Phenotypic Mutations

563 mutations affecting 272 genes are currently displayed.
Mutations Mapped and Identified Based on Phenotype
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1 UTSW Sgk3 woolly 1 9798107-9900845 bp (+) 9886104 Unknown skin/coat/nails
2 UTSW
has video
 Dst tinsel 1 33908225-34308661 bp (+) 34164167 Unknown (2;0)
Autosomal Recessive (3;23) 		behavior/neurological
3 UTSW
has video
 Dst gobble 1 33908225-34308661 bp (+) 34165155 Autosomal Dominant (1;1)
Autosomal Recessive (5;19) 		behavior/neurological
growth/size
4 UTSW Dst phelps 1 33908225-34308661 bp (+) 34223795 Autosomal Semidominant (1;1) growth/size
5 UTSW Zap70 waterfowl 1 36761798-36782818 bp (+) 36770811 Unknown (8;0) B:T cells - increased
CD4+ T cells - decreased
CD4+ T cells in CD3+ T cells - decreased
CD8+ T cells - decreased
T cells - decreased
6 UTSW Zap70 wanna 1 36761798-36782818 bp (+) 36770983 Unknown CD4+ T cells - decreased
CD8+ T cells - decreased
T-dependent humoral response defect- decreased antibody response to rSFV
7 UTSW Zap70 wanna3 1 36761798-36782818 bp (+) 36778218 Autosomal Recessive (25;438)
Autosomal Semidominant (1;4) 		B cells - increased
B:T cells - increased
CD4:CD8 - increased
CD4+ T cells - decreased
CD4+ T cells in CD3+ T cells - decreased
CD44 MFI in CD4 - increased
CD44 MFI in CD8 - increased
CD44+ CD4 T cells - decreased
CD44+ CD8 T cells - decreased
CD44+ T cells - decreased
CD8+ T cells - decreased
CD8+ T cells in CD3+ T cells - decreased
central memory CD4 T cells in CD4 T cells - increased
central memory CD8 T cells in CD8 T cells - increased
effector memory CD4 T cells in CD4 T cells - increased
effector memory CD8 T cells in CD8 T cells - increased
IgD+ B cells - increased
IgM+ B cells - increased
naive CD4 T cells in CD4 T cells - decreased
naive CD8 T cells in CD8 T cells - decreased
OVA-specific IgE - decreased
T cells - decreased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
8 UTSW Zap70 mesa_verde 1 36761798-36782818 bp (+) 36779173 Autosomal Recessive (7;29) CD44 MFI in CD8 - increased
CD44 MFI in T cells - increased
CD44+ CD8 T cells - increased
CD44+ T cells - increased
central memory CD8 T cells in CD8 T cells - increased
T-dependent humoral response defect- decreased antibody response to rSFV
9 APN Zap70 murdock 1 36761798-36782818 bp (+) 36779704 Unknown CD4+ T cells - decreased
CD8 response - decreased
CD8+ T cells - decreased
immune system
10 UTSW Zap70 trebia 1 36761798-36782818 bp (+) 36781025 Unknown CD4+ T cells - decreased
CD8+ T cells - decreased
hematopoietic competition - disadvantage
immune system
11 APN Zap70 mrtless 1 36761798-36782818 bp (+) 36781149 Unknown CD4+ T cells - decreased
CD8 response - decreased
CD8+ T cells - decreased
immune system
12 UTSW Zap70 wanna4 1 36761798-36782818 bp (+) 36781365 Autosomal Recessive (21;366) B:T cells - increased
CD4:CD8 - increased
CD4+ T cells - decreased
CD4+ T cells in CD3+ T cells - decreased
CD44 MFI in CD4 - increased
CD44 MFI in CD8 - increased
CD44 MFI in T cells - increased
CD8+ T cells - decreased
CD8+ T cells in CD3+ T cells - decreased
central memory CD4 T cells in CD4 T cells - increased
central memory CD8 T cells in CD8 T cells - increased
