all of any of 125-03 Response - decreased 125-03 Response - increased 30 min GTT hyperglycemic 30 min GTT hyperglycemic (male) 30 min GTT hyperoglycemic (female) 30 min GTT hypoglycemic 30 min GTT hypoglycemic (female) 30 min GTT hypoglycemic (male) 30 Min. Insulin - decreased 30 Min. Insulin - increased 30 Min. Insulin (Female) - decreased 30 Min. Insulin (Female) - increased 30 Min. Insulin (Male) - decreased 30 Min. Insulin (Male) - increased adenovirus infection of macrophages - decreased adenovirus infection of macrophages - increased adipose tissue anemia Anophthalmia autoimmunity behavior/neurological Blood Analysis Platelet Count - decreased Blood Analysis Platelet Count - increased Blood pressure defect: decrease in SBP day 1 Blood pressure defect: decrease in SBP day 2 Blood pressure defect: increase in SBP day 2 Blood Pressure: DBP Average - decreased Blood Pressure: DBP Average - increased Blood Pressure: DBP Day 1 - decreased Blood Pressure: DBP Day 1 - increased Blood Pressure: DBP Day 2 - decreased Blood Pressure: DBP Day 2 - increased Blood Pressure: DBP Day 3 - decreased Blood Pressure: DBP Day 3 - increased Blood Pressure: DBP Day 4 - decreased Blood Pressure: DBP Day 4 - increased Blood Pressure: HR Average - decreased Blood Pressure: HR Average - increased Blood Pressure: HR Day 1 - decreased Blood Pressure: HR Day 1 - increased Blood Pressure: HR Day 2 - decreased Blood Pressure: HR Day 2 - increased Blood Pressure: HR Day 3 - decreased Blood Pressure: HR Day 3 - increased Blood Pressure: HR Day 4 - decreased Blood Pressure: HR Day 4 - increased Blood Pressure: MBP Average - decreased Blood Pressure: MBP Average - increased Blood Pressure: MBP Day 1 - decreased Blood Pressure: MBP Day 1 - increased Blood Pressure: MBP Day 2 - decreased Blood Pressure: MBP Day 2 - increased Blood Pressure: MBP Day 3 - decreased Blood Pressure: MBP Day 3 - increased Blood Pressure: MBP Day 4 - decreased Blood Pressure: MBP Day 4 - increased Blood Pressure: SBP Average - decreased Blood Pressure: SBP Average - increased Blood Pressure: SBP Day 1 - decreased Blood Pressure: SBP Day 1 - increased Blood Pressure: SBP Day 2 - decreased Blood Pressure: SBP Day 2 - increased Blood Pressure: SBP Day 3 - decreased Blood Pressure: SBP Day 3 - increased Blood Pressure: SBP Day 4 - decreased Blood Pressure: SBP Day 4 - increased Body Weight - decreased Body Weight - increased Body Weight (BP Female) - decreased Body Weight (BP Female) - increased Body Weight (BP Male) - decreased Body Weight (BP Male) - increased Body Weight (BP) - decreased Body Weight (BP) - increased Body Weight (DSS Female) - decreased Body Weight (DSS Female) - increased Body Weight (DSS Male) - decreased Body Weight (DSS Male) - increased Body Weight (DSS) - decreased Body Weight (DSS) - increased Body Weight (Female) - decreased Body Weight (Female) - increased Body Weight (Male) - decreased Body Weight (Male) - increased Bone: Liver Fat - decreased Bone: Liver Fat - increased Bone: Liver Fat (female) - decreased Bone: Liver Fat (female) - increased Bone: Liver Fat (male) - decreased Bone: Liver Fat (male) - increased Bone: Liver Fat (normalized) - decreased Bone: Liver Fat (normalized) - increased Bone: Liver Fat (normalized, female) - decreased Bone: Liver Fat (normalized, female) - increased Bone: Liver Fat (normalized, male) - decreased Bone: Liver Fat (normalized, male) - increased cardiovascular system CD8 response - decreased cellular phenotype craniofacial CTL killing - decreased CTL killing - increased CTL killing dominant epitope - decreased CTL killing dominant epitope - increased CTL killing subdominant epitope - decreased CTL killing subdominant epitope - increased defect in 125-03 response digestive/alimentary dsDNA Antibody - decreased dsDNA Antibody - increased dsDNA induced type I IFN production - decreased dsDNA induced type I IFN production - increased DSS: resistant DSS: resistant day 10 DSS: resistant day 7 DSS: sensitive DSS: sensitive day 10 DSS: sensitive day 7 embryogenesis endocrine/exocrine gland extracellular cGAMP: high response extracellular cGAMP: low response eye: cataract eye: corneal opacity eye: retinal vascular anomaly FACS B cells - decreased FACS B cells - increased FACS B:T cells - decreased FACS B:T cells - increased FACS B1 cells - decreased FACS B1 cells - increased FACS B1a cells - decreased FACS B1a cells - increased FACS B1a cells in B1 cells - decreased FACS B1a cells in B1 cells - increased FACS B1b cells - decreased FACS B1b cells - increased FACS B1b cells in B1 cells - decreased FACS B1b cells in B1 cells - increased FACS B2 cells - decreased FACS B2 cells - increased FACS B220 MFI - decreased FACS B220 MFI - increased FACS CD11b+ DCs (gated in CD11c+ cells) - decreased FACS CD11b+ DCs (gated in CD11c+ cells) - increased FACS CD11c+ DCs - decreased FACS CD11c+ DCs - increased FACS CD4:CD8 - decreased FACS CD4:CD8 - increased FACS CD4+ T cells - decreased FACS CD4+ T cells - increased FACS CD4+ T cells in CD3+ T cells - decreased FACS CD4+ T cells in CD3+ T cells - increased FACS CD44+ CD4 MFI - decreased FACS CD44+ CD4 MFI - increased FACS CD44+ CD4 T cells - decreased FACS CD44+ CD4 T cells - increased FACS CD44+ CD8 MFI - decreased FACS CD44+ CD8 MFI - increased FACS CD44+ CD8 T cells - decreased FACS CD44+ CD8 T cells - increased FACS CD44+ T cells - decreased FACS CD44+ T cells - increased FACS CD44+ T MFI - decreased FACS CD44+ T MFI - increased FACS CD8+ T cells - decreased FACS CD8+ T cells - increased FACS CD8+ T cells in CD3+ T cells - decreased FACS CD8+ T cells in CD3+ T cells - increased FACS CD8a+ DCs (gated in CD11c+ cells) - decreased FACS CD8a+ DCs (gated in CD11c+ cells) - increased FACS central memory CD4 T cells in CD4 T cells - decreased FACS central memory CD4 T cells in CD4 T cells - increased FACS central memory CD8 T cells in CD8 T cells - decreased FACS central memory CD8 T cells in CD8 T cells - increased FACS effector memory CD4 T cells in CD4 T cells - decreased FACS effector memory CD4 T cells in CD4 T cells - increased FACS effector memory CD8 T cells in CD8 T cells - decreased FACS effector memory CD8 T cells in CD8 T cells - increased FACS effector T cells - decreased FACS effector T cells - increased FACS IgD MFI - decreased FACS IgD MFI - increased FACS IgD+ B cell percentage - decreased FACS IgD+ B cell percentage - increased FACS IgM MFI - decreased FACS IgM MFI - increased FACS IgM+ B cells - decreased FACS IgM+ B cells - increased FACS macrophages - decreased FACS macrophages - increased FACS memory T cells - decreased FACS memory T cells - increased FACS naive CD4 T cells in CD4 T cells - decreased FACS naive CD4 T cells in CD4 T cells - increased FACS naive CD8 T cells in CD8 T cells - decreased FACS naive CD8 T cells in CD8 T cells - increased FACS naïve T cells - decreased FACS naïve T cells - increased FACS neutrophils - decreased FACS neutrophils - increased FACS NK cells - decreased FACS NK cells - increased FACS NK T cells - decreased FACS NK T cells - increased FACS NKT cells (tet) - decreased FACS NKT cells (tet) - increased FACS pDCs - decreased FACS pDCs - increased FACS T cells - decreased FACS T cells - increased fasting hyperglycemia fasting hyperglycemia (female) fasting hyperglycemia (male) fasting hypoglycemia fasting hypoglycemia (female) fasting hypoglycemia (male) Fasting Insulin - decreased Fasting Insulin - increased Fasting Insulin (Female) - decreased Fasting Insulin (Female) - increased Fasting Insulin (Male) - decreased Fasting Insulin (Male) - increased growth/size hearing/vestibular/ear hematopoietic competition - disadvantage hematopoietic system homeostasis/metabolism hypersensitivity to TLR CpGODN + IFNg hyposensitivity to TLR CpGODN + IFNg IgA response to 2nd OVA/Alum Challenge (day 7) - decreased IgA response to 2nd OVA/Alum Challenge (day 7) - increased IgE response to a Cysteine Protease (Papain) - decreased IgE response to a Cysteine Protease (Papain) - increased IgG1 response to a Cysteine Protease (Papain) - decreased IgG1 response to a Cysteine Protease (Papain) - increased immune system impaired response to dsDNA- type I IFN production by macrophages inflammatory bowel disease phenotype influenza proliferation in macrophages - decreased influenza proliferation in macrophages - increased influenza resistance iron deficiency iron excess LCMV clone 13 resistance lethality-embryonic/perinatal lethality-postnatal life span-post-weaning/aging limbs/digits/tail phenotype liver/biliary system LPS Hypersensitivity - decreased LPS Hypersensitivity - increased LPS-induced Necroptosis - decreased LPS-induced Necroptosis - increased Macrophage necroptosis: high Macrophage necroptosis: low MCMV proliferation in macrophages - decreased MCMV proliferation in macrophages - increased MCMV resistance MCMV susceptibility Motor: rotarod weight Motor: Rotarod Weight - decreased Motor: Rotarod Weight - increased MTT dsDNA PECs - decreased MTT dsDNA PECs - increased MTT Value of PECs - decreased MTT Value of PECs - increased muscle naive T cells - increased NALP3 inflammasome signaling defect nervous system NK cell response - decreased NK killing - decreased NK killing - increased Nlrc4 inflammasome: high response Nlrc4 inflammasome: low response NLRP3 inflammasome: high response NLRP3 inflammasome: low response no phenotypic analysis normal phenotype other phenotype OVA-specific IgE - decreased OVA-specific IgE - increased OVA-specific IgE after 2nd OVA/Alum - decreased OVA-specific IgE after 2nd OVA/Alum - increased Peritoneal exudates B1a cell % - decreased Peritoneal exudates B1a cell % - increased Peritoneal exudates B1a cell numbers - decreased Peritoneal exudates B1a cell numbers - increased Peritoneal exudates B1b cell % - decreased Peritoneal exudates B1b cell % - increased Peritoneal exudates B1b cell numbers - decreased Peritoneal exudates B1b cell numbers - increased Peritoneal exudates macrophage % - decreased Peritoneal exudates macrophage % - increased Peritoneal exudates macrophage numbers - decreased Peritoneal exudates macrophage numbers - increased Peritoneal exudates neutrophil % - decreased Peritoneal exudates neutrophil % - increased Peritoneal exudates neutrophil numbers - decreased Peritoneal exudates neutrophil numbers - increased phagocytosis in PECs - decreased phagocytosis in PECs - increased pigmentation polycythemia post-MCMV FACS B cells - decreased post-MCMV FACS B cells - increased post-MCMV FACS B:T cells - decreased post-MCMV FACS B:T cells - increased post-MCMV FACS B1 cells - decreased post-MCMV FACS B1 cells - increased post-MCMV FACS B1a cells - decreased post-MCMV FACS B1a cells - increased post-MCMV FACS B1a cells in B1 cells - decreased post-MCMV FACS B1a cells in B1 cells - increased post-MCMV FACS B1b cells - decreased post-MCMV FACS B1b cells - increased post-MCMV FACS B1b cells in B1 cells - decreased post-MCMV FACS B1b cells in B1 cells - increased post-MCMV FACS B2 cells - decreased post-MCMV FACS B2 cells - increased post-MCMV FACS B220 MFI - decreased post-MCMV FACS B220 MFI - increased post-MCMV FACS CD11b+ DCs (gated in CD11c+ cells) - decreased post-MCMV FACS CD11b+ DCs (gated in CD11c+ cells) - increased post-MCMV FACS CD11c+ DCs - decreased post-MCMV FACS CD11c+ DCs - increased post-MCMV FACS CD4:CD8 - decreased post-MCMV FACS CD4:CD8 - increased post-MCMV FACS CD4+ T cells - decreased post-MCMV FACS CD4+ T cells - increased post-MCMV FACS CD4+ T cells in CD3+ T cells - decreased post-MCMV FACS CD4+ T cells in CD3+ T cells - increased post-MCMV FACS CD44+ CD4 MFI - decreased post-MCMV FACS CD44+ CD4 MFI - increased post-MCMV FACS CD44+ CD4 T cells - decreased post-MCMV FACS CD44+ CD4 T cells - increased post-MCMV FACS CD44+ CD8 MFI - decreased post-MCMV FACS CD44+ CD8 MFI - increased post-MCMV FACS CD44+ CD8 T cells - decreased post-MCMV FACS CD44+ CD8 T cells - increased post-MCMV FACS CD44+ T cells - decreased post-MCMV FACS CD44+ T cells - increased post-MCMV FACS CD44+ T MFI - decreased post-MCMV FACS CD44+ T MFI - increased post-MCMV FACS CD8 response - decreased post-MCMV FACS CD8 response - increased post-MCMV FACS CD8+ T cells - decreased post-MCMV FACS CD8+ T cells - increased post-MCMV FACS CD8+ T cells in CD3+ T cells - decreased post-MCMV FACS CD8+ T cells in CD3+ T cells - increased post-MCMV FACS CD8a+ DCs (gated in CD11c+ cells) - decreased post-MCMV FACS CD8a+ DCs (gated in CD11c+ cells) - increased post-MCMV FACS central memory CD4 T cells in CD4 T cells - decreased post-MCMV FACS central memory CD4 T cells in CD4 T cells - increased