cells - decreased
Fasting Insulin (Female) - increased
T-dependent humoral response defect- decreased antibody response to rSFV
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
Total IgE After 2nd OVA/Alum Challenge (day 7) - increased
|