naive CD4 T cells in CD4 T cells - decreased
naive CD8 T cells in CD8 T cells - decreased
T cells - decreased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
13 UTSW Zap70 wanna2 1 36761798-36782818 bp (+) 36781412 Autosomal Recessive (5;62) T-dependent humoral response defect- decreased antibody response to rSFV
14 UTSW Stat1 roccoco 1 52119440-52161865 bp (+) 52123209 Autosomal Recessive (10;105) CD44 MFI in CD4 - increased
CD44 MFI in CD8 - increased
CD44 MFI in T cells - increased
CD44+ CD4 T cells - increased
CD44+ T cells - increased
CTL killing - decreased
effector memory CD4 T cells in CD4 T cells - increased
effector memory CD8 T cells in CD8 T cells - increased
naive CD4 T cells in CD4 T cells - decreased
naive CD8 T cells in CD8 T cells - decreased
15 UTSW Stat1 special 1 52119440-52161865 bp (+) 52139264 Autosomal Dominant (4;24)
Autosomal Recessive (10;91)

Autosomal Semidominant (2;15) 		B cells - decreased
B:T cells - decreased
B1 cells - decreased
CD4:CD8 - increased
CD4+ T cells in CD3+ T cells - increased
CD44 MFI in CD8 - increased
CD44 MFI in T cells - increased
CD8+ T cells - decreased
CD8+ T cells in CD3+ T cells - decreased
effector memory CD8 T cells in CD8 T cells - increased
naive CD8 T cells in CD8 T cells - decreased
NK cells - decreased
NK T cells - increased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
16 UTSW Stat1 domino 1 52119440-52161865 bp (+) 52140588 Unknown (3;0) immune system
MCMV proliferation in macrophages - increased
MCMV susceptibility
NK cell response - decreased
response to injected CpG DNA - decreased
RVFV susceptibility
17 UTSW Stat1 poison 1 52119440-52161865 bp (+) 52151225 Unknown (2;0) immune system
MCMV susceptibility
NK cell response - decreased
18 UTSW Stat1 rollo 1 52119440-52161865 bp (+) 52153923 Autosomal Recessive (4;26) NK killing - decreased
19 UTSW Casp8 amontillado 1 58795374-58847503 bp (+) 58844770 Autosomal Recessive (8;55) CD4:CD8 - decreased
CD4+ T cells - decreased
CD4+ T cells in CD3+ T cells - decreased
CD44 MFI in CD8 - increased
CD8+ T cells in CD3+ T cells - increased
effector memory CD8 T cells in CD8 T cells - increased
naive CD8 T cells in CD8 T cells - decreased
20 UTSW Crygd L23 1 65061872-65063452 bp (-) 65063084 Unknown vision/eye
21 UTSW
has photo
 Crygb L10 1 65080219-65082288 bp (-) 65082157 Unknown vision/eye
22 UTSW Epha4 frog 1 77367189-77515088 bp (-) 77481076 Unknown behavior/neurological
immune system
nervous system
23 UTSW
has photo
 Pax3 Widget 1 78101267-78197134 bp (-) 78122590 Unknown (1;0) pigmentation
skin/coat/nails
24 UTSW Pax3 Nidoqueen 1 78101267-78197134 bp (-) 78132232 Unknown (1;0) pigmentation
skin/coat/nails
25 UTSW Col4a4 aoba 1 82448423-82586849 bp (-) 82535740 Unknown (1;0) digestive/alimentary
hearing/vestibular/ear
renal/urinary system
26 UTSW Pde6d costume 1 86542994-86582629 bp (-) 86547526 Unknown (2;0)
Autosomal Recessive (3;16) 		Body Weight - decreased
Body Weight (Female) - decreased
27 UTSW Inpp5d styx 1 87620312-87720507 bp (+) 87669784 Unknown (1;0) CTL killing - decreased
growth/size
hematopoietic system
homeostasis/metabolism
immune system
life span-post-weaning/aging
respiratory system