post-MCMV FACS central memory CD8 T cells in CD8 T cells - decreased post-MCMV FACS central memory CD8 T cells in CD8 T cells - increased post-MCMV FACS effector memory CD4 T cells in CD4 T cells - decreased post-MCMV FACS effector memory CD4 T cells in CD4 T cells - increased post-MCMV FACS effector memory CD8 T cells in CD8 T cells - decreased post-MCMV FACS effector memory CD8 T cells in CD8 T cells - increased post-MCMV FACS effector T cells - decreased post-MCMV FACS effector T cells - increased post-MCMV FACS IgD MFI - decreased post-MCMV FACS IgD MFI - increased post-MCMV FACS IgD+ B cell percentage - decreased post-MCMV FACS IgD+ B cell percentage - increased post-MCMV FACS IgM MFI - decreased post-MCMV FACS IgM MFI - increased post-MCMV FACS IgM+ B cells - decreased post-MCMV FACS IgM+ B cells - increased post-MCMV FACS macrophages - decreased post-MCMV FACS macrophages - increased post-MCMV FACS memory T cells - decreased post-MCMV FACS memory T cells - increased post-MCMV FACS naive CD4 T cells in CD4 T cells - decreased post-MCMV FACS naive CD4 T cells in CD4 T cells - increased post-MCMV FACS naive CD8 T cells in CD8 T cells - decreased post-MCMV FACS naive CD8 T cells in CD8 T cells - increased post-MCMV FACS naïve T cells - decreased post-MCMV FACS naïve T cells - increased post-MCMV FACS neutrophils - decreased post-MCMV FACS neutrophils - increased post-MCMV FACS NK cell response - decreased post-MCMV FACS NK cell response - increased post-MCMV FACS NK cells - decreased post-MCMV FACS NK cells - increased post-MCMV FACS NK T cells - decreased post-MCMV FACS NK T cells - increased post-MCMV FACS NKT cells (tet) - decreased post-MCMV FACS NKT cells (tet) - increased post-MCMV FACS pDCs - decreased post-MCMV FACS pDCs - increased post-MCMV FACS T cells - decreased post-MCMV FACS T cells - increased ratio of OVA-specific IgE over the total IgE - decreased ratio of OVA-specific IgE over the total IgE - increased renal/urinary system reproductive system respiratory system response to injected CpG DNA - decreased RVFV proliferation in macrophages - decreased RVFV proliferation in macrophages - increased RVFV susceptibility secretory SlgA after 2nd OVA/Alum Challenge (day 7) - decreased secretory SlgA after 2nd OVA/Alum Challenge (day 7) - increased skeleton phenotype skin/coat/nails taste/olfaction T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization T-dependent humoral response defect- decreased antibody response to rSFV T-dependent humoral response defect- increased antibody response to OVA+ alum immunization T-dependent humoral response defect- increased antibody response to rSFV T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization T-independent B cell response defect- increased TNP-specific IgM to TNP-Ficoll immunization TLR signaling defect: hypersensitivity to CpG TLR signaling defect: hypersensitivity to CpG + IFNg TLR signaling defect: hypersensitivity to LPS TLR signaling defect: hypersensitivity to MALP2 TLR signaling defect: hypersensitivity to PAM3CSK4 TLR signaling defect: hypersensitivity to poly I:C TLR signaling defect: hypersensitivity to poly I:C + IFNg TLR signaling defect: hypersensitivity to R848 TLR signaling defect: hyposensitivity to CpG TLR signaling defect: hyposensitivity to CpG + IFNg TLR signaling defect: hyposensitivity to LPS TLR signaling defect: hyposensitivity to MALP2 TLR signaling defect: hyposensitivity to PAM3CSK4 TLR signaling defect: hyposensitivity to poly I:C TLR signaling defect: hyposensitivity to poly I:C + IFNg TLR signaling defect: hyposensitivity to R848 TLR signaling defect: TNF production by macrophages TLR signaling defect: type I IFN production by macrophages TLR signaling defect: type I IFN production by pDC Total Cholesterol - decreased Total Cholesterol - increased total IgE after 2nd OVA/Alum - decreased total IgE after 2nd OVA/Alum - increased Total IgE After 2nd OVA/Alum Challenge (day 7) - decreased Total IgE After 2nd OVA/Alum Challenge (day 7) - increased total IgE level - decreased total IgE level - increased touch/vibrissae tumorigenesis vision/eye
and any of none of 125-03 Response - decreased 125-03 Response - increased 30 min GTT hyperglycemic 30 min GTT hyperglycemic (male) 30 min GTT hyperoglycemic (female) 30 min GTT hypoglycemic 30 min GTT hypoglycemic (female) 30 min GTT hypoglycemic (male) 30 Min. Insulin - decreased 30 Min. Insulin - increased 30 Min. Insulin (Female) - decreased 30 Min. Insulin (Female) - increased 30 Min. Insulin (Male) - decreased 30 Min. Insulin (Male) - increased adenovirus infection of macrophages - decreased adenovirus infection of macrophages - increased adipose tissue anemia Anophthalmia autoimmunity behavior/neurological Blood Analysis Platelet Count - decreased Blood Analysis Platelet Count - increased Blood pressure defect: decrease in SBP day 1 Blood pressure defect: decrease in SBP day 2 Blood pressure defect: increase in SBP day 2 Blood Pressure: DBP Average - decreased Blood Pressure: DBP Average - increased Blood Pressure: DBP Day 1 - decreased Blood Pressure: DBP Day 1 - increased Blood Pressure: DBP Day 2 - decreased Blood Pressure: DBP Day 2 - increased Blood Pressure: DBP Day 3 - decreased Blood Pressure: DBP Day 3 - increased Blood Pressure: DBP Day 4 - decreased Blood Pressure: DBP Day 4 - increased Blood Pressure: HR Average - decreased Blood Pressure: HR Average - increased Blood Pressure: HR Day 1 - decreased Blood Pressure: HR Day 1 - increased Blood Pressure: HR Day 2 - decreased Blood Pressure: HR Day 2 - increased Blood Pressure: HR Day 3 - decreased Blood Pressure: HR Day 3 - increased Blood Pressure: HR Day 4 - decreased Blood Pressure: HR Day 4 - increased Blood Pressure: MBP Average - decreased Blood Pressure: MBP Average - increased Blood Pressure: MBP Day 1 - decreased Blood Pressure: MBP Day 1 - increased Blood Pressure: MBP Day 2 - decreased Blood Pressure: MBP Day 2 - increased Blood Pressure: MBP Day 3 - decreased Blood Pressure: MBP Day 3 - increased Blood Pressure: MBP Day 4 - decreased Blood Pressure: MBP Day 4 - increased Blood Pressure: SBP Average - decreased Blood Pressure: SBP Average - increased Blood Pressure: SBP Day 1 - decreased Blood Pressure: SBP Day 1 - increased Blood Pressure: SBP Day 2 - decreased Blood Pressure: SBP Day 2 - increased Blood Pressure: SBP Day 3 - decreased Blood Pressure: SBP Day 3 - increased Blood Pressure: SBP Day 4 - decreased Blood Pressure: SBP Day 4 - increased Body Weight - decreased Body Weight - increased Body Weight (BP Female) - decreased Body Weight (BP Female) - increased Body Weight (BP Male) - decreased Body Weight (BP Male) - increased Body Weight (BP) - decreased Body Weight (BP) - increased Body Weight (DSS Female) - decreased Body Weight (DSS Female) - increased Body Weight (DSS Male) - decreased Body Weight (DSS Male) - increased Body Weight (DSS) - decreased Body Weight (DSS) - increased Body Weight (Female) - decreased Body Weight (Female) - increased Body Weight (Male) - decreased Body Weight (Male) - increased Bone: Liver Fat - decreased Bone: Liver Fat - increased Bone: Liver Fat (female) - decreased Bone: Liver Fat (female) - increased Bone: Liver Fat (male) - decreased Bone: Liver Fat (male) - increased Bone: Liver Fat (normalized) - decreased Bone: Liver Fat (normalized) - increased Bone: Liver Fat (normalized, female) - decreased Bone: Liver Fat (normalized, female) - increased Bone: Liver Fat (normalized, male) - decreased Bone: Liver Fat (normalized, male) - increased cardiovascular system CD8 response - decreased cellular phenotype craniofacial CTL killing - decreased CTL killing - increased CTL killing dominant epitope - decreased CTL killing dominant epitope - increased CTL killing subdominant epitope - decreased CTL killing subdominant epitope - increased defect in 125-03 response digestive/alimentary dsDNA Antibody - decreased dsDNA Antibody - increased dsDNA induced type I IFN production - decreased dsDNA induced type I IFN production - increased DSS: resistant DSS: resistant day 10 DSS: resistant day 7 DSS: sensitive DSS: sensitive day 10 DSS: sensitive day 7 embryogenesis endocrine/exocrine gland extracellular cGAMP: high response extracellular cGAMP: low response eye: cataract eye: corneal opacity eye: retinal vascular anomaly FACS B cells - decreased FACS B cells - increased FACS B:T cells - decreased FACS B:T cells - increased FACS B1 cells - decreased FACS B1 cells - increased FACS B1a cells - decreased FACS B1a cells - increased FACS B1a cells in B1 cells - decreased FACS B1a cells in B1 cells - increased FACS B1b cells - decreased FACS B1b cells - increased FACS B1b cells in B1 cells - decreased FACS B1b cells in B1 cells - increased FACS B2 cells - decreased FACS B2 cells - increased FACS B220 MFI - decreased FACS B220 MFI - increased FACS CD11b+ DCs (gated in CD11c+ cells) - decreased FACS CD11b+ DCs (gated in CD11c+ cells) - increased FACS CD11c+ DCs - decreased FACS CD11c+ DCs - increased FACS CD4:CD8 - decreased FACS CD4:CD8 - increased FACS CD4+ T cells - decreased FACS CD4+ T cells - increased FACS CD4+ T cells in CD3+ T cells - decreased FACS CD4+ T cells in CD3+ T cells - increased FACS CD44+ CD4 MFI - decreased FACS CD44+ CD4 MFI - increased FACS CD44+ CD4 T cells - decreased FACS CD44+ CD4 T cells - increased FACS CD44+ CD8 MFI - decreased FACS CD44+ CD8 MFI - increased FACS CD44+ CD8 T cells - decreased FACS CD44+ CD8 T cells - increased FACS CD44+ T cells - decreased FACS CD44+ T cells - increased FACS CD44+ T MFI - decreased FACS CD44+ T MFI - increased FACS CD8+ T cells - decreased FACS CD8+ T cells - increased FACS CD8+ T cells in CD3+ T cells - decreased FACS CD8+ T cells in CD3+ T cells - increased FACS CD8a+ DCs (gated in CD11c+ cells) - decreased FACS CD8a+ DCs (gated in CD11c+ cells) - increased FACS central memory CD4 T cells in CD4 T cells - decreased FACS central memory CD4 T cells in CD4 T cells - increased FACS central memory CD8 T cells in CD8 T cells - decreased FACS central memory CD8 T cells in CD8 T cells - increased FACS effector memory CD4 T cells in CD4 T cells - decreased FACS effector memory CD4 T cells in CD4 T cells - increased FACS effector memory CD8 T cells in CD8 T cells - decreased FACS effector memory CD8 T cells in CD8 T cells - increased FACS effector T cells - decreased FACS effector T cells - increased FACS IgD MFI - decreased FACS IgD MFI - increased FACS IgD+ B cell percentage - decreased FACS IgD+ B cell percentage - increased FACS IgM MFI - decreased FACS IgM MFI - increased FACS IgM+ B cells - decreased FACS IgM+ B cells - increased FACS macrophages - decreased FACS macrophages - increased FACS memory T cells - decreased FACS memory T cells - increased FACS naive CD4 T cells in CD4 T cells - decreased FACS naive CD4 T cells in CD4 T cells - increased FACS naive CD8 T cells in CD8 T cells - decreased FACS naive CD8 T cells in CD8 T cells - increased FACS naïve T cells - decreased FACS naïve T cells - increased FACS neutrophils - decreased FACS neutrophils - increased FACS NK cells - decreased FACS NK cells - increased FACS NK T cells - decreased FACS NK T cells - increased FACS NKT cells (tet) - decreased FACS NKT cells (tet) - increased FACS pDCs - decreased FACS pDCs - increased FACS T cells - decreased FACS T cells - increased fasting hyperglycemia fasting hyperglycemia (female) fasting hyperglycemia (male) fasting hypoglycemia fasting hypoglycemia (female) fasting hypoglycemia (male) Fasting Insulin - decreased Fasting Insulin - increased Fasting Insulin (Female) - decreased Fasting Insulin (Female) - increased Fasting Insulin (Male) - decreased Fasting Insulin (Male) - increased growth/size hearing/vestibular/ear hematopoietic competition - disadvantage hematopoietic system homeostasis/metabolism hypersensitivity to TLR CpGODN + IFNg hyposensitivity to TLR CpGODN + IFNg IgA response to 2nd OVA/Alum Challenge (day 7) - decreased IgA response to 2nd OVA/Alum Challenge (day 7) - increased IgE response to a Cysteine Protease (Papain) - decreased IgE response to a Cysteine Protease (Papain) - increased IgG1 response to a Cysteine Protease (Papain) - decreased IgG1 response to a Cysteine Protease (Papain) - increased immune system impaired response to dsDNA- type I IFN production by macrophages inflammatory bowel disease phenotype influenza proliferation in macrophages - decreased influenza proliferation in macrophages - increased influenza resistance iron deficiency iron excess LCMV clone 13 resistance lethality-embryonic/perinatal lethality-postnatal life span-post-weaning/aging