28 UTSW Inpp5d Orange 1 87620312-87720507 bp (+) 87697546 Autosomal Dominant (13;25)
Autosomal Recessive (5;8)

Autosomal Semidominant (15;48) 		B cells - decreased
IgD+ B cells - decreased
IgM+ B cells - decreased
29 UTSW Inpp5d Sailing 1 87620312-87720507 bp (+) 87705964 Unknown (2;0) IgM MFI in B cells - decreased
NK cells - decreased
30 UTSW
has photo
 Mlph beau 1 90915085-90951142 bp (+) 90928122 Autosomal Recessive (1;4) pigmentation
skin/coat/nails
31 UTSW Mlph koala 1 90915085-90951142 bp (+) 90933301 Unknown pigmentation
skin/coat/nails
32 UTSW Per2 Kortiku 1 91415982-91459324 bp (-) 91423829 Autosomal Recessive (2;24)
Autosomal Semidominant (2;33) 		Circadian defect: decrease in circadian active phase duration
Circadian defect: decrease in circadian phase angle intercept
Circadian defect: decrease in circadian tau DD by eye
Circadian defect: decrease in tau chi squared periodogram
Circadian rhythm
33 UTSW
has video
 Syt2 kringle 1 134646677-134762593 bp (+) 134747620 Autosomal Recessive (1;3)
Autosomal Semidominant (1;1) 		behavior/neurological
growth/size
lethality-postnatal
nervous system
34 UTSW Ptprc guotie 1 138062861-138175708 bp (-) 138068401 Autosomal Recessive (49;486)
Autosomal Semidominant (7;48) 		B cells - decreased
B:T cells - decreased
B1 cells - increased
B1a cells in B1 cells - decreased
CD4:CD8 - increased
CD4+ T cells - decreased
CD4+ T cells in CD3+ T cells - increased
CD44 MFI in CD8 - decreased
CD44 MFI in T cells - decreased
CD44+ CD4 T cells - decreased
CD44+ CD8 T cells - decreased
CD44+ T cells - decreased
CD8+ T cells - decreased
CD8+ T cells in CD3+ T cells - decreased
IgM+ B cells - decreased
immune system
naive CD8 T cells in CD8 T cells - decreased
neutrophils - increased
pDCs in CD11c+ cells - increased
T cells - decreased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
35 APN Ptprc lochy 1 138062861-138175708 bp (-) 138083790 Unknown B cells - decreased
CD4+ T cells - decreased
CD8+ T cells - decreased
hematopoietic system
immune system
36 UTSW Ptprc guotie2 1 138062861-138175708 bp (-) 138094299 Autosomal Recessive (18;94)
Autosomal Semidominant (2;10) 		B cells - decreased
B1a cells in B1 cells - decreased
B1b cells - increased
B2 cells - decreased
B220 MFI in B cells - decreased
CD44 MFI in CD8 - increased
CD8+ T cells - decreased
IgD MFI in B cells - decreased
IgD+ B cells - decreased
IgM+ B cells - decreased
naive CD4 T cells in CD4 T cells - decreased
T cells - decreased
37 UTSW Ptprc fuchsia 1 138062861-138175708 bp (-) 138101041 Autosomal Recessive (17;235)
Autosomal Semidominant (1;17) 		B cells - decreased
B:T cells - decreased
B1 cells - increased
B220 MFI in B cells - decreased
CD4+ T cells - decreased
CD4+ T cells in CD3+ T cells - increased
CD44 MFI in CD4 - increased
CD44 MFI in CD8 - increased
CD44 MFI in T cells - increased
CD8+ T cells - decreased
CD8+ T cells in CD3+ T cells - decreased
central memory CD4 T cells in CD4 T cells - increased
central memory CD8 T cells in CD8 T cells - increased
effector memory CD4 T cells in CD4 T cells - increased
effector memory CD8 T cells in CD8 T cells - increased
naive CD4 T cells in CD4 T cells - decreased
naive CD8 T cells in CD8 T cells - decreased
T cells - decreased