limbs/digits/tail phenotype liver/biliary system LPS Hypersensitivity - decreased LPS Hypersensitivity - increased LPS-induced Necroptosis - decreased LPS-induced Necroptosis - increased Macrophage necroptosis: high Macrophage necroptosis: low MCMV proliferation in macrophages - decreased MCMV proliferation in macrophages - increased MCMV resistance MCMV susceptibility Motor: rotarod weight Motor: Rotarod Weight - decreased Motor: Rotarod Weight - increased MTT dsDNA PECs - decreased MTT dsDNA PECs - increased MTT Value of PECs - decreased MTT Value of PECs - increased muscle naive T cells - increased NALP3 inflammasome signaling defect nervous system NK cell response - decreased NK killing - decreased NK killing - increased Nlrc4 inflammasome: high response Nlrc4 inflammasome: low response NLRP3 inflammasome: high response NLRP3 inflammasome: low response no phenotypic analysis normal phenotype other phenotype OVA-specific IgE - decreased OVA-specific IgE - increased OVA-specific IgE after 2nd OVA/Alum - decreased OVA-specific IgE after 2nd OVA/Alum - increased Peritoneal exudates B1a cell % - decreased Peritoneal exudates B1a cell % - increased Peritoneal exudates B1a cell numbers - decreased Peritoneal exudates B1a cell numbers - increased Peritoneal exudates B1b cell % - decreased Peritoneal exudates B1b cell % - increased Peritoneal exudates B1b cell numbers - decreased Peritoneal exudates B1b cell numbers - increased Peritoneal exudates macrophage % - decreased Peritoneal exudates macrophage % - increased Peritoneal exudates macrophage numbers - decreased Peritoneal exudates macrophage numbers - increased Peritoneal exudates neutrophil % - decreased Peritoneal exudates neutrophil % - increased Peritoneal exudates neutrophil numbers - decreased Peritoneal exudates neutrophil numbers - increased phagocytosis in PECs - decreased phagocytosis in PECs - increased pigmentation polycythemia post-MCMV FACS B cells - decreased post-MCMV FACS B cells - increased post-MCMV FACS B:T cells - decreased post-MCMV FACS B:T cells - increased post-MCMV FACS B1 cells - decreased post-MCMV FACS B1 cells - increased post-MCMV FACS B1a cells - decreased post-MCMV FACS B1a cells - increased post-MCMV FACS B1a cells in B1 cells - decreased post-MCMV FACS B1a cells in B1 cells - increased post-MCMV FACS B1b cells - decreased post-MCMV FACS B1b cells - increased post-MCMV FACS B1b cells in B1 cells - decreased post-MCMV FACS B1b cells in B1 cells - increased post-MCMV FACS B2 cells - decreased post-MCMV FACS B2 cells - increased post-MCMV FACS B220 MFI - decreased post-MCMV FACS B220 MFI - increased post-MCMV FACS CD11b+ DCs (gated in CD11c+ cells) - decreased post-MCMV FACS CD11b+ DCs (gated in CD11c+ cells) - increased post-MCMV FACS CD11c+ DCs - decreased post-MCMV FACS CD11c+ DCs - increased post-MCMV FACS CD4:CD8 - decreased post-MCMV FACS CD4:CD8 - increased post-MCMV FACS CD4+ T cells - decreased post-MCMV FACS CD4+ T cells - increased post-MCMV FACS CD4+ T cells in CD3+ T cells - decreased post-MCMV FACS CD4+ T cells in CD3+ T cells - increased post-MCMV FACS CD44+ CD4 MFI - decreased post-MCMV FACS CD44+ CD4 MFI - increased post-MCMV FACS CD44+ CD4 T cells - decreased post-MCMV FACS CD44+ CD4 T cells - increased post-MCMV FACS CD44+ CD8 MFI - decreased post-MCMV FACS CD44+ CD8 MFI - increased post-MCMV FACS CD44+ CD8 T cells - decreased post-MCMV FACS CD44+ CD8 T cells - increased post-MCMV FACS CD44+ T cells - decreased post-MCMV FACS CD44+ T cells - increased post-MCMV FACS CD44+ T MFI - decreased post-MCMV FACS CD44+ T MFI - increased post-MCMV FACS CD8 response - decreased post-MCMV FACS CD8 response - increased post-MCMV FACS CD8+ T cells - decreased post-MCMV FACS CD8+ T cells - increased post-MCMV FACS CD8+ T cells in CD3+ T cells - decreased post-MCMV FACS CD8+ T cells in CD3+ T cells - increased post-MCMV FACS CD8a+ DCs (gated in CD11c+ cells) - decreased post-MCMV FACS CD8a+ DCs (gated in CD11c+ cells) - increased post-MCMV FACS central memory CD4 T cells in CD4 T cells - decreased post-MCMV FACS central memory CD4 T cells in CD4 T cells - increased post-MCMV FACS central memory CD8 T cells in CD8 T cells - decreased post-MCMV FACS central memory CD8 T cells in CD8 T cells - increased post-MCMV FACS effector memory CD4 T cells in CD4 T cells - decreased post-MCMV FACS effector memory CD4 T cells in CD4 T cells - increased post-MCMV FACS effector memory CD8 T cells in CD8 T cells - decreased post-MCMV FACS effector memory CD8 T cells in CD8 T cells - increased post-MCMV FACS effector T cells - decreased post-MCMV FACS effector T cells - increased post-MCMV FACS IgD MFI - decreased post-MCMV FACS IgD MFI - increased post-MCMV FACS IgD+ B cell percentage - decreased post-MCMV FACS IgD+ B cell percentage - increased post-MCMV FACS IgM MFI - decreased post-MCMV FACS IgM MFI - increased post-MCMV FACS IgM+ B cells - decreased post-MCMV FACS IgM+ B cells - increased post-MCMV FACS macrophages - decreased post-MCMV FACS macrophages - increased post-MCMV FACS memory T cells - decreased post-MCMV FACS memory T cells - increased post-MCMV FACS naive CD4 T cells in CD4 T cells - decreased post-MCMV FACS naive CD4 T cells in CD4 T cells - increased post-MCMV FACS naive CD8 T cells in CD8 T cells - decreased post-MCMV FACS naive CD8 T cells in CD8 T cells - increased post-MCMV FACS naïve T cells - decreased post-MCMV FACS naïve T cells - increased post-MCMV FACS neutrophils - decreased post-MCMV FACS neutrophils - increased post-MCMV FACS NK cell response - decreased post-MCMV FACS NK cell response - increased post-MCMV FACS NK cells - decreased post-MCMV FACS NK cells - increased post-MCMV FACS NK T cells - decreased post-MCMV FACS NK T cells - increased post-MCMV FACS NKT cells (tet) - decreased post-MCMV FACS NKT cells (tet) - increased post-MCMV FACS pDCs - decreased post-MCMV FACS pDCs - increased post-MCMV FACS T cells - decreased post-MCMV FACS T cells - increased ratio of OVA-specific IgE over the total IgE - decreased ratio of OVA-specific IgE over the total IgE - increased renal/urinary system reproductive system respiratory system response to injected CpG DNA - decreased RVFV proliferation in macrophages - decreased RVFV proliferation in macrophages - increased RVFV susceptibility secretory SlgA after 2nd OVA/Alum Challenge (day 7) - decreased secretory SlgA after 2nd OVA/Alum Challenge (day 7) - increased skeleton phenotype skin/coat/nails taste/olfaction T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization T-dependent humoral response defect- decreased antibody response to rSFV T-dependent humoral response defect- increased antibody response to OVA+ alum immunization T-dependent humoral response defect- increased antibody response to rSFV T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization T-independent B cell response defect- increased TNP-specific IgM to TNP-Ficoll immunization TLR signaling defect: hypersensitivity to CpG TLR signaling defect: hypersensitivity to CpG + IFNg TLR signaling defect: hypersensitivity to LPS TLR signaling defect: hypersensitivity to MALP2 TLR signaling defect: hypersensitivity to PAM3CSK4 TLR signaling defect: hypersensitivity to poly I:C TLR signaling defect: hypersensitivity to poly I:C + IFNg TLR signaling defect: hypersensitivity to R848 TLR signaling defect: hyposensitivity to CpG TLR signaling defect: hyposensitivity to CpG + IFNg TLR signaling defect: hyposensitivity to LPS TLR signaling defect: hyposensitivity to MALP2 TLR signaling defect: hyposensitivity to PAM3CSK4 TLR signaling defect: hyposensitivity to poly I:C TLR signaling defect: hyposensitivity to poly I:C + IFNg TLR signaling defect: hyposensitivity to R848 TLR signaling defect: TNF production by macrophages TLR signaling defect: type I IFN production by macrophages TLR signaling defect: type I IFN production by pDC Total Cholesterol - decreased Total Cholesterol - increased total IgE after 2nd OVA/Alum - decreased total IgE after 2nd OVA/Alum - increased Total IgE After 2nd OVA/Alum Challenge (day 7) - decreased Total IgE After 2nd OVA/Alum Challenge (day 7) - increased total IgE level - decreased total IgE level - increased touch/vibrissae tumorigenesis vision/eye
and none of any of 125-03 Response - decreased 125-03 Response - increased 30 min GTT hyperglycemic 30 min GTT hyperglycemic (male) 30 min GTT hyperoglycemic (female) 30 min GTT hypoglycemic 30 min GTT hypoglycemic (female) 30 min GTT hypoglycemic (male) 30 Min. Insulin - decreased 30 Min. Insulin - increased 30 Min. Insulin (Female) - decreased 30 Min. Insulin (Female) - increased 30 Min. Insulin (Male) - decreased 30 Min. Insulin (Male) - increased adenovirus infection of macrophages - decreased adenovirus infection of macrophages - increased adipose tissue anemia Anophthalmia autoimmunity behavior/neurological Blood Analysis Platelet Count - decreased Blood Analysis Platelet Count - increased Blood pressure defect: decrease in SBP day 1 Blood pressure defect: decrease in SBP day 2 Blood pressure defect: increase in SBP day 2 Blood Pressure: DBP Average - decreased Blood Pressure: DBP Average - increased Blood Pressure: DBP Day 1 - decreased Blood Pressure: DBP Day 1 - increased Blood Pressure: DBP Day 2 - decreased Blood Pressure: DBP Day 2 - increased Blood Pressure: DBP Day 3 - decreased Blood Pressure: DBP Day 3 - increased Blood Pressure: DBP Day 4 - decreased Blood Pressure: DBP Day 4 - increased Blood Pressure: HR Average - decreased Blood Pressure: HR Average - increased Blood Pressure: HR Day 1 - decreased Blood Pressure: HR Day 1 - increased Blood Pressure: HR Day 2 - decreased Blood Pressure: HR Day 2 - increased Blood Pressure: HR Day 3 - decreased Blood Pressure: HR Day 3 - increased Blood Pressure: HR Day 4 - decreased Blood Pressure: HR Day 4 - increased Blood Pressure: MBP Average - decreased Blood Pressure: MBP Average - increased Blood Pressure: MBP Day 1 - decreased Blood Pressure: MBP Day 1 - increased Blood Pressure: MBP Day 2 - decreased Blood Pressure: MBP Day 2 - increased Blood Pressure: MBP Day 3 - decreased Blood Pressure: MBP Day 3 - increased Blood Pressure: MBP Day 4 - decreased Blood Pressure: MBP Day 4 - increased Blood Pressure: SBP Average - decreased Blood Pressure: SBP Average - increased Blood Pressure: SBP Day 1 - decreased Blood Pressure: SBP Day 1 - increased Blood Pressure: SBP Day 2 - decreased Blood Pressure: SBP Day 2 - increased Blood Pressure: SBP Day 3 - decreased Blood Pressure: SBP Day 3 - increased Blood Pressure: SBP Day 4 - decreased Blood Pressure: SBP Day 4 - increased Body Weight - decreased Body Weight - increased Body Weight (BP Female) - decreased Body Weight (BP Female) - increased Body Weight (BP Male) - decreased Body Weight (BP Male) - increased Body Weight (BP) - decreased Body Weight (BP) - increased Body Weight (DSS Female) - decreased Body Weight (DSS Female) - increased Body Weight (DSS Male) - decreased Body Weight (DSS Male) - increased Body Weight (DSS) - decreased Body Weight (DSS) - increased Body Weight (Female) - decreased Body Weight (Female) - increased Body Weight (Male) - decreased Body Weight (Male) - increased Bone: Liver Fat - decreased Bone: Liver Fat - increased Bone: Liver Fat (female) - decreased Bone: Liver Fat (female) - increased Bone: Liver Fat (male) - decreased Bone: Liver Fat (male) - increased Bone: Liver Fat (normalized) - decreased Bone: Liver Fat (normalized) - increased Bone: Liver Fat (normalized, female) - decreased Bone: Liver Fat (normalized, female) - increased Bone: Liver Fat (normalized, male) - decreased Bone: Liver Fat (normalized, male) - increased cardiovascular system CD8 response - decreased cellular phenotype craniofacial CTL killing - decreased CTL killing - increased CTL killing dominant epitope - decreased CTL killing dominant epitope - increased CTL killing subdominant epitope - decreased CTL killing subdominant epitope - increased defect in 125-03 response digestive/alimentary dsDNA Antibody - decreased dsDNA Antibody - increased dsDNA induced type I IFN production - decreased dsDNA induced type I IFN production - increased DSS: resistant DSS: resistant day 10 DSS: resistant day 7 DSS: sensitive DSS: sensitive day 10 DSS: sensitive day 7 embryogenesis endocrine/exocrine gland extracellular cGAMP: high response extracellular cGAMP: low response eye: cataract eye: corneal opacity eye: retinal vascular anomaly FACS B cells - decreased FACS B cells - increased FACS B:T cells - decreased FACS B:T cells - increased FACS B1 cells - decreased FACS B1 cells - increased FACS B1a