38 UTSW Ptprc belittle 1 138062861-138175708 bp (-) 138137493 Unknown CD4+ T cells - decreased
CD8+ T cells - decreased
hematopoietic system
immune system
39 UTSW Nek7 Cuties 1 138482875-138620141 bp (-) 138544242 Autosomal Semidominant (2;10) NALP3 inflammasome signaling defect
NLRP3 inflammasome: low response
40 UTSW Pappa2 Lilliputian 1 158711727-158980490 bp (-) 158716990 Autosomal Semidominant (2;11) Body Weight - decreased
growth/size
41 UTSW Pappa2 lilliputian3 1 158711727-158980490 bp (-) 158782403 Autosomal Recessive (2;10) Body Weight - decreased
42 UTSW Pappa2 Lilliputian2 1 158711727-158980490 bp (-) 158834918 Unknown (2;0)
Autosomal Dominant (2;8)

Autosomal Semidominant (1;5) 		Body Weight - decreased
Body Weight (Female) - decreased
Circadian defect: decrease in final body weight
growth/size
43 APN Rc3h1 sanroque 1 160906418-160974978 bp (+) 160940830 Unknown autoimmunity
immune system
44 UTSW
has photo
 Rc3h1 curlyfry 1 160906418-160974978 bp (+) 160959399 Unknown (1;0)
Autosomal Recessive (3;16)

Autosomal Semidominant (4;17) 		Body Weight - decreased
growth/size
limbs/digits/tail phenotype
45 UTSW Fasl riogrande2 1 161780691-161788495 bp (-) 161787138 Autosomal Recessive (1;6) T-dependent humoral response defect- decreased antibody response to rSFV
46 UTSW Sell dim_sum2 1 164061982-164084181 bp (+) 164065661 Autosomal Recessive (4;54) naive CD4 T cells in CD4 T cells - decreased
naive CD8 T cells in CD8 T cells - decreased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
47 UTSW Sell dim_sum 1 164061982-164084181 bp (+) 164066201 Autosomal Dominant (1;4)
Autosomal Recessive (7;45) 		naive CD4 T cells in CD4 T cells - decreased
48 UTSW Cd247 allia 1 165788681-165877277 bp (+) 165855214 Unknown hematopoietic competition - disadvantage
immune system
49 UTSW
has video
 Mpz taz 1 171150711-171161130 bp (+) 171158810 Autosomal Recessive (1;4) behavior/neurological
nervous system
50 UTSW
has photo
 a garfield 2 154791402-155051012 bp (+) Unknown pigmentation
skin/coat/nails
51 UTSW
has photo
 a killer_whale 2 154791402-155051012 bp (+) Unknown pigmentation
skin/coat/nails
52 UTSW
has photo
 a yellowbelly 2 154791402-155051012 bp (+) Unknown pigmentation
skin/coat/nails
53 UTSW Dclre1c kiwis 2 3424131-3464130 bp (+) 3436475 Autosomal Recessive (23;217) B cells - decreased
B1a cells - decreased
B1b cells - increased
B2 cells - decreased
B220 MFI in B cells - decreased
CD11c+ DCs - increased
CD4+ T cells - decreased
CD44 MFI in CD4 - increased
CD44 MFI in CD8 - increased
CD44 MFI in T cells - increased
CD8+ T cells - decreased
IgD MFI in B cells - decreased
IgD+ B cells - decreased
IgM+ B cells - decreased
macrophages - increased
neutrophils - increased
NK cells - increased
NK T cells - decreased
T cells - decreased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
54 UTSW Prkcq celina2 2 11172108-11301222 bp (+) 11226986 Autosomal Recessive (1;4) T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
55 UTSW Prkcq celina 2 11172108-11301222 bp (+) 11283849 Autosomal Recessive (1;6) T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
56 UTSW
has photo
 Rxra pinkie 2 27676440-27762957 bp (+) 27752334 Unknown hematopoietic system