cells - decreased FACS B1a cells - increased FACS B1a cells in B1 cells - decreased FACS B1a cells in B1 cells - increased FACS B1b cells - decreased FACS B1b cells - increased FACS B1b cells in B1 cells - decreased FACS B1b cells in B1 cells - increased FACS B2 cells - decreased FACS B2 cells - increased FACS B220 MFI - decreased FACS B220 MFI - increased FACS CD11b+ DCs (gated in CD11c+ cells) - decreased FACS CD11b+ DCs (gated in CD11c+ cells) - increased FACS CD11c+ DCs - decreased FACS CD11c+ DCs - increased FACS CD4:CD8 - decreased FACS CD4:CD8 - increased FACS CD4+ T cells - decreased FACS CD4+ T cells - increased FACS CD4+ T cells in CD3+ T cells - decreased FACS CD4+ T cells in CD3+ T cells - increased FACS CD44+ CD4 MFI - decreased FACS CD44+ CD4 MFI - increased FACS CD44+ CD4 T cells - decreased FACS CD44+ CD4 T cells - increased FACS CD44+ CD8 MFI - decreased FACS CD44+ CD8 MFI - increased FACS CD44+ CD8 T cells - decreased FACS CD44+ CD8 T cells - increased FACS CD44+ T cells - decreased FACS CD44+ T cells - increased FACS CD44+ T MFI - decreased FACS CD44+ T MFI - increased FACS CD8+ T cells - decreased FACS CD8+ T cells - increased FACS CD8+ T cells in CD3+ T cells - decreased FACS CD8+ T cells in CD3+ T cells - increased FACS CD8a+ DCs (gated in CD11c+ cells) - decreased FACS CD8a+ DCs (gated in CD11c+ cells) - increased FACS central memory CD4 T cells in CD4 T cells - decreased FACS central memory CD4 T cells in CD4 T cells - increased FACS central memory CD8 T cells in CD8 T cells - decreased FACS central memory CD8 T cells in CD8 T cells - increased FACS effector memory CD4 T cells in CD4 T cells - decreased FACS effector memory CD4 T cells in CD4 T cells - increased FACS effector memory CD8 T cells in CD8 T cells - decreased FACS effector memory CD8 T cells in CD8 T cells - increased FACS effector T cells - decreased FACS effector T cells - increased FACS IgD MFI - decreased FACS IgD MFI - increased FACS IgD+ B cell percentage - decreased FACS IgD+ B cell percentage - increased FACS IgM MFI - decreased FACS IgM MFI - increased FACS IgM+ B cells - decreased FACS IgM+ B cells - increased FACS macrophages - decreased FACS macrophages - increased FACS memory T cells - decreased FACS memory T cells - increased FACS naive CD4 T cells in CD4 T cells - decreased FACS naive CD4 T cells in CD4 T cells - increased FACS naive CD8 T cells in CD8 T cells - decreased FACS naive CD8 T cells in CD8 T cells - increased FACS naïve T cells - decreased FACS naïve T cells - increased FACS neutrophils - decreased FACS neutrophils - increased FACS NK cells - decreased FACS NK cells - increased FACS NK T cells - decreased FACS NK T cells - increased FACS NKT cells (tet) - decreased FACS NKT cells (tet) - increased FACS pDCs - decreased FACS pDCs - increased FACS T cells - decreased FACS T cells - increased fasting hyperglycemia fasting hyperglycemia (female) fasting hyperglycemia (male) fasting hypoglycemia fasting hypoglycemia (female) fasting hypoglycemia (male) Fasting Insulin - decreased Fasting Insulin - increased Fasting Insulin (Female) - decreased Fasting Insulin (Female) - increased Fasting Insulin (Male) - decreased Fasting Insulin (Male) - increased growth/size hearing/vestibular/ear hematopoietic competition - disadvantage hematopoietic system homeostasis/metabolism hypersensitivity to TLR CpGODN + IFNg hyposensitivity to TLR CpGODN + IFNg IgA response to 2nd OVA/Alum Challenge (day 7) - decreased IgA response to 2nd OVA/Alum Challenge (day 7) - increased IgE response to a Cysteine Protease (Papain) - decreased IgE response to a Cysteine Protease (Papain) - increased IgG1 response to a Cysteine Protease (Papain) - decreased IgG1 response to a Cysteine Protease (Papain) - increased immune system impaired response to dsDNA- type I IFN production by macrophages inflammatory bowel disease phenotype influenza proliferation in macrophages - decreased influenza proliferation in macrophages - increased influenza resistance iron deficiency iron excess LCMV clone 13 resistance lethality-embryonic/perinatal lethality-postnatal life span-post-weaning/aging limbs/digits/tail phenotype liver/biliary system LPS Hypersensitivity - decreased LPS Hypersensitivity - increased LPS-induced Necroptosis - decreased LPS-induced Necroptosis - increased Macrophage necroptosis: high Macrophage necroptosis: low MCMV proliferation in macrophages - decreased MCMV proliferation in macrophages - increased MCMV resistance MCMV susceptibility Motor: rotarod weight Motor: Rotarod Weight - decreased Motor: Rotarod Weight - increased MTT dsDNA PECs - decreased MTT dsDNA PECs - increased MTT Value of PECs - decreased MTT Value of PECs - increased muscle naive T cells - increased NALP3 inflammasome signaling defect nervous system NK cell response - decreased NK killing - decreased NK killing - increased Nlrc4 inflammasome: high response Nlrc4 inflammasome: low response NLRP3 inflammasome: high response NLRP3 inflammasome: low response no phenotypic analysis normal phenotype other phenotype OVA-specific IgE - decreased OVA-specific IgE - increased OVA-specific IgE after 2nd OVA/Alum - decreased OVA-specific IgE after 2nd OVA/Alum - increased Peritoneal exudates B1a cell % - decreased Peritoneal exudates B1a cell % - increased Peritoneal exudates B1a cell numbers - decreased Peritoneal exudates B1a cell numbers - increased Peritoneal exudates B1b cell % - decreased Peritoneal exudates B1b cell % - increased Peritoneal exudates B1b cell numbers - decreased Peritoneal exudates B1b cell numbers - increased Peritoneal exudates macrophage % - decreased Peritoneal exudates macrophage % - increased Peritoneal exudates macrophage numbers - decreased Peritoneal exudates macrophage numbers - increased Peritoneal exudates neutrophil % - decreased Peritoneal exudates neutrophil % - increased Peritoneal exudates neutrophil numbers - decreased Peritoneal exudates neutrophil numbers - increased phagocytosis in PECs - decreased phagocytosis in PECs - increased pigmentation polycythemia post-MCMV FACS B cells - decreased post-MCMV FACS B cells - increased post-MCMV FACS B:T cells - decreased post-MCMV FACS B:T cells - increased post-MCMV FACS B1 cells - decreased post-MCMV FACS B1 cells - increased post-MCMV FACS B1a cells - decreased