immune system
pigmentation
skeleton phenotype
skin/coat/nails
vision/eye
57 UTSW Neurod1 cruz 2 79452521-79456751 bp (-) 79454595 Autosomal Recessive (5;21) behavior/neurological
Circadian defect: decrease in circadian active phase duration
Circadian defect: decrease in circadian tau activity onset
Circadian defect: decrease in tau chi squared periodogram
hearing/vestibular/ear
58 UTSW
has photo
 Alx4 goofy 2 93642384-93681339 bp (+) 93675369 Unknown craniofacial
limbs/digits/tail phenotype
59 UTSW Rag2 snowcock 2 101624718-101632529 bp (+) 101630603 Autosomal Recessive (15;106)
Autosomal Semidominant (1;4) 		B cells - decreased
B2 cells - decreased
CD4+ T cells - decreased
CD44 MFI in CD4 - increased
CD44 MFI in CD8 - increased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
60 UTSW Rag1 huckle 2 101638282-101649501 bp (-) 101641223 Unknown B cells - decreased
CD4+ T cells - decreased
CD8+ T cells - decreased
immune system
61 UTSW Rag1 maladaptive 2 101638282-101649501 bp (-) 101645647 Unknown (1;0) B cells - decreased
CD4+ T cells - decreased
CD8+ T cells - decreased
hematopoietic system
immune system
RVFV susceptibility
62 UTSW Eif2ak4 atchoum 2 118388618-118475234 bp (+) 118400653 Unknown (2;0) adenovirus infection of macrophages - increased
immune system
MCMV proliferation in macrophages - increased
63 UTSW Trp53bp1 lentil2 2 121193281-121271407 bp (-) 121207887 Autosomal Recessive (8;62) CD44 MFI in CD8 - increased
central memory CD8 T cells in CD8 T cells - increased
IgD MFI in B cells - decreased
IgD+ B cells - decreased
naive CD8 T cells in CD8 T cells - decreased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
64 UTSW Trp53bp1 verily 2 121193281-121271407 bp (-) 121211313 Autosomal Recessive (1;6)
Autosomal Semidominant (1;4) 		IgD MFI in B cells - decreased
65 UTSW Trp53bp1 lentil 2 121193281-121271407 bp (-) 121251868 Autosomal Recessive (4;18) B:T cells - increased
CD4+ T cells - decreased
CD44 MFI in T cells - increased
IgD MFI in B cells - decreased
T cells - decreased
66 UTSW Trp53bp1 concur 2 121193281-121271407 bp (-) 121270319 Autosomal Dominant (1;4)
Autosomal Recessive (1;4) 		IgD MFI in B cells - decreased
67 UTSW Gatm mrbig 2 122594467-122611303 bp (-) 122600744 Autosomal Recessive (3;23)
Autosomal Semidominant (1;7) 		Body Weight - decreased
DSS: sensitive day 10
DSS: sensitive day 7
68 UTSW Sppl2a abra2 2 126890391-126933235 bp (-) 126920313 Autosomal Recessive (5;44)
Autosomal Semidominant (1;4) 		T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
69 UTSW Sppl2a abra 2 126890391-126933235 bp (-) 126923594 Autosomal Recessive (1;5) T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
70 UTSW
has photo
 Tgm3 tortellini 2 130012349-130050399 bp (+) 130024585 Unknown (1;0) immune system
RVFV susceptibility
skin/coat/nails
71 UTSW Pax1 wavy 2 147361925-147393295 bp (+) 147365802 Unknown (1;0)
Autosomal Semidominant (3;12) 		limbs/digits/tail phenotype
72 UTSW Itch scratch 2 155133509-155226855 bp (+) 155172561 Autosomal Recessive (3;18)
Autosomal Semidominant (1;2) 		IgE response to a Cysteine Protease (Papain) - increased
total IgE level - increased