post-MCMV FACS B1a cells - increased post-MCMV FACS B1a cells in B1 cells - decreased post-MCMV FACS B1a cells in B1 cells - increased post-MCMV FACS B1b cells - decreased post-MCMV FACS B1b cells - increased post-MCMV FACS B1b cells in B1 cells - decreased post-MCMV FACS B1b cells in B1 cells - increased post-MCMV FACS B2 cells - decreased post-MCMV FACS B2 cells - increased post-MCMV FACS B220 MFI - decreased post-MCMV FACS B220 MFI - increased post-MCMV FACS CD11b+ DCs (gated in CD11c+ cells) - decreased post-MCMV FACS CD11b+ DCs (gated in CD11c+ cells) - increased post-MCMV FACS CD11c+ DCs - decreased post-MCMV FACS CD11c+ DCs - increased post-MCMV FACS CD4:CD8 - decreased post-MCMV FACS CD4:CD8 - increased post-MCMV FACS CD4+ T cells - decreased post-MCMV FACS CD4+ T cells - increased post-MCMV FACS CD4+ T cells in CD3+ T cells - decreased post-MCMV FACS CD4+ T cells in CD3+ T cells - increased post-MCMV FACS CD44+ CD4 MFI - decreased post-MCMV FACS CD44+ CD4 MFI - increased post-MCMV FACS CD44+ CD4 T cells - decreased post-MCMV FACS CD44+ CD4 T cells - increased post-MCMV FACS CD44+ CD8 MFI - decreased post-MCMV FACS CD44+ CD8 MFI - increased post-MCMV FACS CD44+ CD8 T cells - decreased post-MCMV FACS CD44+ CD8 T cells - increased post-MCMV FACS CD44+ T cells - decreased post-MCMV FACS CD44+ T cells - increased post-MCMV FACS CD44+ T MFI - decreased post-MCMV FACS CD44+ T MFI - increased post-MCMV FACS CD8 response - decreased post-MCMV FACS CD8 response - increased post-MCMV FACS CD8+ T cells - decreased post-MCMV FACS CD8+ T cells - increased post-MCMV FACS CD8+ T cells in CD3+ T cells - decreased post-MCMV FACS CD8+ T cells in CD3+ T cells - increased post-MCMV FACS CD8a+ DCs (gated in CD11c+ cells) - decreased post-MCMV FACS CD8a+ DCs (gated in CD11c+ cells) - increased post-MCMV FACS central memory CD4 T cells in CD4 T cells - decreased post-MCMV FACS central memory CD4 T cells in CD4 T cells - increased post-MCMV FACS central memory CD8 T cells in CD8 T cells - decreased post-MCMV FACS central memory CD8 T cells in CD8 T cells - increased post-MCMV FACS effector memory CD4 T cells in CD4 T cells - decreased post-MCMV FACS effector memory CD4 T cells in CD4 T cells - increased post-MCMV FACS effector memory CD8 T cells in CD8 T cells - decreased post-MCMV FACS effector memory CD8 T cells in CD8 T cells - increased post-MCMV FACS effector T cells - decreased post-MCMV FACS effector T cells - increased post-MCMV FACS IgD MFI - decreased post-MCMV FACS IgD MFI - increased post-MCMV FACS IgD+ B cell percentage - decreased post-MCMV FACS IgD+ B cell percentage - increased post-MCMV FACS IgM MFI - decreased post-MCMV FACS IgM MFI - increased post-MCMV FACS IgM+ B cells - decreased post-MCMV FACS IgM+ B cells - increased post-MCMV FACS macrophages - decreased post-MCMV FACS macrophages - increased post-MCMV FACS memory T cells - decreased post-MCMV FACS memory T cells - increased post-MCMV FACS naive CD4 T cells in CD4 T cells - decreased post-MCMV FACS naive CD4 T cells in CD4 T cells - increased post-MCMV FACS naive CD8 T cells in CD8 T cells - decreased post-MCMV FACS naive CD8 T cells in CD8 T cells - increased post-MCMV FACS naïve T cells - decreased post-MCMV FACS naïve T cells - increased post-MCMV FACS neutrophils - decreased post-MCMV FACS neutrophils - increased post-MCMV FACS NK cell response - decreased post-MCMV FACS NK cell response - increased post-MCMV FACS NK cells - decreased post-MCMV FACS NK cells - increased post-MCMV FACS NK T cells - decreased post-MCMV FACS NK T cells - increased post-MCMV FACS NKT cells (tet) - decreased post-MCMV FACS NKT cells (tet) - increased post-MCMV FACS pDCs - decreased post-MCMV FACS pDCs - increased post-MCMV FACS T cells - decreased post-MCMV FACS T cells - increased ratio of OVA-specific IgE over the total IgE - decreased ratio of OVA-specific IgE over the total IgE - increased renal/urinary system reproductive system respiratory system response to injected CpG DNA - decreased RVFV proliferation in macrophages - decreased RVFV proliferation in macrophages - increased RVFV susceptibility secretory SlgA after 2nd OVA/Alum Challenge (day 7) - decreased secretory SlgA after 2nd OVA/Alum Challenge (day 7) - increased skeleton phenotype skin/coat/nails taste/olfaction T-dependent humoral response defect- decreased antibody response to OVA+ alum immunization T-dependent humoral response defect- decreased antibody response to rSFV T-dependent humoral response defect- increased antibody response to OVA+ alum immunization T-dependent humoral response defect- increased antibody response to rSFV T-independent B cell response defect- decreased TNP-specific IgM to TNP-Ficoll immunization T-independent B cell response defect- increased TNP-specific IgM to TNP-Ficoll immunization TLR signaling defect: hypersensitivity to CpG TLR signaling defect: hypersensitivity to CpG + IFNg TLR signaling defect: hypersensitivity to LPS TLR signaling defect: hypersensitivity to MALP2 TLR signaling defect: hypersensitivity to PAM3CSK4 TLR signaling defect: hypersensitivity to poly I:C TLR signaling defect: hypersensitivity to poly I:C + IFNg TLR signaling defect: hypersensitivity to R848 TLR signaling defect: hyposensitivity to CpG TLR signaling defect: hyposensitivity to CpG + IFNg TLR signaling defect: hyposensitivity to LPS TLR signaling defect: hyposensitivity to MALP2 TLR signaling defect: hyposensitivity to PAM3CSK4 TLR signaling defect: hyposensitivity to poly I:C TLR signaling defect: hyposensitivity to poly I:C + IFNg TLR signaling defect: hyposensitivity to R848 TLR signaling defect: TNF production by macrophages TLR signaling defect: type I IFN production by macrophages TLR signaling defect: type I IFN production by pDC Total Cholesterol - decreased Total Cholesterol - increased total IgE after 2nd OVA/Alum - decreased total IgE after 2nd OVA/Alum - increased Total IgE After 2nd OVA/Alum Challenge (day 7) - decreased Total IgE After 2nd OVA/Alum Challenge (day 7) - increased total IgE level - decreased total IgE level - increased touch/vibrissae tumorigenesis vision/eye
and validated validated (with ENU) validated (without ENU) excluded untested (pending) untested (not pending) validated validated (with ENU) validated (without ENU) excluded untested