73 UTSW Rims4 demure 2 163859751-163918683 bp (-) 163864120 Autosomal Recessive (3;14) Body Weight - decreased
growth/size
74 UTSW Rims4 diminutive 2 163859751-163918683 bp (-) 163864865 Autosomal Recessive (2;13) Body Weight - decreased
growth/size
75 UTSW Cd40 bluebonnet 2 165055627-165072948 bp (+) 165062301 Autosomal Recessive (2;12)
Autosomal Semidominant (1;3) 		OVA-specific IgE - increased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
76 UTSW Cd40 noelle 2 165055627-165072948 bp (+) 165063563 Autosomal Dominant (1;4)
Autosomal Recessive (3;35)

Autosomal Semidominant (1;4) 		T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
total IgE level - decreased
77 UTSW Cp iron10 3 19957054-20009145 bp (+) 19989148 Unknown iron deficiency
78 UTSW
has photo
 Hps3 gandalf 3 19995945-20035315 bp (-) 20012796 Autosomal Recessive (1;2) pigmentation
skin/coat/nails
79 UTSW
has photo
 Hps3 pam_gray 3 19995945-20035315 bp (-) 20017173 Unknown (1;0) DSS: sensitive day 7
pigmentation
skin/coat/nails
80 UTSW
has photo
 Hps3 blue 3 19995945-20035315 bp (-) 20030796 Autosomal Semidominant (1;1) pigmentation
skin/coat/nails
81 UTSW Tlr2 languid 3 83836272-83841767 bp (-) 83837315 Unknown (1;0) immune system
TLR signaling defect: TNF production by macrophages
82 UTSW Rorc chestnut 3 94372831-94397839 bp (+) 94377609 Autosomal Recessive (4;22)
Autosomal Semidominant (3;14) 		CD4+ T cells - decreased
CD8+ T cells - decreased
83 UTSW Rorc macadamias2 3 94372831-94397839 bp (+) 94387193 Autosomal Recessive (17;113) B:T cells - increased
B1a cells - increased
B1b cells - increased
B2 cells - decreased
CD4:CD8 - decreased
CD4+ T cells - decreased
CD4+ T cells in CD3+ T cells - decreased
CD44 MFI in CD4 - increased
CD44 MFI in CD8 - increased
CD8+ T cells in CD3+ T cells - increased
effector memory CD4 T cells in CD4 T cells - increased
effector memory CD8 T cells in CD8 T cells - increased
IgD MFI in B cells - increased
macrophages - increased
naive CD8 T cells in CD8 T cells - decreased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
84 UTSW Rorc macadamias 3 94372831-94397839 bp (+) 94397302 Autosomal Recessive (1;8) T-dependent humoral response defect- decreased antibody response to rSFV
85 UTSW
has photo
 Gja8 L1 3 96918863-96926020 bp (-) 96920197 Unknown vision/eye
86 UTSW Nfkb1 Finlay 3 135584655-135691547 bp (-) 135595053 Unknown (1;0)
Autosomal Recessive (1;3)

Autosomal Semidominant (2;8) 		Nlrc4 inflammasome: low response
NLRP3 inflammasome: low response
T-dependent humoral response defect- decreased antibody response to rSFV
87 UTSW Nfkb1 Roomba 3 135584655-135691547 bp (-) 135612412 Autosomal Recessive (1;4)
Autosomal Semidominant (4;22) 		central memory CD8 T cells in CD8 T cells - increased
DSS: sensitive day 10
T-dependent humoral response defect- decreased antibody response to rSFV
total IgE level - decreased
88 UTSW Nfkb1 kookaburra 3 135584655-135691547 bp (-) 135626611 Autosomal Dominant (1;7)
Autosomal Recessive (4;54)

Autosomal Semidominant (5;29) 		B1 cells - decreased
CD44 MFI in CD8 - increased
central memory CD4 T cells in CD4 T cells - decreased
central memory CD8 T cells in CD8 T cells - increased
effector memory CD4 T cells in CD4 T cells - decreased
naive CD8 T cells in CD8 T cells - decreased
T-dependent humoral response defect- decreased antibody response to rSFV
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
total IgE after 2nd OVA/Alum - decreased
Total IgE After 2nd OVA/Alum Challenge (day 7) - decreased
89 UTSW
has photo
 Dock7 moonlight 4 98936675-99120860 bp (-) Unknown behavior/neurological
DSS: sensitive day 7
pigmentation
skin/coat/nails
90 UTSW Lyn Pacific 4 3678115-3813122 bp (+) 3745330 Autosomal Dominant (1;4)
Autosomal Recessive (1;4)

Autosomal Semidominant (5;26) 		B1 cells - increased
CD11c+ DCs - increased
CD4+ T cells - decreased
CD8+ T cells - decreased
macrophages - increased
NK cells - decreased
T cells - decreased
91 UTSW Lyn Lemon 4 3678115-3813122 bp (+) 3746768 Autosomal Recessive (1;5)
Autosomal Semidominant (3;14) 		B cells - decreased
IgD+ B cells - decreased
IgM+ B cells - decreased
neutrophils - increased
92 UTSW Lyn Cress 4 3678115-3813122 bp (+) 3789908 Autosomal Dominant (6;31)
Autosomal Recessive (4;18)

Autosomal Semidominant (12;70) 		B cells - decreased
B:T cells - decreased
B1a cells - increased
B1a cells in B1 cells - increased
B220 MFI in B cells - decreased
CD4+ T cells - increased
CD8+ T cells - increased
IgD+ B cells - decreased
IgM+ B cells - decreased
T cells - increased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
93 UTSW
has video
 Esrp1 triaka 4 11331933-11386783 bp (-) 11379300 Unknown (1;0) behavior/neurological
hearing/vestibular/ear
nervous system
94 UTSW Aqp3 phoebus 4 41092722-41098183 bp (-) 41095252 Unknown (1;0) DSS: sensitive
immune system
95 UTSW Pax5 glacier 4 44531145-44710487 bp (-) 44679494 Autosomal Recessive (2;21)
Autosomal Semidominant (1;7) 		B1 cells - increased
B1b cells in B1 cells - decreased
96 UTSW Pax5 glacier2 4 44531145-44710487 bp (-) 44710407 Autosomal Recessive (13;215)
Autosomal Semidominant (2;32) 		B cells - decreased
B:T cells - decreased
B1 cells - decreased
B220 MFI in B cells - decreased
CD4+ T cells - increased
CD8+ T cells - increased
IgD MFI in B cells - decreased
IgD+ B cells - decreased
IgM MFI in B cells - decreased
IgM+ B cells - decreased
T cells - increased
T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization
T-dependent humoral response defect- decreased antibody response to rSFV
T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization
97 UTSW Tlr4 Lops 4 66827584-66930284 bp (+) 66833880 Autosomal Semidominant (3;15) NLRP3 inflammasome: low response
TLR signaling defect: hyposensitivity to LPS
TLR signaling defect: TNF production by macrophages
98 UTSW Tlr4 bugsy 4 66827584-66930284 bp (+) 66839254 Autosomal Recessive (3;27) Macrophage necroptosis: high
TLR signaling defect: hyposensitivity to LPS
TLR signaling defect: TNF production by macrophages
99 UTSW Tlr4 Guardiola 4 66827584-66930284 bp (+) 66839303 Unknown (1;0)
Autosomal Recessive (1;6)

Autosomal Semidominant (3;19) 		Nlrc4 inflammasome: low response
TLR signaling defect: hyposensitivity to LPS
100 UTSW Tlr4 milquetoast 4 66827584-66930284 bp (+) 66839444 Autosomal Recessive (1;4) TLR signaling defect: hyposensitivity to LPS
TLR signaling defect: TNF production by macrophages
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